| G protein beta subunits regulate Cav3.3 T-type channel activity and current kinetics via interaction with the Cav3.3 C-terminus. | G protein β subunits regulate Ca(v)3.3 T-type channel activity and current kinetics via interaction with the Ca(v)3.3 C-terminus.
Jeong S, Lee BY, Rhee JS, Lee JH. | 06/27/2024 |
| Whole Exome Sequencing of Hemiplegic Migraine Patients Shows an Increased Burden of Missense Variants in CACNA1H and CACNA1I Genes. | Whole Exome Sequencing of Hemiplegic Migraine Patients Shows an Increased Burden of Missense Variants in CACNA1H and CACNA1I Genes.
Maksemous N, Harder AVE, Ibrahim O, Vijfhuizen LS, Sutherland H, Pelzer N, de Boer I, Terwindt GM, Lea RA, van den Maagdenberg AMJM, Griffiths LR., Free PMC Article | 04/26/2023 |
| Analysing an allelic series of rare missense variants of CACNA1I in a Swedish schizophrenia cohort. | Analysing an allelic series of rare missense variants of CACNA1I in a Swedish schizophrenia cohort.
Baez-Nieto D, Allen A, Akers-Campbell S, Yang L, Budnik N, Pupo A, Shin YC, Genovese G, Liao M, Pérez-Palma E, Heyne H, Lal D, Lipscombe D, Pan JQ., Free PMC Article | 06/11/2022 |
| Study identified an association between single nucleotide polymorphisms in CADM2 and Sensation Seeking and Drug Experimentation via single variant, gene- and transcriptome-based analyses; CADM2 has been previously implicated in numerous traits related to risk taking. In addition, we identified an association between variants in CACNA1I and Negative Urgency via single-variant and gene-based analyses. | Genome-Wide Association Studies of Impulsive Personality Traits (BIS-11 and UPPS-P) and Drug Experimentation in up to 22,861 Adult Research Participants Identify Loci in the CACNA1I and CADM2 genes.
Sanchez-Roige S, Fontanillas P, Elson SL, Gray JC, de Wit H, MacKillop J, Palmer AA., Free PMC Article | 03/21/2020 |
| analyses suggest that a single copy of Chr22: 39665939G > A CACNA1I has the capacity to disrupt CaV3.3 channel-dependent functions, including rebound bursting in TRN neurons, with potential implications for schizophrenia pathophysiology. | A rare schizophrenia risk variant of CACNA1I disrupts Ca(V)3.3 channel activity.
Andrade A, Hope J, Allen A, Yorgan V, Lipscombe D, Pan JQ., Free PMC Article | 06/16/2018 |
| low-voltage activation characteristics of CaV3.3 channels | Contribution of S4 segments and S4-S5 linkers to the low-voltage activation properties of T-type CaV3.3 channels.
Sanchez-Sandoval AL, Herrera Carrillo Z, Díaz Velásquez CE, Delgadillo DM, Rivera HM, Gomora JC., Free PMC Article | 06/9/2018 |
| CACNA1I is a risk gene for schizophrenia in the Han Chinese population | Further evidence for the genetic association between CACNA1I and schizophrenia.
Xie Y, Huang D, Wei L, Luo XJ., Free PMC Article | 04/14/2018 |
| human Cav3.1, Cav3.2, and Cav3.3 T-type channels specifically associate with CaM at helix 2 of the gating brake in the I-II linker of the channels. | Calmodulin regulates Ca(v)3 T-type channels at their gating brake.
Chemin J, Taiakina V, Monteil A, Piazza M, Guan W, Stephens RF, Kitmitto A, Pang ZP, Dolphin AC, Perez-Reyes E, Dieckmann T, Guillemette JG, Spafford JD., Free PMC Article | 01/6/2018 |
| In gastric cancer, expression of all the CACNA (1G, 1H, 1I) genes was associated with overall survival (OS) among stage I-IV patients. By combining the three potential biomarkers, a TTCC signature was developed, which retained a significant association with OS both in stage IV and stage I-III patients. Alterations in CACNA gene expression are linked to tumour prognosis. | Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation.
Fornaro L, Vivaldi C, Lin D, Xue H, Falcone A, Wang Y, Crea F, Bootman MD., Free PMC Article | 10/21/2017 |
| significant association exists between the CACNA1I gene and schizophrenia in the Uighur Chinese population | Genetic risk between the CACNA1I gene and schizophrenia in Chinese Uygur population.
Xu W, Liu Y, Chen J, Guo Q, Liu K, Wen Z, Zhou Z, Song Z, Zhou J, He L, Yi Q, Shi Y., Free PMC Article | 08/19/2017 |
| CACNA1I variant is associated with differential antiepileptic drug response in childhood absence epilepsy. | Pharmacogenetics of antiepileptic drug efficacy in childhood absence epilepsy.
Glauser TA, Holland K, O'Brien VP, Keddache M, Martin LJ, Clark PO, Cnaan A, Dlugos D, Hirtz DG, Shinnar S, Grabowski G, Childhood Absence Epilepsy Study Group., Free PMC Article | 07/1/2017 |
| CaV3.1, CaV3.2 and CaV3.3 channels, are best recognized for their negative voltage of activation and inactivation thresholds that allow them to operate near the resting membrane potential of neurons. | T-type channels: release a brake, engage a gear.
Weiss N, Lacinova L., Free PMC Article | 12/17/2016 |
| Extracellular pressure increases [Ca(2+)]i via Cav3.3, driving a PKC-beta- IKK- IkB-NF-kB pathway that stimulates cancer cell proliferation | Increased extracellular pressure stimulates tumor proliferation by a mechanosensitive calcium channel and PKC-β.
Basson MD, Zeng B, Downey C, Sirivelu MP, Tepe JJ., Free PMC Article | 09/26/2015 |
| Ethanol primarily affects the CaV3.2 isoform of T-type Ca(2)+ channels, acting through protein kinase C. | Ethanol inhibition of a T-type Ca²+ channel through activity of protein kinase C.
Shan HQ, Hammarback JA, Godwin DW., Free PMC Article | 01/25/2014 |
| The sodium channel toxins tetrodotoxin and saxitoxin interact with the alpha-subunit of T-type Ca 2+ channels. | Differential interactions of Na+ channel toxins with T-type Ca2+ channels.
Sun H, Varela D, Chartier D, Ruben PC, Nattel S, Zamponi GW, Leblanc N., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | CACNA1I is not associated with childhood absence epilepsy in the Chinese Han population.
Wang J, Zhang Y, Liang J, Pan H, Wu H, Xu K, Liu X, Jiang Y, Shen Y, Wu X. | 03/13/2008 |
| two distinct regions of the Cav3.3 channel are necessary and sufficient for complete M1 receptor-mediated channel inhibition | Selective inhibition of Cav3.3 T-type calcium channels by Galphaq/11-coupled muscarinic acetylcholine receptors.
Hildebrand ME, David LS, Hamid J, Mulatz K, Garcia E, Zamponi GW, Snutch TP. | 01/21/2010 |
| CatSper1 and CatSper2 can associate with and modulate the function of the Ca(v)3.3 channel, which might be important in the regulation of sperm function. | Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity.
Zhang D, Chen J, Saraf A, Cassar S, Han P, Rogers JC, Brioni JD, Sullivan JP, Gopalakrishnan M. | 01/21/2010 |
| intracellular regions after repeats I and IV play a role in gating interdependently, suggesting a direct interaction, and splice variation of Cav3.3 channels provides a mechanism for fine-tuning latency and duration of low-threshold spikes. | Functional impact of alternative splicing of human T-type Cav3.3 calcium channels.
Murbartián J, Arias JM, Perez-Reyes E. | 01/21/2010 |
| Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability. | Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability.
Chemin J, Monteil A, Perez-Reyes E, Bourinet E, Nargeot J, Lory P., Free PMC Article | 01/21/2010 |