| Identification of CD8(+) T-cell epitope from multiple myeloma-specific antigen AKAP4. | Identification of CD8(+) T-cell epitope from multiple myeloma-specific antigen AKAP4.
Ma N, Liu H, Zhang Y, Liu W, Liang Z, Wang Q, Sun Y, Wang L, Li Y, Ren H, Dong Y., Free PMC Article | 09/3/2022 |
| Silencing of A-kinase anchor protein 4 inhibits the metastasis and growth of non-small cell lung cancer. | Silencing of A-kinase anchor protein 4 inhibits the metastasis and growth of non-small cell lung cancer.
Zhang B, Hu Q, Zhang J, Jin Z, Ruan Y, Xia L, Wang C., Free PMC Article | 04/16/2022 |
| Loss-of-function missense variant of AKAP4 induced male infertility through reduced interaction with QRICH2 during sperm flagella development. | Loss-of-function missense variant of AKAP4 induced male infertility through reduced interaction with QRICH2 during sperm flagella development.
Zhang G, Li D, Tu C, Meng L, Tan Y, Ji Z, Cheng J, Lu G, Lin G, Zhang H, Sun J, Wang M, Du J, Xu W. | 04/16/2022 |
| A new hemizygous missense mutation, c.454TC (p.S152P), in AKAP4 gene is associated with asthenozoospermia. | A new hemizygous missense mutation, c.454T＞C (p.S152P), in AKAP4 gene is associated with asthenozoospermia.
Gu L, Liu X, Yang J, Bai J. | 04/9/2022 |
| A-kinase anchor protein 4 downregulation inhibits various malignant properties and enhances the cytotoxic effect of paclitaxel, and this combinatorial approach could be useful for triple-negative breast cancer treatment. | Knockdown of A-kinase anchor protein 4 inhibits proliferation of triple-negative breast cancer cells in vitro and in vivo.
Jagadish N, Devi S, Gupta N, Suri V, Suri A. | 05/9/2020 |
| Knockdown of AKAP4 inhibits hypoxia-induced epithelial-mesenchymal transition in human gastric cancer cells, at least in part, via inactivation of the Wnt/beta-catenin signaling pathway. | Knockdown of A-kinase anchor protein 4 inhibits hypoxia-induced epithelial-to-mesenchymal transition via suppression of the Wnt/β-catenin pathway in human gastric cancer cells.
Li Q, Tang H, Hu F, Qin C. | 12/21/2019 |
| pro-AKAP4 protein in the fibrous sheath of human ejaculated spermatozoa and in elongating/elongated spermatids in the human testis. In normozoospermia, there were high interindividual variations in pro-AKAP4 levels, and these latter were associated with sperm motility. | A-kinase anchor protein 4 precursor (pro-AKAP4) in human spermatozoa.
Jumeau F, Sigala J, Dossou-Gbete F, Frimat K, Barbotin AL, Buée L, Béhal H, Sergeant N, Mitchell V. | 12/14/2019 |
| This study showed the role of Lactobacilli in down-regulation of TSGA10, AURKC, OIP5 and AKAP4 genes. Such expression change might be involved in the anticancer effects of these Lactobacilli. The underlying mechanisms of these observations are not clear but epigenetic modulatory mechanisms may participate in this process. | Down-regulation of TSGA10, AURKC, OIP5 and AKAP4 genes by Lactobacillus rhamnosus GG and Lactobacillus crispatus SJ-3C-US supernatants in HeLa cell line.
Nouri Z, Neyazi N, Modarressi, Karami F, Abedin-Do A, Taherian-Esfahani Z, Ghafouri-Fard S, Motevaseli E. | 09/7/2019 |
| High AKAP4 expression is associated with reduced sperm motility. | RNASET2 impairs the sperm motility via PKA/PI3K/calcium signal pathways.
Xu Y, Fan Y, Fan W, Jing J, Xue K, Zhang X, Ye B, Ji Y, Liu Y, Ding Z. | 11/3/2018 |
| A significant association was found between AKAP4 gene expression and metastasis (P-value: 0.045), expression of the CTAG1B (NY-ESO-1) gene was not observed in our cases. | AKAP4, SPAG9 and NY-ESO-1 in Iranian Colorectal Cancer Patients as Probable Diagnostic and Prognostic Biomarkers.
Tavakoli Koudehi A, Mahjoubi B, Mirzaei R, Shabani S, Mahjoubi F., Free PMC Article | 08/25/2018 |
| the physiological role of the negative crosstalk between the cAMP/PKA/AKAP4 and the PKC/ERK1/2 pathways is to regulate capacitation and acrosome reaction. | A-Kinase Anchoring Protein 4 (AKAP4) is an ERK1/2 substrate and a switch molecule between cAMP/PKA and PKC/ERK1/2 in human spermatozoa.
Rahamim Ben-Navi L, Almog T, Yao Z, Seger R, Naor Z., Free PMC Article | 06/2/2018 |
| AKAP4 role in the proliferation and metastasis of thyroid cancer.AKAP4 is highly expressed in thyroid cancer. | Silencing of A-Kinase Anchor Protein 4 (AKAP4) Inhibits Proliferation and Progression of Thyroid Cancer.
Han J, Gao W, Su D, Liu Y., Free PMC Article | 03/31/2018 |
| AKAP4 appears to be a novel Colorectal cancer-associated antigen with a potential for developing as a new clinical therapeutic target | A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer.
Jagadish N, Parashar D, Gupta N, Agarwal S, Purohit S, Kumar V, Sharma A, Fatima R, Topno AP, Shaha C, Suri A., Free PMC Article | 09/10/2016 |
| AKAP4 is a highly accurate biomarker for the detection of early stage lung cancer. | AKAP4 is a circulating biomarker for non-small cell lung cancer.
Gumireddy K, Li A, Chang DH, Liu Q, Kossenkov AV, Yan J, Korst RJ, Nam BT, Xu H, Zhang L, Ganepola GA, Showe LC, Huang Q., Free PMC Article | 05/21/2016 |
| SP17/AKAP4/PTTG1 are expressed in both human NSCLC cell lines and primary tumors and can elicit an immunogenic response in lung cancer patients. | Novel antigens in non-small cell lung cancer: SP17, AKAP4, and PTTG1 are potential immunotherapeutic targets.
Mirandola L, Figueroa JA, Phan TT, Grizzi F, Kim M, Rahman RL, Jenkins MR, Cobos E, Jumper C, Alalawi R, Chiriva-Internati M., Free PMC Article | 12/5/2015 |
| The putative role of AKAP4 in early tumorigenesis is implicated as a biomarker and immunotherapeutic target for cervical cancer. | Expression and humoral response of A-kinase anchor protein 4 in cervical cancer.
Agarwal S, Saini S, Parashar D, Verma A, Jagadish N, Batra A, Suri S, Bhatnagar A, Gupta A, Ansari AS, Lohiya NK, Suri A. | 02/8/2014 |
| Ablation of AKAP4 protein caused significant inhibition in cellular proliferation, colony-forming ability, migration and invasion ability of tumor cells. | Gene silencing of A-kinase anchor protein 4 inhibits cervical cancer growth in vitro and in vivo.
Saini S, Agarwal S, Sinha A, Verma A, Parashar D, Gupta N, Ansari AS, Lohiya NK, Jagadish N, Suri A. | 02/8/2014 |
| data suggests that AKAP4 may be used as serum based diagnostic test for an early detection and diagnosis of breast cancer and may be a potential target for immunotherapeutic use | A novel cancer testis antigen, A-kinase anchor protein 4 (AKAP4) is a potential biomarker for breast cancer.
Saini S, Jagadish N, Gupta A, Bhatnagar A, Suri A., Free PMC Article | 09/28/2013 |
| We demonstrate the aberrant expression of AKAP-4 in prostate cancer, which will potentially be developed as a biomarker in prostate cancer. | Identification of AKAP-4 as a new cancer/testis antigen for detection and immunotherapy of prostate cancer.
Chiriva-Internati M, Yu Y, Mirandola L, D'Cunha N, Hardwicke F, Cannon MJ, Cobos E, Kast WM. | 01/21/2012 |
| Role of AKAP4 in sperm motility is unclear, vut absent or weak AKAP4-labelling is associated with absent or weak sperm. motility. | Localization of AKAP4 and tubulin proteins in sperm with reduced motility.
Moretti E, Scapigliati G, Pascarelli NA, Baccetti B, Collodel G. | 01/21/2010 |
| AKAP4 is a novel target for protein S-nitrosylation in spermatozoa. | Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide?
Lefièvre L, Chen Y, Conner SJ, Scott JL, Publicover SJ, Ford WC, Barratt CL., Free PMC Article | 01/21/2010 |