| This case series highlights the clinical presentations and features of 5 affected children (3 Arab families) who harbored the same homozygous RGS9 frameshift mutation, which seems to represent a founder effect for the Arabian Peninsula. | The clinical presentation of bradyopsia in children.
Khan AO. | 06/16/2018 |
| To identify single-nucleotide polymorphisms that contribute to the genetic susceptibility to schizophrenia, we examined the potential association between schizophrenia and 9 single nucleotide polymorphisms in the G-protein signaling 9 gene | Regulators of G-protein signaling 9 genetic variations in Chinese subjects with schizophrenia.
Zhu YS, Li YX, Qiao XM, Zhang HB. | 06/28/2016 |
| These findings indicate a role for RGS9 gene polymorphisms in heroin dependence and may be informative for future genetic or biological studies on heroin dependence. | Evidence for the contribution of genetic variations in regulator of G protein signaling 9 to the genetic susceptibility of heroin dependence.
Zhu Y, Zhang H. | 03/26/2016 |
| the GAP activity of RGS9-2 showed a strong receptor preference for D2R over MOR. Finally, RGS7 displayed an four times greater GAP activity relative to RGS9-2. | Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells.
Masuho I, Xie K, Martemyanov KA., Free PMC Article | 12/14/2013 |
| These studies with humans, rats and mice implicate RGS9-2 as a factor in regulating body weight. | Association between regulator of G protein signaling 9-2 and body weight.
Waugh JL, Celver J, Sharma M, Dufresne RL, Terzi D, Risch SC, Fairbrother WG, Neve RL, Kane JP, Malloy MJ, Pullinger CR, Gu HF, Tsatsanis C, Hamilton SP, Gold SJ, Zachariou V, Kovoor A., Free PMC Article | 04/7/2012 |
| beta-Arrestin2 is required for the inhibition of D3R signaling by RGS9-2. | β-arrestin2 plays permissive roles in the inhibitory activities of RGS9-2 on G protein-coupled receptors by maintaining RGS9-2 in the open conformation.
Zheng M, Cheong SY, Min C, Jin M, Cho DI, Kim KM., Free PMC Article | 01/28/2012 |
| Type 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors | Type 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors.
Masuho I, Wakasugi-Masuho H, Posokhova EN, Patton JR, Martemyanov KA., Free PMC Article | 09/3/2011 |
| The main goal of this review is to illustrate how various functions are fulfilled through the interplay between the intrinsic molecular properties of RGS9 isoforms. | Biology and functions of the RGS9 isoforms.
Martemyanov KA, Arshavsky VY. | 07/30/2011 |
| The expression of RGS9-2 inhibits dopamine-mediated cellular internalization of the dopamine 2 (D2) receptor. | RGS9-2 mediates specific inhibition of agonist-induced internalization of D2-dopamine receptors.
Celver J, Sharma M, Kovoor A. | 10/23/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.
Wang J, Lippman SM, Lee JJ, Yang H, Khuri FR, Kim E, Lin J, Chang DW, Lotan R, Hong WK, Wu X., Free PMC Article | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator) | Integrative predictive model of coronary artery calcification in atherosclerosis.
McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF., Free PMC Article | 04/7/2010 |
| no association with schizophrenia in an Israeli Jewish population | No association between regulator of G-protein signaling 9 (RGS9) and schizophrenia in a Jewish population.
Greenbaum L, Pelov I, Teltsh O, Lerer B, Kohn Y. | 03/1/2010 |
| This is the first report describing a nonsense mutation in RGS9. | Novel mutations and electrophysiologic findings in RGS9- and R9AP-associated retinal dysfunction (Bradyopsia).
Michaelides M, Li Z, Rana NA, Richardson EC, Hykin PG, Moore AT, Holder GE, Webster AR. | 02/22/2010 |
| In the haplotype analysis, a significant association of the AGG haplotype (rs8077696-rs8070231-rs2292593) of the RGS9 gene was found (permutation P = 0.007) | Analysis of genetic variations in the RGS9 gene and antipsychotic-induced tardive dyskinesia in schizophrenia.
Liou YJ, Chen ML, Wang YC, Chen JY, Liao DL, Bai YM, Lin CC, Chen TT, Mo GH, Lai IC, Liou YJ, Chen ML, Wang YC, Chen JY, Liao DL, Bai YM, Lin CC, Chen TT, Mo GH, Lai IC. | 01/21/2010 |
| Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.
Need AC, Keefe RS, Ge D, Grossman I, Dickson S, McEvoy JP, Goldstein DB., Free PMC Article | 02/11/2009 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Analysis of genetic variations in the RGS9 gene and antipsychotic-induced tardive dyskinesia in schizophrenia.
Liou YJ, Chen ML, Wang YC, Chen JY, Liao DL, Bai YM, Lin CC, Chen TT, Mo GH, Lai IC, Liou YJ, Chen ML, Wang YC, Chen JY, Liao DL, Bai YM, Lin CC, Chen TT, Mo GH, Lai IC. | 06/29/2008 |
| Observational study of genotype prevalence. (HuGE Navigator) | [Analysis of GUCA1B,GNGT1 and RGS9 genes in patients with retinitis pigmentosa].
Zhang QJ, Li W, Xiao XS, Li SQ, Guo XM. | 03/13/2008 |
| homozygous mutations in RGS9 gene that encodes the photoreceptor GTPase accelerating protein and its anchor protein, respectively, have been identifird in patients with bradyopsia. | Bradyopsia in an Asian man.
Cheng JY, Luu CD, Yong VH, Mathur R, Aung T, Vithana EN. | 01/21/2010 |
| five unrelated patients with recessive mutations in the genes encoding either RGS9 or R9AP who report difficulty adapting to sudden changes in luminance levels mediated by cones | Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation.
Nishiguchi KM, Sandberg MA, Kooijman AC, Martemyanov KA, Pott JW, Hagstrom SA, Arshavsky VY, Berson EL, Dryja TP. | 01/21/2010 |
| under certain conditions, RGS9 and Gbeta5 may possibly function as betagamma dimer | Enhancement of pheromone response by RGS9 and Gbeta5 in yeast.
Ajit SK, Young KH. | 01/21/2010 |