| Upregulated lncHRK2:1 prompts nucleus pulposus cell senescence in intervertebral disc degeneration. | Upregulated lnc‑HRK‑2:1 prompts nucleus pulposus cell senescence in intervertebral disc degeneration.
Liang D, Hong D, Tang F, Wang Y, Li J, Li L, Chen H., Free PMC Article | 05/15/2021 |
| YAP-Mediated Repression of HRK Regulates Tumor Growth, Therapy Response, and Survival Under Tumor Environmental Stress in Neuroblastoma. | YAP-Mediated Repression of HRK Regulates Tumor Growth, Therapy Response, and Survival Under Tumor Environmental Stress in Neuroblastoma.
Shim J, Lee JY, Jonus HC, Arnold A, Schnepp RW, Janssen KM, Maximov V, Goldsmith KC. | 02/6/2021 |
| Characterization of an alternative BAK-binding site for BH3 peptides. | Characterization of an alternative BAK-binding site for BH3 peptides.
Ye K, Meng WX, Sun H, Wu B, Chen M, Pang YP, Gao J, Wang H, Wang J, Kaufmann SH, Dai H., Free PMC Article | 09/5/2020 |
| In individuals with susceptible genetic backgrounds, Coxsackie B viral infection alters the epigenome to activate the pathological pathways leading to polymyositis-dermatomyositis via mitochondrial dysfunction and HRK up-regulation. | Mitochondrial dysfunction and role of harakiri in the pathogenesis of myositis.
Boehler JF, Horn A, Novak JS, Li N, Ghimbovschi S, Lundberg IE, Alexanderson H, Alemo Munters L, Jaiswal JK, Nagaraju K., Free PMC Article | 04/18/2020 |
| The apoptosis phenotype was partly dependent on HRK upregulation, as HRK knockdown significantly abrogated the sensitization. KDM2B-silenced tumors exhibited slower growth in vivo. Taken together, our findings suggest a novel mechanism, where the key apoptosis components are under epigenetic control of KDM2B in glioblastoma multiforme cells. | KDM2B, an H3K36-specific demethylase, regulates apoptotic response of GBM cells to TRAIL.
Kurt IC, Sur I, Kaya E, Cingoz A, Kazancioglu S, Kahya Z, Toparlak OD, Senbabaoglu F, Kaya Z, Ozyerli E, Karahüseyinoglu S, Lack NA, Gümüs ZH, Onder TT, Bagci-Onder T., Free PMC Article | 04/14/2018 |
| miR-23a-3p, miR-23b-3p, and miR-149-5p, were downregulated by cytokines and selected for further studies. These miRNAs were found to regulate the expression of the proapoptotic Bcl-2 proteins DP5 and PUMA and consequent human beta-cell apoptosis. | MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells.
Grieco FA, Sebastiani G, Juan-Mateu J, Villate O, Marroqui L, Ladrière L, Tugay K, Regazzi R, Bugliani M, Marchetti P, Dotta F, Eizirik DL., Free PMC Article | 06/10/2017 |
| our findings suggest that induction of the BH3-only protein Hrk is a critical step in 2-ME activation of the JNK-induced apoptotic pathway, targeting mitochondria by liberating proapoptotic protein Bak. | Hrk mediates 2-methoxyestradiol-induced mitochondrial apoptotic signaling in prostate cancer cells.
Chang I, Majid S, Saini S, Zaman MS, Yamamura S, Chiyomaru T, Shahryari V, Fukuhara S, Deng G, Dahiya R, Tanaka Y. | 03/1/2014 |
| SUZ12 promotes the proliferation of human EOC cells by inhibiting apoptosis and HRK is a novel SUZ12 target gene whose upregulation contributes to apoptosis induced by SUZ12 knockdown. | SUZ12 promotes human epithelial ovarian cancer by suppressing apoptosis via silencing HRK.
Li H, Cai Q, Wu H, Vathipadiekal V, Dobbin ZC, Li T, Hua X, Landen CN, Birrer MJ, Sánchez-Beato M, Zhang R., Free PMC Article | 07/6/2013 |
| Diva binds peptides derived from the BH3 domain of several other proapoptotic Bcl-2 proteins, including mouse Harakiri, Bid, Bak and Bmf. | Nuclear magnetic resonance study of protein-protein interactions involving apoptosis regulator Diva (Boo) and the BH3 domain of proapoptotic Bcl-2 members.
Santiveri CM, Sborgi L, de Alba E. | 04/27/2013 |
| The BH3-only protein harakiri (HRK) is transactivated by ATF4 in severe hypoxia through direct binding of ATF4 to the promoter region. | ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia.
Pike LR, Phadwal K, Simon AK, Harris AL. | 04/13/2013 |
| Data suggest that DP5 and PUMA/BBC3 (p53 up-regulated modulator of apoptosis/bcl-2-binding component 3) contribute to palmitate-induced apoptosis of pancreatic beta-cells via lipotoxic endoplasmic reticulum stress. | Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis.
Cunha DA, Igoillo-Esteve M, Gurzov EN, Germano CM, Naamane N, Marhfour I, Fukaya M, Vanderwinden JM, Gysemans C, Mathieu C, Marselli L, Marchetti P, Harding HP, Ron D, Eizirik DL, Cnop M., Free PMC Article | 01/26/2013 |
| These results are used to propose a tentative structural model of how Harakiri works. | Intrinsic order and disorder in the bcl-2 member harakiri: insights into its proapoptotic activity.
Barrera-Vilarmau S, Obregón P, de Alba E., Free PMC Article | 11/5/2011 |
| analysis of a novel interaction between Bcl-2 members Diva and Harakiri | Characterization of a novel interaction between Bcl-2 members Diva and Harakiri.
Sborgi L, Barrera-Vilarmau S, Obregón P, de Alba E., Free PMC Article | 07/9/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma.
Kelly JL, Novak AJ, Fredericksen ZS, Liebow M, Ansell SM, Dogan A, Wang AH, Witzig TE, Call TG, Kay NE, Habermann TM, Slager SL, Cerhan JR., Free PMC Article | 12/5/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Aberrant 5'-CpG methylation status and loss of heterozygosity on 12q13.1 are associated with HRK expression in human malignancies, including prostate cancers, astrocytic tumors and primary central nervous system lymphomas. Review. | The role of HRK gene in human cancer.
Nakamura M, Shimada K, Konishi N. | 01/21/2010 |
| HRK appears to be inactivated principally by promoter hypermethylation in prostate cancers and decreased expression may play an important role in tumor progression by modulating apoptotic cell death | HRK inactivation associated with promoter methylation and LOH in prostate cancer.
Higuchi T, Nakamura M, Shimada K, Ishida E, Hirao K, Konishi N. | 01/21/2010 |
| in response to PAHs, Ahr-mediated activation of the harakiri, BCL2 interacting protein (contains only BH3 domain), was necessary for execution of cell death. | Maternal exposure to polycyclic aromatic hydrocarbons diminishes murine ovarian reserve via induction of Harakiri.
Jurisicova A, Taniuchi A, Li H, Shang Y, Antenos M, Detmar J, Xu J, Matikainen T, Benito Hernández A, Nunez G, Casper RF., Free PMC Article | 01/21/2010 |
| Data report that human oocytes and fragmenting preimplantation embryos possess transcripts encoding Harakiri and caspase-3. | Expression of apoptosis-related genes during human preimplantation embryo development: potential roles for the Harakiri gene product and Caspase-3 in blastomere fragmentation.
Jurisicova A, Antenos M, Varmuza S, Tilly JL, Casper RF. | 01/21/2010 |
| apoptosis inducers as diverse as oncoprotein inhibitors and cell death receptor activators trigger Hrk expression via blockade of DREAM in leukemia cells | Fas signaling and blockade of Bcr-Abl kinase induce apoptotic Hrk protein via DREAM inhibition in human leukemia cells.
Sanz C, Horita M, Fernandez-Luna JL. | 01/21/2010 |
| HRK is a target of epigenetic inactivation in colorectal and gastric cancer | Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer.
Obata T, Toyota M, Satoh A, Sasaki Y, Ogi K, Akino K, Suzuki H, Murai M, Kikuchi T, Mita H, Itoh F, Issa JP, Tokino T, Imai K. | 01/21/2010 |
| Hrk is involved in the induction of apoptosis in RGCs after optic nerve transection. | Up-regulation of Hrk, a regulator of cell death, in retinal ganglion cells of axotomized rat retina.
Wakabayashi T, Kosaka J, Hommura S. | 01/21/2010 |
| The interaction between HRK and cellular protein p32 was studied. HRK-induced apoptosis was suppresssed by the expression of p32 mutants lacking the N-terminal sequences 74-282 and the C-terminal sequences 1-221. | Physical and functional interaction between BH3-only protein Hrk and mitochondrial pore-forming protein p32.
Sunayama J, Ando Y, Itoh N, Tomiyama A, Sakurada K, Sugiyama A, Kang D, Tashiro F, Gotoh Y, Kuchino Y, Kitanaka C. | 01/21/2010 |