| The Helix-Loop-Helix motif of human EIF3A regulates translation of proliferative cellular mRNAs. | The Helix-Loop-Helix motif of human EIF3A regulates translation of proliferative cellular mRNAs.
Volegova MP, Hermosillo C, Cate JHD., Free PMC Article | 10/24/2023 |
| eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content. | eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content.
Duan H, Zhang S, Zarai Y, Öllinger R, Wu Y, Sun L, Hu C, He Y, Tian G, Rad R, Kong X, Cheng Y, Tuller T, Wolf DA., Free PMC Article | 07/6/2023 |
| Translation initiation factor eIF3a regulates glucose metabolism and cell proliferation via promoting small GTPase Rheb synthesis and AMPK activation. | Translation initiation factor eIF3a regulates glucose metabolism and cell proliferation via promoting small GTPase Rheb synthesis and AMPK activation.
Ma S, Dong Z, Huang Y, Liu JY, Zhang JT., Free PMC Article | 07/30/2022 |
| YTHDF3 Facilitates eIF2AK2 and eIF3A Recruitment on mRNAs to Regulate Translational Processes in Oxaliplatin-Resistant Colorectal Cancer. | YTHDF3 Facilitates eIF2AK2 and eIF3A Recruitment on mRNAs to Regulate Translational Processes in Oxaliplatin-Resistant Colorectal Cancer.
Zhao Y, Zhao H, Zhang D, Quan Q, Ge Y, Li L, Guo L. | 07/23/2022 |
| eIF3a regulation of mTOR signaling and translational control via HuR in cellular response to DNA damage. | eIF3a regulation of mTOR signaling and translational control via HuR in cellular response to DNA damage.
Ma S, Dong Z, Huang Y, Liu JY, Zhang JT., Free PMC Article | 05/7/2022 |
| eIF3a R803K mutation mediates chemotherapy resistance by inducing cellular senescence in small cell lung cancer. | eIF3a R803K mutation mediates chemotherapy resistance by inducing cellular senescence in small cell lung cancer.
Chen YX, Wang CJ, Xiao DS, He BM, Li M, Yi XP, Zhang W, Yin JY, Liu ZQ. | 03/12/2022 |
| Knockdown of eIF3a attenuated cell growth in K1 human thyroid cancer cells. | Knockdown of eIF3a attenuated cell growth in K1 human thyroid cancer cells.
Zheng X, Wang S, Hong S, Liu J, Jiang C. | 01/29/2022 |
| The effect of eIF3a on anthracycline-based chemotherapy resistance by regulating DSB DNA repair. | The effect of eIF3a on anthracycline-based chemotherapy resistance by regulating DSB DNA repair.
Chen J, Liu JY, Dong ZZ, Zou T, Wang Z, Shen Y, Zhuo W, Li XP, Xiao D, Liu HT, Chen X, Zhou HH, Liu ZQ, Zhang JT, Yin JY. | 11/22/2021 |
| LncRNA H19 promotes keloid formation through targeting the miR-769-5p/EIF3A pathway. | LncRNA H19 promotes keloid formation through targeting the miR-769-5p/EIF3A pathway.
Xu L, Sun N, Li G, Liu L. | 08/7/2021 |
| MicroRNA8755p inhibits tumor growth and metastasis of hepatocellular carcinoma by targeting eukaryotic translation initiation factor 3 subunit a. | MicroRNA‑875‑5p inhibits tumor growth and metastasis of hepatocellular carcinoma by targeting eukaryotic translation initiation factor 3 subunit a.
Chen T, Sun L, Yao B, Wang L, Wang Y, Niu Y, Liu R, Mo H, Liu Z, Tu K, Liu Q., Free PMC Article | 07/10/2021 |
| Results found EIF3A highly expressed lung cancer and has a significant effect on the survival rate of the patients. | Circular RNA screening from EIF3a in lung cancer.
Huang MS, Yuan FQ, Gao Y, Liu JY, Chen YX, Wang CJ, He BM, Zhou HH, Liu ZQ., Free PMC Article | 08/12/2020 |
| Here, the authors show that human eukaryotic translation initiation factor 3 (eIF3) acts as a distinct repressor of FTL mRNA translation, and eIF3-mediated FTL repression is disrupted by a subset of single nucleotide polymorphisms in FTL that cause hyperferritinemia. | Repression of ferritin light chain translation by human eIF3.
Pulos-Holmes MC, Srole DN, Juarez MG, Lee AS, McSwiggen DT, Ingolia NT, Cate JH., Free PMC Article | 02/15/2020 |
| siRNA-mediated silencing of eIF3a reduced the polysome-to-monosome ratio in F508del-expressing cells, which, in turn, decreased the translation of CFTR variants, leading to increased CFTR stability, trafficking, and function at the cell surface. | Correcting the F508del-CFTR variant by modulating eukaryotic translation initiation factor 3-mediated translation initiation.
Hutt DM, Loguercio S, Roth DM, Su AI, Balch WE., Free PMC Article | 03/9/2019 |
| miRNA-488 participates in eIF3a mediated cisplatin resistance in non-small-cell lung cance cells. | MiR-488 inhibits proliferation and cisplatin sensibility in non-small-cell lung cancer (NSCLC) cells by activating the eIF3a-mediated NER signaling pathway.
Fang C, Chen YX, Wu NY, Yin JY, Li XP, Huang HS, Zhang W, Zhou HH, Liu ZQ., Free PMC Article | 10/27/2018 |
| Knockdown of elF3a inhibits TGFB1-induced extracellular matrix protein expression in keloid fibroblasts. | Knockdown of elF3a inhibits TGF‑β1‑induced extracellular matrix protein expression in keloid fibroblasts.
Li T, Zhao J. | 08/18/2018 |
| An association between eukaryotic translation initiation factor 3a (eIF3a) gene rs77382849 polymorphism and susceptibility to gastric cancer was observed in Chinese patients. | Impact of a Eukaryotic Translation Initiation Factor 3a Polymorphism on Susceptibility to Gastric Cancer.
Liu K, Lei Z, Yao H, Lei S, Zhao H., Free PMC Article | 07/12/2018 |
| Studies suggest that eukaryotic initiation factor eIF3, which coordinates the progress of most of the initiation steps, does not come off the initiation complex upon subunit joining, but instead it remains bound to 80S ribosomes. | Embraced by eIF3: structural and functional insights into the roles of eIF3 across the translation cycle.
Valášek LS, Zeman J, Wagner S, Beznosková P, Pavlíková Z, Mohammad MP, Hronová V, Herrmannová A, Hashem Y, Gunišová S., Free PMC Article | 12/2/2017 |
| DHX29 and eIF3 cooperate in scanning on structured mRNAs. Our findings support previous genetic data on the role of eIF3 during scanning | DHX29 and eIF3 cooperate in ribosomal scanning on structured mRNAs during translation initiation.
Pisareva VP, Pisarev AV., Free PMC Article | 07/8/2017 |
| interaction involves the first FF motif of p190A and the winged helix/PCI domain of eIF3A, is enhanced by serum stimulation and reduced by phosphatase treatment | Interaction of p190A RhoGAP with eIF3A and Other Translation Preinitiation Factors Suggests a Role in Protein Biosynthesis.
Parasuraman P, Mulligan P, Walker JA, Li B, Boukhali M, Haas W, Bernards A., Free PMC Article | 07/8/2017 |
| The eIF3a Arg803Lys C>T polymorphism is connected with a higher susceptibility to cervical carcinoma and may affect chemoradiotherapy efficacy in and prognosis of cervical carcinoma. | The eIF3a Arg803Lys genetic polymorphism is associated with susceptibility to and chemoradiotherapy efficacy in cervical carcinoma.
Xu JZ, Wen F, Wang XR. | 07/1/2017 |
| The human eIF3b and octameric eIF3a subunits serve as the nucleation core around which other subunits assemble in an ordered way into two interconnected modules: the yeast-like core and the octamer. | Human eIF3b and eIF3a serve as the nucleation core for the assembly of eIF3 into two interconnected modules: the yeast-like core and the octamer.
Wagner S, Herrmannová A, Šikrová D, Valášek LS., Free PMC Article | 06/24/2017 |
| eIF3a may function as a novel regulator to modulate hepatic stellate cell activation, potentially through inhibiting the TGF-beta1/Smad3 signaling pathway. | Knockdown of eIF3a attenuates the pro-fibrogenic response of hepatic stellate cells induced by TGF-β1.
He P, Yu ZJ, Sun CY, Jiao SJ, Jiang HQ. | 01/28/2017 |
| Collybistin forms a complex with mTOR and eIF3 and by sequestering these proteins downregulates mTORC1 signaling and protein synthesis potentially contributing to intellectual disability and autism. | Collybistin binds and inhibits mTORC1 signaling: a potential novel mechanism contributing to intellectual disability and autism.
Machado CO, Griesi-Oliveira K, Rosenberg C, Kok F, Martins S, Passos-Bueno MR, Sertie AL., Free PMC Article | 09/24/2016 |
| eIF3 has a role in controlling cell size independently of S6K1-activity | eIF3 controls cell size independently of S6K1-activity.
Schipany K, Rosner M, Ionce L, Hengstschläger M, Kovacic B., Free PMC Article | 08/13/2016 |
| eIF3a improves ovarian cancer patients' response to cisplatin-based chemotherapy by down regulating XPC and p27(Kip1). | eIF3a improve cisplatin sensitivity in ovarian cancer by regulating XPC and p27Kip1 translation.
Zhang Y, Yu JJ, Tian Y, Li ZZ, Zhang CY, Zhang SF, Cao LQ, Zhang Y, Qian CY, Zhang W, Zhou HH, Yin JY, Liu ZQ., Free PMC Article | 07/30/2016 |