Insulin receptor substrate 2 gene Gly1057Asp polymorphism is a risk factor for nonalcoholic fatty liver disease.
Nouri S, Mahmoudi T, Hojjati F, Najafabadi ZN, Shafiee R, Sayedsalehi S, Dehghanitafti A, Ardalani A, Kohansal K, Rezamand G, Asadi A, Nobakht H, Dabiri R, Farahani H, Tabaeian SP, Zali MR.

Influence of polymorphisms in IRS1, IRS2, MC3R, and MC4R on metabolic and inflammatory status and food intake in Brazilian adults: An exploratory pilot study.
Fajardo CM, Cerda A, Bortolin RH, de Oliveira R, Stefani TIM, Dos Santos MA, Braga AA, Dorea EL, Bernik MMS, Bastos GM, Sampaio MF, Damasceno NRT, Verlengia R, de Oliveira MRM, Hirata MH, Hirata RDC.

The IGF-Independent Role of IRS-2 in the Secretion of MMP-9 Enhances the Growth of Prostate Carcinoma Cell Line PC3.
Furuta H, Sheng Y, Takahashi A, Nagano R, Kataoka N, Perks CM, Barker R, Hakuno F, Takahashi SI., Free PMC Article

Association of IRS-1 and IRS-2 polymorphisms with predisposition to type-2 diabetes (T2D): a meta-analysis and trial sequential analysis.
Luo Q, Ling Z, Huang X, Zuo Y.

Enhancer RNA IRS2e is essential for IRS2 expression and the oncogenic properties in oral squamous cell carcinoma.
Yan L, Wang J, Guo J, Jia R.

Identification of the ageing-related prognostic gene signature, and the associated regulation axis in skin cutaneous melanoma.
Tian C, Liu S, Huo R., Free PMC Article

Structural Consequences of IRS-2 nsSNPs and Implication for Insulin Receptor Substrate-2 Protein Stability.
Zia A, Shams S, Shah M, Afridi SG, Khan A.

MicroRNA-7 Regulates Insulin Signaling Pathway by Targeting IRS1, IRS2, and RAF1 Genes in Gestational Diabetes Mellitus.
Bhushan R, Rani A, Gupta D, Ali A, Dubey PK.

Single nucleotide polymorphisms in binding site of miRNA-135a and targeted gene IRS2 are correlated with multiple clinical features of PCOS: A study in Chinese women.
Gu H, Li L, Zhou B, Li M, Zhong W, Wei X, Zhong X., Free PMC Article

Circular RNA circPRKDC promotes tumorigenesis of gastric cancer via modulating insulin receptor substrate 2 (IRS2) and mediating microRNA-493-5p.
Liu Z, Wang Y, Ding Y., Free PMC Article

SHP2 knockdown ameliorates liver insulin resistance by activating IRS-2 phosphorylation through the AKT and ERK1/2 signaling pathways.
Yue X, Han T, Hao W, Wang M, Fu Y., Free PMC Article

Association of IRS1 (Gly972Arg) and IRS2 (Gly1057Asp) genes polymorphisms with OSA and NAFLD in Asian Indians.
Bhatt SP, Guleria R., Free PMC Article

Multi-layered epigenetic regulation of IRS2 expression in the liver of obese individuals with type 2 diabetes.
Krause C, Geißler C, Tackenberg H, El Gammal AT, Wolter S, Spranger J, Mann O, Lehnert H, Kirchner H., Free PMC Article

The inflammatory role of dysregulated IRS2 in pulmonary vascular remodeling under hypoxic conditions.
Nakahara M, Ito H, Skinner JT, Lin Q, Tamosiuniene R, Nicolls MR, Keegan AD, Johns RA, Yamaji-Kegan K., Free PMC Article

YAP-TEAD up-regulates IRS2 expression to induce and deteriorate oesophageal cancer.
Xu X, Nie J, Lu L, Du C, Meng F, Song D., Free PMC Article

Polymorphism analysis of the Gly972Arg IRS-1 and Gly1057Asp IRS-2 genes in obese pregnant women.
Górska A, Wolek M, Czerny B, Uzar I, Seremak-Mrozikiewicz A, Olbromski P, Baraniak J, Kania-Dobrowolska M, Sienko M, Bogacz A.

The Insulin Receptor Adaptor IRS2 is an APC/C Substrate That Promotes Cell Cycle Protein Expression and a Robust Spindle Assembly Checkpoint.
Manohar S, Yu Q, Gygi SP, King RW., Free PMC Article

SOX21-AS1 modulates neuronal injury of MMP(+)-treated SH-SY5Y cells via targeting miR-7-5p and inhibiting IRS2.
Xie Y, Zhang S, Lv Z, Long T, Luo Y, Li Z.

Repression of Irs2 by let-7 miRNAs is essential for homeostasis of the telencephalic neuroepithelium.
Fernández V, Martínez-Martínez MÁ, Prieto-Colomina A, Cárdenas A, Soler R, Dori M, Tomasello U, Nomura Y, López-Atalaya JP, Calegari F, Borrell V., Free PMC Article

MiRNA-200a-3p suppresses the proliferation, migration and invasion of non-small cell lung cancer through targeting IRS2.
Tan T, Xu XH, Lu XH, Wang XW.

Night-Shift Work Duration and Risk of Colorectal Cancer According to IRS1 and IRS2 Expression.
Shi Y, Liu L, Hamada T, Nowak JA, Giannakis M, Ma Y, Song M, Nevo D, Kosumi K, Gu M, Kim SA, Morikawa T, Wu K, Sui J, Papantoniou K, Wang M, Chan AT, Fuchs CS, Meyerhardt JA, Giovannucci E, Ogino S, Schernhammer ES, Nishihara R, Zhang X., Free PMC Article

A 3'-untranslated region variant (rs2289046) of insulin receptor substrate 2 gene is associated with susceptibility to nonalcoholic fatty liver disease.
Dabiri R, Mahmoudi T, Sabzikarian M, Asadi A, Farahani H, Nobakht H, Maleki I, Mansour-Ghanaei F, Derakshshan F, Zali MR.

Oncogenic ERG Represses PI3K Signaling through Downregulation of IRS2.
Mao N, Gao D, Hu W, Gadal S, Hieronymus H, Wang S, Lee YS, Sullivan P, Zhang Z, Choi D, Rosen N, Sawyers CL, Gopalan A, Chen Y, Carver BS., Free PMC Article

Circ_0000003 promotes the proliferation and metastasis of non-small cell lung cancer cells via miR-338-3p/insulin receptor substrate 2.
Li S, Niu X, Li H, Liang Y, Sun Z, Yan Y., Free PMC Article

microRNA-448 inhibits the progression of non-small-cell lung cancer through regulating IRS2.
Gao J, Feng X, Wang F, Wang J, Wang H, Li H, Zhang W, Hao L, Shi Z.