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    RUNX1 RUNX family transcription factor 1 [ Homo sapiens (human) ]

    Gene ID: 861, updated on 3-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    CDK9 phosphorylates RUNX1 to promote megakaryocytic fate in megakaryocytic-erythroid progenitors.

    CDK9 phosphorylates RUNX1 to promote megakaryocytic fate in megakaryocytic-erythroid progenitors.
    Kwon N, Lu YC, Thompson EN, Mancuso RI, Wang L, Zhang PX, Krause DS.,

    10/25/2024
    RUNX1-PDIA5 Axis Promotes Malignant Progression of Glioblastoma by Regulating CCAR1 Protein Expression.

    RUNX1-PDIA5 Axis Promotes Malignant Progression of Glioblastoma by Regulating CCAR1 Protein Expression.
    Ji Q, Tu Z, Liu J, Zhou Z, Li F, Zhu X, Huang K., Free PMC Article

    09/17/2024
    RUNX1 interacts with lncRNA SMANTIS to regulate monocytic cell functions.

    RUNX1 interacts with lncRNA SMANTIS to regulate monocytic cell functions.
    Weiss LM, Warwick T, Zehr S, Günther S, Wolf S, Schmachtel T, Izquierdo Ponce J, Pálfi K, Teichmann T, Schneider A, Stötzel J, Knapp S, Weigert A, Savai R, Rieger MA, Oellerich T, Wittig I, Oo JA, Brandes RP, Leisegang MS., Free PMC Article

    09/17/2024
    RUNX1/miR-429 feedback loop promotes growth, metastasis, and epithelial-mesenchymal transition in oral squamous cell carcinoma by targeting ITGB1.

    RUNX1/miR-429 feedback loop promotes growth, metastasis, and epithelial-mesenchymal transition in oral squamous cell carcinoma by targeting ITGB1.
    Lu X, Yang Y, Chen J, Zhao T, Zhao X.

    09/10/2024
    [Acute myeloid leukemia with mutated RUNX1 at the university hospitals of Strasbourg].

    [Acute myeloid leukemia with mutated RUNX1 at the university hospitals of Strasbourg].
    Panaget B, Mauvieux L, Miguet L, Fornecker LM, Lioure B, Ledoux MP, Rolland D, Mayeur-Rousse C.

    09/4/2024
    RUNX1 regulates promoter activity in the absence of cognate DNA binding motifs.

    RUNX1 regulates promoter activity in the absence of cognate DNA binding motifs.
    Woodworth AM, Hardy K, Taberlay PC, Dickinson JL, Holloway AF.

    07/11/2024
    RUNX1-induced upregulation of PTGS2 enhances cell growth, migration and invasion in colorectal cancer cells.

    RUNX1-induced upregulation of PTGS2 enhances cell growth, migration and invasion in colorectal cancer cells.
    Zheng W, Guo Y, Kahar A, Bai J, Zhu Q, Huang X, Li Y, Xu B, Jia X, Wu G, Zhang C, Zhu Y., Free PMC Article

    05/30/2024
    A novel t(X;21)(p11.4;q22.12) translocation adds to the role of BCOR and RUNX1 in myelodysplastic syndromes and acute myeloid leukemias.

    A novel t(X;21)(p11.4;q22.12) translocation adds to the role of BCOR and RUNX1 in myelodysplastic syndromes and acute myeloid leukemias.
    Mavridou E, Lema Fernandez AG, Nardelli C, Pierini V, Quintini M, Arniani S, Di Giacomo D, Crescenzi B, Matteucci C, Sambani C, Mecucci C.

    05/7/2024
    The role of RUNX1/NF-kappaB in regulating PVAT inflammation in aortic dissection.

    The role of RUNX1/NF-κB in regulating PVAT inflammation in aortic dissection.
    Wang A, Dong S, Liu B, Liu D, Zou M, Han Y, Yang L, Wang Y., Free PMC Article

    05/6/2024
    RUNX1-BMP2 promotes vasculogenic mimicry in laryngeal squamous cell carcinoma via activation of the PI3K-AKT signaling pathway.

    RUNX1-BMP2 promotes vasculogenic mimicry in laryngeal squamous cell carcinoma via activation of the PI3K-AKT signaling pathway.
    Zhu Q, Zhang X, Lu F, Miao S, Zhang C, Liu Z, Gao Z, Qi M, An X, Geng P, Wang S, Ren H, Han F, Zhang R, Zha D., Free PMC Article

    04/17/2024
    Altered platelet-megakaryocyte endocytosis and trafficking of albumin and fibrinogen in RUNX1 haplodeficiency.

    Altered platelet-megakaryocyte endocytosis and trafficking of albumin and fibrinogen in RUNX1 haplodeficiency.
    Del Carpio-Cano F, Mao G, Goldfinger LE, Wurtzel J, Guan L, Alam MA, Lee K, Poncz M, Rao AK., Free PMC Article

    04/2/2024
    Human umbilical cord mesenchymal stem cells overexpressing RUNX1 promote tendon-bone healing by inhibiting osteolysis, enhancing osteogenesis and promoting angiogenesis.

    Human umbilical cord mesenchymal stem cells overexpressing RUNX1 promote tendon-bone healing by inhibiting osteolysis, enhancing osteogenesis and promoting angiogenesis.
    Guo D, Yang J, Liu D, Zhang P, Sun H, Wang J.

    03/25/2024
    LncRNA H19 Inhibits Keratinocyte Cell Proliferation and Migration by Targeting miR-17-5p/RUNX1 Axis in Chronic Wounds.

    LncRNA H19 Inhibits Keratinocyte Cell Proliferation and Migration by Targeting miR-17-5p/RUNX1 Axis in Chronic Wounds.
    Ji W, Zhang Q, Sun Z, Cheng Y.

    03/12/2024
    Increased RUNX1 mutations in breast cancer disease progression.

    Increased RUNX1 mutations in breast cancer disease progression.
    Ariffin NS.

    02/28/2024
    Clinical characteristics and prognosis of acute myeloid leukemia patients with Runt-related transcription factor 1 mutation: A single-center retrospective analysis.

    Clinical characteristics and prognosis of acute myeloid leukemia patients with Runt-related transcription factor 1 mutation: A single-center retrospective analysis.
    Wang LY, Li Y, Jiang Q, Jiang H, Wang Y, Xu LP, Zhang XH, Liu KY, Tang FF.

    02/21/2024
    RUNX1-IT1 acts as a scaffold of STAT1 and NuRD complex to promote ROS-mediated NF-kappaB activation and ovarian cancer progression.

    RUNX1-IT1 acts as a scaffold of STAT1 and NuRD complex to promote ROS-mediated NF-κB activation and ovarian cancer progression.
    Yu X, Zhao P, Luo Q, Wu X, Wang Y, Nan Y, Liu S, Gao W, Li B, Liu Z, Cui Z.

    02/5/2024
    Genomic landscape of patients with germline RUNX1 variants and familial platelet disorder with myeloid malignancy.

    Genomic landscape of patients with germline RUNX1 variants and familial platelet disorder with myeloid malignancy.
    Yu K, Deuitch N, Merguerian M, Cunningham L, Davis J, Bresciani E, Diemer J, Andrews E, Young A, Donovan F, Sood R, Craft K, Chong S, Chandrasekharappa S, Mullikin J, Liu PP., Free PMC Article

    02/2/2024
    RUNX1 methylation as a cancer biomarker in differentiating papillary thyroid cancer from benign thyroid nodules.

    RUNX1 methylation as a cancer biomarker in differentiating papillary thyroid cancer from benign thyroid nodules.
    Li J, Yin Y, Huang H, Li M, Li H, Zhang M, Jiang C, Yang R.

    01/17/2024
    Hematopoietic Transcription Factor RUNX1 is Essential for Promoting Macrophage-Myofibroblast Transition in Non-Small-Cell Lung Carcinoma.

    Hematopoietic Transcription Factor RUNX1 is Essential for Promoting Macrophage-Myofibroblast Transition in Non-Small-Cell Lung Carcinoma.
    Tang PC, Chan MK, Chung JY, Chan AS, Zhang D, Li C, Leung KT, Ng CS, Wu Y, To KF, Lan HY, Tang PM., Free PMC Article

    01/11/2024
    MYCT1 inhibits hematopoiesis in diffuse large B-cell lymphoma by suppressing RUNX1 transcription.

    MYCT1 inhibits hematopoiesis in diffuse large B-cell lymphoma by suppressing RUNX1 transcription.
    Liang Y, Wei X, Yue PJ, Zhang HC, Li ZN, Wang XX, Sun YY, Fu WN., Free PMC Article

    01/10/2024
    RUNX1 knockdown induced apoptosis and impaired EMT in high-grade serous ovarian cancer cells.

    RUNX1 knockdown induced apoptosis and impaired EMT in high-grade serous ovarian cancer cells.
    Chen Y, He Z, Yang S, Chen C, Xiong W, He Y, Liu S., Free PMC Article

    12/18/2023
    Single-cell RNA-seq reveals novel immune-associated biomarkers for predicting prognosis in AML patients with RUNX1::RUNX1T1.

    Single-cell RNA-seq reveals novel immune-associated biomarkers for predicting prognosis in AML patients with RUNX1::RUNX1T1.
    Li XP, Dai Y, Zhang WN, Pan MM, Mao J, Zhao B, Jiang L, Gao Y.

    11/28/2023
    RUNX1 predicts poor prognosis and correlates with tumor progression in clear cell renal carcinoma.

    RUNX1 predicts poor prognosis and correlates with tumor progression in clear cell renal carcinoma.
    Ma J, He S, Li M, Peng Y, Yang X, Chen L, Jia Q, Liu Y.

    11/14/2023
    RUNX1 promotes proliferation and migration in non-small cell lung cancer cell lines via the mTOR pathway.

    RUNX1 promotes proliferation and migration in non-small cell lung cancer cell lines via the mTOR pathway.
    Ma H, Jiang S, Yuan Y, Li J, Li Y, Lv Y, Du T, Guan J, Jiang X, Tian L, Zheng Q, Yang L, Li Q.

    10/28/2023
    Somatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in RUNX1, GATA2, and DDX41.

    Somatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in RUNX1, GATA2, and DDX41.
    Homan CC, Drazer MW, Yu K, Lawrence DM, Feng J, Arriola-Martinez L, Pozsgai MJ, McNeely KE, Ha T, Venugopal P, Arts P, King-Smith SL, Cheah J, Armstrong M, Wang P, Bödör C, Cantor AB, Cazzola M, Degelman E, DiNardo CD, Duployez N, Favier R, Fröhling S, Rio-Machin A, Klco JM, Krämer A, Kurokawa M, Lee J, Malcovati L, Morgan NV, Natsoulis G, Owen C, Patel KP, Preudhomme C, Raslova H, Rienhoff H, Ripperger T, Schulte R, Tawana K, Velloso E, Yan B, Kim E, Sood R, Hsu AP, Holland SM, Phillips K, Poplawski NK, Babic M, Wei AH, Forsyth C, Mar Fan H, Lewis ID, Cooney J, Susman R, Fox LC, Blombery P, Singhal D, Hiwase D, Phipson B, Schreiber AW, Hahn CN, Scott HS, Liu P, Godley LA, Brown AL, NISC Comparative Sequencing Program., Free PMC Article

    10/26/2023
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