| THOC5 regulates human osteoclastogenesis. | THOC5 regulates human osteoclastogenesis.
Mun SH, Oh B, Lee MJ, Bae S, Yang Y, Park-Min KH., Free PMC Article | 08/13/2022 |
| RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization. | RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization.
Alqassim EY, Sharma S, Khan ANMNH, Emmons TR, Cortes Gomez E, Alahmari A, Singel KL, Mark J, Davidson BA, Robert McGray AJ, Liu Q, Lichty BD, Moysich KB, Wang J, Odunsi K, Segal BH, Baysal BE., Free PMC Article | 07/3/2021 |
| Polymorphism of the THOC5 of the transcription/export multiprotein complex and its correlation with the lipid and metabolic profile in middle-aged women. | Polymorphism of the THOC5 of the transcription/export multiprotein complex and its correlation with the lipid and metabolic profile in middle-aged women.
Loja-Chango R, Salazar-Pousada D, Escobar-Valdivieso GS, Ramírez-Morán C, Espinoza-Caicedo J, Pérez-López FR, Gavilanes AWD, Chedraui P. | 02/13/2021 |
| Human THO maintains the stability of repetitive DNA. | Human THO maintains the stability of repetitive DNA.
Katahira J, Senokuchi K, Hieda M. | 12/12/2020 |
| THOC5 regulates transcription termination and subsequent transcript release from the HSPA1A locus. | Human THO coordinates transcription termination and subsequent transcript release from the HSP70 locus.
Katahira J, Ishikawa H, Tsujimura K, Kurono S, Hieda M. | 05/18/2019 |
| Data suggest that the suppression of the multiple THOC5 target genes may represent a novel strategy for hepatocellular carcinoma (HCC) therapy. | Depletion of three combined THOC5 mRNA export protein target genes synergistically induces human hepatocellular carcinoma cell death.
Saran S, Tran DD, Ewald F, Koch A, Hoffmann A, Koch M, Nashan B, Tamura T. | 09/16/2017 |
| THOC5 to be a novel gene involved in the regulation of serum HDL-C levels | THOC5: a novel gene involved in HDL-cholesterol metabolism.
Keller M, Schleinitz D, Förster J, Tönjes A, Böttcher Y, Fischer-Rosinsky A, Breitfeld J, Weidle K, Rayner NW, Burkhardt R, Enigk B, Müller I, Halbritter J, Koriath M, Pfeiffer A, Krohn K, Groop L, Spranger J, Stumvoll M, Kovacs P., Free PMC Article | 05/17/2014 |
| Authors suggest a model in which human Thoc5 controls polyadenylation site choice through the co-transcriptional loading of CFIm68 onto target genes. | Human TREX component Thoc5 affects alternative polyadenylation site choice by recruiting mammalian cleavage factor I.
Katahira J, Okuzaki D, Inoue H, Yoneda Y, Maehara K, Ohkawa Y., Free PMC Article | 11/16/2013 |
| show that THOC5 Y225 phosphorylation governs mRNA binding. In addition, CXCL12 is shown to induce THOC5 Y225 phosphorylation, and site-directed mutagenesis demonstrates that this modulates motile response | A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5.
Griaud F, Pierce A, Gonzalez Sanchez MB, Scott M, Abraham SA, Holyoake TL, Tran DD, Tamura T, Whetton AD. | 06/8/2013 |
| show here that DNA damage drastically decreased the cytoplasmic pool of a set of THOC5-dependent mRNAs and impaired the THOC5/mRNA complex formation | An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5.
Ramachandran S, Tran DD, Klebba-Faerber S, Kardinal C, Whetton AD, Tamura T., Free PMC Article | 11/26/2011 |
| Thoc5 exhibits in vitro RNA-binding activity and is associated with HSP70 mRNPs in vivo as a component of the stable THO complex | Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA.
Katahira J, Inoue H, Hurt E, Yoneda Y., Free PMC Article | 01/21/2010 |
| THOC7 (50-137, amino acid numbers) binds to the N-terminal portion (1-199) of FMIP directly. | Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP).
El Bounkari O, Guria A, Klebba-Faerber S, Claussen M, Pieler T, Griffiths JR, Whetton AD, Koch A, Tamura T. | 01/21/2010 |
| THOC5 protein expression can potentiate receptor signalling to transcription factor expression and monocyte differentiation. | THOC5 couples M-CSF receptor signaling to transcription factor expression.
Carney L, Pierce A, Rijnen M, Gonzalez Sanchez MB, Hamzah HG, Zhang L, Tamura T, Whetton AD. | 01/21/2010 |