| Single-molecule quantitation of RNA-binding protein occupancy and stoichiometry defines a role for Yra1 (Aly/REF) in nuclear mRNP organization. | Single-molecule quantitation of RNA-binding protein occupancy and stoichiometry defines a role for Yra1 (Aly/REF) in nuclear mRNP organization.
Asada R, Dominguez A, Montpetit B., Free PMC Article | 12/6/2023 |
| the data provide evidence that Yra1 plays a crucial role in DSB repair via homologous recombination. While Yra1 sumoylation and/or ubiquitination are dispensable, the Yra1 C-box region is essential in this process. | The mRNA export adaptor Yra1 contributes to DNA double-strand break repair through its C-box domain.
Infantino V, Tutucci E, Yeh Martin N, Zihlmann A, Garcia-Molinero V, Silvano G, Palancade B, Stutz F., Free PMC Article | 12/21/2019 |
| Yra1 binds RNA-DNA hybrids in vitro and, when artificially overexpressed, can be recruited to chromatin in an RNA-DNA hybrid-dependent manner, stabilizing R loops and converting them into replication obstacles in vivo | Yra1-bound RNA-DNA hybrids cause orientation-independent transcription-replication collisions and telomere instability.
García-Rubio M, Aguilera P, Lafuente-Barquero J, Ruiz JF, Simon MN, Geli V, Rondón AG, Aguilera A., Free PMC Article | 08/11/2018 |
| Both THO and Yra1-C stimulated Sub2's intrinsic ATPase activity. The authors propose that THO surveys common landmarks in each nuclear mRNP to localize Sub2 for targeted loading of Yra1. | Structural and biochemical analyses of the DEAD-box ATPase Sub2 in association with THO or Yra1.
Ren Y, Schmiege P, Blobel G., Free PMC Article | 02/10/2018 |
| YRA1 overexpression causes a cell senescence-like phenotype and telomere shortening | Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability, Replication Impairment and Telomere Shortening.
Gavaldá S, Santos-Pereira JM, García-Rubio ML, Luna R, Aguilera A., Free PMC Article | 08/27/2016 |
| These data show that Yra1 inhibits unwinding in a concentration-dependent manner by preventing the association of Dbp2 with single-stranded RNA. | Recruitment, Duplex Unwinding and Protein-Mediated Inhibition of the Dead-Box RNA Helicase Dbp2 at Actively Transcribed Chromatin.
Ma WK, Paudel BP, Xing Z, Sabath IG, Rueda D, Tran EJ., Free PMC Article | 08/20/2016 |
| the phospho-CTD is likely involved directly in the cotranscriptional recruitment of Yra1. | Cotranscriptional association of mRNA export factor Yra1 with C-terminal domain of RNA polymerase II.
MacKellar AL, Greenleaf AL., Free PMC Article | 12/10/2011 |
| Data indicate that Edc3p-mediated YRA1 pre-mRNA decay occurs independently of translation and also requires Mex67p. | Degradation of YRA1 Pre-mRNA in the cytoplasm requires translational repression, multiple modular intronic elements, Edc3p, and Mex67p.
Dong S, Jacobson A, He F., Free PMC Article | 09/6/2010 |
| Yra1 binds directly to the Zn finger/Clp1 region of Pcf11, the pol II CTD-binding subunit of CF1A. | Cotranscriptional recruitment of the mRNA export factor Yra1 by direct interaction with the 3' end processing factor Pcf11.
Johnson SA, Cubberley G, Bentley DL., Free PMC Article | 01/21/2010 |
| Nap1 interacts directly with Yra1. The recruitment of Nap1 to the coding region of actively transcribed genes is Yra1 dependent. | Nap1 links transcription elongation, chromatin assembly, and messenger RNP complex biogenesis.
Del Rosario BC, Pemberton LF., Free PMC Article | 01/21/2010 |
| YRA1p can bind to nascent mRNAs, heat shock RNA was exported efficiently in temperature-sensitive YRA1 mutant strains | Following temperature stress, export of heat shock mRNA occurs efficiently in cells with mutations in genes normally important for mRNA export.
Rollenhagen C, Hodge CA, Cole CN., Free PMC Article | 01/21/2010 |
| YRA1 exon 1 sequences in cis and Yra1p in trans inhibit YRA1 pre-mRNA splicing and commit the pre-mRNA to nuclear export. | YRA1 autoregulation requires nuclear export and cytoplasmic Edc3p-mediated degradation of its pre-mRNA.
Dong S, Li C, Zenklusen D, Singer RH, Jacobson A, He F., Free PMC Article | 01/21/2010 |
| Dia2 binding to replication origins is significantly reduced when association with Yra1 is compromised | Yra1 is required for S phase entry and affects Dia2 binding to replication origins.
Swaminathan S, Kile AC, MacDonald EM, Koepp DM., Free PMC Article | 01/21/2010 |
| We propose that appropriate levels of Yra1p are maintained by inefficient cotranscriptional splicing. | Autoregulation of the mRNA export factor Yra1p requires inefficient splicing of its pre-mRNA.
Preker PJ, Guthrie C., Free PMC Article | 01/21/2010 |