| Single-molecule study reveals Hmo1, not Hho1, promotes chromatin assembly in budding yeast. | Single-molecule study reveals Hmo1, not Hho1, promotes chromatin assembly in budding yeast.
Wang M, Li J, Wang Y, Fu H, Qiu H, Li Y, Li M, Lu Y, Fu YV., Free PMC Article | 09/7/2023 |
| Targeting of Hmo1 to subcompartments of the budding yeast nucleolus. | Targeting of Hmo1 to subcompartments of the budding yeast nucleolus.
Girke P, Seufert W., Free PMC Article | 02/24/2023 |
| Hmo1 Protein Affects the Nucleosome Structure and Supports the Nucleosome Reorganization Activity of Yeast FACT. | Hmo1 Protein Affects the Nucleosome Structure and Supports the Nucleosome Reorganization Activity of Yeast FACT.
Malinina DK, Sivkina AL, Korovina AN, McCullough LL, Formosa T, Kirpichnikov MP, Studitsky VM, Feofanov AV., Free PMC Article | 10/22/2022 |
| Interphase chromosome condensation in nutrient-starved conditions requires Cdc14 and Hmo1, but not condensin, in yeast. | Interphase chromosome condensation in nutrient-starved conditions requires Cdc14 and Hmo1, but not condensin, in yeast.
Takeichi Y, Takuma T, Ohara K, Tasnin MN, Ushimaru T. | 05/28/2022 |
| Physiological function of FKBP12, a primary target of rapamycin/FK506: a newly identified role in transcription of ribosomal protein genes in yeast. | Physiological function of FKBP12, a primary target of rapamycin/FK506: a newly identified role in transcription of ribosomal protein genes in yeast.
Kasahara K. | 09/4/2021 |
| Promotion of Hyperthermic-Induced rDNA Hypercondensation in Saccharomyces cerevisiae. | Promotion of Hyperthermic-Induced rDNA Hypercondensation in Saccharomyces cerevisiae.
Shen D, Skibbens RV., Free PMC Article | 01/23/2021 |
| Persistent induction of DNA double-strand breaks or mTORC1 inhibition by rapamycin results in reduced levels of HMO1 mRNA, but only in the presence of Tor1p. This down-regulation is accompanied by eviction of Ifh1p and recruitment of Crf1p, followed by concerted dissociation of Hmo1p and Tor1p. | DNA damage regulates direct association of TOR kinase with the RNA polymerase II-transcribed HMO1 gene.
Panday A, Gupta A, Srinivasa K, Xiao L, Smith MD, Grove A., Free PMC Article | 11/18/2017 |
| HMO1 appears to have evolved a unique linker histone-like function involving the ability to stabilize both conventional nucleosome arrays as well as DNA regions characterized by low nucleosome density or the presence of noncanonical nucleosomes. | Yeast HMO1: Linker Histone Reinvented.
Panday A, Grove A., Free PMC Article | 10/21/2017 |
| studied the genome-wide binding patterns of Nhp6, Hmo1 and the SWI/SNF complex, finding that most of gene promoters presenting high occupancy of this complex also display high enrichment of these HMG proteins. | Role of Nhp6 and Hmo1 in SWI/SNF occupancy and nucleosome landscape at gene regulatory regions.
Hepp MI, Smolle M, Gidi C, Amigo R, Valenzuela N, Arriagada A, Maureira A, Gogol MM, Torrejón M, Workman JL, Gutiérrez JL., Free PMC Article | 08/19/2017 |
| Hmo1p functions to control DNA end resection, thereby preventing error-prone A-EJ repair and directing repairs towards classical NHEJ. The very low efficiency of DSB repair in kuDeltahmo1Delta cells further suggests that excessive DNA resection is inhibitory for A-EJ. | Control of DNA end resection by yeast Hmo1p affects efficiency of DNA end-joining.
Panday A, Xiao L, Gupta A, Grove A. | 07/29/2017 |
| Both HMG boxes in Hmo1 are essential for DNA binding | Both HMG boxes in Hmo1 are essential for DNA binding in vitro and in vivo.
Higashino A, Shiwa Y, Yoshikawa H, Kokubo T, Kasahara K. | 12/19/2015 |
| Saccharomyces cerevisiae HMGB protein HMO1 stabilizes chromatin as evidenced by faster chromatin remodeling in its absence. | Yeast high mobility group protein HMO1 stabilizes chromatin and is evicted during repair of DNA double strand breaks.
Panday A, Xiao L, Grove A., Free PMC Article | 10/31/2015 |
| Hmo1's C-terminal tail, implicated in chromatin bending, facilitates the formation of catenations/hemicatenations and mediates the roles of Hmo1 in DNA damage tolerance pathway choice and sister chromatid junction formation. | DNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity.
Gonzalez-Huici V, Szakal B, Urulangodi M, Psakhye I, Castellucci F, Menolfi D, Rajakumara E, Fumasoni M, Bermejo R, Jentsch S, Branzei D., Free PMC Article | 04/19/2014 |
| Aurhors propose that Hmo1 has acquired species-specific functions and shares with UBF1 and Schizosaccharomyces pombe-Hmo1 an ancestral function to stimulate rDNA transcription. | Structure-function analysis of Hmo1 unveils an ancestral organization of HMG-Box factors involved in ribosomal DNA transcription from yeast to human.
Albert B, Colleran C, Léger-Silvestre I, Berger AB, Dez C, Normand C, Perez-Fernandez J, McStay B, Gadal O., Free PMC Article | 02/15/2014 |
| The HMO1 promoter is regulated by TOR signaling through an HMO1- and Fhl1-dependent mechanism. | Expression of yeast high mobility group protein HMO1 is regulated by TOR signaling.
Xiao L, Kamau E, Donze D, Grove A. | 12/3/2011 |
| Hmo1 plays a novel role in transcription by forming the 5'-boundary (instead of -1 nucleosome on many other promoters) for the pre-initiation complex assembly zone on a subset of ribosomal protein genes promoters. | Hmo1 directs pre-initiation complex assembly to an appropriate site on its target gene promoters by masking a nucleosome-free region.
Kasahara K, Ohyama Y, Kokubo T., Free PMC Article | 08/13/2011 |
| the combined activity of the Hmo 1 and the Ixr1 proteins provides efficient correction of both repair and replication errors. | [IXR1 and HMO1 genes jointly control the level of spontaneous mutagenesis in yeast Saccharomyces cerevisiae].
Fedorov DV, Koval'tsova SV, Peshekhonov VT, Korolev VG. | 10/4/2010 |
| The C-terminal domain of yeast high mobility group protein HMO1 mediates lateral protein accretion and in-phase DNA bending | The C-terminal domain of yeast high mobility group protein HMO1 mediates lateral protein accretion and in-phase DNA bending.
Xiao L, Williams AM, Grove A. | 06/28/2010 |
| Studies confirmed the promoter occupancy of RPS3 by Rap1p and other transcription factors Sfp1p, Hmo1p and Crf1p. | Determination of the core promoter regions of the Saccharomyces cerevisiae RPS3 gene.
Joo YJ, Kim JH, Baek JH, Seong KM, Lee JY, Kim J. | 03/15/2010 |
| Data indicate that Top2 is dispensable for transcription and that Hmo1 and Top2 bind in the proximity of genes transcribed in S phase suppressing chromosome fragility at the mitosis-G1 transition. | Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription.
Bermejo R, Capra T, Gonzalez-Huici V, Fachinetti D, Cocito A, Natoli G, Katou Y, Mori H, Kurokawa K, Shirahige K, Foiani M. | 01/21/2010 |
| Study concludes that hmo1Delta suppression of the DNA pol delta mutation, pol3-14, occurs by a mechanism whereby normal controls on DNA integrity are breached and lesions flow into RAD52-mediated repair and error-prone pathways. | Suppression of a DNA polymerase delta mutation by the absence of the high mobility group protein Hmo1 in Saccharomyces cerevisiae.
Kim H, Livingston DM. | 01/21/2010 |
| Data demonstrate that actively transcribed rRNA genes are largely devoid of histone molecules, but instead associate with the high-mobility group protein Hmo1. | Actively transcribed rRNA genes in S. cerevisiae are organized in a specialized chromatin associated with the high-mobility group protein Hmo1 and are largely devoid of histone molecules.
Merz K, Hondele M, Goetze H, Gmelch K, Stoeckl U, Griesenbeck J., Free PMC Article | 01/21/2010 |
| Data show that Hmo1 is directly involved in coordinating rDNA transcription by Pol I and ribosomal protein gene expression by Pol II under the control of the TOR pathway. | Hmo1 is required for TOR-dependent regulation of ribosomal protein gene transcription.
Berger AB, Decourty L, Badis G, Nehrbass U, Jacquier A, Gadal O., Free PMC Article | 01/21/2010 |
| HMO1 may participate in start site selection of a subset of class II genes presumably via its interaction with TFIID. | Saccharomyces cerevisiae HMO1 interacts with TFIID and participates in start site selection by RNA polymerase II.
Kasahara K, Ki S, Aoyama K, Takahashi H, Kokubo T., Free PMC Article | 01/21/2010 |
| Hmo1 has a role in coordinating the transcription of rRNA and RP genes. | An HMG protein, Hmo1, associates with promoters of many ribosomal protein genes and throughout the rRNA gene locus in Saccharomyces cerevisiae.
Hall DB, Wade JT, Struhl K., Free PMC Article | 01/21/2010 |