| Androgen-dependent tissue factor pathway inhibitor regulating protein: a review of its peripheral actions and association with cardiometabolic diseases. | Androgen-dependent tissue factor pathway inhibitor regulating protein: a review of its peripheral actions and association with cardiometabolic diseases.
Kee Z, Ong SM, Heng CK, Ooi DSQ. | 03/26/2022 |
| GATA2 regulates the CAD susceptibility gene ADTRP rs6903956 through preferential interaction with the G allele. | GATA2 regulates the CAD susceptibility gene ADTRP rs6903956 through preferential interaction with the G allele.
Luo C, Tang B, Qin S, Yuan C, Du Y, Yang J. | 06/26/2021 |
| Detection of ADTRP in circulation and its role as a novel biomarker for coronary artery disease. | Detection of ADTRP in circulation and its role as a novel biomarker for coronary artery disease.
Ooi DSQ, Ong SM, Eng MH, Chan YH, Lee YS, Low AFH, Chan MY, Heng CK., Free PMC Article | 10/10/2020 |
| Data identify POU1F1 as a transcription factor that regulates TFPI transcription in response to ADTRP, and link POU1F1 variants to risk of CAD for the first time. | ADTRP regulates TFPI expression via transcription factor POU1F1 involved in coronary artery disease.
Luo C, Pook E, Wang F, Archacki SR, Tang B, Zhang W, Hu JS, Yang J, Leineweber K, Bechem M, Huang W, Song Y, Cheung SH, Laux V, Ke T, Ren X, Tu X, Chen Q, Wang QK, Xu C. | 08/1/2020 |
| These data suggest that one molecular mechanism by which androgen confers protection against coronary artery disease is stimulation of ADTRP expression. | Androgen inhibits key atherosclerotic processes by directly activating ADTRP transcription.
Luo C, Pook E, Tang B, Zhang W, Li S, Leineweber K, Cheung SH, Chen Q, Bechem M, Hu JS, Laux V, Wang QK., Free PMC Article | 12/1/2018 |
| ADTRP positively regulates PIK3R3 expression, which leads to activation of AKT and up-regulation of MIA3/TANGO1, thereby regulating endothelial cell functions directly relevant to atherosclerosis. | Identification of a molecular signaling gene-gene regulatory network between GWAS susceptibility genes ADTRP and MIA3/TANGO1 for coronary artery disease.
Luo C, Wang F, Ren X, Ke T, Xu C, Tang B, Qin S, Yao Y, Chen Q, Wang QK., Free PMC Article | 12/1/2018 |
| ADTRP increases the number of S phase cells during cell cycle. | Coronary artery disease susceptibility gene ADTRP regulates cell cycle progression, proliferation, and apoptosis by global gene expression regulation.
Luo C, Wang F, Qin S, Chen Q, Wang QK., Free PMC Article | 02/3/2018 |
| These results indicate that AIG1 and ADTRP are founding members of an evolutionarily conserved class of transmembrane threonine hydrolases involved in bioactive lipid metabolism. | AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs.
Parsons WH, Kolar MJ, Kamat SS, Cognetta AB 3rd, Hulce JJ, Saez E, Kahn BB, Saghatelian A, Cravatt BF., Free PMC Article | 09/3/2016 |
| association of ADTRP with the pathogenesis of early-onset CAD | Common Variants in Promoter of ADTRP Associate with Early-Onset Coronary Artery Disease in a Southern Han Chinese Population.
Huang EW, Peng LY, Zheng JX, Wang D, Xu QY, Huang L, Wu QP, Tang SB, Luo B, Liu SP, Liu XS, Li ZH, Quan L, Li Y, Shi H, Lv GL, Zhao J, Cheng JD, Liu C., Free PMC Article | 05/28/2016 |
| SNP rs6903956 associated with asymptomatic hyperuricemia susceptibility in Han Chinese | A coronary artery disease-associated SNP rs6903956 contributed to asymptomatic hyperuricemia susceptibility in Han Chinese.
Meng J, Tan W, Zhu Y, Wang F, Li X, Zhang M., Free PMC Article | 04/9/2016 |
| Activation of PPARG increases the expression of C6ORF105 in human macrophages and atherosclerotic lesions. | The coronary artery disease-associated gene C6ORF105 is expressed in human macrophages under the transcriptional control of PPARĪ³.
Chinetti-Gbaguidi G, Copin C, Derudas B, Vanhoutte J, Zawadzki C, Jude B, Haulon S, Pattou F, Marx N, Staels B. | 04/18/2015 |
| ADTRP polymorphism is associated with the development of coronary atherosclerosis. | Associations between the CDKN2A/B, ADTRP and PDGFD polymorphisms and the development of coronary atherosclerosis in Japanese patients.
Dechamethakun S, Ikeda S, Arai T, Sato N, Sawabe M, Muramatsu M. | 04/4/2015 |
| The single nucleotide polymorphism rs6903956 within the ADTRP gene on chromosome 6p24.1 is significantly associated with coronary artery disease in different ethnic groups of the Singaporean population. | Association of single nucleotide polymorphism rs6903956 on chromosome 6p24.1 with coronary artery disease and lipid levels in different ethnic groups of the Singaporean population.
Tayebi N, Ke T, Foo JN, Friedlander Y, Liu J, Heng CK. | 12/14/2013 |
| This study confirms ADTRP expression and colocalization with TFPI and caveolin-1 in endothelial cell. | Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen.
Lupu C, Zhu H, Popescu NI, Wren JD, Lupu F., Free PMC Article | 12/24/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | High throughput SNP and expression analyses of candidate genes for non-syndromic oral clefts.
Park JW, Cai J, McIntosh I, Jabs EW, Fallin MD, Ingersoll R, Hetmanski JB, Vekemans M, Attie-Bitach T, Lovett M, Scott AF, Beaty TH., Free PMC Article | 03/13/2008 |