| Further Delineation of Central Congenital Hypothyroidism due to Variants in TBL1X and IRS4. | Further Delineation of Central Congenital Hypothyroidism due to Variants in TBL1X and IRS4.
Lauffer P, Naafs JC, Bikker H, Garrelfs MR, Mooij CF, Boelen A, Zwaveling-Soonawala N, van Trotsenburg ASP. | 07/19/2023 |
| Patients with Invasive Lobular Carcinoma Show a Significant Increase in IRS-4 Expression Compared to Infiltrative Ductal Carcinoma-A Histopathological Study. | Patients with Invasive Lobular Carcinoma Show a Significant Increase in IRS-4 Expression Compared to Infiltrative Ductal Carcinoma-A Histopathological Study.
Ortega MA, Fraile-Martinez O, García-Montero C, Borja-Vergel S, Torres-Carranza D, Pekarek L, Arribas CB, De León-Luis JA, Sánchez-Rojo C, Alvarez-Mon MA, García-Honduvilla N, Buján J, Coca S, Alvarez-Mon M, Saez MA, Guijarro LG., Free PMC Article | 07/2/2022 |
| FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells. | FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells.
Zhang Y, Xiong X, Zhu Q, Zhang J, Chen S, Wang Y, Cao J, Chen L, Hou L, Zhao X, Hao P, Chen J, Zhuang M, Li D, Fan G., Free PMC Article | 05/28/2022 |
| Screening for Mutations in Isolated Central Hypothyroidism Reveals a Novel Mutation in Insulin Receptor Substrate 4. | Screening for Mutations in Isolated Central Hypothyroidism Reveals a Novel Mutation in Insulin Receptor Substrate 4.
Patyra K, Makkonen K, Haanpää M, Karppinen S, Viikari L, Toppari J, Reeve MP, Kero J., Free PMC Article | 01/22/2022 |
| Chronic venous disease patients show increased IRS-4 expression in the great saphenous vein wall. | Chronic venous disease patients show increased IRS-4 expression in the great saphenous vein wall.
Ortega MA, Fraile-Martínez O, García-Montero C, Ruiz-Grande F, Barrena S, Montoya H, Pekarek L, Zoullas S, Alvarez-Mon MA, Sainz F, Asúnsolo A, Acero J, Álvarez-Mon M, Buján J, García-Honduvilla N, Guijarro LG., Free PMC Article | 10/9/2021 |
| IRS4 promotes the progression of non-small cell lung cancer and confers resistance to EGFR-TKI through the activation of PI3K/Akt and Ras-MAPK pathways. | IRS4 promotes the progression of non-small cell lung cancer and confers resistance to EGFR-TKI through the activation of PI3K/Akt and Ras-MAPK pathways.
Hao P, Huang Y, Peng J, Yu J, Guo X, Bao F, Dian Z, An S, Xu TR. | 09/25/2021 |
| Mutations in IRS4 are associated with isolated congenital central hypothyroidism (CeH) in male carriers. As IRS4 is involved in leptin signalling, the phenotype may be related to disrupted leptin signalling. | Mutations in IRS4 are associated with central hypothyroidism.
Heinen CA, de Vries EM, Alders M, Bikker H, Zwaveling-Soonawala N, van den Akker ELT, Bakker B, Hoorweg-Nijman G, Roelfsema F, Hennekam RC, Boelen A, van Trotsenburg ASP, Fliers E., Free PMC Article | 12/21/2019 |
| IRS4, as a new substrate of CHIP, is negatively regulated by CK1gamma2 at the posttranslational level. | Phosphorylation of IRS4 by CK1γ2 promotes its degradation by CHIP through the ubiquitin/lysosome pathway.
Li X, Zhong L, Wang Z, Chen H, Liao D, Zhang R, Zhang H, Kang T., Free PMC Article | 08/24/2019 |
| increase of IRS-4 expression may be involved to some extent in colorectal cancer. | Overexpression of insulin receptor substrate-4 is correlated with clinical staging in colorectal cancer patients.
Sanmartín-Salinas P, Toledo-Lobo MV, Noguerales-Fraguas F, Fernández-Contreras ME, Guijarro LG. | 08/18/2018 |
| IRS4 overexpression is associated with cancer. | Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking.
Weischenfeldt J, Dubash T, Drainas AP, Mardin BR, Chen Y, Stütz AM, Waszak SM, Bosco G, Halvorsen AR, Raeder B, Efthymiopoulos T, Erkek S, Siegl C, Brenner H, Brustugun OT, Dieter SM, Northcott PA, Petersen I, Pfister SM, Schneider M, Solberg SK, Thunissen E, Weichert W, Zichner T, Thomas R, Peifer M, Helland A, Ball CR, Jechlinger M, Sotillo R, Glimm H, Korbel JO., Free PMC Article | 09/9/2017 |
| these results demonstrated that miR-493 acts as a tumor suppressor and inhibits cell proliferation and cell cycle in human melanoma by directly targeting IRS4. | Downregulation of miR-493 promoted melanoma proliferation by suppressing IRS4 expression.
Cui A, Jin Z, Gao Z, Jin M, Zhu L, Li L, Jin C, An Y. | 06/24/2017 |
| The association of IRS4 with SSH1 contributes to localized activation of cofilin in membrane protrusions. | Insulin receptor substrate-4 binds to Slingshot-1 phosphatase and promotes cofilin dephosphorylation.
Homma Y, Kanno SI, Sasaki K, Nishita M, Yasui A, Asano T, Ohashi K, Mizuno K., Free PMC Article | 02/7/2015 |
| Overexpression of IRS4 in U2OS cells activates PI3K signalling. | Effect of IRS4 levels on PI 3-kinase signalling.
Hoxhaj G, Dissanayake K, MacKintosh C., Free PMC Article | 06/14/2014 |
| We genotyped single-nucleotide polymorphisms of IGF1, IGF2, IGF1R, IGF2R, IGFBP1, IGFBP3, IGFBP5, IRS1, IRS2, and IRS in pancreatic cancer patients | Insulin-like growth factor axis gene polymorphisms modify risk of pancreatic cancer.
Dong X, Li Y, Tang H, Chang P, Hess KR, Abbruzzese JL, Li D. | 07/21/2012 |
| This study clearly demonstrates associations between body mass index and IRS-4 variants in schizophrenia patients, but not in healthy controls, pointing to a possible involvement of IRS-4 in the control of body weight in schizophrenia. | Association between body mass index and insulin receptor substrate-4 (IRS-4) gene polymorphisms in patients with schizophrenia.
Melkersson K, Persson B. | 03/24/2012 |
| Study for the first time identified IRS4 mutations in T-ALL. | The insulin receptor substrate 4 gene (IRS4) is mutated in paediatric T-cell acute lymphoblastic leukaemia.
Karrman K, Isaksson M, Paulsson K, Johansson B. | 03/3/2012 |
| IRS-4 gene is not of importance for aetiology of the vast majority of schizophrenia cases, but a single patient with schizophrenia and a mutation in IRS-4 points to that the insulin signalling system is of interest in the search for schizophrenia genes | The insulin receptor substrate-4 (IRS-4) gene and schizophrenia: no evidence for a main genetic factor, however one report of a single schizophrenia patient with a mutation.
Melkersson K, Persson B, Hongslo T. | 07/16/2011 |
| The t(X;6) in subungual exostosis results in transcriptional deregulation of the gene for insulin receptor substrate 4. | The t(X;6) in subungual exostosis results in transcriptional deregulation of the gene for insulin receptor substrate 4.
Mertens F, Möller E, Mandahl N, Picci P, Perez-Atayde AR, Samson I, Sciot R, Debiec-Rychter M. | 01/8/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Insulin-like growth factor axis gene polymorphisms and clinical outcomes in pancreatic cancer.
Dong X, Javle M, Hess KR, Shroff R, Abbruzzese JL, Li D., Free PMC Article | 06/30/2010 |
| Transgenic rat gene WDR6 interacts with insulin receptor substrate 4 (IRS-4) in the rat brain and may participate in signaling and regulation of feeding behavior and longevity in the brain. | Identification and characterization of an insulin receptor substrate 4-interacting protein in rat brain: implications for longevity.
Chiba T, Inoue D, Mizuno A, Komatsu T, Fujita S, Kubota H, Luisa Tagliaro M, Park S, Trindade LS, Hayashida T, Hayashi H, Yamaza H, Higami Y, Shimokawa I. | 01/21/2010 |
| 53BP2S interacts and modulates the insulin signals mediated by insulin receptor substrates. | 53BP2S, interacting with insulin receptor substrates, modulates insulin signaling.
Hakuno F, Kurihara S, Watson RT, Pessin JE, Takahashi S. | 01/21/2010 |
| The association and altered regulation of IRS proteins by Ad5E1A contribute to the adenovirus-transformed phenotype and modulates viral infection in an Akt-dependent manner. | Adenovirus 5 E1A is responsible for increased expression of insulin receptor substrate 4 in established adenovirus 5-transformed cell lines and interacts with IRS components activating the PI3 kinase/Akt signalling pathway.
Shimwell NJ, Martin A, Bruton RK, Blackford AN, Sedgwick GG, Gallimore PH, Turnell AS, Grand RJ. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, van 't Slot R, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM. | 09/24/2008 |
| Data demonstrate that IRS4 interacts with the LR. This recruitment is leptin dependent and requires phosphorylation of the Y1077 motif of the LR. | Insulin receptor substrate 4 couples the leptin receptor to multiple signaling pathways.
Wauman J, De Smet AS, Catteeuw D, Belsham D, Tavernier J., Free PMC Article | 01/21/2010 |