| TAG synthesis and levels of PUFA-TAGs were lowered by the diacylglycerol acyltransferase (DGAT)1 inhibitor, T863. The lipase inhibitor, Atglistatin, increased the levels of TAG in both WT and ATGL-deficient mouse Hepatic stellate cell (HSC). Both Atglistatin and T863 inhibited the induction of activation marker, alpha-smooth muscle actin, in rat HSCs, but not in mouse HSCs. | ATGL and DGAT1 are involved in the turnover of newly synthesized triacylglycerols in hepatic stellate cells.
Tuohetahuntila M, Molenaar MR, Spee B, Brouwers JF, Houweling M, Vaandrager AB, Helms JB., Free PMC Article | 08/26/2017 |
| In both wild-type and DGAT-knockdown hepatocytes, oleate co-treatment significantly reduced PA lipid incorporation and overall phospholipid saturation compared to PA-treated hepatocytes | Knockdown of triglyceride synthesis does not enhance palmitate lipotoxicity or prevent oleate-mediated rescue in rat hepatocytes.
Leamy AK, Hasenour CM, Egnatchik RA, Trenary IA, Yao CH, Patti GJ, Shiota M, Young JD., Free PMC Article | 06/3/2017 |
| pharmacological DGAT-1 inhibition leads to an increase in intestinal FAO and ketogenesis when dietary fat is available. | Diacylglycerol acyltransferase-1 inhibition enhances intestinal fatty acid oxidation and reduces energy intake in rats.
Schober G, Arnold M, Birtles S, Buckett LK, Pacheco-López G, Turnbull AV, Langhans W, Mansouri A., Free PMC Article | 11/16/2013 |
| DGAT1 belongs to the family of oligomeric membrane proteins that adopt a dual membrane topology. | Evidence that diacylglycerol acyltransferase 1 (DGAT1) has dual membrane topology in the endoplasmic reticulum of HepG2 cells.
Wurie HR, Buckett L, Zammit VA., Free PMC Article | 12/10/2011 |
| unilateral DGAT1 overexpression can rescue insulin sensitivity, possibly by increasing DAG and TAG turnover in skeletal muscle | Paradoxical increase in TAG and DAG content parallel the insulin sensitizing effect of unilateral DGAT1 overexpression in rat skeletal muscle.
Timmers S, de Vogel-van den Bosch J, Hesselink MK, van Beurden D, Schaart G, Ferraz MJ, Losen M, Martinez-Martinez P, De Baets MH, Aerts JM, Schrauwen P., Free PMC Article | 08/6/2011 |
| Propose isoflavonoids with isoprenyl groups as a novel class of DGAT inhibitors. | Diacylglycerol acyltransferase-inhibitory compounds from Erythrina senegalensis.
Oh WK, Lee C, Seo JH, Chung MY, Cui L, Fomum ZT, Kang JS, Lee HS. | 01/21/2010 |
| the acylation of acylglycerols by DGAT1 is important for dietary fat absorption in the intestine | Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption.
Cheng D, Iqbal J, Devenny J, Chu CH, Chen L, Dong J, Seethala R, Keim WJ, Azzara AV, Lawrence RM, Pelleymounter MA, Hussain MM., Free PMC Article | 01/21/2010 |
| DGAT2, but not DGAT1, has a role in diet-induced hepatic steatosis and insulin resistance | Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance.
Choi CS, Savage DB, Kulkarni A, Yu XX, Liu ZX, Morino K, Kim S, Distefano A, Samuel VT, Neschen S, Zhang D, Wang A, Zhang XM, Kahn M, Cline GW, Pandey SK, Geisler JG, Bhanot S, Monia BP, Shulman GI. | 01/21/2010 |
| Nephrotic syndrome results in up-regulation of hepatic DGAT-1 expression and activity, which can potentially contribute to the associated hypertriglyceridemia by enhancing triglyceride synthesis. | Up-regulation of hepatic Acyl CoA: Diacylglycerol acyltransferase-1 (DGAT-1) expression in nephrotic syndrome.
Vaziri ND, Kim CH, Phan D, Kim S, Liang K. | 01/21/2010 |
| increasing DGAT1, ACAT1, or ACAT2 expression stimulates the assembly and secretion of VLDL from liver cells | Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells.
Liang JJ, Oelkers P, Guo C, Chu PC, Dixon JL, Ginsberg HN, Sturley SL. | 01/21/2010 |
| ontogeny of the two functional diacylglycerol acyltransferase (DGAT) activities (overt and latent) during postnatal development in rat liver | Distinct ontogenic patterns of overt and latent DGAT activities of rat liver microsomes.
Waterman IJ, Price NT, Zammit VA. | 01/21/2010 |
| DGAT1 contributes to the storage of intramyocellular lipids | DGAT1 overexpression in muscle by in vivo DNA electroporation increases intramyocellular lipid content.
Roorda BD, Hesselink MK, Schaart G, Moonen-Kornips E, Martínez-Martínez P, Losen M, De Baets MH, Mensink RP, Schrauwen P. | 01/21/2010 |
| genes induced by FSH in rat Sertoli cells would also show hormonal regulation during rat folliculogenesis | Regulation of protein tyrosine phosphatase 4a1, B-cell translocation gene 2, nuclear receptor subfamily 4a1 and diacylglycerol O-acyltransferase 1 by follicle stimulating hormone in the rat ovary.
Schmidt J, de Avila J, McLean D. | 01/21/2010 |