| Carbonic anhydrase IX and hypoxia-inducible factor 1 attenuate cardiac dysfunction after myocardial infarction. | Carbonic anhydrase IX and hypoxia-inducible factor 1 attenuate cardiac dysfunction after myocardial infarction.
Nolly MB, Vargas LA, Correa MV, Lofeudo JM, Pinilla AO, Rueda JOV, Guerrero-Gimenez ME, Swenson ER, Damiani MT, Alvarez BV. | 02/5/2022 |
| the sodium bicarbonate cotransporter NBCe1-B is expressed in rat and human thyroid | Expression, Localization, and Regulation of the Sodium Bicarbonate Cotransporter NBCe1 in the Thyroid.
Virreira M, Jin L, Djerbib S, De Deken X, Miot F, Massart C, Svoboda M, Van Sande J, Beauwens R, Dumont JE, Boom A. | 02/15/2020 |
| NBCe1 inhibition limits cell death, improves myocardial post-ischemic contractility and mitochondrial state through calcineurin/P38MAPK/HSP27-dependent pathways. | Calcineurin/P38MAPK/HSP27-dependent pathways are involved in the attenuation of postischemic mitochondrial injury afforded by sodium bicarbonate co-transporter (NBCe1) inhibition.
Ciocci Pardo A, González Arbeláez LF, Fantinelli JC, Aiello EA, Mosca SM. | 10/26/2019 |
| Endurance training increased NHE1 and NBC1 genes and proteins expression in both Extensor digitorum longus and Soleus in the diabetic training group compared to control groups. | Modulation of oxidative and glycolytic skeletal muscle fibers Na+/H+ exchanger1 (NHE1) and Na+/HCO3- co-transporter1 (NBC1) genes and proteins expression in type 2 diabetic rat (Streptozotocin + high fat diet) following long term endurance training.
Monazzami A, Rajabi H, Ghrakhanlou R, Yari K, Rahimi Z. | 04/14/2018 |
| NBCe1 is the NBC isoform activated by aldosterone in the heart | The cardiac electrogenic sodium/bicarbonate cotransporter (NBCe1) is activated by aldosterone through the G protein-coupled receptor 30 (GPR 30).
Orlowski A, De Giusti VC, Ciancio MC, Espejo MS, Aiello EA., Free PMC Article | 10/14/2017 |
| NBC1 is diversely expressed in the pancreas at different developmental stages, where it may exert its functions in pancreatic development, especially islet cell growth, through HCO3(-) transport and pH regulation. | Na(+)/HCO(3)(-) cotransporter is expressed on β and α cells during rat pancreatic development.
Cao LH, Xia CC, Shi ZC, Wang N, Gu ZH, Yu LZ, Wan Q, De W., Free PMC Article | 05/6/2017 |
| Aldosterone stimulates NBC by GPR30 activation, reactive oxygen species production and AKT stimulation. | Aldosterone stimulates the cardiac sodium/bicarbonate cotransporter via activation of the g protein-coupled receptor gpr30.
De Giusti VC, Orlowski A, Ciancio MC, Espejo MS, Gonano LA, Caldiz CI, Vila Petroff MG, Villa-Abrille MC, Aiello EA. | 10/1/2016 |
| Results demonstrate that transcriptional regulation and targeting of NBCe1, as well as functional operation of NBCe1, may occur through multiple signaling pathways | Regulation of functional expression of the electrogenic sodium bicarbonate cotransporter 1, NBCe1 (SLC4A4), in mouse astrocytes.
Schrödl-Häußel M, Theparambil SM, Deitmer JW, Roussa E. | 01/16/2016 |
| These results revealed that insulin can stimulate PT sodium transport even in type 2 diabetes with overt nephropathy. | Stimulatory effect of insulin on renal proximal tubule sodium transport is preserved in type 2 diabetes with nephropathy.
Nakamura M, Satoh N, Suzuki M, Kume H, Homma Y, Seki G, Horita S. | 07/25/2015 |
| NBCe1 hyperactivity during myocardial reperfusion leads to Na(+) and Ca(2+) loading, causing Ca(2+) overload and myocardial damage. | The electrogenic cardiac sodium bicarbonate co-transporter (NBCe1) contributes to the reperfusion injury.
Fantinelli JC, Orlowski A, Aiello EA, Mosca SM. | 05/16/2015 |
| Ang II is responsible for the impairment of the NBCe1 in hypertrophied hearts of spontaneously hypertensive rats. | Reduced sarcolemmal expression and function of the NBCe1 isoform of the Na⁺-HCO₃⁻ cotransporter in hypertrophied cardiomyocytes of spontaneously hypertensive rats: role of the renin-angiotensin system.
Orlowski A, Ciancio MC, Caldiz CI, De Giusti VC, Aiello EA. | 10/4/2014 |
| functionally distinct Na-HCO3 co-transporters in colon | Identification of functionally distinct Na-HCO3 co-transporters in colon.
Barmeyer C, Ye JH, Soroka C, Geibel P, Hingsammer LM, Weitgasser L, Atway D, Geibel JP, Binder HJ, Rajendran VM., Free PMC Article | 01/4/2014 |
| the interaction between adenosine 3',5'cyclic monophosphate, volumeregulated anion channels and NBCe1, in the regulation of insulin release from rat pancreatic islets and tumoral insulinproducing cells, was investigated. | Interaction between cAMP, volume‑regulated anion channels and the Na+‑HCO3‑‑cotransporter, NBCe1, in the regulation of nutrient‑ and hypotonicity‑induced insulin release from isolated rat pancreatic islets and tumoral insulin‑producing BRIN‑BD11 cells.
Bulur N, Crutzen R, Malaisse WJ, Sener A, Beauwens R, Golstein P. | 11/16/2013 |
| phosphatidylinositol 4,5-bisphosphate hydrolysis stimulates NBCe1-B and -C variants expressed in Xenopus laevis oocytes | PIP2 hydrolysis stimulates the electrogenic Na+-bicarbonate cotransporter NBCe1-B and -C variants expressed in Xenopus laevis oocytes.
Thornell IM, Wu J, Liu X, Bevensee MO., Free PMC Article | 05/18/2013 |
| NBC4g mediates the efflux of HCO(3)- and contributes to cerebrospinal fluid production. | Identification and properties of a novel variant of NBC4 (Na(+)/HCO(3)- co-transporter 4) that is predominantly expressed in the choroid plexus.
Fukuda H, Hirata T, Nakamura N, Kato A, Kawahara K, Wakabayashi S, Chang MH, Romero MF, Hirose S. | 03/30/2013 |
| study demonstrated that carbonic anhydrase IX forms a complex with extracellular loop 4 of NBCe1, which activates NBCe1-mediated bicarbonate ion influx in the myocardium | Binding of carbonic anhydrase IX to extracellular loop 4 of the NBCe1 Na+/HCO3- cotransporter enhances NBCe1-mediated HCO3- influx in the rat heart.
Orlowski A, De Giusti VC, Morgan PE, Aiello EA, Alvarez BV. | 09/15/2012 |
| Expression of the electrogenic Na(+)-HCO3(-)-cotransporter NBCe1 in tumoral insulin-producing BRIN-BD11 cells is reported. | Expression of the electrogenic Na+-HCO3--cotransporter NBCe1 in tumoral insulin-producing BRIN-BD11 cells.
Bulur N, Virreira M, Soyfoo MS, Louchami K, Delporte C, Perret J, Beauwens R, Malaisse WJ, Sener A. | 01/21/2010 |
| The expression of the electrogenic Na(+)-HCO(3) (-)-cotransporters NBCe1-A and NBCe1-B in rat pancreatic islet cells. | Expression of the electrogenic Na+-HCO3--cotransporters NBCe1-A and NBCe1-B in rat pancreatic islet cells.
Soyfoo MS, Bulur N, Virreira M, Louchami K, Lybaert P, Crutzen R, Perret J, Delporte C, Roussa E, Thevenod F, Best L, Yates AP, Malaisse WJ, Sener A, Beauwens R. | 01/21/2010 |
| Electrogenic NBCe1 (SLC4A4), but not electroneutral NBCn1 (SLC4A7), cotransporter undergoes cholinergic-stimulated endocytosis in salivary ParC5 cells. | Electrogenic NBCe1 (SLC4A4), but not electroneutral NBCn1 (SLC4A7), cotransporter undergoes cholinergic-stimulated endocytosis in salivary ParC5 cells.
Perry C, Quissell DO, Reyland ME, Grichtchenko II., Free PMC Article | 01/21/2010 |
| The alphaA/B primarily labeled neurons intracellularly and alphaC labeled astrocytes at the plasma membrane. In summary, the B and C variants are the predominant NBCe1 variants in rat brain and exhibit different localization profiles. | Localization of electrogenic Na/bicarbonate cotransporter NBCe1 variants in rat brain.
Majumdar D, Maunsbach AB, Shacka JJ, Williams JB, Berger UV, Schultz KP, Harkins LE, Boron WF, Roth KA, Bevensee MO., Free PMC Article | 01/21/2010 |
| Bilateral ureteral obstruction caused a significant reduction in the expression of NHE3, NBC1, NKCC2, NBCn1, and pendrin. | Ureter obstruction alters expression of renal acid-base transport proteins in rat kidney.
Wang G, Li C, Kim SW, Ring T, Wen J, Djurhuus JC, Wang W, Nielsen S, Frøkiaer J. | 01/21/2010 |
| Noradrenaline-induced increases in the expression of NHE-3, NBC-1, BSC-1 and aquaporin-2 are likely to play an important role in the regulation of salt and water transport by noradrenaline in the kidney. | Chronic noradrenaline increases renal expression of NHE-3, NBC-1, BSC-1 and aquaporin-2.
Sonalker PA, Tofovic SP, Bastacky SI, Jackson EK. | 01/21/2010 |
| The NBCe1 current during glutamine removal was more than 50% larger than during glutamine addition, suggesting that NBCe1 enhances glutamine efflux rather than glutamine uptake | The sodium-bicarbonate cotransporter NBCe1 supports glutamine efflux via SNAT3 (SLC38A3) co-expressed in Xenopus oocytes.
Wendel C, Becker HM, Deitmer JW. | 01/21/2010 |
| An altered volume status and NaHCO(3) loading may affect the regulation of NHE3 and NBC1 in the kidney and the endogenous NO system may play a role in the observed effects. | Effects of volume depletion and NaHCO3 loading on the expression of Na+/H+ exchanger isoform 3, Na+: HCO3- cotransporter type 1 and nitric oxide synthase in rat kidney.
Ma SK, Kang JS, Bae EH, Choi C, Lee J, Kim SH, Choi KC, Kim SW. | 01/21/2010 |
| Moreover, the data demonstrate that renal PT and salivary duct epithelia respond to acid-base disturbances by an opposite redistribution pattern for NBCe1-A and NBCe1-B. | Adaptive redistribution of NBCe1-A and NBCe1-B in rat kidney proximal tubule and striated ducts of salivary glands during acid-base disturbances.
Brandes A, Oehlke O, Schümann A, Heidrich S, Thévenod F, Roussa E. | 01/21/2010 |