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    Dnmt1 DNA methyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84350, updated on 9-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    DNMT1 Mediates Chronic Pain-Related Depression by Inhibiting GABAergic Neuronal Activation in the Central Amygdala.

    DNMT1 Mediates Chronic Pain-Related Depression by Inhibiting GABAergic Neuronal Activation in the Central Amygdala.
    Ding X, Lin Y, Chen C, Yan B, Liu Q, Zheng H, Wu Y, Zhou C.

    09/20/2023
    DNMT1-induced miR-133b suppression via methylation promotes myocardial fibrosis after myocardial infarction.

    DNMT1-induced miR-133b suppression via methylation promotes myocardial fibrosis after myocardial infarction.
    Zhang S, Xie H, Du Y, Wang B, Lan B, Wang H.

    09/15/2023
    DNMT1 involved in the analgesic effect of folic acid on gastric hypersensitivity through downregulating ASIC1 in adult offspring rats with prenatal maternal stress.

    DNMT1 involved in the analgesic effect of folic acid on gastric hypersensitivity through downregulating ASIC1 in adult offspring rats with prenatal maternal stress.
    Wang HJ, Zhang FC, Xu TW, Xu YC, Tian YQ, Wu YY, Xu JT, Hu S, Xu GY., Free PMC Article

    08/25/2023
    DNMT1 regulates polarization of macrophage-induced intervertebral disc degeneration by modulating SIRT6 expression and promoting pyroptosis in vivo.

    DNMT1 regulates polarization of macrophage-induced intervertebral disc degeneration by modulating SIRT6 expression and promoting pyroptosis in vivo.
    Hou Y, Shi J, Guo Y, Shi G., Free PMC Article

    06/15/2023
    Runt-related transcription factor 3, mediated by DNA-methyltransferase 1, regulated Schwann cell proliferation and myelination during peripheral nerve regeneration via JAK/STAT signaling pathway.

    Runt-related transcription factor 3, mediated by DNA-methyltransferase 1, regulated Schwann cell proliferation and myelination during peripheral nerve regeneration via JAK/STAT signaling pathway.
    Wu Q, Xie J, Zhu X, He J.

    06/14/2023
    LncRNA XR_351665 Contributes to Chronic Pain-Induced Depression by Upregulating DNMT1 via Sponging miR-152-3p.

    LncRNA XR_351665 Contributes to Chronic Pain-Induced Depression by Upregulating DNMT1 via Sponging miR-152-3p.
    Ding X, Lin Y, Yan B, Jiao X, Liu Q, Miao H, Wu Y, Zhou C.

    03/13/2023
    A Paternal Methylation Error in the Congenital Hydrocephalic Texas (H-Tx) Rat Is Partially Rescued with Natural Folate Supplements.

    A Paternal Methylation Error in the Congenital Hydrocephalic Texas (H-Tx) Rat Is Partially Rescued with Natural Folate Supplements.
    Naz N, Moshkdanian G, Miyan S, Eljabri S, James C, Miyan J., Free PMC Article

    02/4/2023
    RNA interference-mediated silencing of DNA methyltransferase 1 attenuates neuropathic pain by accelerating microglia M2 polarization.

    RNA interference-mediated silencing of DNA methyltransferase 1 attenuates neuropathic pain by accelerating microglia M2 polarization.
    Tan Y, Wang Z, Liu T, Gao P, Xu S, Tan L., Free PMC Article

    10/8/2022
    DNA methyltransferase 1 (DNMT1) suppresses mitophagy and aggravates heart failure via the microRNA-152-3p/ETS1/RhoH axis.

    DNA methyltransferase 1 (DNMT1) suppresses mitophagy and aggravates heart failure via the microRNA-152-3p/ETS1/RhoH axis.
    Deng Z, Yao J, Xiao N, Han Y, Wu X, Ci C, Chen K, Geng X.

    07/30/2022
    DNMT1-Induced miR-152-3p Suppression Facilitates Cardiac Fibroblast Activation in Cardiac Fibrosis.

    DNMT1-Induced miR-152-3p Suppression Facilitates Cardiac Fibroblast Activation in Cardiac Fibrosis.
    Xu SS, Ding JF, Shi P, Shi KH, Tao H.

    02/26/2022
    Histone deacetylase 3 suppresses the expression of SHP-1 via deacetylation of DNMT1 to promote heart failure.

    Histone deacetylase 3 suppresses the expression of SHP-1 via deacetylation of DNMT1 to promote heart failure.
    Wang YY, Gao B, Yang Y, Jia SB, Ma XP, Zhang MH, Wang LJ, Ma AQ, Zhang QN.

    02/12/2022
    Histone Methyltransferases SUV39H1 and G9a and DNA Methyltransferase DNMT1 in Penumbra Neurons and Astrocytes after Photothrombotic Stroke.

    Histone Methyltransferases SUV39H1 and G9a and DNA Methyltransferase DNMT1 in Penumbra Neurons and Astrocytes after Photothrombotic Stroke.
    Sharifulina S, Dzreyan V, Guzenko V, Demyanenko S., Free PMC Article

    12/25/2021
    DNMT1 deregulation of SOCS3 axis drives cardiac fibroblast activation in diabetic cardiac fibrosis.

    DNMT1 deregulation of SOCS3 axis drives cardiac fibroblast activation in diabetic cardiac fibrosis.
    Tao H, Shi P, Zhao XD, Xuan HY, Gong WH, Ding XS.

    10/2/2021
    DNMT1 Methylation of LncRNA GAS5 Leads to Cardiac Fibroblast Pyroptosis via Affecting NLRP3 Axis.

    DNMT1 Methylation of LncRNA GAS5 Leads to Cardiac Fibroblast Pyroptosis via Affecting NLRP3 Axis.
    She Q, Shi P, Xu SS, Xuan HY, Tao H, Shi KH, Yang Y.

    04/3/2021
    DNMT1-mediated lncRNA MEG3 methylation accelerates endothelial-mesenchymal transition in diabetic retinopathy through the PI3K/Akt/mTOR signaling pathway.

    DNMT1-mediated lncRNA MEG3 methylation accelerates endothelial-mesenchymal transition in diabetic retinopathy through the PI3K/Akt/mTOR signaling pathway.
    He Y, Dan Y, Gao X, Huang L, Lv H, Chen J.

    03/28/2021
    Epigenetics and Mitochondrial Stability in the Metabolic Memory Phenomenon Associated with Continued Progression of Diabetic Retinopathy.

    Epigenetics and Mitochondrial Stability in the Metabolic Memory Phenomenon Associated with Continued Progression of Diabetic Retinopathy.
    Kowluru RA, Mohammad G., Free PMC Article

    12/5/2020
    DNA methyltransferase-1 inactivation of androgen receptor axis triggers homocysteine induced cardiac fibroblast autophagy in diabetic cardiac fibrosis.

    DNA methyltransferase-1 inactivation of androgen receptor axis triggers homocysteine induced cardiac fibroblast autophagy in diabetic cardiac fibrosis.
    Tao H, Shi P, Xuan HY, Ding XS.

    11/21/2020
    Myocardial tissue-specific Dnmt1 knockout in rats protects against pathological injury induced by Adriamycin.

    Myocardial tissue-specific Dnmt1 knockout in rats protects against pathological injury induced by Adriamycin.
    Wu TT, Ma YW, Zhang X, Dong W, Gao S, Wang JZ, Zhang LF, Lu D., Free PMC Article

    10/24/2020
    The authors report that DNMT1 expression and lncRNA-H19 methylation are upregulated in the femoral tissues of disuse osteoporosis rats, accompanied with inhibited Erk signaling pathway.

    Overexpression of DNMT1 leads to hypermethylation of H19 promoter and inhibition of Erk signaling pathway in disuse osteoporosis.
    Li B, Zhao J, Ma JX, Li GM, Zhang Y, Xing GS, Liu J, Ma XL.

    03/23/2019
    DNMT1 is the downstream target of the mTOR pathway and mediates the mTOR pathway inhibition-induced reduction in NGF expression in Schwann cells

    DNMT1, a Novel Regulator Mediating mTORC1/mTORC2 Pathway-Induced NGF Expression in Schwann Cells.
    Cheng M, Lv X, Zhang C, Du W, Liu Y, Zhu L, Hao J.

    12/22/2018
    A novel mechanism of DNA methylation mediated by DNMT1 in prevention of Hcy associated cardiovascular disease.

    Homocysteine inhibits endothelial progenitor cells proliferation via DNMT1-mediated hypomethylation of Cyclin A.
    Zhang HP, Wang YH, Ma SC, Zhang H, Yang AN, Yang XL, Zhang MH, Sun JM, Hao YJ, Jiang YD.

    09/8/2018
    hypomethylation of FABP4 was regulated by DNMT1, which was a direct target of miR-152/148a, in pre-eclampsia model

    Modulation of FABP4 hypomethylation by DNMT1 and its inverse interaction with miR-148a/152 in the placenta of preeclamptic rats and HTR-8 cells.
    Yang A, Zhang H, Sun Y, Wang Y, Yang X, Yang X, Zhang H, Guo W, Zhu G, Tian J, Jia Y, Jiang Y.

    10/14/2017
    DNMT1 activates the canonical Wnt signaling in rheumatoid arthritis model rats via a crucial functional crosstalk between miR-152 and the DNMT1, MeCP2

    DNMT1 activates the canonical Wnt signaling in rheumatoid arthritis model rats via a crucial functional crosstalk between miR-152 and the DNMT1, MeCP2.
    Miao CG, Qin D, Du CL, Ye H, Shi WJ, Xiong YY, Zhang XL, Yu H, Dou JF, Ma ST, Qin MS, Liu HZ, Fang YX, Zhou GL, Chen JZ, He X, Huang C, Huang Y, Zhang B, Song TW, Li J.

    07/2/2016
    Results identify LRRFIP1, SMARCA4, and DNMT1 as novel regulators of macrophage multinucleation.

    Integrating phosphoproteome and transcriptome reveals new determinants of macrophage multinucleation.
    Rotival M, Ko JH, Srivastava PK, Kerloc'h A, Montoya A, Mauro C, Faull P, Cutillas PR, Petretto E, Behmoaras J., Free PMC Article

    12/5/2015
    Acute restraint stress evokes adaptive changes in global DNA methylation of rat brain that are independent of the expression of the Dnmt1 gene but might be linked to abnormal expression of the Bdnf gene in the PAG.

    Acute stress affects the global DNA methylation profile in rat brain: modulation by physical exercise.
    Rodrigues GM Jr, Toffoli LV, Manfredo MH, Francis-Oliveira J, Silva AS, Raquel HA, Martins-Pinge MC, Moreira EG, Fernandes KB, Pelosi GG, Gomes MV.

    08/22/2015
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