| Evidence indicates that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors (AMPARs) are important modulators of alcohol self-administration and relapse-like behavior. | Potentiation of amygdala AMPA receptor activity selectively promotes escalated alcohol self-administration in a CaMKII-dependent manner.
Cannady R, Fisher KR, Graham C, Crayle J, Besheer J, Hodge CW., Free PMC Article | 11/4/2017 |
| Study elucidates structures of the GluA2-TARP gamma2 complex in the presence of the partial agonist kainate or the full agonist quisqualate together with a positive allosteric modulator or with quisqualate alone. Structural and computational analysis suggests the full agonist and modulator complex harbors an ion-permeable channel gate, providing the first view of an activated AMPA receptor. | Activation and Desensitization Mechanism of AMPA Receptor-TARP Complex by Cryo-EM.
Chen S, Zhao Y, Wang Y, Shekhar M, Tajkhorshid E, Gouaux E., Free PMC Article | 09/30/2017 |
| cryo-EM structure of the homomeric GluA2 AMPA receptor saturated with TARP gamma2 subunits, showing how the TARPs are arranged with four-fold symmetry around the ion channel domain and make extensive interactions with the M1, M2 and M4 transmembrane helices | Architecture of fully occupied GluA2 AMPA receptor-TARP complex elucidated by cryo-EM.
Zhao Y, Chen S, Yoshioka C, Baconguis I, Gouaux E., Free PMC Article | 09/3/2016 |
| elevated S-nitrosylation of stargazin contributes to AMPAR upregulation during cocaine sensitization selectively in the nucleus accumbens shell. | AMPA receptor upregulation in the nucleus accumbens shell of cocaine-sensitized rats depends upon S-nitrosylation of stargazin.
Selvakumar B, Campbell PW, Milovanovic M, Park DJ, West AR, Snyder SH, Wolf ME., Free PMC Article | 08/30/2014 |
| A significant increase in Stargazin/Cacng2 expression is identified in the whole cerebellum. | c-Fos, Arc, and stargazin expression in rat eyeblink conditioning.
Kim S, Thompson RF. | 12/24/2011 |
| Stargazin and AMPA receptor membrane targeting is altered in mutant rats, potentially contributing to hyperexcitability in somatosensory cortex, with a developmental time course that would suggest a role in the epilepsy phenotype. | Stargazin and AMPA receptor membrane expression is increased in the somatosensory cortex of Genetic Absence Epilepsy Rats from Strasbourg.
Kennard JT, Barmanray R, Sampurno S, Ozturk E, Reid CA, Paradiso L, D'Abaco GM, Kaye AH, Foote SJ, O'Brien TJ, Powell KL. | 12/24/2011 |
| Data show that S-nitrosylation of stargazin increases binding to the AMPAR subunit GluR1, causing increased surface expression of the AMPAR. | S-nitrosylation of stargazin regulates surface expression of AMPA-glutamate neurotransmitter receptors.
Selvakumar B, Huganir RL, Snyder SH., Free PMC Article | 01/21/2010 |
| Stargazin protein expression was also significantly increased in the somatosensory cortex after the onset of spontaneous seizures. The results are of significant importance as they show that an increase in stargazin expression may be pro-epileptic. | Genetic absence epilepsy rats from Strasbourg have increased corticothalamic expression of stargazin.
Powell KL, Kyi M, Reid CA, Paradiso L, D'Abaco GM, Kaye AH, Foote SJ, O'Brien TJ. | 01/21/2010 |
| Fusing the cytoplasmic C terminus of stargazin to the C-terminal domains of either GluR1 or the gonadotropin-releasing hormone receptor permits efficient trafficking from the endoplasmic reticulum and sorting to the basolateral membrane. | The stargazin C terminus encodes an intrinsic and transferable membrane sorting signal.
Bedoukian MA, Whitesell JD, Peterson EJ, Clay CM, Partin KM. | 01/21/2010 |
| is a critical substrate in the bidirectional control of synaptic strength, which is thought to underlie aspects of learning and memory | Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPs.
Tomita S, Stein V, Stocker TJ, Nicoll RA, Bredt DS. | 01/21/2010 |
| SGK3 and stargazin regulate GluR1 independently, and thus, their effects on glutamate-induced currents are additive. | Additive regulation of GluR1 by stargazin and serum- and glucocorticoid-inducible kinase isoform SGK3.
Strutz-Seebohm N, Seebohm G, Korniychuk G, Baltaev R, Ureche O, Striegel M, Lang F. | 01/21/2010 |
| studies show the AMPA receptor/transmembrane AMPA receptor regulatory proteins (TARP) complex is not always stable at the synapse; the regulated interaction with TARPs at the synapse may participate in activity-dependent turnover of AMPA receptors | Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses.
Tomita S, Fukata M, Nicoll RA, Bredt DS. | 01/21/2010 |