| KAT8/SIRT7-mediated Fascin-K41 acetylation/deacetylation regulates tumor metastasis in esophageal squamous cell carcinoma. | KAT8/SIRT7-mediated Fascin-K41 acetylation/deacetylation regulates tumor metastasis in esophageal squamous cell carcinoma.
Li DJ, Cheng YW, Pan JM, Guo ZC, Wang SH, Huang QF, Nie PJ, Shi WQ, Xu XE, Wen B, Zhong JL, Zhang ZD, Wu ZY, Zhao H, Liao LD, Wu JY, Zhang K, Dong G, Li EM, Xu LY. | 04/5/2024 |
| Hotspot Cancer Mutation Impairs KAT8-mediated Nucleosomal Histone Acetylation. | Hotspot Cancer Mutation Impairs KAT8-mediated Nucleosomal Histone Acetylation.
Xuan H, Xu L, Li K, Xuan F, Xu T, Wen H, Shi X., | 03/26/2024 |
| MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC. | MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC.
Zhao K, Zheng M, Su Z, Ghosh S, Zhang C, Zhong W, Ho JWK, Jin G, Zhou Z. | 09/26/2023 |
| Ropivacaine represses the proliferation, invasion, and migration of glioblastoma via modulating the microRNA-21-5p/KAT8 regulatory NSL complex subunit 2 axis. | Ropivacaine represses the proliferation, invasion, and migration of glioblastoma via modulating the microRNA-21-5p/KAT8 regulatory NSL complex subunit 2 axis.
Deng Z, Jian Y, Cai H., Free PMC Article | 04/16/2022 |
| Dysregulation of intercellular signaling by MOF deletion leads to liver injury. | Dysregulation of intercellular signaling by MOF deletion leads to liver injury.
Lei H, denDekker AD, Li G, Zhang Z, Sha L, Schaller MA, Kunkel SL, Rui L, Tao K, Dou Y., Free PMC Article | 08/28/2021 |
| TGFbeta promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy. | TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy.
Zehender A, Li YN, Lin NY, Stefanica A, Nüchel J, Chen CW, Hsu HH, Zhu H, Ding X, Huang J, Shen L, Györfi AH, Soare A, Rauber S, Bergmann C, Ramming A, Plomann M, Eckes B, Schett G, Distler JHW., Free PMC Article | 07/31/2021 |
| The histone acetyltransferase hMOF promotes vascular invasion in hepatocellular carcinoma. | The histone acetyltransferase hMOF promotes vascular invasion in hepatocellular carcinoma.
Poté N, Cros J, Laouirem S, Raffenne J, Negrão M, Albuquerque M, Bedossa P, Godinho Ferreira M, Ait Si Ali S, Fior R, Paradis V. | 07/10/2021 |
| MOF upregulates the estrogen receptor alpha signaling pathway by its acetylase activity in hepatocellular carcinoma. | MOF upregulates the estrogen receptor α signaling pathway by its acetylase activity in hepatocellular carcinoma.
Wei S, Liu W, Sun N, Wu Y, Song H, Wang C, Wang S, Zou R, Lin L, Zeng K, Zhou B, Wang M, Luan R, Yang F, Zhao Y., Free PMC Article | 05/15/2021 |
| Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis. | Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis.
Radzisheuskaya A, Shliaha PV, Grinev VV, Shlyueva D, Damhofer H, Koche R, Gorshkov V, Kovalchuk S, Zhan Y, Rodriguez KL, Johnstone AL, Keogh MC, Hendrickson RC, Jensen ON, Helin K., Free PMC Article | 05/1/2021 |
| Substrate Scope for Human Histone Lysine Acetyltransferase KAT8. | Substrate Scope for Human Histone Lysine Acetyltransferase KAT8.
Proietti G, Wang Y, Punzo C, Mecinović J., Free PMC Article | 04/24/2021 |
| Lysine acetyltransferase 8 is involved in cerebral development and syndromic intellectual disability. | Lysine acetyltransferase 8 is involved in cerebral development and syndromic intellectual disability.
Li L, Ghorbani M, Weisz-Hubshman M, Rousseau J, Thiffault I, Schnur RE, Breen C, Oegema R, Weiss MM, Waisfisz Q, Welner S, Kingston H, Hills JA, Boon EM, Basel-Salmon L, Konen O, Goldberg-Stern H, Bazak L, Tzur S, Jin J, Bi X, Bruccoleri M, McWalter K, Cho MT, Scarano M, Schaefer GB, Brooks SS, Hughes SS, van Gassen KLI, van Hagen JM, Pandita TK, Agrawal PB, Campeau PM, Yang XJ., Free PMC Article | 11/21/2020 |
| Histone Acetyltransferase MOF Orchestrates Outcomes at the Crossroad of Oncogenesis, DNA Damage Response, Proliferation, and Stem Cell Development. | Histone Acetyltransferase MOF Orchestrates Outcomes at the Crossroad of Oncogenesis, DNA Damage Response, Proliferation, and Stem Cell Development.
Singh M, Bacolla A, Chaudhary S, Hunt CR, Pandita S, Chauhan R, Gupta A, Tainer JA, Pandita TK., Free PMC Article | 09/19/2020 |
| Human MOF was highly expressed in endometrial carcinoma and associated with proliferation. High expression of human MOF was associated with late-stage cancer, lymph node metastasis and short survival time, and it was also an independent prognostic risk factor for endometrial carcinoma. | Estrogen/estrogen receptor promotes the proliferation of endometrial carcinoma cells by enhancing hMOF expression.
Qi Y, Tan M, Zheng M, Jin S, Wang H, Liu J, Wang P, Nie X, Gao L, Lin B., Free PMC Article | 06/6/2020 |
| KAT8 is down-regulating virus-induced IFN-I production by acetylating the transcription factor IRF3 at lysine 359, inhibiting the recruitment of IRF3 to IFN-I promoters, and decreasing its transcriptional activity. | KAT8 selectively inhibits antiviral immunity by acetylating IRF3.
Huai W, Liu X, Wang C, Zhang Y, Chen X, Chen X, Xu S, Thomas T, Li N, Cao X., Free PMC Article | 05/9/2020 |
| MOF promotes endometrial cancer cell growth and proliferation in vitro and in vivo. Clinical evidence indicates that expression MOF is decreased and positively correlated with that of ER-alpha in endometrial cancer tissues. | Histone acetyltransferase MOF is involved in suppression of endometrial cancer and maintenance of ERα stability.
Wu Y, Zeng K, Wang C, Wang S, Sun H, Liu W, Wang X, Niu J, Cong SY, Zhou X, Zhao Y. | 11/2/2019 |
| a novel function for the MYST KATs as lysine propionyltransferases | Revealing the protein propionylation activity of the histone acetyltransferase MOF (males absent on the first).
Han Z, Wu H, Kim S, Yang X, Li Q, Huang H, Cai H, Bartlett MG, Dong A, Zeng H, Brown PJ, Yang XJ, Arrowsmith CH, Zhao Y, Zheng YG., Free PMC Article | 01/12/2019 |
| Novel importin alpha1-specific nuclear localization signals were identified in the N-terminal of MOF. | Structural insights into the nuclear import of the histone acetyltransferase males-absent-on-the-first by importin α1.
Zheng W, Wang R, Liu X, Tian S, Yao B, Chen A, Jin S, Li Y. | 12/22/2018 |
| Data describe a trans-histone modification pathway involving PKN1/histone H3 threonine 11 phosphorylation followed by WDR5/MLL histone methyltransferase and KAT8/histone acetyltransferase recruitment to effect androgen-dependent gene activation and prostate cancer cell proliferation. | KAT8 Regulates Androgen Signaling in Prostate Cancer Cells.
Kim JY, Yu J, Abdulkadir SA, Chakravarti D., Free PMC Article | 12/30/2017 |
| These findings provide insight into the regulation of LSD1 and Epithelial-to-Mesenchymal Transition (EMT) and identify MOF as a critical suppressor of EMT and tumor progression. | MOF Acetylates the Histone Demethylase LSD1 to Suppress Epithelial-to-Mesenchymal Transition.
Luo H, Shenoy AK, Li X, Jin Y, Jin L, Cai Q, Tang M, Liu Y, Chen H, Reisman D, Wu L, Seto E, Qiu Y, Dou Y, Casero RA Jr, Lu J. | 10/14/2017 |
| This work identifies MOF as a key regulator of cellular stress response in glomerular podocytes. | MOF maintains transcriptional programs regulating cellular stress response.
Sheikh BN, Bechtel-Walz W, Lucci J, Karpiuk O, Hild I, Hartleben B, Vornweg J, Helmstädter M, Sahyoun AH, Bhardwaj V, Stehle T, Diehl S, Kretz O, Voss AK, Thomas T, Manke T, Huber TB, Akhtar A., Free PMC Article | 09/30/2017 |
| recent results indicate MOF is an upstream regulator of the ATM (ataxia-telangiectasia mutated) protein, the loss of which is responsible for ataxia telangiectasia (AT). ATM is a key regulatory kinase that interacts with and phosphorylates multiple substrates that influence critical, cell-cycle control and DNA damage repair pathways in addition to other pathways. | A multifaceted role for MOF histone modifying factor in genome maintenance.
Mujoo K, Hunt CR, Horikoshi N, Pandita TK., Free PMC Article | 08/12/2017 |
| Histone acetyltransferase activity of MOF is required to sustain MLL-AF9 leukemia and may be important for multiple AML subtypes. | Histone Acetyltransferase Activity of MOF Is Required for MLL-AF9 Leukemogenesis.
Valerio DG, Xu H, Chen CW, Hoshii T, Eisold ME, Delaney C, Cusan M, Deshpande AJ, Huang CH, Lujambio A, Zheng YG, Zuber J, Pandita TK, Lowe SW, Armstrong SA., Free PMC Article | 08/12/2017 |
| our findings reveal that TET1 forms a complex with hMOF to modulate its function and the level of H4K16Ac ultimately affect gene expression and DNA repair. | TET1 modulates H4K16 acetylation by controlling auto-acetylation of hMOF to affect gene regulation and DNA repair function.
Zhong J, Li X, Cai W, Wang Y, Dong S, Yang J, Zhang J, Wu N, Li Y, Mao F, Zeng C, Wu J, Xu X, Sun ZS., Free PMC Article | 06/24/2017 |
| these studies point to the critical and specific role of hMOF Lys-274 autoacetylation in hMOF stability and cognate substrate acetylation and argues that binding of Ac-CoA to hMOF likely drives Lys-274 autoacetylation for subsequent cognate substrate acetylation. | Structural and Functional Role of Acetyltransferase hMOF K274 Autoacetylation.
McCullough CE, Song S, Shin MH, Johnson FB, Marmorstein R., Free PMC Article | 05/13/2017 |
| MOF is a dual-transcriptional regulator of nuclear and mitochondrial genomes connecting epigenetics and metabolism. | MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria.
Chatterjee A, Seyfferth J, Lucci J, Gilsbach R, Preissl S, Böttinger L, Mårtensson CU, Panhale A, Stehle T, Kretz O, Sahyoun AH, Avilov S, Eimer S, Hein L, Pfanner N, Becker T, Akhtar A. | 12/17/2016 |