| USP44 Overexpression Drives a MYC-Like Gene Expression Program in Neuroblastoma through Epigenetic Reprogramming. | USP44 Overexpression Drives a MYC-Like Gene Expression Program in Neuroblastoma through Epigenetic Reprogramming.
Ekstrom TL, Hussain S, Bedekovics T, Ali A, Paolini L, Mahmood H, Rosok RM, Koster J, Johnsen SA, Galardy PJ., Free PMC Article | 10/25/2024 |
| RNA-binding protein NOVA1 promotes acute T-lymphocyte leukemia progression by stabilizing USP44 mRNA. | RNA-binding protein NOVA1 promotes acute T-lymphocyte leukemia progression by stabilizing USP44 mRNA.
Zhang B, Sun R, Gu M, Jiang Z, Wang Y, Zhang L, Liu X, Chi Z. | 02/5/2024 |
| MAD2 activates IGF1R/PI3K/AKT pathway and promotes cholangiocarcinoma progression by interfering USP44/LIMA1 complex. | MAD2 activates IGF1R/PI3K/AKT pathway and promotes cholangiocarcinoma progression by interfering USP44/LIMA1 complex.
Jiang W, Yang X, Shi K, Zhang Y, Shi X, Wang J, Wang Y, Chenyan A, Shan J, Wang Y, Chang J, Chen R, Zhou T, Zhu Y, Yu Y, Li C, Li X. | 11/8/2023 |
| Integrated network findings reveal ubiquitin-specific protease 44 overexpression suppresses tumorigenicity of liver cancer. | Integrated network findings reveal ubiquitin-specific protease 44 overexpression suppresses tumorigenicity of liver cancer.
Zhou H, Yang L, Lin X, Chan TF, Lee NP, Tse WKF, Zhang X, Li R, Lai KP., Free PMC Article | 06/15/2023 |
| USP44 accelerates the growth of T-cell acute lymphoblastic leukemia through interacting with WDR5 and repressing its ubiquitination. | USP44 accelerates the growth of T-cell acute lymphoblastic leukemia through interacting with WDR5 and repressing its ubiquitination.
Chi Z, Zhang B, Sun R, Wang Y, Zhang L, Xu G., Free PMC Article | 12/17/2022 |
| USP44 regulates irradiation-induced DNA double-strand break repair and suppresses tumorigenesis in nasopharyngeal carcinoma. | USP44 regulates irradiation-induced DNA double-strand break repair and suppresses tumorigenesis in nasopharyngeal carcinoma.
Chen Y, Zhao Y, Yang X, Ren X, Huang S, Gong S, Tan X, Li J, He S, Li Y, Hong X, Li Q, Ding C, Fang X, Ma J, Liu N., Free PMC Article | 02/26/2022 |
| USP44 hypermethylation promotes cell proliferation and metastasis in breast cancer. | USP44 hypermethylation promotes cell proliferation and metastasis in breast cancer.
Chen X, Wu X, Lei W. | 09/25/2021 |
| CRADD and USP44 mutations in intellectual disability, mild lissencephaly, brain atrophy, developmental delay, strabismus, behavioural problems and skeletal anomalies. | CRADD and USP44 mutations in intellectual disability, mild lissencephaly, brain atrophy, developmental delay, strabismus, behavioural problems and skeletal anomalies.
Koprulu M, Shabbir RMK, Zaman Q, Nalbant G, Malik S, Tolun A. | 07/10/2021 |
| The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation. | The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation.
Yang J, Wei P, Barbi J, Huang Q, Yang E, Bai Y, Nie J, Gao Y, Tao J, Lu Y, Xie C, Hou X, Ren J, Wu X, Meng J, Zhang Y, Fu J, Kou W, Gao Y, Chen Z, Liang R, Tsun A, Li D, Guo W, Zhang S, Zheng SG, Niu J, Galardy P, Tong X, Shi G, Li H, Pan F, Li B., Free PMC Article | 05/8/2021 |
| USP44 suppresses proliferation and enhances apoptosis in colorectal cancer cells by inactivating the Wnt/beta-catenin pathway via Axin1 deubiquitination. | USP44 suppresses proliferation and enhances apoptosis in colorectal cancer cells by inactivating the Wnt/β-catenin pathway via Axin1 deubiquitination.
Huang T, Zhang Q, Ren W, Yan B, Yi L, Tang T, Lin H, Zhang Y., Free PMC Article | 04/3/2021 |
| Ubiquitin-specific protease-44 inhibits the proliferation and migration of cells via inhibition of JNK pathway in clear cell renal cell carcinoma. | Ubiquitin-specific protease-44 inhibits the proliferation and migration of cells via inhibition of JNK pathway in clear cell renal cell carcinoma.
Zhou J, Wang T, Qiu T, Chen Z, Ma X, Zhang L, Zou J., Free PMC Article | 11/21/2020 |
| Existence of circFOXO3-miR-143-3p-USP44 axis in GC cells was confirmed by RNA-binding protein immunoprecipitation, luciferase reporter assay, and an RNA pull-down experiments. All the data indicate that circFOXO3 promotes GC cell proliferation and migration by upregulating USP44 expression via targeting of miR-143-3p. | CircFOXO3 functions as a molecular sponge for miR-143-3p to promote the progression of gastric carcinoma via upregulating USP44.
Xiang T, Jiang HS, Zhang BT, Liu G. | 08/1/2020 |
| identified USP44 as a positive regulator of MITA; USP44 is recruited to MITA following DNA virus infection and removes K48-linked polyubiquitin moieties from MITA at K236, therefore prevents MITA from proteasome mediated degradation; findings suggest that USP44 plays a specific and critical role in the regulation of innate immune response against DNA viruses | USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA.
Zhang HY, Liao BW, Xu ZS, Ran Y, Wang DP, Yang Y, Luo WW, Wang YY., Free PMC Article | 05/2/2020 |
| USP44 inhibited AKT signaling by stabilizing PTEN in non-small cell lung cancer cells. | Ubiquitin-specific protease 44 inhibits cell growth by suppressing AKT signaling in non-small cell lung cancer.
Zhang YK, Tian WZ, Zhang RS, Zhang YJ, Ma HT. | 02/15/2020 |
| USP44 promotes the tumorigenesis of prostate cancer cells partly by stabilizing EZH2. | USP44 Promotes the Tumorigenesis of Prostate Cancer Cells through EZH2 Protein Stabilization.
Park JM, Lee JE, Park CM, Kim JH., Free PMC Article | 03/30/2019 |
| These data imply a complex picture where regulating factors such as OCT4 may interact with other epigenetic mechanisms to regulate USP44 expression in pluripotent stem cells and testes. | CpG Island Methylation Correlates with the Use of Alternative Promoters for USP44 Gene Expression in Human Pluripotent Stem Cells and Testes.
Tropel P, Jung L, André C, Ndandougou A, Viville S. | 04/21/2018 |
| USP44 protein was widely expressed in most of the tumor samples and no clear association could be established between its expression and DNA ploidy status or tumor size | DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression.
Bernardes VF, Odell EW, Gomez RS, Gomes CC. | 03/24/2018 |
| In summary, we report that the combination of USP44 expression and DNA ploidy status might serve as an independent prognostic marker in gastric cancer. | High ubiquitin-specific protease 44 expression induces DNA aneuploidy and provides independent prognostic information in gastric cancer.
Nishimura S, Oki E, Ando K, Iimori M, Nakaji Y, Nakashima Y, Saeki H, Oda Y, Maehara Y., Free PMC Article | 03/10/2018 |
| USP44 contributes to N-CoR functions in regulating gene expression and is required for efficient invasiveness of triple-negative breast cancer cells. | USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B.
Lan X, Atanassov BS, Li W, Zhang Y, Florens L, Mohan RD, Galardy PJ, Washburn MP, Workman JL, Dent SYR., Free PMC Article | 11/25/2017 |
| USP44+ Cancer Stem Cell Subclones Contribute to Breast Cancer Aggressiveness by Promoting Vasculogenic Mimicry | USP44+ Cancer Stem Cell Subclones Contribute to Breast Cancer Aggressiveness by Promoting Vasculogenic Mimicry.
Liu T, Sun B, Zhao X, Li Y, Zhao X, Liu Y, Yao Z, Gu Q, Dong X, Shao B, Lin X, Liu F, An J. | 06/11/2016 |
| USP44 is epigenetically inactivated in colorectal adenomas, but this alone is not sufficient to cause aneuploidy in colorectal neoplasia. | Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia.
Sloane MA, Wong JW, Perera D, Nunez AC, Pimanda JE, Hawkins NJ, Sieber OM, Bourke MJ, Hesson LB, Ward RL., Free PMC Article | 07/25/2015 |
| findings implicate USP44 in negative regulation of the RNF8/RNF168 pathway | The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases.
Mosbech A, Lukas C, Bekker-Jensen S, Mailand N., Free PMC Article | 08/31/2013 |
| Data identify Cdc20, USP44, and Wee1 as relevant Fcp1 targets. | Fcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit.
Visconti R, Palazzo L, Della Monica R, Grieco D., Free PMC Article | 09/22/2012 |
| These data are consistent with an important role for USP44 in regulating Cdc20-APC/C activity and suggest that high levels of this enzyme may contribute to the pathogenesis of T-cell leukemias. | Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia.
Zhang Y, van Deursen J, Galardy PJ., Free PMC Article | 12/24/2011 |
| a dynamic balance of ubiquitination by the APC and deubiquitination by USP44 contributes to the generation of the switch-like transition controlling anaphase entry | Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.
Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER 3rd, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ. | 01/21/2010 |