| Regenerating gene 4 promotes chemoresistance of colorectal cancer by affecting lipid droplet synthesis and assembly. | Regenerating gene 4 promotes chemoresistance of colorectal cancer by affecting lipid droplet synthesis and assembly.
Zhang CY, Zhang R, Zhang L, Wang ZM, Sun HZ, Cui ZG, Zheng HC., Free PMC Article | 09/29/2023 |
| The effects of REG4 expression on chemoresistance of ovarian cancer. | The effects of REG4 expression on chemoresistance of ovarian cancer.
Xiang LW, Xue H, Ha MW, Yu DY, Xiao LJ, Zheng HC. | 01/14/2023 |
| Upregulation of REG IV gene in human intestinal epithelial cells by lipopolysaccharide via downregulation of microRNA-24. | Upregulation of REG IV gene in human intestinal epithelial cells by lipopolysaccharide via downregulation of microRNA-24.
Takasawa S, Tsuchida C, Sakuramoto-Tsuchida S, Uchiyama T, Makino M, Yamauchi A, Itaya-Hironaka A., Free PMC Article | 09/24/2022 |
| Reg4 Interacts with CD44 to Regulate Proliferation and Stemness of Colorectal and Pancreatic Cancer Cells. | Reg4 Interacts with CD44 to Regulate Proliferation and Stemness of Colorectal and Pancreatic Cancer Cells.
Bishnupuri KS, Sainathan SK, Ciorba MA, Houchen CW, Dieckgraefe BK. | 05/7/2022 |
| Clinicopathological Significance and Prognostic Implications of REG4 Immunohistochemical Expression in Colorectal Cancer. | Clinicopathological Significance and Prognostic Implications of REG4 Immunohistochemical Expression in Colorectal Cancer.
Kang G, Oh I, Pyo J, Kang D, Son B., Free PMC Article | 10/2/2021 |
| CDX2 and Reg IV expression and correlation in gastric cancer. | CDX2 and Reg IV expression and correlation in gastric cancer.
Chai D, Du H, Li K, Zhang X, Li X, Zhao X, Lian X, Xu Y., Free PMC Article | 07/10/2021 |
| A mutant KRAS-induced factor REG4 promotes cancer stem cell properties via Wnt/beta-catenin signaling. | A mutant KRAS-induced factor REG4 promotes cancer stem cell properties via Wnt/β-catenin signaling.
Hwang JH, Yoon J, Cho YH, Cha PH, Park JC, Choi KY. | 09/26/2020 |
| The correlation of CDX2 with Reg IV expression was demonstrated in ovarian mucinous carcinoma. Reg IV expression was enhanced by transfection of CDX2 and was suppressed by inhibition of CDX2 expression. OMC-3 cells with ectopically overexpressed CDX2 showed enhanced apoptosis and sensitivity to 5-FU. | Regulation of REG4 Expression and Prediction of 5-Fluorouracil Sensitivity by CDX2 in Ovarian Mucinous Carcinoma.
Koh I, Nosaka S, Sekine M, Sugimoto J, Hirata E, Kudo Y., Free PMC Article | 03/14/2020 |
| REG4 plays an important role in KRAS-driven lung cancer pathogenesis and is a novel biomarker of lung adenocarcinoma subtype. Future studies are required to clarify the underlying mechanisms of REG4 in the division and proliferation of KC tumors and its potential therapeutic value. | REG4 is an indicator for KRAS mutant lung adenocarcinoma with TTF-1 low expression.
Sun S, Hu Z, Huang S, Ye X, Wang J, Chang J, Wu X, Wang Q, Zhang L, Hu X, Yu H. | 08/31/2019 |
| Our study demonstrated that Reg IV positively regulates the expression of SOX9 and is involved in tumor cell invasion and migration in gastric cancer. | Expression of Reg IV and SOX9 and their correlation in human gastric cancer.
Zhang N, Chai D, Du H, Li K, Xie W, Li X, Yang R, Lian X, Xu Y., Free PMC Article | 12/22/2018 |
| Reg4 inhibited apoptosis through regulating MAPK/Erk/Bim signaling pathway and thereby enhanced the resistance of gastric cancer to 5-Fluorouracil. | Regenerating Family Member 4 (Reg4) Enhances 5-Fluorouracil Resistance of Gastric Cancer Through Activating MAPK/Erk/Bim Signaling Pathway.
Jin J, Lv H, Wu J, Li D, Chen K, Zhang F, Han J, Feng J, Zhang N, Yu H, Su D, Ying L., Free PMC Article | 04/28/2018 |
| Data indicate that REG4 tissue expression is a prognostic marker in subgroups of pancreatic ductal adenocarcinoma patients, and Serum REG4 level might be useful in differential diagnosis between pancreatic ductal adenocarcinoma and chronic pancreatitis. | Prognostic and diagnostic value of REG4 serum and tissue expression in pancreatic ductal adenocarcinoma.
Saukkonen K, Hagström J, Mustonen H, Lehtinen L, Carpen O, Andersson LC, Seppänen H, Haglund C. | 03/31/2018 |
| REG4 promotes peritoneal metastasis of gastric cancer through GPR37 and triggers a positive feedback loop. | REG4 promotes peritoneal metastasis of gastric cancer through GPR37.
Wang H, Hu L, Zang M, Zhang B, Duan Y, Fan Z, Li J, Su L, Yan M, Zhu Z, Liu B, Yang Q., Free PMC Article | 12/16/2017 |
| Study demonstrated that REG4, which is overexpressed in pancreatic ductal adenocarcinoma and secreted by cancer cells, promoted macrophage polarization to M2, through at least in part, activation of ERK1/2 and CREB. | The pancreatic cancer secreted REG4 promotes macrophage polarization to M2 through EGFR/AKT/CREB pathway.
Ma X, Wu D, Zhou S, Wan F, Liu H, Xu X, Xu X, Zhao Y, Tang M. | 10/22/2016 |
| REG4 is a transcriptional target of GATA6 and is essential for colorectal tumorigenesis. | REG4 is a transcriptional target of GATA6 and is essential for colorectal tumorigenesis.
Kawasaki Y, Matsumura K, Miyamoto M, Tsuji S, Okuno M, Suda S, Hiyoshi M, Kitayama J, Akiyama T., Free PMC Article | 08/20/2016 |
| This study identifies REG4 as a potential serum biomarker for histotype-specific detection of mucinous ovarian cancer and suggests serum REG4 measurement as a non-invasive diagnostic tool for follow-up of patients with mucinous ovarian cancer. | REG4 Is Highly Expressed in Mucinous Ovarian Cancer: A Potential Novel Serum Biomarker.
Lehtinen L, Vesterkvist P, Roering P, Korpela T, Hattara L, Kaipio K, Mpindi JP, Hynninen J, Auranen A, Davidson B, Haglund C, Iljin K, Grenman S, Siitari H, Carpen O., Free PMC Article | 07/30/2016 |
| aberrant REG4 expression plays an essential role in early ovarian carcinogenesis and is closely linked to mucinous ovarian tumors, differentiation and adverse prognosis of ovarian cancer by modulating proliferation, apoptosis, migration and invasion. | The role of the REG4 gene and its encoding product in ovarian epithelial carcinoma.
Chen S, Gou WF, Zhao S, Niu ZF, Zhao Y, Takano Y, Zheng HC., Free PMC Article | 02/27/2016 |
| REG4 expression associated with favorable clinicopathological parameters and with higher overall survival from non-mucinous | REG4 independently predicts better prognosis in non-mucinous colorectal cancer.
Kaprio T, Hagström J, Mustonen H, Koskensalo S, Andersson LC, Haglund C., Free PMC Article | 10/10/2015 |
| The Reg IV may be involved in the finetuning of functions exerted by the neuroendocrine cells in the GI-tract. | Reg IV is differently expressed in enteroendocrine cells of human small intestine and colon.
Heiskala K, Andersson LC. | 10/3/2015 |
| Colorectal tumor patients with Reg4- and MMP-7-positive tumors had extremely poor overall survival. | Overexpression of Reg4, alone or combined with MMP-7 overexpression, is predictive of poor prognosis in colorectal cancer.
Zhu X, Han Y, Yuan C, Tu W, Qiu G, Lu S, Lu H, Peng Z, Zhou C. | 08/1/2015 |
| High expression of REG4 is associated with poor therapeutic response, adverse outcome and an aggressive phenotype in rectal cancer patients treated with neoadjuvant chemoradiotherapy. | Overexpression of REG4 confers an independent negative prognosticator in rectal cancers receiving concurrent chemoradiotherapy.
He HL, Lee YE, Shiue YL, Lee SW, Lin LC, Chen TJ, Wu TF, Hsing CH, Huang HY, Wang JY, Li CF. | 02/28/2015 |
| miR-24 functions as a novel tumor suppressor in gastric cancer, and the anti-oncogenic activity may involve its inhibition of the target gene REG4. | Tumor suppressor miR-24 restrains gastric cancer progression by downregulating RegIV.
Duan Y, Hu L, Liu B, Yu B, Li J, Yan M, Yu Y, Li C, Su L, Zhu Z, Xiang M, Liu B, Yang Q., Free PMC Article | 01/17/2015 |
| REG4 expression is common in mucinous borderline ovarian tumors of the intestinal type as it is absent in the endocervical-like form tumors. | Expression of REG4 in ovarian mucinous tumors.
Huang Q, Chen X, Lu W, Lai M, Lu B. | 12/6/2014 |
| the combination of VEGF-C and Reg IV may be a promising factor for clinical staging to supplement the classical TNM classification system. | New molecular staging with G-factors (VEGF-C and Reg IV) by supplementing TNM classification in colorectal cancers.
Sawada T, Yashiro M, Sentani K, Oue N, Yasui W, Miyazaki K, Kai K, Fujita H, Nakamura K, Maeda K, Kakeji Y, Natsugoe S, Shirabe K, Nomura S, Shimada Y, Tomita N, Hirakawa K, Maehara Y., Free PMC Article | 05/17/2014 |
| the stemness properties of control mammospheres and RegIV knockdown mammospheres were compared by tumourigenicity assay in vivo and plate colony formation assay in vitro. | Silencing of RegIV by shRNA causes the loss of stemness properties of cancer stem cells in MKN45 gastric cancer cells.
Zhou W, Sun M, Wang DL, Wang Y, Jin F, Zhang YY, Yang L, Wu XL, Wu YZ. | 05/17/2014 |