| Deficiency of Trps1 in Cementoblasts Impairs Cementogenesis and Tooth Root Formation. | Deficiency of Trps1 in Cementoblasts Impairs Cementogenesis and Tooth Root Formation.
Fujikawa K, Socorro M, Lukashova L, Hoskere P, Keskinidis P, Verdelis K, Napierala D., Free PMC Article | 11/7/2024 |
| Deletion of Trps1 regulatory elements recapitulates postnatal hip joint abnormalities and growth retardation of Trichorhinophalangeal syndrome in mice. | Deletion of Trps1 regulatory elements recapitulates postnatal hip joint abnormalities and growth retardation of Trichorhinophalangeal syndrome in mice.
Saeki N, Inui-Yamamoto C, Ikeda Y, Kanai R, Hata K, Itoh S, Inubushi T, Akiyama S, Ohba S, Abe M. | 10/25/2024 |
| TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity. | TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity.
Tollot-Wegner M, Jessen M, Kim K, Sanz-Moreno A, Spielmann N, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, von Eyss B., Free PMC Article | 05/20/2024 |
| Cis-regulatory control of mammalian Trps1 gene expression. | Cis-regulatory control of mammalian Trps1 gene expression.
Abrar M, Ali S, Hussain I, Khatoon H, Batool F, Ghazanfar S, Corcoran D, Kawakami Y, Abbasi AA., | 03/29/2024 |
| Trps1 acts as a regulator of Sf-1 transcription and testosterone synthesis in mouse Leydig cells. | Trps1 acts as a regulator of Sf-1 transcription and testosterone synthesis in mouse Leydig cells.
Sun J, Lian X, Lv C, Li H, Lin Z, Luo S, Liu Y, Xu Y, Jiang X, Xu W, Liao S, Chen Z, Wang S. | 12/5/2023 |
| Trps1 transcription factor represses phosphate-induced expression of SerpinB2 in osteogenic cells. | Trps1 transcription factor represses phosphate-induced expression of SerpinB2 in osteogenic cells.
Socorro M, Shinde A, Yamazaki H, Khalid S, Monier D, Beniash E, Napierala D., Free PMC Article | 06/26/2021 |
| Study characterized the murine Wnt5a promoter and showed that two alternative Wnt5a transcripts, Ts1 and Ts2, are differentially expressed in the developing skeletal elements. Ts2 expression decreases while Ts1 expression increases during chondrocyte differentiation. The transcription factor Trps1 and the activator form of Gli3 (Gli3A), which is a mediator of Hedgehog signaling, activate Wnt5a expression. | Wnt5a is a transcriptional target of Gli3 and Trps1 at the onset of chondrocyte hypertrophy.
Wuelling M, Schneider S, Schröther VA, Waterkamp C, Hoffmann D, Vortkamp A. | 07/11/2020 |
| These results demonstrated that TRPS1 plays indispensable roles during mouse zygotic genome activation through controlling the expression of zygotic genome activation markers MuERV-L and Zscan4d, transcription factors SOX2 and OCT4, and key histone markers H3K4me3 and H3K27me3. | Atypical GATA protein TRPS1 plays indispensable roles in mouse two-cell embryo.
Liu Y, Xu S, Lian X, Su Y, Zhong Y, Lv R, Mo K, Zhu H, Xiaojiang W, Xu L, Wang S., Free PMC Article | 05/9/2020 |
| TRPS1 can function as a context-dependent tumor suppressor in breast cancer, while being essential for growth and differentiation of normal mammary epithelial cells. | TRPS1 acts as a context-dependent regulator of mammary epithelial cell growth/differentiation and breast cancer development.
Cornelissen LM, Drenth AP, van der Burg E, de Bruijn R, Pritchard CEJ, Huijbers IJ, Zwart W, Jonkers J., Free PMC Article | 02/15/2020 |
| This study has demonstrated that Trps1 is a positive regulator of cell proliferation in both dental mesenchyme and epithelium, suggesting that the microdontia in trichorhinophalangeal syndrome is likely due to decreased cell proliferation in developing tooth organs. | Trps1 transcription factor regulates mineralization of dental tissues and proliferation of tooth organ cells.
Goss M, Socorro M, Monier D, Verdelis K, Napierala D., Free PMC Article | 11/9/2019 |
| our findings partially explain why patients with TRPS show a broad range of congenital cardiac defects, although Trps1 expression is observed in a more restricted fashion. | Fate mapping of Trps1 daughter cells during cardiac development using novel Trps1-Cre mice.
Nomir AG, Takeuchi Y, Fujikawa J, El Sharaby AA, Wakisaka S, Abe M. | 02/4/2017 |
| Taken together, these results show that hair follicle development in Trps1 KO embryos is impaired directly or indirectly by decreased Noggin expression. | Trps1 deficiency inhibits the morphogenesis of secondary hair follicles via decreased Noggin expression.
Sun Y, Nakanishi M, Sato F, Oikawa K, Muragaki Y, Zhou G. | 03/21/2015 |
| association between SNP within TRPS1 and BMD | Trps1 differentially modulates the bone mineral density between male and female mice and its polymorphism associates with BMD differently between women and men.
Wang L, Lu W, Zhang L, Huang Y, Scheib R, Liu X, Myers L, Lu L, Farber CR, Liu G, Wang CY, Deng H, Williams RW, Wang Y, Gu W, Jiao Y., Free PMC Article | 09/13/2014 |
| Trps1 acts as a regulator of hdac1 and hdac4 histone deacetylases during mitosis. | The multi zinc-finger protein Trps1 acts as a regulator of histone deacetylation during mitosis.
Wuelling M, Pasdziernik M, Moll CN, Thiesen AM, Schneider S, Johannes C, Vortkamp A., Free PMC Article | 03/8/2014 |
| The loss of Trps1 suppresses ureteric bud branching because of the activation of TGF-beta signaling. | The loss of Trps1 suppresses ureteric bud branching because of the activation of TGF-β signaling.
Gui T, Sun Y, Gai Z, Shimokado A, Muragaki Y, Zhou G. | 06/29/2013 |
| We found that Trps1 directly represses expression of the hair follicle stem cell regulator Sox9 to control proliferation of the follicle epithelium. | Trps1 and its target gene Sox9 regulate epithelial proliferation in the developing hair follicle and are associated with hypertrichosis.
Fantauzzo KA, Kurban M, Levy B, Christiano AM., Free PMC Article | 05/18/2013 |
| Trps1 is identified as a potent inhibitor of Dspp expression and the subsequent mineralization of dentin. | Transcriptional repression of the Dspp gene leads to dentinogenesis imperfecta phenotype in Col1a1-Trps1 transgenic mice.
Napierala D, Sun Y, Maciejewska I, Bertin TK, Dawson B, D'Souza R, Qin C, Lee B., Free PMC Article | 11/24/2012 |
| analysis of control of mesenchymal lineage progression by microRNAs targeting skeletal gene regulators Trps1 and Runx2 | Control of mesenchymal lineage progression by microRNAs targeting skeletal gene regulators Trps1 and Runx2.
Zhang Y, Xie RL, Gordon J, LeBlanc K, Stein JL, Lian JB, van Wijnen AJ, Stein GS., Free PMC Article | 09/22/2012 |
| These observations underscore the indispensable role played by Trps1 in normal temporomandibular joint development. | Trps1 is necessary for normal temporomandibular joint development.
Michikami I, Fukushi T, Honma S, Yoshioka S, Itoh S, Muragaki Y, Kurisu K, Ooshima T, Wakisaka S, Abe M. | 08/11/2012 |
| Genetic variation in TRPS1 may regulate hip geometry as well as bone mineral density | Genetic variation in TRPS1 may regulate hip geometry as well as bone mineral density.
Ackert-Bicknell CL, Demissie S, Tsaih SW, Beamer WG, Cupples LA, Paigen BJ, Hsu YH, Kiel DP, Karasik D., Free PMC Article | 08/11/2012 |
| Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis. | Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis.
Fantauzzo KA, Christiano AM., Free PMC Article | 02/4/2012 |
| Trps1 binds to the P2 promoter of the Runx1 gene and down-regulates Runx1 expression, which is necessary for normal cartilage formation. | Aberrant expression of the P2 promoter-specific transcript Runx1 in epiphyseal cartilage of Trps1-null mice.
Kanno S, Gui T, Itoh S, Gai Z, Sun Y, Oikawa K, Yoshida M, Muragaki Y. | 05/7/2011 |
| Only missense mutations in exon 6 of the TRPS1 gene are responsible for the severe form of TRPS | A novel missense mutation in the TRPS1 gene in a case of trichorhinophalangeal syndrome type I (TRPS1) with fish-like malodour.
Nakamura M, Sugita K, Tokura Y. | 10/23/2010 |
| Trps1 haploinsufficiency enhances TGF-beta1-induced epithelial-to-mesenchymal transition (EMT) and tubulointerstitial fibrosis by modulating the amount of Smad7 through Arkadia/ubiquitin-mediated degradation. | Trps1 haploinsufficiency promotes renal fibrosis by increasing Arkadia expression.
Gai Z, Zhou G, Gui T, Itoh S, Oikawa K, Uetani K, Muragaki Y., Free PMC Article | 09/27/2010 |
| Trps1 interacts with the activator form of Gli3. | Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3.
Wuelling M, Kaiser FJ, Buelens LA, Braunholz D, Shivdasani RA, Depping R, Vortkamp A. | 01/21/2010 |