| The ICF syndrome protein CDCA7 harbors a unique DNA binding domain that recognizes a CpG dyad in the context of a non-B DNA. | The ICF syndrome protein CDCA7 harbors a unique DNA binding domain that recognizes a CpG dyad in the context of a non-B DNA.
Hardikar S, Ren R, Ying Z, Zhou J, Horton JR, Bramble MD, Liu B, Lu Y, Liu B, Coletta LD, Shen J, Dan J, Zhang X, Cheng X, Chen T., Free PMC Article | 08/27/2024 |
| Circ_0006220 (circ-TADA2A) accelerates prostate cancer cell malignant behaviors through miR-520f-3p/CDCA7 axis. | Circ_0006220 (circ-TADA2A) accelerates prostate cancer cell malignant behaviors through miR-520f-3p/CDCA7 axis.
Wan Z, Liu G. | 08/6/2024 |
| High Expression of CDCA7 in the Prognosis of Glioma and Its Relationship with Ferroptosis and Immunity. | High Expression of CDCA7 in the Prognosis of Glioma and Its Relationship with Ferroptosis and Immunity.
Wang Y, Zhao Y, Zhang Z, Zhang J, Xu Q, Zhou X, Mao L., Free PMC Article | 08/9/2023 |
| CDCA7 promotes TGF-beta-induced epithelial-mesenchymal transition via transcriptionally regulating Smad4/Smad7 in ESCC. | CDCA7 promotes TGF-β-induced epithelial-mesenchymal transition via transcriptionally regulating Smad4/Smad7 in ESCC.
Li H, Wang S, Li X, Weng Y, Guo D, Kong P, Cheng C, Wang Y, Zhang L, Cheng X, Cui Y., Free PMC Article | 01/11/2023 |
| CDCA7-regulated inflammatory mechanism through TLR4/NF-kappaB signaling pathway in stomach adenocarcinoma. | CDCA7-regulated inflammatory mechanism through TLR4/NF-κB signaling pathway in stomach adenocarcinoma.
Guo Y, Zhou K, Zhuang X, Li J, Shen X. | 02/19/2022 |
| Downregulation of cell division cycle-associated protein 7 (CDCA7) suppresses cell proliferation, arrests cell cycle of ovarian cancer, and restrains angiogenesis by modulating enhancer of zeste homolog 2 (EZH2) expression. | Downregulation of cell division cycle-associated protein 7 (CDCA7) suppresses cell proliferation, arrests cell cycle of ovarian cancer, and restrains angiogenesis by modulating enhancer of zeste homolog 2 (EZH2) expression.
Cai C, Peng X, Zhang Y., Free PMC Article | 01/1/2022 |
| CDCA7 and HELLS suppress DNA:RNA hybrid-associated DNA damage at pericentromeric repeats. | CDCA7 and HELLS suppress DNA:RNA hybrid-associated DNA damage at pericentromeric repeats.
Unoki M, Sharif J, Saito Y, Velasco G, Francastel C, Koseki H, Sasaki H., Free PMC Article | 03/13/2021 |
| High expression of CDCA7 predicts tumor progression and poor prognosis in human colorectal cancer. | High expression of CDCA7 predicts tumor progression and poor prognosis in human colorectal cancer.
Li S, Huang J, Qin M, Zhang J, Liao C., Free PMC Article | 02/13/2021 |
| ZBTB24 activates the expression of CDCA7 in T cells. | ZBTB24 regulates the apoptosis of human T cells via CDCA7/TRAIL-receptor axis.
Qin XY, Feng J, Chen G, Dou XW, Dai XQ, Dong HL, Gong FY, Xiao F, Zhao Y, Gao XM, Wang J. | 07/25/2020 |
| the CDCA7 gene may play a tumor-promoting role in lung adenocarcinoma | CDCA7 promotes lung adenocarcinoma proliferation via regulating the cell cycle.
Wang H, Ye L, Xing Z, Li H, Lv T, Liu H, Zhang F, Song Y. | 03/28/2020 |
| The inhibiting effects of FGD5-AS1 knockdown on colorectal cancer (CRC) cell proliferation, migration, and invasion, and the promoting effects on CRC cell apoptosis could be revived by miR-302e suppression or CDCA7 upregulation. | Long noncoding RNA FGD5-AS1 promotes colorectal cancer cell proliferation, migration, and invasion through upregulating CDCA7 via sponging miR-302e.
Li D, Jiang X, Zhang X, Cao G, Wang D, Chen Z. | 01/25/2020 |
| the C-NHEJ defect alone did not cause CG hypomethylation, CDCA7 and HELLS are involved in maintaining CG methylation at centromeric and pericentromeric repeats. The defect in C-NHEJ may account for some common features of immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome cells, including centromeric instability, abnormal chromosome segregation, and apoptosis. | CDCA7 and HELLS mutations undermine nonhomologous end joining in centromeric instability syndrome.
Unoki M, Funabiki H, Velasco G, Francastel C, Sasaki H., Free PMC Article | 11/9/2019 |
| CDCA7 was not required for anchorage-dependent growth of normal fibroblasts or non-malignant lymphocytes, it was essential but not sufficient for anchorage-independent growth of lymphoid tumor cells and for lymphomagenesis. | CDCA7 is a critical mediator of lymphomagenesis that selectively regulates anchorage-independent growth.
Jiménez-P R, Martín-Cortázar C, Kourani O, Chiodo Y, Cordoba R, Domínguez-Franjo MP, Redondo JM, Iglesias T, Campanero MR., Free PMC Article | 10/12/2019 |
| in contrast to Immunodeficiency, Centromeric instability and Facial anomalies syndrome type 1 (ICF1), the subtelomeric methylation patterns in cells of ICF2-4 patients do not differ significantly from those in normal cells, and ICF2-4 cells exhibit a normal telomeric phenotype. Also knocking down the expression of ZBTB24, CDCA7 and HELLS in normal human fibroblasts does not affect subtelomeric methylation. | Subtelomeric methylation distinguishes between subtypes of Immunodeficiency, Centromeric instability and Facial anomalies syndrome.
Toubiana S, Velasco G, Chityat A, Kaindl AM, Hershtig N, Tzur-Gilat A, Francastel C, Selig S. | 05/25/2019 |
| Here, we performed a comparative analysis of perturbed DNA methylation landscapes in a cohort of ICF patients using an array-based assay to (i) evaluate the similarities and differences in methylation landscapes depending on patient genotypes as an index of a functional link between the four ICF factors, (ii) identify genomic regions that rely on DNMT3B, ZBTB24, CDCA7 or HELLS for their methylation status | Comparative methylome analysis of ICF patients identifies heterochromatin loci that require ZBTB24, CDCA7 and HELLS for their methylated state.
Velasco G, Grillo G, Touleimat N, Ferry L, Ivkovic I, Ribierre F, Deleuze JF, Chantalat S, Picard C, Francastel C. | 03/16/2019 |
| Immunohistochemical analysis revealed that the CDCA7/EZH2 axis was clinical relevant. These findings suggest CDCA7 plays a crucial role in TNBC progression by transcriptionally upregulating EZH2. | Overexpression of CDCA7 predicts poor prognosis and induces EZH2-mediated progression of triple-negative breast cancer.
Ye L, Li F, Song Y, Yu D, Xiong Z, Li Y, Shi T, Yuan Z, Lin C, Wu X, Ren L, Li X, Song L. | 03/9/2019 |
| HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex; immunodeficiency-centromeric instability-facial anomalies syndrome has a defective HELLS and CDCA7 bipartite nucleosome remodeling complex | HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome.
Jenness C, Giunta S, Müller MM, Kimura H, Muir TW, Funabiki H., Free PMC Article | 07/28/2018 |
| Transcriptome analysis identified Cdca7 as the top down-regulated gene in Zbtb24 homozygous mutant mESCs, which can be restored by ectopic ZBTB24 expression. Finally, we show that this regulation is conserved between species and that CDCA7 levels are reduced in patients carrying ZBTB24 nonsense mutations | Converging disease genes in ICF syndrome: ZBTB24 controls expression of CDCA7 in mammals.
Wu H, Thijssen PE, de Klerk E, Vonk KK, Wang J, den Hamer B, Aytekin C, van der Maarel SM, Daxinger L. | 07/22/2017 |
| Missense mutations in CDCA7 cause immunodeficiency-centromeric instability-facial anomalies syndrome type 3. | Mutations in CDCA7 and HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome.
Thijssen PE, Ito Y, Grillo G, Wang J, Velasco G, Nitta H, Unoki M, Yoshihara M, Suyama M, Sun Y, Lemmers RJ, de Greef JC, Gennery A, Picco P, Kloeckener-Gruissem B, Güngör T, Reisli I, Picard C, Kebaili K, Roquelaure B, Iwai T, Kondo I, Kubota T, van Ostaijen-Ten Dam MM, van Tol MJ, Weemaes C, Francastel C, van der Maarel SM, Sasaki H., Free PMC Article | 04/16/2016 |
| Data indicate that cell division cycle associated 7 protein (Cdca7) is strongly up-regulated in the hemogenic population during embryonic stem cell hematopoietic differentiation in a Notch-dependent manner. | Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence.
Guiu J, Bergen DJ, De Pater E, Islam AB, Ayllón V, Gama-Norton L, Ruiz-Herguido C, González J, López-Bigas N, Menendez P, Dzierzak E, Espinosa L, Bigas A., Free PMC Article | 04/25/2015 |
| The CDCA7 transcription factor regulates cell proliferation. | Chromosome 2q31.1 associates with ESRD in women with type 1 diabetes.
Sandholm N, McKnight AJ, Salem RM, Brennan EP, Forsblom C, Harjutsalo V, Mäkinen VP, McKay GJ, Sadlier DM, Williams WW, Martin F, Panduru NM, Tarnow L, Tuomilehto J, Tryggvason K, Zerbini G, Comeau ME, Langefeld CD, FIND Consortium, Godson C, Hirschhorn JN, Maxwell AP, Florez JC, Groop PH, FinnDiane Study Group and the GENIE Consortium., Free PMC Article | 11/30/2013 |
| CDCA7 associates with MYC and this association is modulated in a phosphorylation-dependent manner. | The MYC-associated protein CDCA7 is phosphorylated by AKT to regulate MYC-dependent apoptosis and transformation.
Gill RM, Gabor TV, Couzens AL, Scheid MP., Free PMC Article | 03/9/2013 |
| JPO1/CDCA7 is a unique transcription regulator whose expression is activated by E2F1 as well as c-Myc. | JPO1/CDCA7, a novel transcription factor E2F1-induced protein, possesses intrinsic transcriptional regulator activity.
Goto Y, Hayashi R, Muramatsu T, Ogawa H, Eguchi I, Oshida Y, Ohtani K, Yoshida K. | 01/21/2010 |