| the presence of Flotillin-1, in addition to Flotillin-2 in the cardiac intercalated disc, is reported. | Flotillins in the intercalated disc are potential modulators of cardiac excitability.
Kessler EL, van Stuijvenberg L, van Bavel JJA, van Bennekom J, Zwartsen A, Rivaud MR, Vink A, Efimov IR, Postma AV, van Tintelen JP, Remme CA, Vos MA, Banning A, de Boer TP, Tikkanen R, van Veen TAB. | 01/11/2020 |
| Data suggest that flotillin-1 and flotillin-2 function as thyroglobulin-binding proteins in lipid rafts of thyrocytes; these interactions appear to exert negative-feedback effects on gene expression in thyrocytes. | A Novel Role for Flotillin-Containing Lipid Rafts in Negative-Feedback Regulation of Thyroid-Specific Gene Expression by Thyroglobulin.
Luo Y, Akama T, Okayama A, Yoshihara A, Sue M, Oda K, Hayashi M, Ishido Y, Hirano H, Hiroi N, Katoh R, Suzuki K. | 02/10/2018 |
| upregulation of reggie-1 in mammalian neurons provides nerve cells with neuron-intrinsic properties required for axon growth and successful regeneration | Upregulation of reggie-1/flotillin-2 promotes axon regeneration in the rat optic nerve in vivo and neurite growth in vitro.
Koch JC, Solis GP, Bodrikov V, Michel U, Haralampieva D, Shypitsyna A, Tönges L, Bähr M, Lingor P, Stuermer CA. | 07/27/2013 |
| Flot-2 expression decreases after spinal cord injury. | Expression profile of flotillin-2 and its pathophysiological role after spinal cord injury.
Santiago JM, Torrado AI, Arocho LC, Rosas OR, Rodríguez AE, Toro FK, Salgado IK, Torres YA, Silva WI, Miranda JD., Free PMC Article | 06/29/2013 |
| flotillins have a role in NPC1L1-mediated cholesterol uptake and NPC1L1-flotillins-postive cholesterol-enriched membrane microdomains are involved in the mechanism for efficient cholesterol absorption | Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake.
Ge L, Qi W, Wang LJ, Miao HH, Qu YX, Li BL, Song BL., Free PMC Article | 02/26/2011 |
| Endocytosis of flotillins is regulated by the Src family kinase Fyn. | Endocytosis of flotillin-1 and flotillin-2 is regulated by Fyn kinase.
Riento K, Frick M, Schafer I, Nichols BJ., Free PMC Article | 01/21/2010 |
| NMDARs were significantly more colocalized with flot-1 than flot-2 in cultured hippocampal neurons | NMDA receptors interact with flotillin-1 and -2, lipid raft-associated proteins.
Swanwick CC, Shapiro ME, Yi Z, Chang K, Wenthold RJ. | 01/21/2010 |
| deletion mutants of reggie-1/flotillin-2 accumulate in the Golgi complex, suggesting Golgi-dependent trafficking of reggie-1/flotillin-2 | Trafficking of the microdomain scaffolding protein reggie-1/flotillin-2.
Langhorst MF, Reuter A, Jaeger FA, Wippich FM, Luxenhofer G, Plattner H, Stuermer CA. | 01/21/2010 |
| Reggie-1 and reggie-2 are localized in microdomains different from caveolae, and the function of reggies is different from and independent of caveolin-1. | Reggie-1 and reggie-2 localize in non-caveolar rafts in epithelial cells: cellular localization is not dependent on the expression of caveolin proteins.
Fernow I, Icking A, Tikkanen R. | 01/21/2010 |
| Myristoylation and palmitoylation of flotillin-2 are necessary for raft membrane association. | Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression.
Neumann-Giesen C, Falkenbach B, Beicht P, Claasen S, Lüers G, Stuermer CA, Herzog V, Tikkanen R., Free PMC Article | 01/21/2010 |
| Preformed reggie/flotillin caps are stable priming platforms for the assembly of multiprotein complexes controlling actin reorganization during T cell activation. | Preformed reggie/flotillin caps: stable priming platforms for macrodomain assembly in T cells.
Langhorst MF, Reuter A, Luxenhofer G, Boneberg EM, Legler DF, Plattner H, Stuermer CA. | 01/21/2010 |
| basic structural units of reggie microdomains are reggie homo- and hetero-tetramers, which are dependent on the presence of reggie-1 | Reggie/flotillin proteins are organized into stable tetramers in membrane microdomains.
Solis GP, Hoegg M, Munderloh C, Schrock Y, Malaga-Trillo E, Rivera-Milla E, Stuermer CA., Free PMC Article | 01/21/2010 |