| DNA demethylation in the hypothalamus promotes transcription of Agtr1a and Slc12a2 and hypertension development. | DNA demethylation in the hypothalamus promotes transcription of Agtr1a and Slc12a2 and hypertension development.
Ghosh K, Zhou JJ, Shao JY, Chen SR, Pan HL., Free PMC Article | 02/26/2024 |
| NKCC1 and KCC2 Chloride Transporters Have Different Membrane Dynamics on the Surface of Hippocampal Neurons. | NKCC1 and KCC2 Chloride Transporters Have Different Membrane Dynamics on the Surface of Hippocampal Neurons.
Pol E, Côme E, Merlaud Z, Gouhier J, Russeau M, Scotto-Lomassese S, Moutkine I, Marques X, Lévi S., Free PMC Article | 11/2/2023 |
| Dietary Na[+] depletion up-regulates NKCC1 expression and enhances electrogenic Cl[-] secretion in rat proximal colon. | Dietary Na(+) depletion up-regulates NKCC1 expression and enhances electrogenic Cl(-) secretion in rat proximal colon.
Nickerson AJ, Rajendran VM., Free PMC Article | 07/20/2023 |
| Age-appropriate potassium clearance from perinatal cerebrospinal fluid depends on choroid plexus NKCC1. | Age-appropriate potassium clearance from perinatal cerebrospinal fluid depends on choroid plexus NKCC1.
Fame RM, Xu H, Pragana A, Lehtinen M., Free PMC Article | 06/23/2023 |
| NLRP3 inflammasome-mediated choroid plexus hypersecretion contributes to hydrocephalus after intraventricular hemorrhage via phosphorylated NKCC1 channels. | NLRP3 inflammasome-mediated choroid plexus hypersecretion contributes to hydrocephalus after intraventricular hemorrhage via phosphorylated NKCC1 channels.
Zhang Z, Tan Q, Guo P, Huang S, Jia Z, Liu X, Feng H, Chen Y., Free PMC Article | 07/2/2022 |
| Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study. | Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study.
Xu H, Miyajima M, Nakajima M, Ogino I, Kawamura K, Akiba C, Kamohara C, Sakamoto K, Karagiozov K, Nakamura E, Tada N, Arai H, Kondo A., Free PMC Article | 06/11/2022 |
| Kidney Injury Causes Accumulation of Renal Sodium That Modulates Renal Lymphatic Dynamics. | Kidney Injury Causes Accumulation of Renal Sodium That Modulates Renal Lymphatic Dynamics.
Liu J, Shelton EL, Crescenzi R, Colvin DC, Kirabo A, Zhong J, Delpire EJ, Yang HC, Kon V., Free PMC Article | 03/19/2022 |
| Overexpression of chloride importer NKCC1 contributes to the sensory-affective and sociability phenotype of rats following neonatal maternal separation. | Overexpression of chloride importer NKCC1 contributes to the sensory-affective and sociability phenotype of rats following neonatal maternal separation.
Gazzo G, Melchior M, Caussaint A, Gieré C, Lelièvre V, Poisbeau P. | 06/12/2021 |
| NKCC-1 mediated Cl(-) uptake in immature CA3 pyramidal neurons is sufficient to compensate phasic GABAergic inputs. | NKCC-1 mediated Cl(-) uptake in immature CA3 pyramidal neurons is sufficient to compensate phasic GABAergic inputs.
Kolbaev SN, Mohapatra N, Chen R, Lombardi A, Staiger JF, Luhmann HJ, Jedlicka P, Kilb W., Free PMC Article | 03/13/2021 |
| Acute Hyperglycemia Aggravates Lung Injury via Activation of the SGK1-NKCC1 Pathway. | Acute Hyperglycemia Aggravates Lung Injury via Activation of the SGK1-NKCC1 Pathway.
Wu CP, Huang KL, Peng CK, Lan CC., Free PMC Article | 02/20/2021 |
| Differential expression of Na(+)/K(+)/Cl(-) cotransporter 1 in neurons and glial cells within the superficial spinal dorsal horn of rodents. | Differential expression of Na(+)/K(+)/Cl(-) cotransporter 1 in neurons and glial cells within the superficial spinal dorsal horn of rodents.
Javdani F, Hegedűs K, Miranda CO, Hegyi Z, Holló K, Antal M., Free PMC Article | 01/9/2021 |
| Androgenic Modulation of the Chloride Transporter NKCC1 Contributes to Age-dependent Isoflurane Neurotoxicity in Male Rats. | Androgenic Modulation of the Chloride Transporter NKCC1 Contributes to Age-dependent Isoflurane Neurotoxicity in Male Rats.
Chinn GA, Sasaki Russell JM, Yabut NA, Maharjan D, Sall JW., Free PMC Article | 11/21/2020 |
| Five weeks post-incomplete cervical contusion: 1) neither membrane-bound nor cytosolic NKCC1 expression were significantly changed, although the membrane/cytosolic ratio increased, consistent with net chloride influx; and 2) both membrane and cytosolic KCC2 expression increased, although the membrane/cytosolic ratio decreased, consistent with net chloride efflux. | Cervical spinal contusion alters Na(+)-K(+)-2Cl- and K(+)-Cl- cation-chloride cotransporter expression in phrenic motor neurons.
Allen LL, Seven YB, Baker TL, Mitchell GS., Free PMC Article | 04/6/2019 |
| Study assessed the nonsynaptic epileptiform activities (NEA) induced in the dentate gyrus after 4weeks of ethanol consumption; increment of the cotransporter expression was determined, and the effects of NKCC1 increasing the ictogenesis of the group treated with a low dosage of ethanol and the neurodegenerative process after ictal-like activity on the group treated with a high dosage were demonstrated. | Long-term alcohol exposure elicits hippocampal nonsynaptic epileptiform activity changes associated with expression and functional changes in NKCC1, KCC2 co-transporters and Na(+)/K(+)-ATPase.
Santos LEC, Rodrigues AM, Lopes MR, Costa VDC, Scorza CA, Scorza FA, Cavalheiro EA, Almeida AG. | 11/11/2017 |
| Early IGF-1 primes visual cortex maturation and accelerates developmental switch between NKCC1 and KCC2 chloride transporters in enriched animals. Early enrichment and IGF-1 administration produced a decrease in the ratio between NKCC1 and KCC2 cation/chloride transporters, suggesting that enrichment, via IGF-1, may hasten the developmental switch of neuronal GABAergic responses from excitation to inhibition. | Early IGF-1 primes visual cortex maturation and accelerates developmental switch between NKCC1 and KCC2 chloride transporters in enriched animals.
Baroncelli L, Cenni MC, Melani R, Deidda G, Landi S, Narducci R, Cancedda L, Maffei L, Berardi N. | 07/1/2017 |
| Findings suggest that aberrant regulation of the plasma membrane levels of NKCC1 might contribute to the impartment of GABAergic neurotransmission and that NKCC1 dysfunction might be relevant for the initial appearance of spontaneous seizures. | Regulation of the cell surface expression of chloride transporters during epileptogenesis.
González MI., Free PMC Article | 06/24/2017 |
| Cata suggest that chronic stress impairs GABAergic inhibition, resulting in hypothalamic-pituitary-adrenal axis hyperactivity through upregulation of the cation chloride cotransporter Na+-K+-Cl--Cl- . | Chronic Unpredictable Mild Stress Induces Loss of GABA Inhibition in Corticotrophin-Releasing Hormone-Expressing Neurons through NKCC1 Upregulation.
Gao Y, Zhou JJ, Zhu Y, Kosten T, Li DP., Free PMC Article | 05/13/2017 |
| This study demonstrated that disregulation nkcc1 and nkcc2 in neuropathic pain. | Early increasing-intensity treadmill exercise reduces neuropathic pain by preventing nociceptor collateral sprouting and disruption of chloride cotransporters homeostasis after peripheral nerve injury.
López-Álvarez VM, Modol L, Navarro X, Cobianchi S. | 05/21/2016 |
| NKCC1 mediates traumatic brain injury-induced hippocampal neurogenesis through CREB phosphorylation and HIF-1alpha expression. | NKCC1 mediates traumatic brain injury-induced hippocampal neurogenesis through CREB phosphorylation and HIF-1α expression.
Lu KT, Huang TC, Wang JY, You YS, Chou JL, Chan MW, Wo PY, Amstislavskaya TG, Tikhonova MA, Yang YL. | 04/16/2016 |
| NKCC1 may have a role in periventricular leukomalacia, as shown by bumetanide protection against white matter injury in a rodent model | Chloride cotransporter NKCC1 inhibitor bumetanide protects against white matter injury in a rodent model of periventricular leukomalacia.
Jantzie LL, Hu MY, Park HK, Jackson MC, Yu J, Maxwell JR, Jensen FE. | 04/9/2016 |
| Results indicate that NKCC1 activity transiently decreases in dorsal root ganglion neurons at fetal stages near term | NKCC1 downregulation induces hyperpolarizing shift of GABA responsiveness at near term fetal stages in rat cultured dorsal root ganglion neurons.
Chabwine JN, Talavera K, Van Den Bosch L, Callewaert G., Free PMC Article | 03/26/2016 |
| Na-K-Cl co-transporter 1 plays important roles in the proliferation of oligodendrocyte precursor cells under oxygen glucose deprivation -induced stress. | Bumetanide-induced NKCC1 inhibition attenuates oxygen-glucose deprivation-induced decrease in proliferative activity and cell cycle progression arrest in cultured OPCs via p-38 MAPKs.
Fu P, Tang R, Yu Z, Huang S, Xie M, Luo X, Wang W. | 02/20/2016 |
| Results showed that manganese induced oxidation/nitration of NKCC1 in astrocytes | Antioxidants and NOS inhibitors selectively targets manganese-induced cell volume via Na-K-Cl cotransporter-1 in astrocytes.
Alahmari KA, Prabhakaran H, Prabhakaran K, Chandramoorthy HC, Ramugounder R. | 02/13/2016 |
| Paclitaxel disrupts intracellular NKCC1 trafficking by interfering with microtubule dynamics and associated motor proteins | Increased spinal cord Na⁺-K⁺-2Cl⁻ cotransporter-1 (NKCC1) activity contributes to impairment of synaptic inhibition in paclitaxel-induced neuropathic pain.
Chen SR, Zhu L, Chen H, Wen L, Laumet G, Pan HL., Free PMC Article | 01/24/2015 |
| in addition to SPAK and OSR1, WNK4 is able to anchor itself to the N-terminal domain of NKCC1 and to promote cotransporter activation. | A novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase with no lysine member 4 (WNK4) in the activation of Na-K-Cl cotransporters.
Ponce-Coria J, Markadieu N, Austin TM, Flammang L, Rios K, Welling PA, Delpire E., Free PMC Article | 10/11/2014 |