| Temporal profile and utility of serum neurofilament light in a rat model of mild traumatic brain injury. | Temporal profile and utility of serum neurofilament light in a rat model of mild traumatic brain injury.
O'Brien WT, Pham L, Brady RD, Bain J, Yamakawa GR, Sun M, Mychasiuk R, O'Brien TJ, Monif M, Shultz SR, McDonald SJ. | 10/9/2021 |
| Evaluation of neurofilament light chain in the cerebrospinal fluid and blood as a biomarker for neuronal damage in experimental pneumococcal meningitis. | Evaluation of neurofilament light chain in the cerebrospinal fluid and blood as a biomarker for neuronal damage in experimental pneumococcal meningitis.
Le ND, Muri L, Grandgirard D, Kuhle J, Leppert D, Leib SL., Free PMC Article | 08/7/2021 |
| miR-7a ameliorated neuropathic pain via blocking the signal transducer and activator of transcription signaling pathway by repressing neurofilament light polypeptide. | MicroRNA-7a ameliorates neuropathic pain in a rat model of spinal nerve ligation via the neurofilament light polypeptide-dependent signal transducer and activator of transcription signaling pathway.
Yang FR, Chen J, Yi H, Peng LY, Hu XL, Guo QL., Free PMC Article | 05/30/2020 |
| Furthermore, the effect of CaMKP on self-assembly of NFL was examined. Electron microscopy revealed that CaMKP markedly prevented NFL from forming large filamentous aggregates, suggesting that CaMKP-binding to NFL inhibits its filament association. These findings may provide new insights into a novel mechanism for regulating network formation of neurofilaments during neuronal differentiation. | Ca(2+)/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F) interacts with neurofilament L and inhibits its filament association.
Ozaki H, Katoh T, Nakagawa R, Ishihara Y, Sueyoshi N, Kameshita I, Taniguchi T, Hirano T, Yamazaki T, Ishida A. | 05/27/2017 |
| Data suggest that tetrahydropapaveroline (an endogenous catechol) causes oxidative stress resulting in astrocyte/neuronal cell death via generation of reactive oxygen species and modification/aggregation of NF-L (as in neurodegenerative diseases). | Oxidative modification of neurofilament-L and neuronal cell death induced by the catechol neurotoxin, tetrahydropapaveroline.
Kyeong IG, Eum WS, Choi SY, Kang JH. | 03/9/2013 |
| LANP directly regulates expression of the neurofilament light chain, an important neuron-specific cytoskeletal gene, by binding to the promoter of this gene and modulating histone acetylation levels | Neuronal differentiation is regulated by leucine-rich acidic nuclear protein (LANP), a member of the inhibitor of histone acetyltransferase complex.
Kular RK, Cvetanovic M, Siferd S, Kini AR, Opal P., Free PMC Article | 01/21/2010 |
| Data show that as a consequence of RhoA knockdown, the process which expresses neurofilament is markedly induced in C12 cells. | Marked effect of RhoA-specific shRNA-producing plasmids on neurite growth in PC12 cells.
Fan YM, Pang CP, Harvey AR, Cui Q. | 01/21/2010 |
| 68-kDa neurofilament light chain (NF-L) as identified as a binding protein of amino-terminal PH domain of PLC-gamma1. | Pleckstrin homology domain of phospholipase C-gamma1 directly binds to 68-kDa neurofilament light chain.
Kim SK, Choi JH, Suh PG, Chang JS. | 01/21/2010 |
| The amount of NF-L correlated with the morphological retinal and optic nerve damage in rats | Alterations in neurofilament light in optic nerve in rat kainate and monkey ocular hypertension models.
Taniguchi T, Shimazawa M, Hara H. | 01/21/2010 |
| In cultured cortical neurons, hamartin and tuberin co-localize with neurofilament light chain preferentially in the proximal to central growth cone region | The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton.
Haddad LA, Smith N, Bowser M, Niida Y, Murthy V, Gonzalez-Agosti C, Ramesh V. | 01/21/2010 |
| Rat pituitary cells from the proopiomelanocortin lineage nearly completely lack NF68 immunoreactivity. | Cells of proopiomelanocortin lineage from the rodent anterior pituitary lack sexually dimorphic expression of neurofilaments.
Fiordelisio T, Millán-Aldaco D, Hernández-Cruz A. | 01/21/2010 |
| Increased neuritic degeneration was observed in neuronal cells overexpressing neurofilament light mutants. | Mutations in the neurofilament light gene linked to Charcot-Marie-Tooth disease cause defects in transport.
Pérez-Ollé R, López-Toledano MA, Goryunov D, Cabrera-Poch N, Stefanis L, Brown K, Liem RK. | 01/21/2010 |