| Tear film instability is associated with weakened colocalization between occludin and MUC5AC in scopolamine-induced dry eye disease (DED) rats. | Tear film instability is associated with weakened colocalization between occludin and MUC5AC in scopolamine-induced dry eye disease (DED) rats.
Xu K, Liu XN, Zhang HB, Zhu XP, Zhang XJ. | 03/1/2023 |
| Function and Biomarkers of the Blood-Brain Barrier in a Neonatal Germinal Matrix Haemorrhage Model. | Function and Biomarkers of the Blood-Brain Barrier in a Neonatal Germinal Matrix Haemorrhage Model.
Andersson EA, Rocha-Ferreira E, Hagberg H, Mallard C, Ek CJ., Free PMC Article | 10/30/2021 |
| Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal Tubular Development. | Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal Tubular Development.
Xu X, Zhang X, Gao L, Liu C, You K., Free PMC Article | 09/11/2021 |
| Lactobacillus casei LC01 Regulates Intestinal Epithelial Permeability through miR-144 Targeting of OCLN and ZO1. | Lactobacillus casei LC01 Regulates Intestinal Epithelial Permeability through miR-144 Targeting of OCLN and ZO1.
Hou Q, Huang Y, Wang Y, Liao L, Zhu Z, Zhang W, Liu Y, Li P, Chen X, Liu F., Free PMC Article | 06/26/2021 |
| The magnitude of physical exercise-induced hyperthermia is associated with changes in the intestinal permeability and expression of tight junction genes in rats. | The magnitude of physical exercise-induced hyperthermia is associated with changes in the intestinal permeability and expression of tight junction genes in rats.
Ribeiro Hudson AS, Nascimento Soares AD, Coelho Horta NA, Fuscaldi LL, Machado-Moreira CA, Soares DD, Coimbra CC, de Oliveira Poletini M, Cardoso VN, Wanner SP. | 05/29/2021 |
| we demonstrate that administration of IPA modulates the microbiota composition in the gut and inhibits microbial dysbiosis in rats fed a high-fat diet. IPA induces the expression of tight junction proteins, such as ZO-1 and Occludin, and maintains intestinal epithelium homeostasis, leading to a reduction in plasma endotoxin levels. | Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats.
Zhao ZH, Xin FZ, Xue Y, Hu Z, Han Y, Ma F, Zhou D, Liu XL, Cui A, Liu Z, Liu Y, Gao J, Pan Q, Li Y, Fan JG., Free PMC Article | 06/27/2020 |
| Study, found that the stimulation of alpha7 nicotinic acetylcholine receptor but not alpha4beta2 nicotinic acetylcholine receptor decreased sodium-fluorescein permeability and increased cell transendothelial electrical resistance in rat brain endothelial cells (RBEC) monolayers and increased the protein levels of claudin-5 and occludin in RBECs. | Activation of the α7 nicotinic acetylcholine receptor upregulates blood-brain barrier function through increased claudin-5 and occludin expression in rat brain endothelial cells.
Kimura I, Dohgu S, Takata F, Matsumoto J, Kawahara Y, Nishihira M, Sakada S, Saisho T, Yamauchi A, Kataoka Y. | 06/22/2019 |
| The TLR4/PKCalpha/occludin signaling pathway was closely related to blood-brain barrier damage. | TLR4/PKCα/occludin signaling pathway may be related to blood‑brain barrier damage.
Tang Z, Guo D, Xiong L, Wu B, Xu X, Fu J, Kong L, Liu Z, Xie C. | 10/20/2018 |
| blood occludin levels correlate well with the extent of blood brain barrie damage. | Blood Occludin Level as a Potential Biomarker for Early Blood Brain Barrier Damage Following Ischemic Stroke.
Pan R, Yu K, Weatherwax T, Zheng H, Liu W, Liu KJ., Free PMC Article | 10/20/2018 |
| Both upregulation of claudin-4 and downregulation of occludin might increase paracellular NaCl transport in the kidney, resulting in impaired pressure natriuresis in SS rats. | Alteration of Tight Junction Protein Expression in Dahl Salt-Sensitive Rat Kidney.
Jo CH, Kim S, Oh IH, Park JS, Kim GH. | 09/1/2018 |
| Up-regulation of miR-144 could promote intestinal hyperpermeability and impair the protective effect of the epithelial barrier by directly targeting OCLN and ZO-1. | MiR-144 Increases Intestinal Permeability in IBS-D Rats by Targeting OCLN and ZO1.
Hou Q, Huang Y, Zhu S, Li P, Chen X, Hou Z, Liu F. | 03/17/2018 |
| We provide quantitative evidence that claudin-11 contributes significantly to Sertoli cell tight junction function in vitro. Interestingly, occludin, which is hormonally regulated but not implicated in infertility until late adulthood, is also a significant contributor to barrier function. | Claudin-11 and occludin are major contributors to Sertoli cell tight junction function, in vitro.
McCabe MJ, Foo CF, Dinger ME, Smooker PM, Stanton PG., Free PMC Article | 03/11/2017 |
| Immunoexpressions of embryonic and nonembryonic stem cell markers (Nanog, Thy-1, c-kit) and cellular connections (connexin 43 and occludin) on testicular tissue in thyrotoxicosis rat model | Immunoexpressions of embryonic and nonembryonic stem cell markers (Nanog, Thy-1, c-kit) and cellular connections (connexin 43 and occludin) on testicular tissue in thyrotoxicosis rat model.
Oltulu F, Aktug H, Uysal A, Turgan N, Oktem G, Erbas O, Yavasoglu NK, Yavasoglu A. | 03/5/2016 |
| Colonic glands without a fecal stream showed a reduction in claudin-3 content independent of the time and reduction in occludin content after 12 weeks of intestinal exclusion. | Claudin-3 and occludin tissue content in the glands of colonic mucosa with and without a fecal stream.
Martinez CA, de Campos FG, de Carvalho VR, de Castro Ferreira C, Rodrigues MR, Sato DT, Pereira JA. | 12/19/2015 |
| The data indicated that early exercise significantly inhibited the ischemia-induced reduction of occludin, and an increase in MMP-9 promoted TIMP-1 expression. | Early exercise protects the blood-brain barrier from ischemic brain injury via the regulation of MMP-9 and occludin in rats.
Zhang Y, Zhang P, Shen X, Tian S, Wu Y, Zhu Y, Jia J, Wu J, Hu Y., Free PMC Article | 06/27/2015 |
| In severe acute pancreatitis, downregulated expression of alphaSNAP in intestinal epithelial cells leads to reduced occludin expression, apoptosis of intestinal epithelial cells, and increased permeability of the intestinal barrier. | The loss of αSNAP downregulates the expression of occludin in the intestinal epithelial cell of acute pancreatitis model.
Chen D, Li L, Yan J, Yang X, You Y, Zhou Y, Ling X. | 06/20/2015 |
| a novel mechanism of occludin Ser490 phosphorylation and ubiquitination downstream of VEGFR2 activation associated with early reperfusion injuty-induced vascular permeability. | Ischemia-reperfusion injury induces occludin phosphorylation/ubiquitination and retinal vascular permeability in a VEGFR-2-dependent manner.
Muthusamy A, Lin CM, Shanmugam S, Lindner HM, Abcouwer SF, Antonetti DA., Free PMC Article | 05/3/2014 |
| actin cytoskeletal dynamics is detrimental to METH-induced BBB dysfunction by increasing internalization of occludin. | Methamphetamine-induced occludin endocytosis is mediated by the Arp2/3 complex-regulated actin rearrangement.
Park M, Kim HJ, Lim B, Wylegala A, Toborek M., Free PMC Article | 01/25/2014 |
| cells transfected with Cx43 siRNA and grown in N medium showed significant downregulation in occludin (78 +/- 8% of control) and ZO-1 (81 +/- 6% of control) expression, and exhibited increased cell monolayer permeability. | Effects of high glucose-induced Cx43 downregulation on occludin and ZO-1 expression and tight junction barrier function in retinal endothelial cells.
Tien T, Barrette KF, Chronopoulos A, Roy S., Free PMC Article | 11/23/2013 |
| Results identified a crucial role of occludin in submandibular epithelial cells, and more importantly, demonstrated that occludin was required to mediate TRPV1-modulated paracellular permeability. | Occludin is required for TRPV1-modulated paracellular permeability in the submandibular gland.
Cong X, Zhang Y, Yang NY, Li J, Ding C, Ding QW, Su YC, Mei M, Guo XH, Wu LL, Yu GY. | 11/2/2013 |
| High temperature inhibited the proliferation of rat Sertoli cells in vitro, and decreased the expression of OCLN. | [High temperature reduces the proliferation of and occludin expression in rat Sertoli cells in vitro].
Hu JT, Shao CH, Wang PT, Liu Y, Hao WY, Feng YL, Liu SH, Wang XS. | 06/29/2013 |
| Disruption of pulmonary epithelium induced by hyperoxia is due in part to decreased expression of occludin and zona occludens (ZO)-1 proteins. | Hyperoxia disrupts pulmonary epithelial barrier in newborn rats via the deterioration of occludin and ZO-1.
You K, Xu X, Fu J, Xu S, Yue X, Yu Z, Xue X., Free PMC Article | 06/15/2013 |
| Reverse-flow perfusions of mesenteric venules showed numerous small gaps in occludin expression on the endothelium. Similar gaps were not seen in vessels perfused in the forward direction. | Microvascular permeability to water is independent of shear stress, but dependent on flow direction.
Adamson RH, Sarai RK, Altangerel A, Clark JF, Weinbaum S, Curry FE., Free PMC Article | 06/8/2013 |
| data indicate the possibility that interleukin 6 might be involved in the downregulation of occludin expression and in the modulation of blood-testis barrier permeability that occur in rats undergoing autoimmune orchitis | Loss of occludin expression and impairment of blood-testis barrier permeability in rats with autoimmune orchitis: effect of interleukin 6 on Sertoli cell tight junctions.
Pérez CV, Sobarzo CM, Jacobo PV, Pellizzari EH, Cigorraga SB, Denduchis B, Lustig L. | 04/27/2013 |
| Occludin and Zo-1 were reduced in intestinal mucosa both in mRNA and protein levels in the rat tail-suspension model. | Effects of simulated weightlessness on tight junction protein occludin and Zonula Occluden-1 expression levels in the intestinal mucosa of rats.
Ying C, Chunmin Y, Qingsen L, Mingzhou G, Yunsheng Y, Gaoping M, Ping W. | 04/20/2013 |