| Human-specific elimination of epithelial Siglec-XII suppresses the risk of inflammation-driven colorectal cancers. | Human-specific elimination of epithelial Siglec-XII suppresses the risk of inflammation-driven colorectal cancers.
Cuello HA, Sinha S, Verhagen AL, Varki N, Varki A, Ghosh P., Free PMC Article | 10/25/2024 |
| The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis. | The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis.
He X, Zhang X, Wu B, Deng J, Zhang Y, Zhu A, Yuan Y, Lin Y, Chen A, Feng J, Wang X, Wu S, Liu Y, Liu J, Wang Y, Li R, Liang C, Yuan Q, Liang Y, Fang Q, Xi Z, Li W, Liang L, Zhang Z, Tang H, Peng Y, Ke C, Ma X, Cai W, Pan T, Liu B, Deng K, Chen J, Zhao J, Wei X, Chen R, Zhang Y, Zhang H. | 04/16/2024 |
| The prognostic impact of SIGLEC5-induced impairment of CD8[+] T cell activation in sepsis. | The prognostic impact of SIGLEC5-induced impairment of CD8(+) T cell activation in sepsis.
Lozano-Rodríguez R, Avendaño-Ortíz J, Montalbán-Hernández K, Ruiz-Rodríguez JC, Ferrer R, Martín-Quirós A, Maroun-Eid C, González-López JJ, Fàbrega A, Terrón-Arcos V, Gutiérrez-Fernández M, Alonso-López E, Cubillos-Zapata C, Fernández-Velasco M, Pérez de Diego R, Pelegrin P, García-Palenciano C, Cueto FJ, Del Fresno C, López-Collazo E., Free PMC Article | 11/15/2023 |
| O-Acetylation of Capsular Polysialic Acid Enables Escherichia coli K1 Escaping from Siglec-Mediated Innate Immunity and Lysosomal Degradation of E. coli-Containing Vacuoles in Macrophage-Like Cells. | O-Acetylation of Capsular Polysialic Acid Enables Escherichia coli K1 Escaping from Siglec-Mediated Innate Immunity and Lysosomal Degradation of E. coli-Containing Vacuoles in Macrophage-Like Cells.
Yang J, Ma W, Wu Y, Zhou H, Song S, Cao Y, Wang C, Liu X, Ren J, Duan J, Pei Z, Jin C., Free PMC Article | 02/12/2022 |
| Siglecs-7/9 function as inhibitory immune checkpoints in vivo and can be targeted to enhance therapeutic antitumor immunity. | Siglecs-7/9 function as inhibitory immune checkpoints in vivo and can be targeted to enhance therapeutic antitumor immunity.
Ibarlucea-Benitez I, Weitzenfeld P, Smith P, Ravetch JV., Free PMC Article | 12/4/2021 |
| Polysialic acid and Siglec-E orchestrate negative feedback regulation of microglia activation. | Polysialic acid and Siglec-E orchestrate negative feedback regulation of microglia activation.
Thiesler H, Beimdiek J, Hildebrandt H., Free PMC Article | 03/6/2021 |
| Immunosuppressive Siglec-E ligands on mouse aorta are up-regulated by LPS via NF-kappaB pathway. | Immunosuppressive Siglec-E ligands on mouse aorta are up-regulated by LPS via NF-κB pathway.
Liu H, Zheng Y, Zhang Y, Li J, Fernandes SM, Zeng D, Li X, Schnaar RL, Jia Y. | 10/3/2020 |
| The Siglec-E-deficient dendritic cells were defective for TRIF-mediated IFN-beta production in response to E. coli infection. | Siglec-E Negatively Regulates the Activation of TLR4 by Controlling Its Endocytosis.
Wu Y, Ren D, Chen GY., Free PMC Article | 09/30/2017 |
| This study demonstrated that virulent parasite Leishmania donovani (AG83+Sias) establish a unique sialic acids-mediated binding and subsequent phagocytosis in the host cell through the selective exploitation of siglec-1. | Leishmania donovani Utilize Sialic Acids for Binding and Phagocytosis in the Macrophages through Selective Utilization of Siglecs and Impair the Innate Immune Arm.
Roy S, Mandal C., Free PMC Article | 07/22/2017 |
| new data relating to the structure and function of Siglec-E, the major CD33-related Siglec expressed on mouse neutrophils, monocytes, macrophages, and dendritic cells. | Studies on the Detection, Expression, Glycosylation, Dimerization, and Ligand Binding Properties of Mouse Siglec-E.
Siddiqui S, Schwarz F, Springer S, Khedri Z, Yu H, Deng L, Verhagen A, Naito-Matsui Y, Jiang W, Kim D, Zhou J, Ding B, Chen X, Varki N, Varki A., Free PMC Article | 06/3/2017 |
| indicate that Siglec-9 affects several different signaling pathways in IL-4-stimulated macrophages, which resulted in enhanced induction of Arg1 in Siglec-9-expressing RAW264 cells | Siglec-9 modulated IL-4 responses in the macrophage cell line RAW264.
Higuchi H, Shoji T, Murase Y, Iijima S, Nishijima K. | 10/22/2016 |
| Competitive ELISA assays confirmed the involvement of sulfated epitopes in the affinity between Siglec-E and cruzipain, probably modified by natural protein environment | Involvement of sulfates from cruzipain, a major antigen of Trypanosoma cruzi, in the interaction with immunomodulatory molecule Siglec-E.
Ferrero MR, Heins AM, Soprano LL, Acosta DM, Esteva MI, Jacobs T, Duschak VG. | 10/22/2016 |
| Data indicate a role for neuraminidase 1 (Neu1) in regulating Siglec E protein-toll-like receptor 4 (TLR4) interaction and endotoxemia. | Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1.
Chen GY, Brown NK, Wu W, Khedri Z, Yu H, Chen X, van de Vlekkert D, D'Azzo A, Zheng P, Liu Y., Free PMC Article | 06/27/2015 |
| Siglec-E-deficient macrophages showed a propensity toward a tumor-promoting M2 polarization, indicating a secondary role of CD33-related Siglecs in limiting cancer-promoting inflammation and tumor growth. | Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer.
Läubli H, Pearce OM, Schwarz F, Siddiqui SS, Deng L, Stanczak MA, Deng L, Verhagen A, Secrest P, Lusk C, Schwartz AG, Varki NM, Bui JD, Varki A., Free PMC Article | 05/2/2015 |
| Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo. | Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo.
Chang YC, Olson J, Beasley FC, Tung C, Zhang J, Crocker PR, Varki A, Nizet V., Free PMC Article | 02/14/2015 |
| siglec-E functions as an inhibitory receptor of neutrophils via positive regulation of NADPH oxidase activation and ROS production | Siglec-E promotes β2-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung.
McMillan SJ, Sharma RS, Richards HE, Hegde V, Crocker PR., Free PMC Article | 10/11/2014 |
| These results suggest that sSiglec-9 has an antitumor benefit against MUC1-expressing tumor in the transgenic mice. | A soluble form of Siglec-9 provides an antitumor benefit against mammary tumor cells expressing MUC1 in transgenic mice.
Tomioka Y, Morimatsu M, Nishijima K, Usui T, Yamamoto S, Suyama H, Ozaki K, Ito T, Ono E. | 09/27/2014 |
| Siglec-9 expressed on immune cells may play a role as a potential counterreceptor for MUC1 and that this signaling may be another MUC1-mediated pathway and function in parallel with a growth factor-dependent pathway. | Binding of the sialic acid-binding lectin, Siglec-9, to the membrane mucin, MUC1, induces recruitment of β-catenin and subsequent cell growth.
Tanida S, Akita K, Ishida A, Mori Y, Toda M, Inoue M, Ohta M, Yashiro M, Sawada T, Hirakawa K, Nakada H., Free PMC Article | 01/4/2014 |
| Siglec-E is an important negative regulator of neutrophil recruitment to the lung and beta2 integrin-dependent signaling. | Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin-dependent signaling.
McMillan SJ, Sharma RS, McKenzie EJ, Richards HE, Zhang J, Prescott A, Crocker PR., Free PMC Article | 05/18/2013 |
| Early murine T-lymphocyte activation is accompanied by a switch from N-Glycolyl- to N-acetyl-neuraminic acid and generation of ligands for siglec-E | Early murine T-lymphocyte activation is accompanied by a switch from N-Glycolyl- to N-acetyl-neuraminic acid and generation of ligands for siglec-E.
Redelinghuys P, Antonopoulos A, Liu Y, Campanero-Rhodes MA, McKenzie E, Haslam SM, Dell A, Feizi T, Crocker PR., Free PMC Article | 12/10/2011 |
| Siglec-E is induced in a MyD88-dependent manner. Once up-regulated, it can control TLR-dependent NF-kappaB antiviral responses by directly inhibiting TLR-induced antiviral cytokine production. | Siglec-E is up-regulated and phosphorylated following lipopolysaccharide stimulation in order to limit TLR-driven cytokine production.
Boyd CR, Orr SJ, Spence S, Burrows JF, Elliott J, Carroll HP, Brennan K, Ní Gabhann J, Coulter WA, Jones C, Crocker PR, Johnston JA, Jefferies CA., Free PMC Article | 02/15/2010 |
| Siglec-E interacted with the pathogenic Tulahuen strain, but showed a diminished binding to the Tehuantepec strain of Trypanosoma cruzi | Sialylated ligands on pathogenic Trypanosoma cruzi interact with Siglec-E (sialic acid-binding Ig-like lectin-E).
Erdmann H, Steeg C, Koch-Nolte F, Fleischer B, Jacobs T. | 01/21/2010 |
| are a family of sialic acid receptor proteins expressed in immune cells, recognize their ligands and play a role in the signal transduction. | [Functions and molecular evolution of Siglecs, a family of sialic acid receptor proteins].
Angata T. | 01/21/2010 |