| In the present study, PCDH11Yb, but not PCDH11Ya or PCDH11Yc, was expressed in germ cells isolated from the semen of all 13 men with proven fertility. However, in several subjects from various infertility classes, there was complete absence or a significant reduction in the expression of PCDH11Yb. In conclusion, expression levels of PCDH11Yb in germ cells in the semen were correlated with the fertility status of men. | Expression of protocadherin 11Yb (PCDH11Yb) in seminal germ cells is correlated with fertility status in men.
Anilkumar TR, Devi AN, Pillai SM, Jayakrishnan K, Oommen OV, Kumar PG. | 07/21/2018 |
| PCDH11Y expression was detected in the fetal neocortex, ganglionic eminences, cerebellum, and inferior olive. In the adult brain, the cerebral cortex, hippocampal formation, and cerebellum and brain stem were immunoreactive. | Protocadherin 11X/Y a human-specific gene pair: an immunohistochemical survey of fetal and adult brains.
Priddle TH, Crow TJ., Free PMC Article | 03/1/2014 |
| the PCDH11X/Y gene pair determines cerebral asymmetry by initiating the right shift in Homo sapiens | The protocadherin 11X/Y (PCDH11X/Y) gene pair as determinant of cerebral asymmetry in modern Homo sapiens.
Priddle TH, Crow TJ., Free PMC Article | 08/10/2013 |
| Our data...extended the lack of association of late-onset Alzheimer's disease to common PCDH11Y variants. | Lack of association between protocadherin 11-X/Y (PCDH11X and PCDH11Y) polymorphisms and late onset Alzheimer's disease.
Miar A, Alvarez V, Corao AI, Alonso B, Díaz M, Menéndez M, Martínez C, Calatayud M, Morís G, Coto E. | 08/6/2011 |
| The present article investigated the patterns of alternative splicing and expression of the PCDH11X/Y genes. | Quantitative analysis of alternative transcripts of human PCDH11X/Y genes.
Ahn K, Huh JW, Kim DS, Ha HS, Kim YJ, Lee JR, Kim HS. | 06/28/2010 |
| a candidate for the evolution of hominid-specific characteristics including the sexual dimorphism of cerebral asymmetry, a putative correlate of language | Accelerated evolution of Protocadherin11X/Y: a candidate gene-pair for cerebral asymmetry and language.
Williams NA, Close JP, Giouzeli M, Crow TJ. | 12/28/2009 |
| This study provided the evidence for positive selection on Protocadherin Y gene in human lineage for schizophrenia. | Evidence for positive selection on Protocadherin Y gene in Homo sapiens: implications for schizophrenia.
Kalmady SV, Venkatasubramanian G. | 01/21/2010 |
| We consider that a stronger case can be mounted for the Protocadherin11X/Y gene pair located in the hominid specific Xq21.3/Yp11.2 region of homology that was generated by a duplication from the X | Where and what is the right shift factor or cerebral dominance gene? A critique of Francks et al. (2007).
Crow TJ, Close JP, Dagnall AM, Priddle TH. | 01/21/2010 |
| Findings do not support the role of PCDH11Y, or more generally of a frequent specific Y chromosome, in the susceptibility to these neuropsychiatric disorders. | Expression and genetic variability of PCDH11Y, a gene specific to Homo sapiens and candidate for susceptibility to psychiatric disorders.
Durand CM, Kappeler C, Betancur C, Delorme R, Quach H, Goubran-Botros H, Melke J, Nygren G, Chabane N, Bellivier F, Szoke A, Schurhoff F, Rastam M, Anckarsäter H, Gillberg C, Leboyer M, Bourgeron T., Free PMC Article | 01/21/2010 |
| Our findings suggest a novel mechanism for the progression of CaP involving expression of PCDH-PC. This novel protocadherin induces Wnt signaling, promotes malignant behavior and hormone-resistance of CaP cells. | Protocadherin-PC promotes androgen-independent prostate cancer cell growth.
Terry S, Queires L, Gil-Diez-de-Medina S, Chen MW, de la Taille A, Allory Y, Tran PL, Abbou CC, Buttyan R, Vacherot F., Free PMC Article | 01/21/2010 |
| A 4.8 kb cDNA was cloned from TPA-resistance LNCaP prostate cancer cells. It is an unusual protocadherin family gene with 2 large overlapping ORFs encoding homologous polypeptides, one with and one without a signal sequence. [protocadherin-PC] | The emergence of protocadherin-PC expression during the acquisition of apoptosis-resistance by prostate cancer cells.
Chen MW, Vacherot F, De La Taille A, Gil-Diez-De-Medina S, Shen R, Friedman RA, Burchardt M, Chopin DK, Buttyan R. | 01/21/2010 |