| A novel pathogenic variant in the FZD6 gene causes recessive nail dysplasia in a Moroccan family. | A novel pathogenic variant in the FZD6 gene causes recessive nail dysplasia in a Moroccan family.
Lanvin PL, Lebreton L, Lasseaux E, Creveaux I, Léauté-Labrèze C, Boralevi F, Morice-Picard F. | 11/20/2023 |
| FZD6 Promotes Melanoma Cell Invasion but Not Proliferation by Regulating Canonical Wnt Signaling and Epithelial-Mesenchymal Transition. | FZD6 Promotes Melanoma Cell Invasion but Not Proliferation by Regulating Canonical Wnt Signaling and Epithelial‒Mesenchymal Transition.
Dong B, Simonson L, Vold S, Oldham E, Barten L, Ahmad N, Chang H., Free PMC Article | 03/27/2023 |
| FZD6 triggers Wnt-signalling driven by WNT10B(IVS1) expression and highlights new targets in T-cell acute lymphoblastic leukemia. | FZD6 triggers Wnt-signalling driven by WNT10B(IVS1) expression and highlights new targets in T-cell acute lymphoblastic leukemia.
Cassaro A, Grillo G, Notaro M, Gliozzo J, Esposito I, Reda G, Trojani A, Valentini G, Di Camillo B, Cairoli R, Beghini A., Free PMC Article | 08/21/2021 |
| MiR-302b Suppresses Tumor Metastasis by Targeting Frizzled 6 in OSCC. | MiR-302b Suppresses Tumor Metastasis by Targeting Frizzled 6 in OSCC.
Sun S, Wang J, Liu J, Yin F, Xin C, Zeng X, Li J, Chen Q. | 07/17/2021 |
| The prognostic role of FZD6 in esophageal squamous cell carcinoma patients. | The prognostic role of FZD6 in esophageal squamous cell carcinoma patients.
Zhang J, Wang JL, Zhang CY, Ma YF, Zhao R, Wang YY. | 03/27/2021 |
| Mesenchymal stem cell-derived extracellular vesicles suppress the fibroblast proliferation by downregulating FZD6 expression in fibroblasts via micrRNA-29b-3p in idiopathic pulmonary fibrosis. | Mesenchymal stem cell-derived extracellular vesicles suppress the fibroblast proliferation by downregulating FZD6 expression in fibroblasts via micrRNA-29b-3p in idiopathic pulmonary fibrosis.
Wan X, Chen S, Fang Y, Zuo W, Cui J, Xie S. | 03/20/2021 |
| Somatic mutations in planar cell polarity genes in neural tissue from human fetuses with neural tube defects. | Somatic mutations in planar cell polarity genes in neural tissue from human fetuses with neural tube defects.
Tian T, Lei Y, Chen Y, Karki M, Jin L, Finnell RH, Wang L, Ren A., Free PMC Article | 09/26/2020 |
| findings demonstrate that suppression of Wnt signaling by upregulation of FZD6 is a mechanism underlying luteolin-induced inhibition of prostate cancer stemness. | Luteolin attenuates Wnt signaling via upregulation of FZD6 to suppress prostate cancer stemness revealed by comparative proteomics.
Han K, Lang T, Zhang Z, Zhang Y, Sun Y, Shen Z, Beuerman RW, Zhou L, Min D., Free PMC Article | 10/12/2019 |
| Mutations in FZD6 gene were found to be associated with autosomal recessive nail dysplasia. | A possible founder mutation in FZD6 gene in a Turkish family with autosomal recessive nail dysplasia.
Saygı C, Alanay Y, Sezerman U, Yenenler A, Özören N., Free PMC Article | 08/24/2019 |
| Given the key role of FZD6 in planar cell polarity, our results raise the possibility that asymmetric phosphorylation of FZD6 rather than asymmetric protein distribution accounts for polarized receptor signaling | Dishevelled enables casein kinase 1-mediated phosphorylation of Frizzled 6 required for cell membrane localization.
Strakova K, Kowalski-Jahn M, Gybel T, Valnohova J, Dhople VM, Harnos J, Bernatik O, Ganji RS, Zdrahal Z, Mulder J, Lindskog C, Bryja V, Schulte G., Free PMC Article | 05/4/2019 |
| Cys-161, Cys-181, and Cys-185 residues in the linker domain region of FZD6 are crucial for receptor membrane expression and recruitment of DVL2 protein. | Functional dissection of the N-terminal extracellular domains of Frizzled 6 reveals their roles for receptor localization and Dishevelled recruitment.
Valnohova J, Kowalski-Jahn M, Sunahara RK, Schulte G., Free PMC Article | 04/13/2019 |
| FZD6 is highly expressed in liver cancer cells and liver tumor-initiating cells.FZD6 is required for liver tumor-initiating cells self-renewal.LncFZD6 interacts and recruits BRG1 to FZD6 promoter to initiate transcription. | LncFZD6 initiates Wnt/β-catenin and liver TIC self-renewal through BRG1-mediated FZD6 transcriptional activation.
Chen Z, Gao Y, Yao L, Liu Y, Huang L, Yan Z, Zhao W, Zhu P, Weng H., Free PMC Article | 03/9/2019 |
| miR-125b/miR-20b and Wnt signalling have roles in glioblastoma phenotypes in a pathway that involves FZD6 | A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways.
Huang T, Alvarez AA, Pangeni RP, Horbinski CM, Lu S, Kim SH, James CD, J Raizer J, A Kessler J, Brenann CW, Sulman EP, Finocchiaro G, Tan M, Nishikawa R, Lu X, Nakano I, Hu B, Cheng SY., Free PMC Article | 10/6/2018 |
| Study reports a novel pathogenic variant of the FZD6 gene in autosomal recessive nonsyndromic congenital nail disorder in consanguineous Iranian family. | A novel pathogenic variant in the FZD6 gene causes recessive nail dysplasia in a large Iranian kindred.
Mohammadi-Asl J, Pourreza MR, Mohammadi A, Eskandari A, Mozafar-Jalali S, Tabatabaiefar MA. | 05/26/2018 |
| In this paper we report 3 further families with mutations in FZD6 causing Isolated recessive nail dysplasia. | Isolated recessive nail dysplasia caused by FZD6 mutations: report of three families and review of the literature.
Kasparis C, Reid D, Wilson NJ, Okur V, Cole C, Hansen CD, Bosse K, Betz RC, Khan M, Smith FJ., Free PMC Article | 01/13/2018 |
| monomeric rather than dimeric form is active signal initiating unit of the receptor complex; constitutive signaling to ERK1/2 can be affected by modulating the dimeric status | Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling.
Petersen J, Wright SC, Rodríguez D, Matricon P, Lahav N, Vromen A, Friedler A, Strömqvist J, Wennmalm S, Carlsson J, Schulte G., Free PMC Article | 11/26/2017 |
| the FZD6-fibronectin actin axis identified in our study could be exploited for drug development in highly metastatic forms of breast cancer | Functional and prognostic significance of the genomic amplification of frizzled 6 (FZD6) in breast cancer.
Corda G, Sala G, Lattanzio R, Iezzi M, Sallese M, Fragassi G, Lamolinara A, Mirza H, Barcaroli D, Ermler S, Silva E, Yasaei H, Newbold RF, Vagnarelli P, Mottolese M, Natali PG, Perracchio L, Quist J, Grigoriadis A, Marra P, Tutt AN, Piantelli M, Iacobelli S, De Laurenzi V, Sala A., Free PMC Article | 05/20/2017 |
| we found that FZD6 expression was negatively regulated by miR199a5p | FZD6 expression is negatively regulated by miR-199a-5p in human colorectal cancer.
Kim BK, Yoo HI, Kim I, Park J, Kim Yoon S., Free PMC Article | 04/23/2016 |
| The rs3808553 of FZD6 is obviously associated with neural tube defects in Han population of northern China | Polymorphisms in FZD3 and FZD6 genes and risk of neural tube defects in a northern Han Chinese population.
Shi OY, Yang HY, Shen YM, Sun W, Cai CY, Cai CQ. | 11/14/2015 |
| It is associated with poor prognosis in glioblastoma patients. | Immunoreactivity of Wnt5a, Fzd2, Fzd6, and Ryk in glioblastoma: evaluative methodology for DAB chromogenic immunostaining.
Hirano H, Yonezawa H, Yunoue S, Habu M, Uchida H, Yoshioka T, Kishida S, Kishida M, Oyoshi T, Fujio S, Sugata S, Yamahata H, Hanaya R, Arita K. | 06/20/2015 |
| This study confirms our speculation that down-regulation of FZD6 by beta-Carotene is causally related to the observed up-regulation of cancer related genes | Role of Frizzled6 in the molecular mechanism of beta-carotene action in the lung.
Piga R, van Dartel D, Bunschoten A, van der Stelt I, Keijer J. | 06/28/2014 |
| DVL is a master regulator of FZD6/G-protein signaling | Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6.
Kilander MB, Petersen J, Andressen KW, Ganji RS, Levy FO, Schuster J, Dahl N, Bryja V, Schulte G. | 06/21/2014 |
| FZD6 should be screened for pachyonychia congenita as it is a candidate gene for hereditary nail dysplasias. | Recessive mutations in the gene encoding frizzled 6 cause twenty nail dystrophy--expanding the differential diagnosis for pachyonychia congenita.
Wilson NJ, Hansen CD, Azkur D, Kocabas CN, Metin A, Coskun Z, Schwartz ME, Hull PR, McLean WH, Smith FJ. | 10/19/2013 |
| sequence analysis revealed a novel homozygous missense mutation (c.1266G>A; p.Gly422Asp) located in the transmembrane domain of the protein FZD6 in individuals of a consanguineous family exhibiting features of nail dysplasia | A novel missense mutation in the gene FZD6 underlies autosomal recessive nail dysplasia.
Raza SI, Muhammad N, Khan S, Ahmad W. | 08/31/2013 |
| The present results emphasize the role of FZD6 mutation in Wnt pathways in nail development. | FZD6 encoding the Wnt receptor frizzled 6 is mutated in autosomal-recessive nail dysplasia.
Naz G, Pasternack SM, Perrin C, Mattheisen M, Refke M, Khan S, Gul A, Simons M, Ahmad W, Betz RC. | 07/14/2012 |