| Identification of Crucial Genes and Key Functions in Type 2 Diabetic Hearts by Bioinformatic Analysis. | Identification of Crucial Genes and Key Functions in Type 2 Diabetic Hearts by Bioinformatic Analysis.
Huang X, Zhang KJ, Jiang JJ, Jiang SY, Lin JB, Lou YJ., Free PMC Article | 03/12/2022 |
| Overexpression of Capns1 Predicts Poor Prognosis and Correlates with Tumor Progression in Renal Cell Carcinoma. | Overexpression of Capns1 Predicts Poor Prognosis and Correlates with Tumor Progression in Renal Cell Carcinoma.
Zhuang Q, Fan M, Shen J, Chen Z, Xue D, Lu H, Xu R, He X, Hou J. | 11/27/2021 |
| Circular RNA ABCB10 promotes cell proliferation and invasion, but inhibits apoptosis via regulating the microRNA1271mediated Capn4/Wnt/betacatenin signaling pathway in epithelial ovarian cancer. | Circular RNA ABCB10 promotes cell proliferation and invasion, but inhibits apoptosis via regulating the microRNA‑1271‑mediated Capn4/Wnt/β‑catenin signaling pathway in epithelial ovarian cancer.
Lin X, Chen Y, Ye X, Xia X., Free PMC Article | 05/8/2021 |
| Capn4 contributes to tumor invasion and metastasis in gastric cancer via activation of the Wnt/beta-catenin/MMP9 signalling pathways. | Capn4 contributes to tumor invasion and metastasis in gastric cancer via activation of the Wnt/β-catenin/MMP9 signalling pathways.
Zhao C, Yuan G, Jiang Y, Xu J, Ye L, Zhan W, Wang J. | 03/6/2021 |
| Capn4 coordination with LMP1 enhances NPC migration. | Capn4 is induced by and required for Epstein-Barr virus latent membrane protein 1 promotion of nasopharyngeal carcinoma metastasis through ERK/AP-1 signaling.
Zheng P, Chen X, Xie J, Chen X, Lin S, Ye L, Chen L, Lin J, Yu X, Zheng M., Free PMC Article | 01/18/2020 |
| our results show that enhanced Capn4 expression activates the Wnt/beta-catenin signaling pathway, resulting in increased ZEB1 expression and the promotion of esophageal squamous cell carcinoma (ESCC) cell metastasis. | Capn4 promotes esophageal squamous cell carcinoma metastasis by regulating ZEB1 through the Wnt/β-catenin signaling pathway.
Zhao YL, Li JB, Li YJ, Li SJ, Zhou SH, Xia H., Free PMC Article | 08/24/2019 |
| Collectively, these data suggested the tumor suppressive role of miR-337-3p in ccRCC. MiR-337-3p suppressed cell proliferation and metastasis in lear cell renal cell carcinoma partially via targeting Capn4. | MiR-337-3p suppresses the proliferation and metastasis of clear cell renal cell carcinoma cells via modulating Capn4.
Zhuang Q, Shen J, Chen Z, Zhang M, Fan M, Xue D, Lu H, Xu R, He X, Hou J. | 04/6/2019 |
| Suppression of Capn4 by miR-520b inhibits the growth and invasion of prostate cancer cells associated with downregulated Wnt/beta-catenin signaling. | Capn4 expression is modulated by microRNA-520b and exerts an oncogenic role in prostate cancer cells by promoting Wnt/β-catenin signaling.
Ren W, Wang D, Li C, Shu T, Zhang W, Fu X. | 03/2/2019 |
| Low calpain 4 expression is associated with ovarian cancer. | Calpain system protein expression and activity in ovarian cancer.
Zhang S, Deen S, Storr SJ, Chondrou PS, Nicholls H, Yao A, Rungsakaolert P, Martin SG., Free PMC Article | 03/2/2019 |
| that Capn4 promotes cell proliferation by increasing MAPK7 expression | Capn4 promotes colorectal cancer cell proliferation by increasing MAPK7 through activation of the Wnt/β-Catenin pathway.
Cheng F, Mohanmed MM, Li Z, Zhu L, Zhang Q, Huang Q, Shen W. | 11/17/2018 |
| Calpain small subunit 1 (Capn4) overexpression increased the protein level of cleaved talin and and activated the focal adhesion kinase (FAK)/AKT/MAPK signaling in 786-O cells, while Capn4 silencing decreased the protein level of cleaved talin in Caki-1 cells. | Capn4 contributes to tumor invasion and metastasis in clear cell renal cell carcinoma cells via modulating talin-focal adhesion kinase signaling pathway.
Zhuang Q, Luo W, Zhang M, Fan M, Lu H, Xu R, He X. | 10/6/2018 |
| Capn4 and miR-1271 may serve as potential therapeutic targets for the treatment of colorectal cancer. | Suppression of Capn4 by microRNA-1271 impedes the proliferation and invasion of colorectal cancer cells.
Li J, Xu J, Yan X, Jin K, Li W, Zhang R. | 08/25/2018 |
| MALAT1 and Capn4 were up-regulated while miR-124 expression was down-regulated in nasopharyngeal carcinoma cell lines. | MALAT1/miR-124/Capn4 axis regulates proliferation, invasion and EMT in nasopharyngeal carcinoma cells.
Shi B, Wang Y, Yin F., Free PMC Article | 07/7/2018 |
| Capn4 promotes epithelial-mesenchymal transition in human melanoma cells through activation of the Wnt/beta-catenin pathway. | Capn4 promotes epithelial-mesenchymal transition in human melanoma cells through activation of the Wnt/β-catenin pathway.
Wang E, Wang D, Li B, Ma H, Wang C, Guan L, Zhang H, Yi L, Li S. | 03/25/2017 |
| CAPNS1 depletion is coupled to impairment of breast cancer cell growth. | Calpain restrains the stem cells compartment in breast cancer.
Raimondi M, Marcassa E, Cataldo F, Arnandis T, Mendoza-Maldonado R, Bestagno M, Schneider C, Demarchi F., Free PMC Article | 10/22/2016 |
| High levels of Capn4 expression were associated with lymph node metastasis and large tumor size in non-small cell lung cancer patients.Capn4 promotes non-small cell lung cancer progression via upregulation of matrix metalloproteinase 2. | Capn4 promotes non-small cell lung cancer progression via upregulation of matrix metalloproteinase 2.
Gu J, Xu FK, Zhao GY, Lu CL, Lin ZW, Ding JY, Ge D. | 04/30/2016 |
| HBXIP was able to up-regulate Capn4 at the levels of promoter. | The oncoprotein HBXIP enhances migration of breast cancer cells through increasing filopodia formation involving MEKK2/ERK1/2/Capn4 signaling.
Li Y, Zhang Z, Zhou X, Li L, Liu Q, Wang Z, Bai X, Zhao Y, Shi H, Zhang X, Ye L. | 03/7/2015 |
| The overexpression of Capn4 is a novel negative prognostic marker, and Capn4 may be used as a new target in therapeutic strategies for human glioma. | Increased expression of Capn4 is associated with the malignancy of human glioma.
Cai JJ, Qi ZX, Hua W, Zhu JJ, Zhang X, Yao Y, Mao Y., Free PMC Article | 12/27/2014 |
| Capn4 can contribute to hepatocellular carcinoma growth and metastasis | Capn4 contributes to tumour growth and metastasis of hepatocellular carcinoma by activation of the FAK-Src signalling pathways.
Dai Z, Zhou SL, Zhou ZJ, Bai DS, Xu XY, Fu XT, Chen Q, Zhao YM, Zhu K, Yu L, Yang GH, Wang Z, Wu WZ, Zhou J, Fan J. | 12/20/2014 |
| Capn4 mRNA and protein are increased in human clear cell renal cell carcinoma tissues and higher Capn4 levels are associated with advanced clinical tumour stage and shorter overall survival. | Capn4 mRNA level is correlated with tumour progression and clinical outcome in clear cell renal cell carcinoma.
Zhuang Q, Qian X, Cao Y, Fan M, Xu X, He X. | 11/22/2014 |
| This study suggests that augmented calpain activity is associated with increased incidence of thrombosis under hypoxic environments. | Altered expression of platelet proteins and calpain activity mediate hypoxia-induced prothrombotic phenotype.
Tyagi T, Ahmad S, Gupta N, Sahu A, Ahmad Y, Nair V, Chatterjee T, Bajaj N, Sengupta S, Ganju L, Singh SB, Ashraf MZ. | 04/26/2014 |
| Capn4 overexpression was implicated in ICC metastasis/invasion, and Capn4 overexpression may be used as a molecular therapeutic target for intrahepatic cholangiocarcinoma | Prognostic significance of Capn4 overexpression in intrahepatic cholangiocarcinoma.
Zhang C, Bai DS, Huang XY, Shi GM, Ke AW, Yang LX, Yang XR, Zhou J, Fan J., Free PMC Article | 07/20/2013 |
| The expression of both CAPN 1 and CAPNS 1 is increased in transplant kidneys with acute rejection, and increased expression of CAPN 1 alone was observed in kidneys with chronic rejection. | Critical role of the calpain/calpastatin balance in acute allograft rejection.
Letavernier E, Dansou B, Lochner M, Perez J, Bellocq A, Lindenmeyer MT, Cohen CD, Haymann JP, Eberl G, Baud L. | 04/9/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |