| downregulation of CSN4 in Arabidopsis and in tobacco cells leads to delayed G1/S transition comparable to that observed when TCTP is downregulated. Loss-of-function of AtTCTP leads to increased fraction of deneddylated CUL1, suggesting that AtTCTP interferes negatively with COP9 function. Similar defects in cell proliferation and CUL1 neddylation status were observed in Drosophila knockdown for dCSN4 or dTCTP | TCTP and CSN4 control cell cycle progression and development by regulating CULLIN1 neddylation in plants and animals.
Betsch L, Boltz V, Brioudes F, Pontier G, Girard V, Savarin J, Wipperman B, Chambrier P, Tissot N, Benhamed M, Mollereau B, Raynaud C, Bendahmane M, Szécsi J., Free PMC Article | 03/16/2019 |
| ALF4 binds to RBX1 and inhibits the activity of SCF(TIR)(1), an E3 ligase responsible for degradation of the Aux/IAA transcriptional repressors. In vivo, the alf4 mutation destabilizes the CUL1 subunit of the SCF | The Arabidopsis ALF4 protein is a regulator of SCF E3 ligases.
Bagchi R, Melnyk CW, Christ G, Winkler M, Kirchsteiner K, Salehin M, Mergner J, Niemeyer M, Schwechheimer C, Calderón Villalobos LIA, Estelle M., Free PMC Article | 09/15/2018 |
| The axr6-101 phenotype is caused by the E716K substitution of the CUL1 protein, which is likely to affect its ability to bind to the C-terminal RING domain of RING-box 1 (RBX1). | A new temperature-insensitive allele of the Arabidopsis AXR6/CUL1 locus derived from a missense mutation in the C-terminal RBX1 binding region.
Mori Y, Hayashi M, Nishimura M, Yamamoto KT., Free PMC Article | 09/24/2016 |
| a new viable recessive allele of the Arabidopsis CULLIN1 gene in the non-reference Wassilewskija (Ws-4) accession, was identified. | A novel viable allele of Arabidopsis CULLIN1 identified in a screen for superroot2 suppressors by next generation sequencing-assisted mapping.
Pacurar DI, Pacurar ML, Pacurar AM, Gutierrez L, Bellini C., Free PMC Article | 10/17/2015 |
| icu13 is a novel recessive allele of AUXIN RESISTANT6 (AXR6), which encodes CULLIN1, an invariable component of the SCF complex.[ICU13] [ncurvata13] | incurvata13, a novel allele of AUXIN RESISTANT6, reveals a specific role for auxin and the SCF complex in Arabidopsis embryogenesis, vascular specification, and leaf flatness.
Esteve-Bruna D, Pérez-Pérez JM, Ponce MR, Micol JL., Free PMC Article | 07/7/2014 |
| CUL1-based SCF E3 ligase activity is required for Della protein degradation. | Biochemical insights on degradation of Arabidopsis DELLA proteins gained from a cell-free assay system.
Wang F, Zhu D, Huang X, Li S, Gong Y, Yao Q, Fu X, Fan LM, Deng XW., Free PMC Article | 01/21/2010 |
| the first reported allele of CUL1 to directly affect subunit interactions at the CUL1 C terminus | Isolation and characterization of cul1-7, a recessive allele of CULLIN1 that disrupts SCF function at the C terminus of CUL1 in Arabidopsis thaliana.
Gilkerson J, Hu J, Brown J, Jones A, Sun TP, Callis J., Free PMC Article | 01/21/2010 |
| CUL1 is required for TOC1 degradation and suggests that this protein is the functional cullin circadian clock. | CUL1 regulates TOC1 protein stability in the Arabidopsis circadian clock.
Harmon F, Imaizumi T, Gray WM., Free PMC Article | 01/21/2010 |
| The disruption of the CAND1-CUL1 interaction results in an increased abundance of assembled SCF(TIR1) complex; stabilization of the CAND1-CUL1 interaction diminishes SCF(TIR1) complex abundance. | Genetic analysis of CAND1-CUL1 interactions in Arabidopsis supports a role for CAND1-mediated cycling of the SCFTIR1 complex.
Zhang W, Ito H, Quint M, Huang H, Noël LD, Gray WM., Free PMC Article | 01/21/2010 |
| Genetic and physiological data to directly demonstrate that AtCUL1 is necessary for normal JA responses are presented. | Point mutations in Arabidopsis Cullin1 reveal its essential role in jasmonate response.
Ren C, Pan J, Peng W, Genschik P, Hobbie L, Hellmann H, Estelle M, Gao B, Peng J, Sun C, Xie D. | 01/21/2010 |
| A viable and fertile weak allele of CUL1, called cul1-6, is described. | A new CULLIN 1 mutant has altered responses to hormones and light in Arabidopsis.
Moon J, Zhao Y, Dai X, Zhang W, Gray WM, Huq E, Estelle M., Free PMC Article | 01/21/2010 |