| Light-induced LLPS of the CRY2/SPA1/FIO1 complex regulating mRNA methylation and chlorophyll homeostasis in Arabidopsis. | Light-induced LLPS of the CRY2/SPA1/FIO1 complex regulating mRNA methylation and chlorophyll homeostasis in Arabidopsis.
Jiang B, Zhong Z, Gu L, Zhang X, Wei J, Ye C, Lin G, Qu G, Xiang X, Wen C, Hummel M, Bailey-Serres J, Wang Q, He C, Wang X, Lin C., Free PMC Article | 01/31/2024 |
| Arabidopsis phytochromes A and B synergistically repress SPA1 under blue light. | Arabidopsis phytochromes A and B synergistically repress SPA1 under blue light.
Jia X, Song M, Wang S, Liu T, Wang L, Guo L, Su L, Shi Y, Zheng X, Yang J. | 04/5/2023 |
| Functional comparison of the WD-repeat domains of SPA1 and COP1 in suppression of photomorphogenesis. | Functional comparison of the WD-repeat domains of SPA1 and COP1 in suppression of photomorphogenesis.
Kerner K, Nagano S, Lübbe A, Hoecker U. | 01/8/2022 |
| SPA1 acts as a serine/threonine kinase and directly phosphorylates PIF1 in vitro and in vivo. | A phyB-PIF1-SPA1 kinase regulatory complex promotes photomorphogenesis in Arabidopsis.
Paik I, Chen F, Ngoc Pham V, Zhu L, Kim JI, Huq E., Free PMC Article | 01/11/2020 |
| The WD-repeat domain of SPA1 is necessary for the interaction between SPA1 and COL12. | The Transcription Factor COL12 Is a Substrate of the COP1/SPA E3 Ligase and Regulates Flowering Time and Plant Architecture.
Ordoñez-Herrera N, Trimborn L, Menje M, Henschel M, Robers L, Kaufholdt D, Hänsch R, Adrian J, Ponnu J, Hoecker U., Free PMC Article | 12/22/2018 |
| COP1/SPA complex associates with and stabilizes PHYTOCHROME INTERACTING FACTOR 3 (PIF3) to repress photomorphogenesis in the dark. | Noncanonical role of Arabidopsis COP1/SPA complex in repressing BIN2-mediated PIF3 phosphorylation and degradation in darkness.
Ling JJ, Li J, Zhu D, Deng XW., Free PMC Article | 07/14/2018 |
| SPA proteins have a dual role: (1) they are required for light-responsiveness of COP1 subcellular localization, and (2) they promote COP1 activity in darkness in a fashion that is independent of the nuclear import/nuclear retention of COP1. | SPA Proteins Affect the Subcellular Localization of COP1 in the COP1/SPA Ubiquitin Ligase Complex during Photomorphogenesis.
Balcerowicz M, Kerner K, Schenkel C, Hoecker U., Free PMC Article | 01/20/2018 |
| The N-terminal kinase-like domain is primarily responsible for the respective light-responsiveness of SPA1 and SPA2. | The functional divergence between SPA1 and SPA2 in Arabidopsis photomorphogenesis maps primarily to the respective N-terminal kinase-like domain.
Chen S, Wirthmueller L, Stauber J, Lory N, Holtkotte X, Leson L, Schenkel C, Ahmad M, Hoecker U., Free PMC Article | 08/19/2017 |
| CUL4(COP1-SPA) E3 ubiquitin ligase is necessary for the light-induced degradation of PIF1 in Arabidopsis. | CUL4 forms an E3 ligase with COP1 and SPA to promote light-induced degradation of PIF1.
Zhu L, Bu Q, Xu X, Paik I, Huang X, Hoecker U, Deng XW, Huq E. | 04/9/2016 |
| Interaction of phyB with SPA1 promotes COP1-SPA1 dissociation and photomorphogenic development. | Red-light-dependent interaction of phyB with SPA1 promotes COP1-SPA1 dissociation and photomorphogenic development in Arabidopsis.
Lu XD, Zhou CM, Xu PB, Luo Q, Lian HL, Yang HQ. | 02/20/2016 |
| It was shown show that mutations in the key repressor of light signaling, the COP1/SPA complex, cause a strong hyperaccumulation of anthocyanins not only under normal light but also under high light conditions. | COP1/SPA ubiquitin ligase complexes repress anthocyanin accumulation under low light and high light conditions.
Maier A, Hoecker U., Free PMC Article | 10/31/2015 |
| The MID protein plays a role in COP1/SPA1-controlled repression of flowering under short-day conditions. | MIDGET cooperates with COP1 and SPA1 to repress flowering in Arabidopsis thaliana.
Schrader A, Uhrig J., Free PMC Article | 06/21/2014 |
| these results provide insights into SPA1- and MYC2-mediated transcriptional regulation of the Z- and G-box containing promoters in light signaling pathways. | The regulation of the Z- and G-box containing promoters by light signaling components, SPA1 and MYC2, in Arabidopsis.
Gangappa SN, Maurya JP, Yadav V, Chattopadhyay S., Free PMC Article | 11/30/2013 |
| PHYB plays a role in repressing far-red (FR) light signaling. Activity modulation of the COP1-SPA E3 complex by light-activated phytochromes is an effective and pivotal regulatory step in light signaling. | Arabidopsis phytochrome B promotes SPA1 nuclear accumulation to repress photomorphogenesis under far-red light.
Zheng X, Wu S, Zhai H, Zhou P, Song M, Su L, Xi Y, Li Z, Cai Y, Meng F, Yang L, Wang H, Yang J., Free PMC Article | 11/2/2013 |
| COP1/SPA activity, via LONG HYPOCOTYL IN FR LIGHT1, is required for shade-induced modulation of the auxin biosynthesis pathway and thereby enhances cell elongation in low red:far red. | Arabidopsis COP1 and SPA genes are essential for plant elongation but not for acceleration of flowering time in response to a low red light to far-red light ratio.
Rolauffs S, Fackendahl P, Sahm J, Fiene G, Hoecker U., Free PMC Article | 05/18/2013 |
| CRY2 directly interacts with SPA1 in nuclei | Degradation of Arabidopsis CRY2 is regulated by SPA proteins and phytochrome A.
Weidler G, Zur Oven-Krockhaus S, Heunemann M, Orth C, Schleifenbaum F, Harter K, Hoecker U, Batschauer A., Free PMC Article | 12/8/2012 |
| SPA1 Is Required for the CRY2-Mediated Photoperiodic Regulation of Floral Initiation. | Blue light-dependent interaction of CRY2 with SPA1 regulates COP1 activity and floral initiation in Arabidopsis.
Zuo Z, Liu H, Liu B, Liu X, Lin C., Free PMC Article | 09/17/2011 |
| demonstrated the genetic and molecular relationships of MYC2 and SPA1 in light and JA (jasmonic acid) signaling pathways. Here, we have further shown the genetic interactions between these two proteins in flowering time and lateral root development | MYC2, a bHLH transcription factor, modulates the adult phenotype of SPA1.
Gangappa SN, Chattopadhyay S., Free PMC Article | 08/27/2011 |
| CRY1 interacts physically with SPA1 in a blue-light-dependent manner. | Blue-light-dependent interaction of cryptochrome 1 with SPA1 defines a dynamic signaling mechanism.
Lian HL, He SB, Zhang YC, Zhu DM, Zhang JY, Jia KP, Sun SX, Li L, Yang HQ., Free PMC Article | 07/9/2011 |
| results are consistent with a hypothesis that photoexcited CRY1 interacts with SPA1 to modulate COP1 activity and plant development. | Arabidopsis cryptochrome 1 interacts with SPA1 to suppress COP1 activity in response to blue light.
Liu B, Zuo Z, Liu H, Liu X, Lin C., Free PMC Article | 07/9/2011 |
| SPA1 acts in the phloem to regulate seedling de-etiolation, leaf expansion and flowering time. | The Arabidopsis repressor of light signaling SPA1 acts in the phloem to regulate seedling de-etiolation, leaf expansion and flowering time.
Ranjan A, Fiene G, Fackendahl P, Hoecker U. | 07/2/2011 |
| SPA1 and SPA2 proteins are rapidly de-stabilized upon light exposure. | Light exposure of Arabidopsis seedlings causes rapid de-stabilization as well as selective post-translational inactivation of the repressor of photomorphogenesis SPA2.
Balcerowicz M, Fittinghoff K, Wirthmueller L, Maier A, Fackendahl P, Fiene G, Koncz C, Hoecker U. | 06/18/2011 |
| MYC2 and SPA1 act redundantly to suppress photomorphogenic growth in the dark. | Functional interconnection of MYC2 and SPA1 in the photomorphogenic seedling development of Arabidopsis.
Gangappa SN, Prasad VB, Chattopadhyay S., Free PMC Article | 02/26/2011 |
| Results show that SPA1 and DET1 act together to control photomorphogenesis throughout plant development. | SPA1 and DET1 act together to control photomorphogenesis throughout plant development.
Nixdorf M, Hoecker U. | 05/10/2010 |
| SPA1 protein can self-associate or interact with each other, forming stable heterogeneous group of SPA-COP1 complexes regardless of light conditions but exhibit distinct expression profiles in different tissues and light conditions. | Biochemical characterization of Arabidopsis complexes containing CONSTITUTIVELY PHOTOMORPHOGENIC1 and SUPPRESSOR OF PHYA proteins in light control of plant development.
Zhu D, Maier A, Lee JH, Laubinger S, Saijo Y, Wang H, Qu LJ, Hoecker U, Deng XW., Free PMC Article | 01/21/2010 |