| Thyroid Hormone Signaling in Embryonic Stem Cells: Crosstalk with the Retinoic Acid Pathway. | Thyroid Hormone Signaling in Embryonic Stem Cells: Crosstalk with the Retinoic Acid Pathway.
Fernández M, Pannella M, Baldassarro VA, Flagelli A, Alastra G, Giardino L, Calzà L., Free PMC Article | 03/6/2021 |
| Alteration of thyroid hormone signaling triggers the diabetes-induced pathological growth, remodeling, and dedifferentiation of podocytes. | Alteration of thyroid hormone signaling triggers the diabetes-induced pathological growth, remodeling, and dedifferentiation of podocytes.
Benedetti V, Lavecchia AM, Locatelli M, Brizi V, Corna D, Todeschini M, Novelli R, Benigni A, Zoja C, Remuzzi G, Xinaris C., Free PMC Article | 10/3/2020 |
| This study demonstrated that reduction of the thyroid hormone receptor alfa (Tralpha1)mRNA expression in hippocampus of thyroidectomized Wistar rats. | Antidepressant behavior in thyroidectomized Wistar rats is induced by hippocampal hypothyroidism.
da Conceição RR, Laureano-Melo R, Oliveira KC, de Carvalho Melo MC, Kasamatsu TS, de Barros Maciel RM, de Souza JS, Giannocco G. | 12/17/2016 |
| The roles of nitric oxide synthase and TRalph1 in hyperthyroid and hypothyroid rats are reported. | Nitric oxide and thyroid hormone receptor alpha 1 contribute to ovarian follicular development in immature hyper- and hypo-thyroid rats.
Zheng K, Sulieman FJ, Li J, Wei Q, Xu M, Shi F. | 12/5/2015 |
| down-regulated in hepatocellular carcinoma | Local hypothyroidism favors the progression of preneoplastic lesions to hepatocellular carcinoma in rats.
Frau C, Loi R, Petrelli A, Perra A, Menegon S, Kowalik MA, Pinna S, Leoni VP, Fornari F, Gramantieri L, Ledda-Columbano GM, Giordano S, Columbano A. | 03/21/2015 |
| role for TRalpha1 in the regulation of hypothalamic TRH mRNA expression, whereas TRbeta plays a dominant role in pituitary and liver thyroid hormone metabolism. | Action of specific thyroid hormone receptor α(1) and β(1) antagonists in the central and peripheral regulation of thyroid hormone metabolism in the rat.
van Beeren HC, Kwakkel J, Ackermans MT, Wiersinga WM, Fliers E, Boelen A. | 06/22/2013 |
| conjugation of SUMO to TR has a TR-isoform preference and is important for T3-dependent gene induction and repression. | Thyroid hormone receptor isoform-specific modification by small ubiquitin-like modifier (SUMO) modulates thyroid hormone-dependent gene regulation.
Liu YY, Kogai T, Schultz JJ, Mody K, Brent GA., Free PMC Article | 12/29/2012 |
| Data show that acute T3-limiting effect on reperfusion injury is mediated, at least in part, via TRalpha1 receptor. | Acute T3 treatment protects the heart against ischemia-reperfusion injury via TRα1 receptor.
Pantos C, Mourouzis I, Saranteas T, Brozou V, Galanopoulos G, Kostopanagiotou G, Cokkinos DV. | 10/22/2011 |
| Data show that thyroid hormone induced rat aorta smooth muscle cell proliferation by up-regulating NOX1 in a TRalpha1-dependent manner. | Thyroid hormone induces artery smooth muscle cell proliferation: discovery of a new TRalpha1-Nox1 pathway.
Wang X, Sun Z., Free PMC Article | 07/2/2011 |
| Acute myocardial infarction in diabetic rats results in TH receptor down-regulation with important physiological consequences | Thyroid hormone can favorably remodel the diabetic myocardium after acute myocardial infarction.
Kalofoutis C, Mourouzis I, Galanopoulos G, Dimopoulos A, Perimenis P, Spanou D, Cokkinos DV, Singh J, Pantos C. | 03/26/2011 |
| Progression to congestive heart failure after myocardial infarction is associated with suppressed expression of TR alpha 1 and results in tissue hypothyroidism. | Thyroid hormone receptor alpha1 downregulation in postischemic heart failure progression: the potential role of tissue hypothyroidism.
Pantos C, Mourouzis I, Galanopoulos G, Gavra M, Perimenis P, Spanou D, Cokkinos DV. | 01/1/2011 |
| TR alpha 1 and TR beta 1 divergently regulate cardiac pacing activity. TH-induced positive chronotropic effects are likely to be mediated by TR alpha 1 through enhanced expression of I(f) pacemaker current and its underlying genes. | Distinct regulation of cardiac I(f) current via thyroid receptors alpha1 and beta1.
Gassanov N, Er F, Endres-Becker J, Wolny M, Schramm C, Hoppe UC. | 01/21/2010 |
| TRalpha1 and TRbeta1 exhibit distinct effects on KCND3 transactivation in cardiomyocytes, with TRalpha1 enhancing and TRbeta1 suppressing KCND3 transcription. | Divergent regulation of cardiac KCND3 potassium channel expression by the thyroid hormone receptors alpha1 and beta1.
Gassanov N, Er F, Michels G, Zagidullin N, Brandt MC, Hoppe UC., Free PMC Article | 01/21/2010 |
| Over-expression of thyroid hormone receptor alpha1 may lead to fetal cardiac phenotype in the absence of thyroid hormone availability. | Thyroid hormone receptor alpha 1: a switch to cardiac cell "metamorphosis"?
Pantos C, Xinaris C, Mourouzis I, Perimenis P, Politi E, Spanou D, Cokkinos DV. | 01/21/2010 |
| The data show that the expression of thyroid hormone receptor alpha 1 and its mRNA levels were increased by the hypothyroid state. | Thyroid hormone receptor alpha 1-beta 1 expression in epididymal epithelium from euthyroid and hypothyroid rats.
De Paul AL, Mukdsi JH, Pellizas CG, Montesinos M, Gutiérrez S, Susperreguy S, Del Río A, Maldonado CA, Torres AI. | 01/21/2010 |
| TRalpha1 mRNA upregulated in hyperthyroid myocardium and downregulated in hypothyroid myocardium. TRalpha2 mRNA downregulated in hyperthyroid myocardium and upregulated in hypothyroid myocardium. | Effects of hyper- and hypothyroid on expression of thyroid hormone receptor mRNA in rat myocardium.
Liu CR, Li LY, Shi F, Zang XY, Liu YM, Sun Y, Kan BH. | 01/21/2010 |
| NCoR, GAF, and TR interact with the CD44 negative T(3)-responsive element to enhance basal transactivation, whereas T(3) induces the remodeling of chromatin structure for repression | A novel mechanism of thyroid hormone-dependent negative regulation by thyroid hormone receptor, nuclear receptor corepressor (NCoR), and GAGA-binding factor on the rat cD44 promoter.
Kim SW, Ho SC, Hong SJ, Kim KM, So EC, Christoffolete M, Harney JW. | 01/21/2010 |
| In outer hair cells, TH enhanced the expression of the prestin gene through TRbeta. Simultaneously Kcnq4 expression was activated in the same cells by derepression of TRalpha1. | Thyroid hormone receptors TRalpha1 and TRbeta differentially regulate gene expression of Kcnq4 and prestin during final differentiation of outer hair cells.
Winter H, Braig C, Zimmermann U, Geisler HS, Fränzer JT, Weber T, Ley M, Engel J, Knirsch M, Bauer K, Christ S, Walsh EJ, McGee J, Köpschall I, Rohbock K, Knipper M. | 01/21/2010 |
| Cardiac dysfunction which occurs at late stages after acute myocardial infarction is associated with increased expression of TR alpha 1 receptor and lower circulating tri-iodothyronine levels. | Time-dependent changes in the expression of thyroid hormone receptor alpha 1 in the myocardium after acute myocardial infarction: possible implications in cardiac remodelling.
Pantos C, Mourouzis I, Xinaris C, Kokkinos AD, Markakis K, Dimopoulos A, Panagiotou M, Saranteas T, Kostopanagiotou G, Cokkinos DV. | 01/21/2010 |
| Diurnal changes in liver TR alpha 1 and TR alpha 2 are controlled by the biological clock in the SCN but not via changes in the daily rhythm of food intake | Diurnal variation in rat liver thyroid hormone receptor (TR)-alpha messenger ribonucleic acid (mRNA) is dependent on the biological clock in the suprachiasmatic nucleus, whereas diurnal variation of TR beta 1 mRNA is modified by food intake.
Zandieh Doulabi B, Platvoet-Ter Schiphorst M, Kalsbeek A, Fliers E, Bakker O, Wiersinga WM. | 01/21/2010 |
| TAK1 and p38 MAP kinase have roles in thyroid hormone-induced cardiac myocyte hypertrophy through thyroid hormone receptor alpha1 | Thyroid hormone induces cardiac myocyte hypertrophy in a thyroid hormone receptor alpha1-specific manner that requires TAK1 and p38 mitogen-activated protein kinase.
Kinugawa K, Jeong MY, Bristow MR, Long CS., Free PMC Article | 01/21/2010 |
| TRalpha2 is a single stranded RNA binding protein; the RNA binding domain localizes to a 41 amino acid region immediately distal to second zinc finger; phosphorylated TRalpha2 is primarily cytoplasmic & unphosphorylated TRalpha2 is primarily nuclear | Regulation of thyroid hormone receptor alpha2 RNA binding and subcellular localization by phosphorylation.
Xu B, Koenig RJ. | 01/21/2010 |
| rapid T3-mediated activation of PI3K by cytosolic TRalpha1 and subsequent activation of the Akt-mTOR-S6K signaling pathway may underlie one of the mechanisms by which thyroid hormone regulates physiological cardiac growth | Thyroid hormone stimulates protein synthesis in the cardiomyocyte by activating the Akt-mTOR and p70S6K pathways.
Kenessey A, Ojamaa K. | 01/21/2010 |
| role for both the proteosome degradation pathway and altered mRNA stability in T3-induced decrease of nuclear TRalpha1 in the cardiomyocyte | Ligand-mediated decrease of thyroid hormone receptor-alpha1 in cardiomyocytes by proteosome-dependent degradation and altered mRNA stability.
Kenessey A, Ojamaa K. | 01/21/2010 |
| thyroid hormone and thyroid hormone receptor TRalpha regulate expression of the Na+/H+ exchanger | Thyroid hormone receptor alpha 1 regulates expression of the Na+/H+ exchanger (NHE1).
Li X, Misik AJ, Rieder CV, Solaro RJ, Lowen A, Fliegel L. | 01/21/2010 |