| A Novel Mutation in the ADAMTS10 Associated with Weil-Marchesani Syndrome with a Unique Presentation of Developed Membranes Causing Severe Stenosis of the Supra Pulmonic, Supramitral, and Subaortic Areas in the Heart. | A Novel Mutation in the ADAMTS10 Associated with Weil-Marchesani Syndrome with a Unique Presentation of Developed Membranes Causing Severe Stenosis of the Supra Pulmonic, Supramitral, and Subaortic Areas in the Heart.
Levitas A, Aspit L, Lowenthal N, Shaki D, Krymko H, Slanovic L, Yagev R, Parvari R., Free PMC Article | 08/23/2023 |
| ADAMTS10 inhibits aggressiveness via JAK/STAT/c-MYC pathway and reprograms macrophage to create an anti-malignant microenvironment in gastric cancer. | ADAMTS10 inhibits aggressiveness via JAK/STAT/c-MYC pathway and reprograms macrophage to create an anti-malignant microenvironment in gastric cancer.
Zhou J, Li T, Chen H, Jiang Y, Zhao Y, Huang J, Chen Z, Tang X, Huang Z, Yang Z. | 10/29/2022 |
| Using siRNA, over-expression and mutagenesis, it was found ADAMTS6 inhibits and ADAMTS10 is required for focal adhesions, epithelial cell-cell junction formation, and microfibril deposition. | ADAMTS-10 and -6 differentially regulate cell-cell junctions and focal adhesions.
Cain SA, Mularczyk EJ, Singh M, Massam-Wu T, Kielty CM., Free PMC Article | 05/5/2018 |
| These findings support the Gly661Arg mutation of ADAMTS10 as the likely cause of POAG in beagles. | Screening ADAMTS10 in dog populations supports Gly661Arg as the glaucoma-causing variant in beagles.
Kuchtey J, Kunkel J, Esson D, Sapienza JS, Ward DA, Plummer CE, Gelatt KN, Kuchtey RW., Free PMC Article | 05/11/2013 |
| ADAMTS10 participates in microfibril biogenesis rather than in fibrillin-1 turnover | ADAMTS10 protein interacts with fibrillin-1 and promotes its deposition in extracellular matrix of cultured fibroblasts.
Kutz WE, Wang LW, Bader HL, Majors AK, Iwata K, Traboulsi EI, Sakai LY, Keene DR, Apte SS., Free PMC Article | 07/16/2011 |
| Homozygous mutation in ADAMTS10 causes lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. | Homozygous mutations in ADAMTS10 and ADAMTS17 cause lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature.
Morales J, Al-Sharif L, Khalil DS, Shinwari JM, Bavi P, Al-Mahrouqi RA, Al-Rajhi A, Alkuraya FS, Meyer BF, Al Tassan N., Free PMC Article | 01/21/2010 |
| Mutations in ADAMTS10 gene is not responsible for microspherophakia. | Clinical and genetic investigation of isolated microspherophakia in a consanguineous Tunisian family.
Ben Yahia S, Ouechtati F, Jelliti B, Nouira S, Chakroun S, Abdelhak S, Khairallah M. | 01/21/2010 |
| infer that folding of the complex C-terminal ancillary domain is the rate-limiting step in biosynthesis of ADAMTS10, and that it (but not catalytic domain) is sensitive to subtle changes in efficiency of signal peptide cleavage. | Functional analysis of an ADAMTS10 signal peptide mutation in Weill-Marchesani syndrome demonstrates a long-range effect on secretion of the full-length enzyme.
Kutz WE, Wang LW, Dagoneau N, Odrcic KJ, Cormier-Daire V, Traboulsi EI, Apte SS. | 01/21/2010 |
| Expression in human colonic cell lines. | ADAM-15 inhibits wound healing in human intestinal epithelial cell monolayers.
Charrier L, Yan Y, Driss A, Laboisse CL, Sitaraman SV, Merlin D. | 01/21/2010 |
| ADAMTS10 plays a major role in growth and in skin, lens, and heart development in humans. | ADAMTS10 mutations in autosomal recessive Weill-Marchesani syndrome.
Dagoneau N, Benoist-Lasselin C, Huber C, Faivre L, Mégarbané A, Alswaid A, Dollfus H, Alembik Y, Munnich A, Legeai-Mallet L, Cormier-Daire V., Free PMC Article | 01/21/2010 |
| ADAMTS10 is a functional metalloprotease as demonstrated by cleavage of alpha2-macroglobulin | Discovery and characterization of a novel, widely expressed metalloprotease, ADAMTS10, and its proteolytic activation.
Somerville RP, Jungers KA, Apte SS. | 01/21/2010 |