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    Ntf3 neurotrophin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81737, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Repair effect of neurotrophic factor III (NT-3) on rats with spinal injury model and its mechanism.

    Repair effect of neurotrophic factor III (NT-3) on rats with spinal injury model and its mechanism.
    Zou D, Wang H, Hao S, Chen F.

    02/29/2024
    Neurotrophin-3 into the insular cortex strengthens conditioned taste aversion memory.

    Neurotrophin-3 into the insular cortex strengthens conditioned taste aversion memory.
    Briones-Vidal MG, Reyes-García SE, Escobar ML.

    02/5/2024
    Electroacupuncture facilitates the integration of a grafted TrkC-modified mesenchymal stem cell-derived neural network into transected spinal cord in rats via increasing neurotrophin-3.

    Electroacupuncture facilitates the integration of a grafted TrkC-modified mesenchymal stem cell-derived neural network into transected spinal cord in rats via increasing neurotrophin-3.
    Yang Y, Xu HY, Deng QW, Wu GH, Zeng X, Jin H, Wang LJ, Lai BQ, Li G, Ma YH, Jiang B, Ruan JW, Wang YQ, Ding Y, Zeng YS., Free PMC Article

    02/5/2022
    Governor Vessel Electro-Acupuncture Promotes the Intrinsic Growth Ability of Spinal Neurons through Activating Calcitonin Gene-Related Peptide/alpha-Calcium/Calmodulin-Dependent Protein Kinase/Neurotrophin-3 Pathway after Spinal Cord Injury.

    Governor Vessel Electro-Acupuncture Promotes the Intrinsic Growth Ability of Spinal Neurons through Activating Calcitonin Gene-Related Peptide/α-Calcium/Calmodulin-Dependent Protein Kinase/Neurotrophin-3 Pathway after Spinal Cord Injury.
    Xu H, Yang Y, Deng QW, Zhang BB, Ruan JW, Jin H, Wang JH, Ren J, Jiang B, Sun JH, Zeng YS, Ding Y.

    01/15/2022
    Controlling the Release of Neurotrophin-3 and Chondroitinase ABC Enhances the Efficacy of Nerve Guidance Conduits.

    Controlling the Release of Neurotrophin-3 and Chondroitinase ABC Enhances the Efficacy of Nerve Guidance Conduits.
    Donsante A, Xue J, Poth KM, Hardcastle NS, Diniz B, O'Connor DM, Xia Y, Boulis NM., Free PMC Article

    06/26/2021
    Macrophage-derived neurotrophin-3 promotes heterotopic ossification in rats.

    Macrophage-derived neurotrophin-3 promotes heterotopic ossification in rats.
    Zhang J, Wang L, Chu J, Ao X, Jiang T, Bin Yan, Huang M, Zhang Z.

    10/24/2020
    Effect of NT-3 on infection-induced memory impairment of neonatal rats.

    Effect of NT-3 on infection-induced memory impairment of neonatal rats.
    Liu DB, Yang JS, Lu QB, Zhu ZF, Fang Q.

    08/15/2020
    Neurotrophin-3 promotes the endothelial-mesenchymal transition of heterotopic ossification in rats.

    Neurotrophin-3 acts on the endothelial-mesenchymal transition of heterotopic ossification in rats.
    Zhang J, Wang L, Cao H, Chen N, Yan B, Ao X, Zhao H, Chu J, Huang M, Zhang Z., Free PMC Article

    07/18/2020
    Injury site osteoblast-derived NT-3 is important in promoting growth plate injury site remodeling.

    Osteoblast derived-neurotrophin‑3 induces cartilage removal proteases and osteoclast-mediated function at injured growth plate in rats.
    Su YW, Chim SM, Zhou L, Hassanshahi M, Chung R, Fan C, Song Y, Foster BK, Prestidge CA, Peymanfar Y, Tang Q, Butler LM, Gronthos S, Chen D, Xie Y, Chen L, Zhou XF, Xu J, Xian CJ., Free PMC Article

    07/20/2019
    study suggests that NT-3 may be an osteogenic and angiogenic factor upstream of BMP-2 and VEGF in bony repair, and further studies are required to investigate whether NT-3 may be a potential target for preventing growth plate faulty bony repair or for promoting bone fracture healing.

    Neurotrophin-3 Induces BMP-2 and VEGF Activities and Promotes the Bony Repair of Injured Growth Plate Cartilage and Bone in Rats.
    Su YW, Chung R, Ruan CS, Chim SM, Kuek V, Dwivedi PP, Hassanshahi M, Chen KM, Xie Y, Chen L, Foster BK, Rosen V, Zhou XF, Xu J, Xian CJ.

    12/23/2017
    the combined delivery of NT-3 and anti-NogoA from the DDS in an impact/compression model of SCI increases axon density and improves locomotor function.

    Local Delivery of Neurotrophin-3 and Anti-NogoA Promotes Repair After Spinal Cord Injury.
    Elliott Donaghue I, Tator CH, Shoichet MS.

    11/25/2017
    Compared to the sham group, the expression levels of NT-3 were significantly decreased and electroacupuncture was shown to upregulate the expression of NT-3

    Effects of Electroacupuncture at Governor Vessel Acupoints on Neurotrophin-3 in Rats with Experimental Spinal Cord Injury.
    Mo YP, Yao HJ, Lv W, Song LY, Song HT, Yuan XC, Mao YQ, Jing QK, Shi SH, Li ZG., Free PMC Article

    10/28/2017
    Data show that 5-Aza-dc reversed the alcohol-induced downregulation of neurotrophin-3 (Ntf3), correspondingly the expression of its receptor-neurotrophic receptor tyrosine kinase 3 (TrkC) was reduced.

    5-Aza-2'-deoxycytidine in the medial prefrontal cortex regulates alcohol-related behavior and Ntf3-TrkC expression in rats.
    Qiao X, Yin F, Ji Y, Li Y, Yan P, Lai J., Free PMC Article

    09/30/2017
    results demonstrate that BDNF and NT3 regulate axon initial segmen location and neuronal excitability

    Brain-derived neurotrophic factor/neurotrophin 3 regulate axon initial segment location and affect neuronal excitability in cultured hippocampal neurons.
    Guo Y, Su ZJ, Chen YK, Chai Z.

    08/12/2017
    It has been shown that ischemia influenced the expression of neurotrophins (Bdnf, Ngf, Nt-3) and their receptors (TrkB, TrkA, TrkC, p75) in brain structures outside the lesion focus, including the contralateral hemisphere.

    [Effects of ischemia on the expression of neurotrophins and their receptors in rat brain structures outside the lesion site, including on the opposite hemisphere].
    Dmitrieva VG, Stavchansky VV, Povarova OV, Skvortsova VI, Limborska SA, Dergunova LV.

    03/25/2017
    Neurotrophin 3 activity in spinal cord was higher in balance and coordination trained animals following sciatic nerve crush compared to endurance trained.

    Balance and coordination training, but not endurance training, enhances synaptophysin and neurotrophin-3 immunoreactivity in the lumbar spinal cord after sciatic nerve crush.
    Bonetti LV, Ilha J, Schneider AP, Barbosa S, Faccioni-Heuser MC.

    07/30/2016
    The expressed BDNF and NT3 exert a synergistic effect, which may promote the neuronal differentiation of adiposederived stem cells.

    Effects of brain‑derived neurotrophic factor and neurotrophin‑3 on the neuronal differentiation of rat adipose‑derived stem cells.
    Ji W, Zhang X, Ji L, Wang K, Qiu Y., Free PMC Article

    06/28/2016
    Data suggest that the bone morphogenetic protein (BMP) signaling pathway may be a key regulatory point in neurotrophin-3 (NT-3) transfected neuronal differentiation of mesenchymal stem cells (MSCs).

    Neurotrophine-3 may contribute to neuronal differentiation of mesenchymal stem cells through the activation of the bone morphogenetic protein pathway.
    Li L, Li Y, Jiang H.

    04/30/2016
    Basic fibroblast growth factor and neurotrophin-3, which are released from astrocytes by exposure to thyroid hormone, influence each other to enhance Na+ current density in cultured hippocampal neurons.

    Regulation of neuronal excitability by release of proteins from glial cells.
    Igelhorst BA, Niederkinkhaus V, Karus C, Lange MD, Dietzel ID., Free PMC Article

    02/20/2016
    These results indicate the feasibility of fabricating NT-3-immobilized scaffolds using the adsorption of NT-3/SF coating method, as well as the potential of these scaffolds to induce SCI repair by promoting survival and neuronal differentiation

    The effects of controlled release of neurotrophin-3 from PCLA scaffolds on the survival and neuronal differentiation of transplanted neural stem cells in a rat spinal cord injury model.
    Tang S, Liao X, Shi B, Qu Y, Huang Z, Lin Q, Guo X, Pei F., Free PMC Article

    12/19/2015
    The effects of glial cell-derived neurotrophic factor (GDNF) and neurotrophin-3 (NT-3) on the course of bone marrow mesenchymal stem cell differentiation.

    GDNF and NT-3 induce progenitor bone mesenchymal stem cell differentiation into neurons in fetal gut culture medium.
    Zhu T, Yu D, Feng J, Wu X, Xiang L, Gao H, Zhang X, Wei M.

    11/21/2015
    NT-3 gene-modified bone marrow-derived mesenchymal stem cells via lumbar puncture can strengthen the therapeutic benefits of bone mesenchymal stem cell transplantation

    Transplantation of neurotrophin-3-expressing bone mesenchymal stem cells improves recovery in a rat model of spinal cord injury.
    Wang LJ, Zhang RP, Li JD.

    06/20/2015
    The present study indicates that genetically modified BMSCs co-expressing GDNF and NT-3 are able to differentiate into enteric neuronal cells and express enteric nerve markers when induced by FGCM.

    Differentiation of GDNF and NT-3 dual gene-modified rat bone marrow mesenchymal stem cells into enteric neuron-like cells.
    Gao H, Wei M, Wang Y, Wu X, Zhu T.

    09/13/2014
    A method of hypoglossal-facial nerve anastomosis through an NT3-expressing predegenerated nerve graft engineered by lentiviral vectors is designed to treat complete facial palsy in adult rats.

    Combination of hypoglossal-facial nerve surgical reconstruction and neurotrophin-3 gene therapy for facial palsy.
    Wan H, Zhang L, Blanchard S, Bigou S, Bohl D, Wang C, Liu S.

    11/30/2013
    Our results show that NT-3 modifies the ability of the mossy fiber pathway to present subsequent long-term potentiation

    Plasticity and metaplasticity of adult rat hippocampal mossy fibers induced by neurotrophin-3.
    Ramos-Languren LE, Escobar ML.

    10/19/2013
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