| Chloride intracellular channel protein 2 is secreted and inhibits MMP14 activity, while preventing tumor cell invasion and metastasis. | Chloride intracellular channel protein 2 is secreted and inhibits MMP14 activity, while preventing tumor cell invasion and metastasis.
Ozaki S, Umakoshi A, Yano H, Ohsumi S, Sumida Y, Hayase E, Usa E, Islam A, Choudhury ME, Nishi Y, Yamashita D, Ohtsuka Y, Nishikawa M, Inoue A, Suehiro S, Kuwabara J, Watanabe H, Takada Y, Watanabe Y, Nakano I, Kunieda T, Tanaka J., Free PMC Article | 01/22/2022 |
| Effects of miR-7 on Hcy-induced rat cerebral arterial vascular smooth muscle cell proliferation, migration and inflammatory factor expression by targeting MMP-14 to regulate TLR4/NF-kappaB signaling pathway. | Effects of miR-7 on Hcy-induced rat cerebral arterial vascular smooth muscle cell proliferation, migration and inflammatory factor expression by targeting MMP-14 to regulate TLR4/NF-κB signaling pathway.
Ma H, Wang L, Lv W, Lv Z. | 08/7/2021 |
| our results suggest that mechanical stretching inhibits bone-marrow-derived mesenchymal stem cells invasion by downregulating MT1-MMP expression by suppressing the PI3K/Akt signaling pathway. | MT1-MMP downregulation via the PI3K/Akt signaling pathway is required for the mechanical stretching-inhibited invasion of bone-marrow-derived mesenchymal stem cells.
Fu X, Halim A, Tian B, Luo Q, Song G. | 05/30/2020 |
| Evidence shows that MT1-MMP take action in the beginning of vascular matrix dissolution, endothelial cell growth, vascular remodeling and ultimately in angiogenesis. | Effects of treadmill exercise on cerebral angiogenesis and MT1-MMP expression after cerebral ischemia in rats.
Tang Y, Zhang Y, Zheng M, Chen J, Chen H, Liu N., Free PMC Article | 05/11/2019 |
| The results suggest that MMP-14 is involved in proliferative diabetic retinopathy angiogenesis. | Matrix metalloproteinase-14 is a biomarker of angiogenic activity in proliferative diabetic retinopathy.
Abu El-Asrar AM, Mohammad G, Allegaert E, Ahmad A, Siddiquei MM, Alam K, Gikandi PW, De Hertogh G, Opdenakker G., Free PMC Article | 11/17/2018 |
| expression of MMP-14 was different between cardiac isografts and allografts. MMP-14 could interact with CD44 in allografts. | MMP-14 promotes VSMC migration via up-regulating CD44 expression in cardiac allograft vasculopathy.
Yan D, Liu X, Hua L, Wu K, Sha X, Zhao J, Yang C, Zhang C, Shi J, Wu X. | 03/25/2017 |
| that MT1-MMP contributes to intestinal development, particularly to villi morphogenesis | MT1-MMP and its potential role in the vertebrate intestinal morphogenesis.
Camargo KC, Gomes JR, Loddi MM, de Sordi R, Costa-Ayub CL, Soares MA. | 03/4/2017 |
| Downregulation of miR-193a-3p promoted loss of type II collagen by directly targeting MMP14 in IDD. miR-193a-3p inhibited IDD in vitro and in vivo. miR-193a-3p may be a promising candidate for prevention of degenerative disc disease. | Downregulation of microRNA-193a-3p is involved in invertebral disc degeneration by targeting MMP14.
Ji ML, Zhang XJ, Shi PL, Lu J, Wang SZ, Chang Q, Chen H, Wang C. | 12/31/2016 |
| the endothelium under ANGII stimulation acts as a novel and key activator of latent pro-MT1MMP and pro-MMP2 in smooth muscle cells of rat aorta | A novel role of endothelium in activation of latent pro-membrane type 1 MMP and pro-MMP-2 in rat aorta.
Otto S, Deussen A, Zatschler B, Müller B, Neisser A, Barth K, Morawietz H, Kopaliani I. | 12/17/2016 |
| Heterotrimeric G proteins directly regulate membrane-localized MMP14/MT1-MMP, resulting in HB-EGF release and EGFR transactivation. | Heterotrimeric G proteins directly regulate MMP14/membrane type-1 matrix metalloprotease: a novel mechanism for GPCR-EGFR transactivation.
Overland AC, Insel PA., Free PMC Article | 06/20/2015 |
| MMP-14 induces an elevation in the levels of TGF-beta1/Smad signaling proteins in injured arteries | TGF-β1/Smad signaling, MMP-14, and MSC markers in arterial injury: discovery of the molecular basis of restenosis.
Pang L, Wei C, Duan J, Zou H, Cao W, Qi Y, Jia W, Hu J, Zhao W, Jiang J, Liang W, Li F., Free PMC Article | 05/30/2015 |
| The immunohistochemistry demonstrated greater expression of MMP-2 than MMP-9 and MMP-14 in all masseter muscles and there were few differences in the staining of 4 TIMPs. | Histological, histochemical, and protein changes after induced malocclusion by occlusion alteration of Wistar rats.
Guerra Cde S, Carla Lara Pereira Y, Issa JP, Luiz KG, Guimarães EA, Gerlach RF, Iyomasa MM., Free PMC Article | 03/21/2015 |
| The MMP-1 is present in several brain areas in normal conditions at a detectable level, and its expression increases after kainate-induced seizures. | Type 1 metalloproteinase is selectively expressed in adult rat brain and can be rapidly up-regulated by kainate.
Ierusalimsky VN, Balaban PM. | 12/6/2014 |
| Hepatic stellate cells acquired dependence on collagen for their growth during the transition from quiescent to active states. The intramolecular RGD motifs of collagen were exposed by cleavage with their own membrane type 1 matrix metalloproteinase. | Activated hepatic stellate cells are dependent on self-collagen, cleaved by membrane type 1 matrix metalloproteinase for their growth.
Birukawa NK, Murase K, Sato Y, Kosaka A, Yoneda A, Nishita H, Fujita R, Nishimura M, Ninomiya T, Kajiwara K, Miyazaki M, Nakashima Y, Ota S, Murakami Y, Tanaka Y, Minomi K, Tamura Y, Niitsu Y., Free PMC Article | 10/11/2014 |
| Tissue inhibitor of matrix metalloproteinase 1 was strongly upregulated, whereas matrix metalloproteinases 2 and 9 and transforming growth factor beta1 were diminished in LV of treated animals. | Angiotensin type 2 receptor stimulation ameliorates left ventricular fibrosis and dysfunction via regulation of tissue inhibitor of matrix metalloproteinase 1/matrix metalloproteinase 9 axis and transforming growth factor β1 in the rat heart.
Lauer D, Slavic S, Sommerfeld M, Thöne-Reineke C, Sharkovska Y, Hallberg A, Dahlöf B, Kintscher U, Unger T, Steckelings UM, Kaschina E. | 04/19/2014 |
| EMMPRIN/CD147-regulated MMP-2 and MMP-14, associated with low MMP-3, appear as the main characteristics of extracellular matrix remodeling in early overused tendons. | Early events of overused supraspinatus tendons involve matrix metalloproteinases and EMMPRIN/CD147 in the absence of inflammation.
Attia M, Huet E, Gossard C, Menashi S, Tassoni MC, Martelly I. | 01/18/2014 |
| Membrane type 1 MMP, MMP2, and TIMP2 were present in testis during gonocyte migration and transformation into spermatogenic stem cells. | Is matrix metalloproteinase required in postnatal testicular tubules for germ cell maturation?
Li R, Zhang JG, Churchill J, Sourial M, Southwell BR, Hutson JM. | 02/16/2013 |
| High MT1-MMP is associated with glomerulosclerosis in diabetic nephropathy. | Matrix metalloproteinase-2 (MMP-2) and membrane-type 1 MMP (MT1-MMP) affect the remodeling of glomerulosclerosis in diabetic OLETF rats.
Furuichi K, Hisada Y, Shimizu M, Okumura T, Kitagawa K, Yoshimoto K, Iwata Y, Yokoyama H, Kaneko S, Wada T. | 09/15/2012 |
| We found increased aortic collagen and elastin content in the early phase of hypertension, which were associated with vascular hypertrophy, increased vascular MMP-2 and MMP-14 (but not TIMP-2) levels, and increased gelatinolytic activity. | Time course involvement of matrix metalloproteinases in the vascular alterations of renovascular hypertension.
Ceron CS, Rizzi E, Guimaraes DA, Martins-Oliveira A, Cau SB, Ramos J, Gerlach RF, Tanus-Santos JE. | 08/18/2012 |
| The MT1-MMP expression was widespread in the dental follicle. | MT1-MMP expression in the odontogenic region of rat incisors undergoing interrupted eruption.
Omar NF, Gomes JR, Neves Jdos S, Salmon CR, Novaes PD. | 05/19/2012 |
| MT1-MMP was found in the cytoplasm of cells that may remodel the gubernaculum for eversion. It provides the collagenolysis necessary for migration through the inguinal fat pad. Disruption of these processes may cause cryptorchidism. | Gubernaculum as icebreaker: do matrix metalloproteinases in rodent gubernaculum and inguinal fat pad permit testicular descent?
Churchill JA, Buraundi S, Farmer PJ, Li R, Southwell BR, Hutson JM, Balic A. | 05/19/2012 |
| Mmp8/14 expression seem important in the tissue destruction during periodontal disease in type 1 diabetes. | Sequential IL-23 and IL-17 and increased Mmp8 and Mmp14 expression characterize the progression of an experimental model of periodontal disease in type 1 diabetes.
Silva JA, Ferrucci DL, Peroni LA, Abrahão PG, Salamene AF, Rossa-Junior C, Carvalho HF, Stach-Machado DR. | 04/21/2012 |
| Data show that enhanced cell surface MT1-MMP in response to leptin resulted in enhanced extracellular activation of pro-MMP-2, which was attenuated by inhibition of Rho or ROCK. | Regulation of MT1-MMP and MMP-2 by leptin in cardiac fibroblasts involves Rho/ROCK-dependent actin cytoskeletal reorganization and leads to enhanced cell migration.
Schram K, Ganguly R, No EK, Fang X, Thong FS, Sweeney G. | 07/23/2011 |
| MT1-MMP plays a crucial role in RAGE-activated NADPH oxidase-dependent signaling pathways. | Involvement of membrane type 1-matrix metalloproteinase (MT1-MMP) in RAGE activation signaling pathways.
Kamioka M, Ishibashi T, Ohkawara H, Nagai R, Sugimoto K, Uekita H, Matsui T, Yamagishi S, Ando K, Sakamoto T, Sakamoto N, Takuwa Y, Wada I, Shiomi M, Maruyama Y, Takeishi Y. | 05/21/2011 |
| Sympathetic neurons express and secrete MMP-2 and MT1-MMP to control nerve sprouting via pro-NGF conversion. | Sympathetic neurons express and secrete MMP-2 and MT1-MMP to control nerve sprouting via pro-NGF conversion.
Saygili E, Schauerte P, Pekassa M, Saygili E, Rackauskas G, Schwinger RH, Weis J, Weber C, Marx N, Rana OR. | 05/21/2011 |