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    PSCA prostate stem cell antigen [ Homo sapiens (human) ]

    Gene ID: 8000, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    VDR, CXCR1, CXCR2, PSCA Polymorphisms and Recurrent Urinary Tract Infections in Women: Genetic Association Study.

    VDR, CXCR1, CXCR2, PSCA Polymorphisms and Recurrent Urinary Tract Infections in Women: Genetic Association Study.
    Sarker P, Pereira GMV, Khullar V, Yu J, Cartwright R., Free PMC Article

    05/7/2024
    The PSCA rs2294008 (C/T) Polymorphism Increases the Risk of Gastric and Bladder Cancer: A Meta-Analysis.

    The PSCA rs2294008 (C/T) Polymorphism Increases the Risk of Gastric and Bladder Cancer: A Meta-Analysis.
    Wang XF, Liu DL, Geng L.

    03/8/2023
    Diagnostic Efficacy of PSMA and PSCA mRNAs Combined to PSA in Prostate Cancer Patients.

    Diagnostic Efficacy of PSMA and PSCA mRNAs Combined to PSA in Prostate Cancer Patients.
    Mahmoud MM, Abdel Hamid FF, Abdelgawad I, Ismail A, Malash I, Ibrahim DM., Free PMC Article

    02/4/2023
    LncPSCA in the 8q24.3 risk locus drives gastric cancer through destabilizing DDX5.

    LncPSCA in the 8q24.3 risk locus drives gastric cancer through destabilizing DDX5.
    Zheng Y, Lei T, Jin G, Guo H, Zhang N, Chai J, Xie M, Xu Y, Wang T, Liu J, Shen Y, Song Y, Wang B, Yu J, Yang M., Free PMC Article

    03/19/2022
    Silencing of the proteasome and oxidative stress impair endoplasmic reticulum targeting and signal cleavage of a prostate carcinoma antigen.

    Silencing of the proteasome and oxidative stress impair endoplasmic reticulum targeting and signal cleavage of a prostate carcinoma antigen.
    Hoefer F, Groettrup M.

    07/17/2021
    Polymorphisms PSCA rs2294008, IL-4 rs2243250 and MUC1 rs4072037 are associated with gastric cancer in a high risk population.

    Polymorphisms PSCA rs2294008, IL-4 rs2243250 and MUC1 rs4072037 are associated with gastric cancer in a high risk population.
    Gonzalez-Hormazabal P, Retamales-Ortega R, Musleh M, Bustamante M, Stambuk J, Pisano R, Valladares H, Lanzarini E, Chiong H, Suazo J, Quiñones LA, Varela NM, Castro VG, Jara L, Verdugo RA, Berger Z.

    05/29/2021
    Impact of PSCA Polymorphisms on the Risk of Duodenal Ulcer.

    Impact of PSCA Polymorphisms on the Risk of Duodenal Ulcer.
    Usui Y, Matsuo K, Oze I, Ugai T, Koyanagi Y, Maeda Y, Ito H, Hishida A, Takeuchi K, Tamura T, Tsukamoto M, Kadomatsu Y, Hara M, Nishida Y, Shimoshikiryo I, Takezaki T, Ozaki E, Matsui D, Watanabe I, Suzuki S, Watanabe M, Nakagawa-Senda H, Mikami H, Nakamura Y, Arisawa K, Uemura H, Kuriki K, Takashima N, Kadota A, Ikezaki H, Murata M, Nakatochi M, Momozawa Y, Kubo M, Wakai K., Free PMC Article

    05/8/2021
    The Correlation between PSCA Expression and Neuroendocrine Differentiation in Prostate Cancer.

    The Correlation between PSCA Expression and Neuroendocrine Differentiation in Prostate Cancer.
    Xiang Q, Zhu Z, Luo L, Wang J, Liu Y, Deng Y, Zhou M, Zhao Z., Free PMC Article

    05/1/2021
    Evolutionary History of the Risk of SNPs for Diffuse-Type Gastric Cancer in the Japanese Population.

    Evolutionary History of the Risk of SNPs for Diffuse-Type Gastric Cancer in the Japanese Population.
    Iwasaki RL, Ishiya K, Kanzawa-Kiriyama H, Kawai Y, Gojobori J, Satta Y., Free PMC Article

    03/20/2021
    Risk of gastric ulcer contributed by genetic polymorphisms of PSCA: A case-control study based on Chinese Han population.

    Risk of gastric ulcer contributed by genetic polymorphisms of PSCA: A case-control study based on Chinese Han population.
    Guan F, Han W, Ni T, Zhao L, Zhang B, Li M, Luo X, Zhang L, Li X, Sun W, Zhang T.

    11/28/2020
    Association of MUC1 5640G>A and PSCA 5057C>T polymorphisms with the risk of gastric cancer in Northern Iran.

    Association of MUC1 5640G>A and PSCA 5057C>T polymorphisms with the risk of gastric cancer in Northern Iran.
    Alikhani R, Taravati A, Hashemi-Soteh MB., Free PMC Article

    10/31/2020
    Association between PSCA, TNF-alpha, PARP1 and TP53 Gene Polymorphisms and Gastric Cancer Susceptibility in the Brazilian Population.

    Association between PSCA, TNF-α, PARP1 and TP53 Gene Polymorphisms and Gastric Cancer Susceptibility in the Brazilian Population.
    Dantas RN, Souza AM, Herrero SST, Kassab P, Malheiros CA, Lima EM., Free PMC Article

    10/3/2020
    Impact of PSCA gene polymorphisms in modulating gastric cancer risk in the Chinese population.

    Impact of PSCA gene polymorphisms in modulating gastric cancer risk in the Chinese population.
    Yan K, Wu K, Lin C, Jie Z., Free PMC Article

    09/19/2020
    Prostate Stem Cell Antigen Gene Polymorphism Is Associated with H. pylori-related Promoter DNA Methylation in Nonneoplastic Gastric Epithelium.

    Prostate Stem Cell Antigen Gene Polymorphism Is Associated with H. pylori-related Promoter DNA Methylation in Nonneoplastic Gastric Epithelium.
    Tahara T, Tahara S, Horiguchi N, Kato T, Shinkai Y, Okubo M, Terada T, Yoshida D, Funasaka K, Nagasaka M, Nakagawa Y, Kurahashi H, Shibata T, Tsukamoto T, Ohmiya N.

    08/29/2020
    PSCA single nucleotide polymorphisms are associated with Heliobacter pylori-induced gastric atrophy.

    GWAS analysis reveals a significant contribution of PSCA to the risk of Heliobacter pylori-induced gastric atrophy.
    Hishida A, Ugai T, Fujii R, Nakatochi M, Wu MC, Ito H, Oze I, Tajika M, Niwa Y, Nishiyama T, Nakagawa-Senda H, Suzuki S, Koyama T, Matsui D, Watanabe Y, Kawaguchi T, Matsuda F, Momozawa Y, Kubo M, Naito M, Matsuo K, Wakai K.

    03/21/2020
    Data imply an upregulated expression of PTGER4 and PSCA as well as a downregulated expression of MBOAT7 in gastric tissue as risk-conferring gastric cancer patho-mechanisms.

    Evidence for PTGER4, PSCA, and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level.
    Heinrichs SKM, Hess T, Becker J, Hamann L, Vashist YK, Butterbach K, Schmidt T, Alakus H, Krasniuk I, Höblinger A, Lingohr P, Ludwig M, Hagel AF, Schildberg CW, Veits L, Gyvyte U, Weise K, Schüller V, Böhmer AC, Schröder J, Gehlen J, Kreuser N, Hofer S, Lang H, Lordick F, Malfertheiner P, Moehler M, Pech O, Vassos N, Rodermann E, Izbicki JR, Kruschewski M, Ott K, Schumann RR, Vieth M, Mangold E, Gasenko E, Kupcinskas L, Brenner H, Grimminger P, Bujanda L, Sopeña F, Espinel J, Thomson C, Pérez-Aísa Á, Campo R, Geijo F, Collette D, Bruns C, Messerle K, Gockel I, Nöthen MM, Lippert H, Ridwelski K, Lanas A, Keller G, Knapp M, Leja M, Kupcinskas J, García-González MA, Venerito M, Schumacher J., Free PMC Article

    11/9/2019
    we confirmed that variants in the PSCA gene showed significant GWAS associations in a Korean population for gastric cancer, especially for females and diffuse type gastric cancer.

    Genome-Wide Association of Genetic Variation in the PSCA Gene with Gastric Cancer Susceptibility in a Korean Population.
    Park B, Yang S, Lee J, Woo HD, Choi IJ, Kim YW, Ryu KW, Kim YI, Kim J., Free PMC Article

    08/10/2019
    PSCA expression is a statistically independent predictor of favorable prognosis in prostate cancer. Although its prognostic impact per se is not very strong, PSCA expression analysis could be considered for inclusion in multi-parametric prognostic tests to distinguish prostate cancers with need for radical therapy.

    PSCA expression is associated with favorable tumor features and reduced PSA recurrence in operated prostate cancer.
    Heinrich MC, Göbel C, Kluth M, Bernreuther C, Sauer C, Schroeder C, Möller-Koop C, Hube-Magg C, Lebok P, Burandt E, Sauter G, Simon R, Huland H, Graefen M, Heinzer H, Schlomm T, Heumann A., Free PMC Article

    01/19/2019
    The decreased PSCA m-RNA levels were involved in the progress of bladder cancer. T allele takes more responsibility for PSCA m-RNA down-regulation to promote cell proliferation and migration and hinder cell apoptosis, thus leading to a higher risk.

    PSCArs2294008 T polymorphism increases the risk of bladder cancer in Bai, Dai, and Han ethnicity in China and a potential mechanism.
    Yang J, Li W, Zhang Z, Shen J, Zhang N, Yang M, Yang M, Yu Y.

    11/3/2018
    Men with the rs1045531 AC genotype of prostate stem cell antigen(PSCA) were at higher risk of prostate cancer in Chinese patients undergoing prostate biopsy.

    PSCA rs1045531 Polymorphism and the Risk of Prostate Cancer in a Chinese Population Undergoing Prostate Biopsy.
    Zhang X, Hu Q, Chen Y, Li M, Yin H, Zhou C, Li G, Hou J., Free PMC Article

    11/3/2018
    Study shows that PSCA gene is a target of 8q24 locus in Invasive micropapillary carcinoma (IMPC) of the breast, and the PSCA gene amplification results in PSCA protein overexpression. These results demonstrate an independently worse prognosis for PSCA overexpression in IMPC, and suggest that the differential expression of PSCA is associated with cell adhesion molecules in breast cancer.

    Amplification and overexpression of PSCA at 8q24 in invasive micropapillary carcinoma of breast.
    Meng F, Liu B, Xie G, Song Y, Zheng X, Qian X, Li S, Jia H, Zhang X, Zhang L, Yang YL, Fu L.

    06/9/2018
    the PSCA rs2294008 polymorphism may serve as a biomarker of cervical cancer, particularly of early-stage cervical cancer

    PSCA rs2294008 polymorphism contributes to the decreased risk for cervical cancer in a Chinese population.
    Wang S, Wu S, Zhu H, Ding B, Cai Y, Ni J, Wu Q, Meng Q, Zhang X, Zhang C, Li X, Wang M, Chen R, Jin H, Zhang Z., Free PMC Article

    05/26/2018
    The expression of Ki-67, PSCA, and Cox-2 biomarkers along with other clinicopathologic factors were prognostic factors for biochemical recurrence in patients with clinically localized prostate cancer following radical prostatectomy

    PSCA, Cox-2, and Ki-67 are independent, predictive markers of biochemical recurrence in clinically localized prostate cancer: a retrospective study.
    Kim SH, Park WS, Park BR, Joo J, Joung JY, Seo HK, Chung J, Lee KH., Free PMC Article

    03/31/2018
    Among Chinese Han women, the PSCA rs2294008, rs2978974, and rs2976392 minor alleles are associated with increased breast cancer risk especially in progesterone receptor positive breast cancer patients, with breast cancer risk in postmenopausal women, and with high lymph node metastasis risk, respectively.

    Single-nucleotide polymorphisms in PSCA and the risk of breast cancer in a Chinese population.
    Wang M, Wang X, Fu SW, Liu X, Jin T, Kang H, Ma X, Lin S, Guan H, Zhang S, Liu K, Dai C, Zhu Y, Dai Z., Free PMC Article

    01/20/2018
    PSCA is a novel cell cycle regulator with a key role in prostate cancer cell proliferation.

    PSCA promotes prostate cancer proliferation and cell-cycle progression by up-regulating c-Myc.
    Li E, Liu L, Li F, Luo L, Zhao S, Wang J, Kang R, Luo J, Zhao Z.

    11/4/2017
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