| Calcitonin gene-related peptide and intermedin induce phosphorylation of p44/42 MAPK in primary human lymphatic endothelial cells in vitro. | Calcitonin gene-related peptide and intermedin induce phosphorylation of p44/42 MAPK in primary human lymphatic endothelial cells in vitro.
Hasan SR, Manolis D, Stephenson E, Ryskiewicz-Sokalska OA, Maraveyas A, Nikitenko LL. | 08/3/2024 |
| Reduced PATL2 Impairs the Proliferation of Ovarian Granulosa Cells by Decreasing ADM2 Expression in Patients with PCOS. | Reduced PATL2 Impairs the Proliferation of Ovarian Granulosa Cells by Decreasing ADM2 Expression in Patients with PCOS.
Tan J, Liu PP, Cao LY, Zou Y, Zhang ZY, Huang JL, Zhang ZQ, Xu DF, Fan L, Xia LZ, Xie Q, Tian LF, Xin CL, Li ZM, Wu QF. | 03/27/2024 |
| Intermedin alleviates diabetic vascular calcification by inhibiting GLUT1 through activation of the cAMP/PKA signaling pathway. | Intermedin alleviates diabetic vascular calcification by inhibiting GLUT1 through activation of the cAMP/PKA signaling pathway.
Zhang YR, Liu SM, Chen Y, Zhang LS, Ji DR, Zhao J, Yu YR, Jia MZ, Tang CS, Huang W, Zhou YB, Chai SB, Qi YF. | 11/29/2023 |
| Adrenomedullin 2/intermedin is a slow off-rate, long-acting endogenous agonist of the adrenomedullin2 G protein-coupled receptor. | Adrenomedullin 2/intermedin is a slow off-rate, long-acting endogenous agonist of the adrenomedullin(2) G protein-coupled receptor.
Babin KM, Karim JA, Gordon PH, Lennon J, Dickson A, Pioszak AA., Free PMC Article | 07/13/2023 |
| Intermedin (adrenomedullin 2) promotes breast cancer metastasis via Src/c-Myc-mediated ribosome production and protein translation. | Intermedin (adrenomedullin 2) promotes breast cancer metastasis via Src/c-Myc-mediated ribosome production and protein translation.
Kong L, Xiong Y, Wang D, Huang L, Li M, Feng Z, Zhou Y, Zhang H, Liu F, Xiao F, Wei Y, Zhang W. | 08/27/2022 |
| Study on Protection of Human Umbilical Vein Endothelial Cells from Amiodarone-Induced Damage by Intermedin through Activation of Wnt/beta-Catenin Signaling Pathway. | Study on Protection of Human Umbilical Vein Endothelial Cells from Amiodarone-Induced Damage by Intermedin through Activation of Wnt/β-Catenin Signaling Pathway.
Wang Y, Wang J, Yang J, Kang J, Xue F, Chang S, Ji H, Zang H, Zhou X, Wang G, Fan W, Yan X, Guo J, Ren X, Tian J., Free PMC Article | 01/22/2022 |
| CRIF1 deficiency suppresses endothelial cell migration via upregulation of RhoGDI2. | CRIF1 deficiency suppresses endothelial cell migration via upregulation of RhoGDI2.
Nagar H, Kim S, Lee I, Choi SJ, Piao S, Jeon BH, Shong M, Kim CS., Free PMC Article | 12/11/2021 |
| Altered expression of ADM and ADM2 by hypoxia regulates migration of trophoblast and HLA-G expressiondagger. | Altered expression of ADM and ADM2 by hypoxia regulates migration of trophoblast and HLA-G expression†.
Gu C, Park S, Seok J, Jang HY, Bang YJ, Kim GIJ., Free PMC Article | 11/22/2021 |
| CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells. | CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells.
Clark AJ, Mullooly N, Safitri D, Harris M, de Vries T, MaassenVanDenBrink A, Poyner DR, Gianni D, Wigglesworth M, Ladds G., Free PMC Article | 08/21/2021 |
| Inhibition of Notch1-mediated inflammation by intermedin protects against abdominal aortic aneurysm via PI3K/Akt signaling pathway. | Inhibition of Notch1-mediated inflammation by intermedin protects against abdominal aortic aneurysm via PI3K/Akt signaling pathway.
Ni XQ, Zhang YR, Jia LX, Lu WW, Zhu Q, Ren JL, Chen Y, Zhang LS, Liu X, Yu YR, Jia MZ, Ning ZP, Du J, Tang CS, Qi YF., Free PMC Article | 08/14/2021 |
| Intermedin facilitates hepatocellular carcinoma cell survival and invasion via ERK1/2-EGR1/DDIT3 signaling cascade. | Intermedin facilitates hepatocellular carcinoma cell survival and invasion via ERK1/2-EGR1/DDIT3 signaling cascade.
Xiao F, Li H, Feng Z, Huang L, Kong L, Li M, Wang D, Liu F, Zhu Z, Wei Y, Zhang W., Free PMC Article | 08/7/2021 |
| Intermedin alleviates the inflammatory response and stabilizes the endothelial barrier in LPS-induced ARDS through the PI3K/Akt/eNOS signaling pathway. | Intermedin alleviates the inflammatory response and stabilizes the endothelial barrier in LPS-induced ARDS through the PI3K/Akt/eNOS signaling pathway.
Fan S, Qi D, Yu Q, Tang X, Wen X, Wang D, Deng X. | 05/29/2021 |
| Protective effects of intermedin/adrenomedullin-2 in a cellular model of human pulmonary arterial hypertension. | Protective effects of intermedin/adrenomedullin-2 in a cellular model of human pulmonary arterial hypertension.
Holmes D, Corr M, Thomas G, Harbinson M, Campbell M, Spiers P, Bell D. | 04/17/2021 |
| AM2 signaling is suppressed in adipose tissue in obesity, involving lower receptor expression and ligand availability, likely contributing to insulin resistance and other aspects of the pathophysiology associated with obesity. | Altered Expression of Adrenomedullin 2 and its Receptor in the Adipose Tissue of Obese Patients.
Kim J, Lee SK, Kim D, Choe H, Jang YJ, Park HS, Kim JH, Hong JP, Lee YJ, Heo Y. | 08/1/2020 |
| Consistent with this hypothesis, we showed that acylated truncated ADM/ADM2 analogs of 27-31 residues exhibit potent antagonistic activity toward CLR/RAMP1 and 2. | Development of chimeric and bifunctional antagonists for CLR/RAMP receptors.
Chang CL, Hsu SYT., Free PMC Article | 01/25/2020 |
| Intermedin binds the RAMP1/CLR complex via a triple beta-turn. | Structure-function analyses reveal a triple β-turn receptor-bound conformation of adrenomedullin 2/intermedin and enable peptide antagonist design.
Roehrkasse AM, Booe JM, Lee SM, Warner ML, Pioszak AA., Free PMC Article | 04/27/2019 |
| Study revealed that exogenous intermedin up-regulates the expression of VEGF and RAMP2 at least partially via activating Wnt/beta-catenin signaling, finally promoting angiogenesis of hypoxia and reoxygenation impaired HUVECs in vitro. | Intermedin protects HUVECs from ischemia reperfusion injury via Wnt/β-catenin signaling pathway.
Wang Y, Wu Z, Tian J, Mi Y, Ren X, Kang J, Zhang W, Zhou X, Wang G, Li R., Free PMC Article | 04/20/2019 |
| IMD may be an important self-protective factor in response to sepsis. | Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses.
Xiao F, Wang D, Kong L, Li M, Feng Z, Shuai B, Wang L, Wei Y, Li H, Wu S, Tan C, Zhao H, Hu X, Liu J, Kang Y, Liao X, Zhou Y, Zhang W., Free PMC Article | 12/22/2018 |
| The plasma ADM2 levels were inversely correlated with obesity in humans, and adipo-ADM2-transgenic (tg) mice displayed resistance to high-fat diet-induced obesity with increased energy expenditure. | Adrenomedullin 2 Enhances Beiging in White Adipose Tissue Directly in an Adipocyte-autonomous Manner and Indirectly through Activation of M2 Macrophages.
Lv Y, Zhang SY, Liang X, Zhang H, Xu Z, Liu B, Xu MJ, Jiang C, Shang J, Wang X., Free PMC Article | 06/3/2017 |
| Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (AM), adrenomedullin-2 (AM-2) and calcitonin gene-related peptide (CGRP) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3. | Spatial expression of components of a calcitonin receptor-like receptor (CRL) signalling system (CRL, calcitonin gene-related peptide, adrenomedullin, adrenomedullin-2/intermedin) in mouse and human heart valves.
Pfeil U, Bharathala S, Murtaza G, Mermer P, Papadakis T, Boening A, Kummer W. | 05/27/2017 |
| ADM-2 is a stress-inducible gene controlled by ATF-4. | Intermedin/adrenomedullin 2 is a stress-inducible gene controlled by activating transcription factor 4.
Kovaleva IE, Garaeva AA, Chumakov PM, Evstafieva AG. | 01/28/2017 |
| Intermedin1-53 may attenuate vascular calcification by upregulating alpha-Klotho via the calcitonin receptor/modifying protein complex and protein kinase A signaling. | Intermedin1-53 attenuates vascular calcification in rats with chronic kidney disease by upregulation of α-Klotho.
Chang JR, Guo J, Wang Y, Hou YL, Lu WW, Zhang JS, Yu YR, Xu MJ, Liu XY, Wang XJ, Guan YF, Zhu Y, Du J, Tang CS, Qi YF. | 12/17/2016 |
| Intermedin (IMD) derived from human cardiac microvascular endothelial cell and acting in a paracrine manner on cardiomyocytes, predominantly at AM1 receptors, is more likely to contribute to direct protection by endogenous IMD of cardiomyocytes against acute ischemia reperfusion injury. | Endothelium-derived intermedin/adrenomedullin-2 protects human ventricular cardiomyocytes from ischaemia-reoxygenation injury predominantly via the AM₁ receptor.
Bell D, Campbell M, McAleer SF, Ferguson M, Donaghy L, Harbinson MT. | 11/5/2016 |
| Elevated plasma intermedin levels are independently associated with long-term recurrence and distant metastasis of prostate cancer. | Association of plasma intermedin levels with progression and metastasis in men after radical prostatectomy for localized prostatic cancer.
Wang XL, Wang YY, He HD, Xie X, Yu ZJ, Pan YM. | 10/22/2016 |
| ADM2 may contribute to the physiology of embryo implantation and placental growth via increasing MMP2 and decreasing MUC1 expression to facilitate trophoblast invasion. | Adrenomedullin 2 (ADM2) Regulates Mucin 1 at the Maternal-Fetal Interface in Human Pregnancy.
Chauhan M, Balakrishnan M, Chan R, Yallampalli C., Free PMC Article | 10/8/2016 |