| Investigating the functional role of SETD6 in lung adenocarcinoma. | Investigating the functional role of SETD6 in lung adenocarcinoma.
Xu J, Zhou H, Luo Z, Chen J, Liu M., Free PMC Article | 01/14/2023 |
| TWIST1 methylation by SETD6 selectively antagonizes LINC-PINT expression in glioma. | TWIST1 methylation by SETD6 selectively antagonizes LINC-PINT expression in glioma.
Admoni-Elisha L, Elbaz T, Chopra A, Shapira G, Bedford MT, Fry CJ, Shomron N, Biggar K, Feldman M, Levy D., Free PMC Article | 12/24/2022 |
| SETD6 Regulates E2-Dependent Human Papillomavirus Transcription. | SETD6 Regulates E2-Dependent Human Papillomavirus Transcription.
Jose L, Androphy EJ, DeSmet M., Free PMC Article | 12/3/2022 |
| Structure-function conservation between the methyltransferases SETD3 and SETD6. | Structure-function conservation between the methyltransferases SETD3 and SETD6.
Admoni-Elisha L, Abaev-Schneiderman E, Cohn O, Shapira G, Shomron N, Feldman M, Levy D. | 08/27/2022 |
| BRD4 methylation by the methyltransferase SETD6 regulates selective transcription to control mRNA translation. | BRD4 methylation by the methyltransferase SETD6 regulates selective transcription to control mRNA translation.
Vershinin Z, Feldman M, Werner T, Weil LE, Kublanovsky M, Abaev-Schneiderman E, Sklarz M, Lam EYN, Alasad K, Picaud S, Rotblat B, McAdam RA, Chalifa-Caspi V, Bantscheff M, Chapman T, Lewis HD, Filippakopoulos P, Dawson MA, Grandi P, Prinjha RK, Levy D., Free PMC Article | 04/30/2022 |
| Silencing of SETD6 inhibits the tumorigenesis of oral squamous cell carcinoma by inhibiting methylation of PAK4 and RelA. | Silencing of SETD6 inhibits the tumorigenesis of oral squamous cell carcinoma by inhibiting methylation of PAK4 and RelA.
Huang W, Liu H, Lv T. | 12/25/2021 |
| Lysine methyltransferase SETD6 modifies histones on a glycine-lysine motif. | Lysine methyltransferase SETD6 modifies histones on a glycine-lysine motif.
Binda O., Free PMC Article | 04/24/2021 |
| MiR-411 inhibits gastric cancer proliferation and migration through targeting SETD6. | MiR-411 inhibits gastric cancer proliferation and migration through targeting SETD6.
Bai TL, Liu YB, Li BH. | 09/12/2020 |
| Study demonstrates that SETD6 monomeric, dimeric and trimeric forms are stabilized by the methyl donor, S-adenosyl-l-methionine. SETD6 has auto-methylation activity at K39 and K179, which serves as the major auto-methylation sites with a moderate auto-methylation activity toward K372. Data support a model by which SETD6 auto-methylation and self-interaction positively regulate its enzymatic activity in vitro. | Oligomerization and Auto-methylation of the Human Lysine Methyltransferase SETD6.
Weil LE, Shmidov Y, Kublanovsky M, Morgenstern D, Feldman M, Bitton R, Levy D. | 10/12/2019 |
| During mitosis SETD6 binds and methylates PLK1 | The methyltransferase SETD6 regulates Mitotic progression through PLK1 methylation.
Feldman M, Vershinin Z, Goliand I, Elia N, Levy D., Free PMC Article | 03/30/2019 |
| WDR5 was identified as a substrate of SETD6 and it was revealed that the methylation of specific lysines (K207/K325) of WDR5 was critical for maintaining global histone H3K4me3 levels and promoting breast cancer cell proliferation and migration | Lysines 207 and 325 methylation of WDR5 catalyzed by SETD6 promotes breast cancer cell proliferation and migration.
Yao R, Wang Y, Han D, Ma Y, Ma M, Zhao Y, Tan J, Lu J, Xu G, Li X. | 12/22/2018 |
| Findings suggest that the identified mutation impairs the normal function of SETD6, which may result in the deregulation of the different pathways in which it is involved, contributing to the increased susceptibility to cancer in this FCCTX family. | SETD6 dominant negative mutation in familial colorectal cancer type X.
Martín-Morales L, Feldman M, Vershinin Z, Garre P, Caldés T, Levy D. | 03/24/2018 |
| High SETD6 expression is associated with bladder cancer. | SETD6 regulates NF-κB signaling in urothelial cell survival: Implications for bladder cancer.
Mukherjee N, Cardenas E, Bedolla R, Ghosh R., Free PMC Article | 10/7/2017 |
| PAK4 methylation by SETD6 promotes the activation of the Wnt/beta-catenin pathway. | PAK4 Methylation by SETD6 Promotes the Activation of the Wnt/β-Catenin Pathway.
Vershinin Z, Feldman M, Chen A, Levy D., Free PMC Article | 08/6/2016 |
| these findings demonstrate that SETD6 negatively regulates the Nrf2-mediated oxidative stress response through a physical and catalytically independent interaction with DJ1 at chromatin. | SETD6 is a negative regulator of oxidative stress response.
Chen A, Feldman M, Vershinin Z, Levy D. | 06/28/2016 |
| Several chromatin proteins that associate with SETD6 are identified and SETD6 is described as an essential factor for nuclear receptor signaling and cellular proliferation. | SETD6 controls the expression of estrogen-responsive genes and proliferation of breast carcinoma cells.
O'Neill DJ, Williamson SC, Alkharaif D, Monteiro IC, Goudreault M, Gaughan L, Robson CN, Gingras AC, Binda O., Free PMC Article | 03/7/2015 |
| SETD6 monomethylates H2AZ on lysine 7. | SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal.
Binda O, Sevilla A, LeRoy G, Lemischka IR, Garcia BA, Richard S., Free PMC Article | 09/7/2013 |
| methylation of the NF-kappaB results in repression of NF-kappaB signaling | Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling.
Levy D, Kuo AJ, Chang Y, Schaefer U, Kitson C, Cheung P, Espejo A, Zee BM, Liu CL, Tangsombatvisit S, Tennen RI, Kuo AY, Tanjing S, Cheung R, Chua KF, Utz PJ, Shi X, Prinjha RK, Lee K, Garcia BA, Bedford MT, Tarakhovsky A, Cheng X, Gozani O, Levy D, Kuo AJ, Chang Y, Schaefer U, Kitson C, Cheung P, Espejo A, Zee BM, Liu CL, Tangsombatvisit S, Tennen RI, Kuo AY, Tanjing S, Cheung R, Chua KF, Utz PJ, Shi X, Prinjha RK, Lee K, Garcia BA, Bedford MT, Tarakhovsky A, Cheng X, Gozani O., Free PMC Articles: PMC3074206, PMC3074206 | 05/14/2011 |
| SETD6 mono-methylate Rela on K310 and negatively regulates RelA transcription activity | Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling.
Levy D, Kuo AJ, Chang Y, Schaefer U, Kitson C, Cheung P, Espejo A, Zee BM, Liu CL, Tangsombatvisit S, Tennen RI, Kuo AY, Tanjing S, Cheung R, Chua KF, Utz PJ, Shi X, Prinjha RK, Lee K, Garcia BA, Bedford MT, Tarakhovsky A, Cheng X, Gozani O, Levy D, Kuo AJ, Chang Y, Schaefer U, Kitson C, Cheung P, Espejo A, Zee BM, Liu CL, Tangsombatvisit S, Tennen RI, Kuo AY, Tanjing S, Cheung R, Chua KF, Utz PJ, Shi X, Prinjha RK, Lee K, Garcia BA, Bedford MT, Tarakhovsky A, Cheng X, Gozani O., Free PMC Articles: PMC3074206, PMC3074206 | 02/18/2011 |