| WNT5B promotes the malignant phenotype of non-small cell lung cancer via the FZD3-DVL3-RAC1-PCP-JNK pathway. | WNT5B promotes the malignant phenotype of non-small cell lung cancer via the FZD3-DVL3-RAC1-PCP-JNK pathway.
Zhao H, Wu G, Luo Y, Xie Y, Han Y, Zhang D, Han Q, Zhao X, Qin Y, Li Q, Wang E. | 08/31/2024 |
| FZD3 regulates the viability, apoptosis, and extracellular matrix degradation of vaginal wall fibroblasts in pelvic organ prolapse via the Wnt signaling pathway. | FZD3 regulates the viability, apoptosis, and extracellular matrix degradation of vaginal wall fibroblasts in pelvic organ prolapse via the Wnt signaling pathway.
Li J, Zhang J, Chu Z, Han H, Zhang Y. | 02/21/2024 |
| Frizzled-3 suppression overcomes multidrug chemoresistance by Wnt/beta-catenin signaling pathway inhibition in hepatocellular carcinoma cells. | Frizzled-3 suppression overcomes multidrug chemoresistance by Wnt/β-catenin signaling pathway inhibition in hepatocellular carcinoma cells.
Meng Z, Liu Q, Liu Y, Yang Y, Shao C, Zhang S. | 11/1/2023 |
| Non-coding variants in MYH11, FZD3, and SORCS3 are associated with dementia in women. | Non-coding variants in MYH11, FZD3, and SORCS3 are associated with dementia in women.
Blue EE, Thornton TA, Kooperberg C, Liu S, Wactawski-Wende J, Manson J, Kuller L, Hayden K, Reiner AP., Free PMC Article | 01/15/2022 |
| MiR-340 regulates the growth and metabolism of renal cell carcinoma cells by targeting frizzled class receptor 3. | MiR-340 regulates the growth and metabolism of renal cell carcinoma cells by targeting frizzled class receptor 3.
Xiang M, Huang Y, Dai C, Zou G. | 09/25/2021 |
| Over-expressed LOC101927196 suppressed oxidative stress levels and neuron cell proliferation in a rat model of autism through disrupting the Wnt signaling pathway by targeting FZD3. | Over-expressed LOC101927196 suppressed oxidative stress levels and neuron cell proliferation in a rat model of autism through disrupting the Wnt signaling pathway by targeting FZD3.
Yao W, Huang J, He H. | 08/22/2020 |
| In breast cancer cells 5'-tiRNA(Val) functions as a new tumor-suppressor through inhibition of FZD3/Wnt/beta-Catenin signaling pathway. | A tRNA fragment, 5'-tiRNA(Val), suppresses the Wnt/β-catenin signaling pathway by targeting FZD3 in breast cancer.
Mo D, Jiang P, Yang Y, Mao X, Tan X, Tang X, Wei D, Li B, Wang X, Tang L, Yan F. | 05/2/2020 |
| Changes in gene-expression patterns mediated by FZD3 activity occur in the absence of nuclear beta-catenin function, thus representing an important therapeutic target for the melanoma patients whose disease progresses independent of canonical WNT signaling | Down-regulation of FZD3 receptor suppresses growth and metastasis of human melanoma independently of canonical WNT signaling.
Li C, Nguyen V, Clark KN, Zahed T, Sharkas S, Filipp FV, Boiko AD., Free PMC Article | 04/11/2020 |
| This study identified Circular RNA circ-CBFB as a sponge of miR-607, which targeted FZD3. | Circular RNA circ-CBFB promotes proliferation and inhibits apoptosis in chronic lymphocytic leukemia through regulating miR-607/FZD3/Wnt/β-catenin pathway.
Xia L, Wu L, Bao J, Li Q, Chen X, Xia H, Xia R. | 12/22/2018 |
| schizophrenia may be related to some polymorphisms of gene FZD3 that are in stronger linkage disequilibrium to Chinese than to the other populations studied (Meta-Analysis) | A meta-analysis of FZD3 gene polymorphisms and their association with schizophrenia.
Pantavou KG, Braliou GG, Kontou PI, Dimou NL, Bagos PG. | 02/10/2018 |
| marked reduction in the prominence of TUJ1 bundles in number, thickness, and length. Our results showed that deregulation of the planar cell polarity genes CELSR3 and FZD3 might disrupt the enteric innervation pattern | Deregulation of the planar cell polarity genes CELSR3 and FZD3 in Hirschsprung disease.
Su L, Zhang Z, Gan L, Jiang Q, Xiao P, Zou J, Li Q, Jiang H. | 06/3/2017 |
| seven-transmembrane domain receptors Celsr3 and Fzd3, in particular, control the development of most longitudinal tracts in the central nervous system. [Review] | Celsr3 and Fzd3 in axon guidance.
Chai G, Goffinet AM, Tissir F. | 03/12/2016 |
| Our analysis showed no significant association between the rs2241802 polymorphism in FZD3 gene and neural tube defects | Polymorphisms in FZD3 and FZD6 genes and risk of neural tube defects in a northern Han Chinese population.
Shi OY, Yang HY, Shen YM, Sun W, Cai CY, Cai CQ. | 11/14/2015 |
| DNA methylation aberrations rather than polymorphisms of FZD3 gene increase the risk of spina bifida in a high-risk region for neural tube defects. | DNA methylation aberrations rather than polymorphisms of FZD3 gene increase the risk of spina bifida in a high-risk region for neural tube defects.
Shangguan S, Wang L, Chang S, Lu X, Wang Z, Wu L, Wang J, Wang X, Guan Z, Bao Y, Zhao H, Zou J, Niu B, Zhang T. | 10/3/2015 |
| Wnt3a/Frizzled-3 signaling plays important role in regulating the proliferation and differentiation of neural crest cells and various developmental stages of melanocyte precursors. | The roles of Frizzled-3 and Wnt3a on melanocyte development: in vitro studies on neural crest cells and melanocyte precursor cell lines.
Chang CH, Tsai RK, Tsai MH, Lin YH, Hirobe T. | 02/21/2015 |
| Aberrant methylation modification of the FZD3 gene increases the risk of congenital hydrocephalus by altering chromatin structure and disturbing gene expression. | Impaired methylation modifications of FZD3 alter chromatin accessibility and are involved in congenital hydrocephalus pathogenesis.
Wang L, Shangguan S, Chang S, Wang Z, Lu X, Wu L, Li R, Bao Y, Qiu Z, Niu B, Zhang T. | 01/3/2015 |
| FZD3 signaling sensitized peripheral sensory neurons in pain hypersensitivity. | Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical pathways.
Simonetti M, Agarwal N, Stösser S, Bali KK, Karaulanov E, Kamble R, Pospisilova B, Kurejova M, Birchmeier W, Niehrs C, Heppenstall P, Kuner R. | 09/6/2014 |
| clinical significance of frizzled homolog 3 protein in colorectal cancer patients | Clinical significance of frizzled homolog 3 protein in colorectal cancer patients.
Wong SC, He CW, Chan CM, Chan AK, Wong HT, Cheung MT, Luk LL, Au TC, Chiu MK, Ma BB, Chan AT., Free PMC Article | 09/6/2014 |
| Genetic variants of the FZD3 gene may affect susceptibility to schizophrenia in Chinese Han and Va populations. | Association study of the frizzled 3 gene with Chinese Va schizophrenia.
Kang C, Zhou L, Liu H, Yang J. | 08/18/2012 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression.
Inkster B, Nichols TE, Saemann PG, Auer DP, Holsboer F, Muglia P, Matthews PM. | 04/7/2010 |
| Meta-analysis of gene-disease association. (HuGE Navigator) | Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ, Tanzi RE, Bertram L. | 12/2/2009 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | The Frizzled 3 gene is associated with methamphetamine psychosis in the Japanese population.
Kishimoto M, Ujike H, Okahisa Y, Kotaka T, Takaki M, Kodama M, Inada T, Yamada M, Uchimura N, Iwata N, Sora I, Iyo M, Ozaki N, Kuroda S., Free PMC Article | 09/10/2008 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | See all PubMed (2) articlesMicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
Zhang X, Yang H, Lee JJ, Kim E, Lippman SM, Khuri FR, Spitz MR, Lotan R, Hong WK, Wu X. Two-stage designs to identify the effects of SNP combinations on complex diseases.
Kang G, Yue W, Zhang J, Huebner M, Zhang H, Ruan Y, Lu T, Ling Y, Zuo Y, Zhang D. | 07/13/2008 |
| Fzd3 is expressed in Ewing sarcoma family tumor cell lines. Fzd3 mediated Wnt-3a-dependent neurite outgrowth. | Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism.
Endo Y, Beauchamp E, Woods D, Taylor WG, Toretsky JA, Uren A, Rubin JS., Free PMC Article | 01/21/2010 |
| Observational study and meta-analysis of gene-disease association. (HuGE Navigator) | Investigation of genetic association between human Frizzled homolog 3 gene (FZD3) and schizophrenia: results in a Korean population and evidence from meta-analysis.
Jeong SH, Joo EJ, Ahn YM, Lee KY, Kim YS. | 03/13/2008 |