| N6-methyadenosine modified SUV39H2 regulates homologous recombination through epigenetic repression of DUSP6 in gastric cancer. | N6-methyadenosine modified SUV39H2 regulates homologous recombination through epigenetic repression of DUSP6 in gastric cancer.
Yang J, Xu P, Chen Z, Zhang X, Xia Y, Fang L, Xie L, Li B, Xu Z. | 03/8/2023 |
| Epigenetic hallmarks of age-related macular degeneration are recapitulated in a photosensitive mouse model. | Epigenetic hallmarks of age-related macular degeneration are recapitulated in a photosensitive mouse model.
Luu J, Kallestad L, Hoang T, Lewandowski D, Dong Z, Blackshaw S, Palczewski K., Free PMC Article | 09/4/2021 |
| SUV39H2 elevation contributes to the progression of nasopharyngeal carcinoma via regulation of NRIP1 | Elevated SUV39H2 attributes to the progression of nasopharyngeal carcinoma via regulation of NRIP1.
Chao C, You J, Li H, Xue H, Tan X. | 11/16/2019 |
| Results discovered that SUV39H2 is a potential oncogene in lung adenocarcinoma, whose expression was elevated in tumor tissues. SUV39H2 could potentiate the tumorigenesis and invasion of lung adenocarcinoma cells, probably by repressing OPTN and STOM. | Identification of SUV39H2 as a potential oncogene in lung adenocarcinoma.
Zheng Y, Li B, Wang J, Xiong Y, Wang K, Qi Y, Sun H, Wu L, Yang L., Free PMC Article | 07/27/2019 |
| Study revealed that high SUV39H2 expression positively predicted poor prognosis of CRC patients. Moreover, SUV39H2 promoted CRC proliferation in a SLIT1-dependent manner. | SUV39H2 promotes colorectal cancer proliferation and metastasis via tri-methylation of the SLIT1 promoter.
Shuai W, Wu J, Chen S, Liu R, Ye Z, Kuang C, Fu X, Wang G, Li Y, Peng Q, Shi W, Li Y, Zhou Q, Huang W. | 05/18/2019 |
| Knockdown of SUV39H2 expression by specific siRNAs in human osteosarcoma cell lines markedly suppressed cancer cell growth and caused an increase in the population of cells in G1 phase and induced apoptosis. Overexpression of SUV39H2 promoted cell proliferation, which indicated that SUV39H2 may possess oncogenic activity in human osteosarcoma. | Histone methyltransferase SUV39H2 serves oncogenic roles in osteosarcoma.
Piao L, Yuan X, Zhuang M, Qiu X, Xu X, Kong R, Liu Z. | 02/2/2019 |
| Our finding unveils a novel autoregulatory mechanism of SUV39H2 through lysine automethylation | Automethylation of SUV39H2, an oncogenic histone lysine methyltransferase, regulates its binding affinity to substrate proteins.
Piao L, Nakakido M, Suzuki T, Dohmae N, Nakamura Y, Hamamoto R., Free PMC Article | 12/16/2017 |
| Our data show that the differential expression of SUV39H1 and SUV39H2 is associated with genomic instability and that the modulation of these HMTases can be an attractive approach to prevent CLL evolution | Aberrant levels of SUV39H1 and SUV39H2 methyltransferase are associated with genomic instability in chronic lymphocytic leukemia.
Carvalho Alves-Silva J, do Amaral Rabello D, Oliveira Bravo M, Lucena-Araujo A, Madureira de Oliveira D, Morato de Oliveira F, Magalhaes Rego E, Pittella-Silva F, Saldanha-Araujo F. | 12/2/2017 |
| SUV39H2 functioned cooperatively with MAGE-A11 to increase androgen-dependent AR transcriptional activity. | Androgen receptor regulation by histone methyltransferase Suppressor of variegation 3-9 homolog 2 and Melanoma antigen-A11.
Askew EB, Bai S, Parris AB, Minges JT, Wilson EM., Free PMC Article | 11/25/2017 |
| histone H3 lysine 9 methylation reduction, which may be due to the downregulation of methyltransferase SUV39H2 and the upregulation of demethylase KDM4C, was found in CD4(+) T lymphocytes of Latent autoimmune diabetes in adults patients | Reduced Histone H3 Lysine 9 Methylation Contributes to the Pathogenesis of Latent Autoimmune Diabetes in Adults via Regulation of SUV39H2 and KDM4C.
Liu XY, Li H., Free PMC Article | 10/28/2017 |
| data cannot finally exclude H2AX methylation of SUV39H2 in cells, additional experimental evidence is required to validate this claim. | Investigation of H2AX methylation by the SUV39H2 protein lysine methyltransferase.
Schuhmacher MK, Kudithipudi S, Jeltsch A. | 04/29/2017 |
| Our results reveal the regulatory mechanism of LSD1 protein through its lysine methylation by SUV39H2 in human cancer cells | SUV39H2 methylates and stabilizes LSD1 by inhibiting polyubiquitination in human cancer cells.
Piao L, Suzuki T, Dohmae N, Nakamura Y, Hamamoto R., Free PMC Article | 05/21/2016 |
| We also demonstrate that the N324K mutant in the SET domain of SUV39H2 that has been shown to cause an inherited nasal skin disease in Labrador Retrievers renders SUV39H2 inactive | Activity and specificity of the human SUV39H2 protein lysine methyltransferase.
Schuhmacher MK, Kudithipudi S, Kusevic D, Weirich S, Jeltsch A. | 05/2/2015 |
| Expression of JHDM2A was significantly increased but HDAC2, HDAC7, and SUV39H2 were significantly down-regulated in Systemic Sclerosis B cells relative to controls | Aberrant histone modification in peripheral blood B cells from patients with systemic sclerosis.
Wang Y, Yang Y, Luo Y, Yin Y, Wang Q, Li Y, Kanekura T, Wang J, Liang G, Zhao M, Lu Q, Xiao R. | 11/16/2013 |
| genetic association studies in a Finnish population with type I diabetes: The minor T allele of exonic SNP rs17353856 in SUV39H2 is associated with diabetic retinopathy (in a larger meta-analysis); thus an genetic variation may be protective. | Genetic examination of SETD7 and SUV39H1/H2 methyltransferases and the risk of diabetes complications in patients with type 1 diabetes.
Syreeni A, El-Osta A, Forsblom C, Sandholm N, Parkkonen M, Tarnow L, Parving HH, McKnight AJ, Maxwell AP, Cooper ME, Groop PH, FinnDiane Study Group., Free PMC Article | 12/17/2011 |
| findings suggest that Suv39H1 and Suv39H2 are key hypoxia-induced methyltransferases; their decline in fetal lung during late gestation is critical for epigenetic changes resulting in the developmental induction of SP-A | Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia.
Benlhabib H, Mendelson CR., Free PMC Article | 07/2/2011 |
| The SUV39H2 gene is found in tetrapods (e.g., human, mouse and frog) but not in zebrafish, suggesting that this gene is generated by a tetrapod lineage-specific gene duplication event. | Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes.
Sun XJ, Xu PF, Zhou T, Hu M, Fu CT, Zhang Y, Jin Y, Chen Y, Chen SJ, Huang QH, Liu TX, Chen Z., Free PMC Article | 05/13/2008 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer.
Yoon KA, Hwangbo B, Kim IJ, Park S, Kim HS, Kee HJ, Lee JE, Jang YK, Park JG, Lee JS, Yoon KA, Hwangbo B, Kim IJ, Park S, Kim HS, Kee HJ, Lee JE, Jang YK, Park JG, Lee JS. | 03/13/2008 |
| a novel SUV39H2 polymorphism may have a role in lung cancer susceptibility for smokers | Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer.
Yoon KA, Hwangbo B, Kim IJ, Park S, Kim HS, Kee HJ, Lee JE, Jang YK, Park JG, Lee JS, Yoon KA, Hwangbo B, Kim IJ, Park S, Kim HS, Kee HJ, Lee JE, Jang YK, Park JG, Lee JS. | 01/21/2010 |