| Unraveling the molecular interactions between alpha7 nicotinic receptor and a RIC3 variant associated with backward speech. | Unraveling the molecular interactions between α7 nicotinic receptor and a RIC3 variant associated with backward speech.
Pradhan A, Mounford H, Peixinho J, Rea E, Epeslidou E, Scott JS, Cull J, Maxwell S, Webster R, Beeson D, Dong YY, Prekovic S, Bermudez I, Newbury DF., Free PMC Article | 03/15/2024 |
| Deletion induced splicing in RIC3 drives nicotinic acetylcholine receptor regulation with implications for endoplasmic reticulum stress in human astrocytes. | Deletion induced splicing in RIC3 drives nicotinic acetylcholine receptor regulation with implications for endoplasmic reticulum stress in human astrocytes.
Yadav N, Thelma BK. | 03/21/2023 |
| RIC3 variants are not associated with Parkinson's disease in large European, Latin American, or East Asian cohorts. | RIC3 variants are not associated with Parkinson's disease in large European, Latin American, or East Asian cohorts.
Brolin K, Bandres-Ciga S, Leonard H, Makarious MB, Blauwendraat C, Mata IF, Foo JN, Pihlstrøm L, Swanberg M, Gan-Or Z, Tan MM, International Parkinson's Disease Genomics Consortium., Free PMC Article | 02/19/2022 |
| RIC3, the cholinergic anti-inflammatory pathway, and neuroinflammation. | RIC3, the cholinergic anti-inflammatory pathway, and neuroinflammation.
Ben-David Y, Kagan S, Cohen Ben-Ami H, Rostami J, Mizrahi T, Kulkarni AR, Thakur GA, Vaknin-Dembinsky A, Healy LM, Brenner T, Treinin M. | 03/13/2021 |
| Two RIC3 gene haplotypes of four variants: A-G-C-G, and C-A-C-A might relate to either protection against or increased susceptibility to PD in the Han Chinese population, respectively. | Genetic analysis of the RIC3 gene in Han Chinese patients with Parkinson's disease.
He D, Hu P, Deng X, Song Z, Yuan L, Yuan X, Deng H. | 04/28/2018 |
| RIC3 mutations are not a common cause of PD in the French-Canadian and French populations. | RIC3 variants are not associated with Parkinson's disease in French-Canadians and French.
Ross JP, Dupré N, Dauvilliers Y, Strong S, Dionne-Laporte A, Dion PA, Rouleau GA, Gan-Or Z. | 11/18/2017 |
| RIC3 is a known chaperone of neuronal nicotinic acetylcholine receptor subunit alpha-7 (CHRNA7). | Evidence of mutations in RIC3 acetylcholine receptor chaperone as a novel cause of autosomal-dominant Parkinson's disease with non-motor phenotypes.
Sudhaman S, Muthane UB, Behari M, Govindappa ST, Juyal RC, Thelma BK. | 11/4/2017 |
| 5-HT3A-ICD is not only required but also sufficient for interaction with RIC-3 | Pentameric quaternary structure of the intracellular domain of serotonin type 3A receptors.
Pandhare A, Grozdanov PN, Jansen M., Free PMC Article | 04/1/2017 |
| expression of chaperones such as Ric-3 can influence proteins associating with alpha7-nAChRs | Resistance to Inhibitors of Cholinesterase 3 (Ric-3) Expression Promotes Selective Protein Associations with the Human α7-Nicotinic Acetylcholine Receptor Interactome.
Mulcahy MJ, Blattman SB, Barrantes FJ, Lukas RJ, Hawrot E., Free PMC Article | 05/28/2016 |
| RIC-3 differentially regulates assembly and expression of different nicotinic receptor subunits. These results also show that nicotine-mediated upregulation of alpha4beta2 receptors can be dynamically regulated by the presence of the chaperone, RIC-3. | RIC-3 differentially modulates α4β2 and α7 nicotinic receptor assembly, expression, and nicotine-induced receptor upregulation.
Dau A, Komal P, Truong M, Morris G, Evans G, Nashmi R., Free PMC Article | 02/28/2015 |
| RIC-3 gene rs1528133 variation was not found to be effective over any analyzed obesity related parameter, but associated with higher glycemic load, protein and fat eating behavior and antihypertensive drug use | Relationship of RIC-3 gene rs1528133 polymorphism with varying degrees of body weight and eating behavior.
Koldemir M, Kahveci C, Bayer H, Cagatay P, Yildiz S, Bagriacik N, Susleyici-Duman B. | 07/6/2013 |
| Xenopus laevis RIC-3 is more effective than either the homomeric human or C. elegans protein in chaperoning the expression of nematode nicotinic receptor ACR-16 in Xenopus oocytes. | Xenopus laevis RIC-3 enhances the functional expression of the C. elegans homomeric nicotinic receptor, ACR-16, in Xenopus oocytes.
Bennett HM, Lees K, Harper KM, Jones AK, Sattelle DB, Wonnacott S, Wolstenholme AJ., Free PMC Article | 02/16/2013 |
| RIC-3 exclusively enhances the surface expression of human homomeric 5-hydroxytryptamine type 3A (5-HT3A) receptors despite direct interactions with 5-HT3A, -C, -D, and -E subunits. | RIC-3 exclusively enhances the surface expression of human homomeric 5-hydroxytryptamine type 3A (5-HT3A) receptors despite direct interactions with 5-HT3A, -C, -D, and -E subunits.
Walstab J, Hammer C, Lasitschka F, Möller D, Connolly CN, Rappold G, Brüss M, Bönisch H, Niesler B., Free PMC Article | 09/20/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| The RIC-3e protein is functionally active and enables surface expression of mature alpha7-nAChRs in cell lines not otherwise permissive for the expression of this receptor. | Molecular cloning and characterization of a novel human variant of RIC-3, a putative chaperone of nicotinic acetylcholine receptors.
Seredenina T, Ferraro T, Terstappen GC, Caricasole A, Roncarati R. | 01/21/2010 |
| we describe the generation and functional and pharmacological characterization of a Chinese hamster ovary (CHO)-K1 cell line co-expressing the human alpha7 nAChR and RIC-3 | Functional properties of alpha7 nicotinic acetylcholine receptors co-expressed with RIC-3 in a stable recombinant CHO-K1 cell line.
Roncarati R, Seredenina T, Jow B, Jow F, Papini S, Kramer A, Bothmann H, Dunlop J, Terstappen GC. | 01/21/2010 |
| When expressed in a human cell line, human RIC-3 enhances neuronal nicotinic acetylcholine receptor maturation more efficiently than Drosophila melanogaster RIC-3. | Host-cell specific effects of the nicotinic acetylcholine receptor chaperone RIC-3 revealed by a comparison of human and Drosophila RIC-3 homologues.
Lansdell SJ, Collins T, Yabe A, Gee VJ, Gibb AJ, Millar NS. | 01/21/2010 |
| Immunohistochemistry demonstrated the presence of RIC-3 in rat brain localized, in general, in places where alpha7 nAChRs were found. | Molecular characterization and localization of the RIC-3 protein, an effector of nicotinic acetylcholine receptor expression.
Castelán F, Castillo M, Mulet J, Sala S, Sala F, Domínguez Del Toro E, Criado M. | 01/21/2010 |
| this review provides a brief history of RIC-3--REVIEW | RIC-3: a nicotinic acetylcholine receptor chaperone.
Millar NS., Free PMC Article | 01/21/2010 |
| both isoforms of RIC-3 play a role in determining 5-HT3 receptor composition. | Differential subcellular localization of RIC-3 isoforms and their role in determining 5-HT3 receptor composition.
Cheng A, Bollan KA, Greenwood SM, Irving AJ, Connolly CN. | 01/21/2010 |
| the hric3 locus encodes for multiple transcripts, is likely to produce multiple hric3 isoforms, and hric3 is expressed in neurons and muscles, thus enabling its interactions with nicotinic acetylcholine receptors in vivo | Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression.
Halevi S, Yassin L, Eshel M, Sala F, Sala S, Criado M, Treinin M. | 01/21/2010 |
| Mutations in the ric-3 gene affect maturation of nicotinic acetylcholine receptors. | Role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors.
Castillo M, Mulet J, Gutiérrez LM, Ortiz JA, Castelán F, Gerber S, Sala S, Sala F, Criado M. | 01/21/2010 |
| RIC-3 may play a role in 5-HT(3A) receptor folding, assembly, or transport to the cell surface | Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3.
Cheng A, McDonald NA, Connolly CN. | 01/21/2010 |
| ric-3 appears to be necessary for proper folding and/or assembly of alpha7 receptors in HEK293 cells | Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells.
Williams ME, Burton B, Urrutia A, Shcherbatko A, Chavez-Noriega LE, Cohen CJ, Aiyar J. | 01/21/2010 |