| Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer. | Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer.
Nguyen PM, Dagley LF, Preaudet A, Lam N, Giam M, Fung KY, Aizel K, van Duijneveldt G, Tan CW, Hirokawa Y, Yip HYK, Love CG, Poh AR, Cruz A, Burstroem C, Feltham R, Abdirahman SM, Meiselbach K, Low RRJ, Palmieri M, Ernst M, Webb AI, Burgess T, Sieber OM, Bouillet P, Putoczki TL., Free PMC Article | 07/3/2021 |
| Human BCL-G regulates secretion of inflammatory chemokines but is dispensable for induction of apoptosis by IFN-gamma and TNF-alpha in intestinal epithelial cells. | Human BCL-G regulates secretion of inflammatory chemokines but is dispensable for induction of apoptosis by IFN-γ and TNF-α in intestinal epithelial cells.
Woznicki JA, Flood P, Bustamante-Garrido M, Stamou P, Moloney G, Fanning A, Zulquernain SA, McCarthy J, Shanahan F, Melgar S, Nally K., Free PMC Article | 10/3/2020 |
| these data reveal adjacent gene rearrangements as a class of underexplored genetic aberrations that could be pathological in breast cancer, and identify BCL2L14-ETV6 as a recurrent gene fusion in more aggressive form of Triple-negative breast cancer tumor | Landscape analysis of adjacent gene rearrangements reveals BCL2L14-ETV6 gene fusions in more aggressive triple-negative breast cancer.
Lee S, Hu Y, Loo SK, Tan Y, Bhargava R, Lewis MT, Wang XS., Free PMC Article | 08/1/2020 |
| BCL2L14 knockdown exhibited similar effects similar to those of miR-496 overexpression, and the restored BCL2L14expression reversed the protective effects of miR-496 on SH-SY5Y cells | Upregulation of miR-496 decreases cerebral ischemia/reperfusion injury by negatively regulating BCL2L14.
Yao X, Yao R, Yi J, Huang F. | 09/7/2019 |
| The results show that BCLG is overexpressed more frequently in medullary breast carcinoma than other histological types of basal like carcinomas. | Medullary Breast Carcinoma, a Triple-Negative Breast Cancer Associated with BCLG Overexpression.
Romero P, Benhamo V, Deniziaut G, Fuhrmann L, Berger F, Manié E, Bhalshankar J, Vacher S, Laurent C, Marangoni E, Gruel N, MacGrogan G, Rouzier R, Delattre O, Popova T, Reyal F, Stern MH, Stoppa-Lyonnet D, Marchiò C, Bièche I, Vincent-Salomon A. | 08/17/2019 |
| Data indicate that LRP6, BCL2L14, DUSP16, CREBL2, and CDKN1B were involed in centromeric (12p11.21-12p13.2) deletion in ETV6-RUNX1 B-cell precursor acute lymphoblastic leukemia (BCP-ALL). | Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia.
Al-Shehhi H, Konn ZJ, Schwab CJ, Erhorn A, Barber KE, Wright SL, Gabriel AS, Harrison CJ, Moorman AV. | 05/25/2013 |
| Single nucleotide polymorphism in BCL2L14 is associated with lung cancer. | Multistage analysis of variants in the inflammation pathway and lung cancer risk in smokers.
Spitz MR, Gorlov IP, Dong Q, Wu X, Chen W, Chang DW, Etzel CJ, Caporaso NE, Zhao Y, Christiani DC, Brennan P, Albanes D, Shi J, Thun M, Landi MT, Amos CI., Free PMC Article | 12/22/2012 |
| prior knockdown of Bcl-G expression ablates the stimulation of basal apoptosis by FAU, consistent with an essential downstream role for Bcl-G, itself a candidate tumour suppressor, in mediating the apoptosis regulatory role of FAU. | Candidate tumour suppressor Fau regulates apoptosis in human cells: an essential role for Bcl-G.
Pickard MR, Mourtada-Maarabouni M, Williams GT. | 09/17/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesGermline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma.
Kelly JL, Novak AJ, Fredericksen ZS, Liebow M, Ansell SM, Dogan A, Wang AH, Witzig TE, Call TG, Kay NE, Habermann TM, Slager SL, Cerhan JR. An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
Shimada M, Miyagawa T, Kawashima M, Tanaka S, Honda Y, Honda M, Tokunaga K. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| siRNA downregulation of Bcl-G inhibited breast cancer cell apoptosis. Adding an siRNA against Fau revealed control of Bcl-G by Fau. The most important factors controlling Bcl-G are post-translational modification by Fau & MELK, not transcription rate. | Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer.
Pickard MR, Green AR, Ellis IO, Caldas C, Hedge VL, Mourtada-Maarabouni M, Williams GT., Free PMC Article | 03/1/2010 |
| Increased BclG(L) expression may contribute to the aberrant CD4+ T cell apoptosis which causes an inappropriate immune response and impaired homeostasis in systemic lupus erythematosus. | Upregulated BclG(L) expression enhances apoptosis of peripheral blood CD4+ T lymphocytes in patients with systemic lupus erythematosus.
Luo N, Wu Y, Chen Y, Yang Z, Guo S, Fei L, Zhou D, Yang C, Wu S, Ni B, Hao F, Wu Y. | 01/21/2010 |
| JAB1 is involved in the regulation of mitochondrial apoptotic pathway through specific interaction with BclGs. | JAB1 accelerates mitochondrial apoptosis by interaction with proapoptotic BclGs.
Liu X, Pan Z, Zhang L, Sun Q, Wan J, Tian C, Xing G, Yang J, Liu X, Jiang J, He F. | 01/21/2010 |
| the kinase activity of MELK is likely to affect mammary carcinogenesis through inhibition of the pro-apoptotic function of Bcl-GL | Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family.
Lin ML, Park JH, Nishidate T, Nakamura Y, Katagiri T., Free PMC Article | 01/21/2010 |
| There was no somatic mutation of BH3 domains of Bad, Bmf and Bcl-G genes in transitional cell carcinoma samples. The data presented here indicate that BH3 domain mutation of these genes is rare in TCCs and may not contribute to the pathogenesis of TCCs. | BH3 domain mutation of proapoptotic genes Bad, Bmf and Bcl-G is rare in transitional cell carcinomas of the urinary bladder.
Soung YH, Lee JW, Park WS, Nam SW, Lee JY, Yoo NJ, Lee SH. | 01/21/2010 |
| data presented here indicate that BH3 domain mutation of the proapoptotic genes Bad, Bmf and Bcl-G is rare in laryngeal squamous cell carcinoma and may not contribute to the apoptosis-resistance mechanisms of laryngeal squamous cell carcinoma | Mutational analysis of the BH3 domains of proapoptotic Bcl-2 family genes Bad, Bmf and Bcl-G in laryngeal squamous cell carcinomas.
Yoo NJ, Soung YH, Lee SH, Jeong EG, Lee SH. | 01/21/2010 |