| Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis. | Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis.
Zhang J, Hu Z, Chung HH, Tian Y, Lau KW, Ser Z, Lim YT, Sobota RM, Leong HF, Chen BJ, Yeo CJ, Tan SYX, Kang J, Tan DEK, Sou IF, McClurg UL, Lakshmanan M, Vaiyapuri TS, Raju A, Wong ESM, Tergaonkar V, Rajarethinam R, Pathak E, Tam WL, Tan EY, Tee WW., Free PMC Article | 05/3/2023 |
| Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve. | Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve.
Chignon A, Argaud D, Boulanger MC, Mkannez G, Bon-Baret V, Li Z, Thériault S, Bossé Y, Mathieu P., Free PMC Article | 02/19/2022 |
| Overexpression of NELFE contributes to gastric cancer progression via Wnt/beta-catenin signaling-mediated activation of CSNK2B expression. | Overexpression of NELFE contributes to gastric cancer progression via Wnt/β-catenin signaling-mediated activation of CSNK2B expression.
Yu S, Li L, Cai H, He B, Gao Y, Li Y., Free PMC Article | 09/11/2021 |
| NELF complex fosters BRCA1 and RAD51 recruitment to DNA damage sites and modulates sensitivity to PARP inhibition. | NELF complex fosters BRCA1 and RAD51 recruitment to DNA damage sites and modulates sensitivity to PARP inhibition.
Bishara LA, Machour FE, Awwad SW, Ayoub N. | 08/14/2021 |
| NELFE-Dependent MYC Signature Identifies a Unique Cancer Subtype in Hepatocellular Carcinoma. | NELFE-Dependent MYC Signature Identifies a Unique Cancer Subtype in Hepatocellular Carcinoma.
Dang H, Pomyen Y, Martin SP, Dominguez DA, Yim SY, Lee JS, Budhu A, Shah AP, Bodzin AS, Wang XW., Free PMC Article | 09/26/2020 |
| NELFE expression was increased in pancreatic cancer (PC) tissues compared with the paired normal tissues. NELFE expression was upregulated in PC cells when compared with normal pancreatic cells. Knockdown of NELFE inhibited the proliferation, invasion and migration of PC cells. NELFE activates the Wnt/betacatenin signaling pathway and epithelialtomesenchymal transition by decreasing the stabilization of NDRG2 mRNA in PC. | NELFE promoted pancreatic cancer metastasis and the epithelial‑to‑mesenchymal transition by decreasing the stabilization of NDRG2 mRNA.
Han L, Zan Y, Huang C, Zhang S., Free PMC Article | 04/4/2020 |
| define two mutually exclusive complexes CBC-NELF-E and CBC-ARS2-PHAX, which likely act in respectively earlier and later phases of transcription | Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2.
Schulze WM, Cusack S., Free PMC Article | 09/8/2018 |
| A positively charged face of NELF-AC is involved in RNA binding, whereas the opposite face of the NELF-AC subcomplex binds NELF-B. NELF-B is predicted to form a HEAT repeat fold, also binds RNA in vivo, and anchors the subunit NELF-E, which is confirmed to bind RNA in vivo. | Architecture and RNA binding of the human negative elongation factor.
Vos SM, Pöllmann D, Caizzi L, Hofmann KB, Rombaut P, Zimniak T, Herzog F, Cramer P., Free PMC Article | 11/25/2017 |
| novel actions of BRD4 and of NELF-E in GR-controlled gene induction have been uncovered. | Kinetically Defined Mechanisms and Positions of Action of Two New Modulators of Glucocorticoid Receptor-regulated Gene Induction.
Pradhan MA, Blackford JA Jr, Devaiah BN, Thompson PS, Chow CC, Singer DS, Simons SS Jr., Free PMC Article | 05/21/2016 |
| Following NELF-E knockdown or tumor necrosis factor alpha stimulation, promoter-proximal RNAP II levels increase up to 3-fold, and there is a dramatic increase in RNAP II levels within the HIV genome. | Negative elongation factor is required for the maintenance of proviral latency but does not induce promoter-proximal pausing of RNA polymerase II on the HIV long terminal repeat.
Jadlowsky JK, Wong JY, Graham AC, Dobrowolski C, Devor RL, Adams MD, Fujinaga K, Karn J., Free PMC Article | 07/12/2014 |
| these results describe the RNA binding behavior of NELF-E and supports a biological role for NELF-E in promoter-proximal pausing of both HIV-1 and cellular genes. | Defining NELF-E RNA binding in HIV-1 and promoter-proximal pause regions.
Pagano JM, Kwak H, Waters CT, Sprouse RO, White BS, Ozer A, Szeto K, Shalloway D, Craighead HG, Lis JT., Free PMC Article | 06/21/2014 |
| Multivariate analysis revealed that RDBP protein levels were an independent risk factor for early intrahepatic recurrence of HCC within 2 years of surgery. | Overexpression of the RD RNA binding protein in hepatitis C virus-related hepatocellular carcinoma.
Iida M, Iizuka N, Tsunedomi R, Tsutsui M, Yoshida S, Maeda Y, Tokuhisa Y, Sakamoto K, Yoshimura K, Tamesa T, Oka M. | 01/26/2013 |
| the transcription elongation of KSHV OriLytL-K7 lytic genes is inhibited by NELF during latency, but can also be promptly reactivated in an RTA-independent manner upon external stimuli | Negative elongation factor-mediated suppression of RNA polymerase II elongation of Kaposi's sarcoma-associated herpesvirus lytic gene expression.
Toth Z, Brulois KF, Wong LY, Lee HR, Chung B, Jung JU., Free PMC Article | 11/24/2012 |
| data show that NELF subunits exhibit highly specific subcellular localizations, such as in NELF bodies or in midbodies, and some shuttle actively between the nucleus and cytoplasm; loss of NELF from cells can lead to enlarged and/or multiple nuclei | Cellular dynamics of the negative transcription elongation factor NELF.
Yung TM, Narita T, Komori T, Yamaguchi Y, Handa H. | 11/17/2012 |
| Transient NELF-E knock-down in pituitary increased coincidentally prolactin expression and enhanced transcription of a prolactin-promoter reporter gene. | Transcription elongation factors are involved in programming hormone production in pituitary neuroendocrine GH4C1 cells.
Fujita T, Piuz I, Schlegel W. | 06/14/2010 |
| Our results do not support any major role of the 4 AMD-associated variants in the risk of developing PCV, but favor a predominant association with the RDBP-SKIV2L variants | Role of RDBP and SKIV2L variants in the major histocompatibility complex class III region in polypoidal choroidal vasculopathy etiology.
Kondo N, Honda S, Kuno S, Negi A, Kondo N, Honda S, Kuno S, Negi A. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesHigh-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA. Role of RDBP and SKIV2L variants in the major histocompatibility complex class III region in polypoidal choroidal vasculopathy etiology.
Kondo N, Honda S, Kuno S, Negi A, Kondo N, Honda S, Kuno S, Negi A. Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1.
Valdes AM, Thomson G, Type 1 Diabetes Genetics Consortium. | 03/25/2009 |
| Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator) | Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).
Limou S, Le Clerc S, Coulonges C, Carpentier W, Dina C, Delaneau O, Labib T, Taing L, Sladek R, Deveau C, Ratsimandresy R, Montes M, Spadoni JL, Lelièvre JD, Lévy Y, Therwath A, Schächter F, Matsuda F, Gut I, Froguel P, Delfraissy JF, Hercberg S, Zagury JF, ANRS Genomic Group. | 02/11/2009 |
| RNA binding to NELF-E RRM induces formation of a helix in the C-terminus. RNA-bound form of NELF-E RRM is very similar to RNA-bound form of U1A RRM, although C-terminus of NELF-E RRM is unstructured in free protein, whereas it is helical in U1A protein. | NELF-E RRM undergoes major structural changes in flexible protein regions on target RNA binding.
Rao JN, Schweimer K, Wenzel S, Wöhrl BM, Rösch P. | 01/21/2010 |
| Negative elongation factor (NELF) is a four subunit transcription factor. Our results point to a surprising role of NELF in the 3' end processing of histone mRNAs and suggest that NELF is a new factor that coordinates mRNA processing in transcription. | NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs.
Narita T, Yung TM, Yamamoto J, Tsuboi Y, Tanabe H, Tanaka K, Yamaguchi Y, Handa H. | 01/21/2010 |
| NELF E RRM binds to the single-stranded TAR RNAs with K(d) values in the low-micromolar range. | Structural studies on the RNA-recognition motif of NELF E, a cellular negative transcription elongation factor involved in the regulation of HIV transcription.
Rao JN, Neumann L, Wenzel S, Schweimer K, Rösch P, Wöhrl BM., Free PMC Article | 01/21/2010 |
| 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity-inducing factor (DSIF)- and NELF-mediated transcriptional pausing has a dual function in regulating immediate-early expression of the human junB gene. | Transcriptional pausing caused by NELF plays a dual role in regulating immediate-early expression of the junB gene.
Aida M, Chen Y, Nakajima K, Yamaguchi Y, Wada T, Handa H., Free PMC Article | 01/21/2010 |
| Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA | Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA.
Yamaguchi Y, Inukai N, Narita T, Wada T, Handa H., Free PMC Article | 01/21/2010 |
| NELF-C and NELF-D are highly related or identical to the protein called TH1, of unknown function. NELF-B and NELF-C or NELF-D are integral subunits that bring NELF-A and NELF-E together. [NELF-B] [NELF-C] | Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex.
Narita T, Yamaguchi Y, Yano K, Sugimoto S, Chanarat S, Wada T, Kim DK, Hasegawa J, Omori M, Inukai N, Endoh M, Yamada T, Handa H., Free PMC Article | 01/21/2010 |