| FOXD3-mediated transactivation of ALKBH5 promotes neuropathic pain via m[6]A-dependent stabilization of 5-HT3A mRNA in sensory neurons. | FOXD3-mediated transactivation of ALKBH5 promotes neuropathic pain via m(6)A-dependent stabilization of 5-HT3A mRNA in sensory neurons.
Huang Z, Zhang Y, Wang S, Qi R, Tao Y, Sun Y, Jiang D, Jiang X, Tao J., Free PMC Article | 02/21/2024 |
| Role of 5-HT1A and 5-HT3 receptors in serotonergic activation of sensory neurons in relation to itch and pain behavior in the rat. | Role of 5-HT1A and 5-HT3 receptors in serotonergic activation of sensory neurons in relation to itch and pain behavior in the rat.
Domocos D, Selescu T, Ceafalan LC, Iodi Carstens M, Carstens E, Babes A., Free PMC Article | 09/18/2021 |
| Stereological investigation of 5-HT3 receptors in the substantia nigra and dorsal raphe nucleus in the rat. | Stereological investigation of 5-HT(3) receptors in the substantia nigra and dorsal raphe nucleus in the rat.
Belliveau S, Kang W, Bovaird S, Hamadjida A, Bédard D, Dancause N, Stroh T, Huot P. | 07/17/2021 |
| Results demonstrate that exogenous serotonin acts on 5-HT2 and 5-HT3 receptors in the lumbosacral defecation center and activates the parasympathetic nervous system to enhance colorectal motility in cooperation with noradrenaline and dopamine. | Exogenous serotonin regulates colorectal motility via the 5-HT(2) and 5-HT(3) receptors in the spinal cord of rats.
Nakamori H, Naitou K, Sano Y, Shimaoka H, Shiina T, Shimizu Y. | 11/2/2019 |
| Results found that 5-HT3aR plays a role in lacrimal gland secretory functions and confirmed that extracellular Ca2+ entry participates in [Ca2+]i mobilization stimulated by 5-HT. | Serotonin hormonally regulates lacrimal gland secretory function via the serotonin type 3a receptor.
Imada T, Nakamura S, Hisamura R, Izuta Y, Jin K, Ito M, Kitamura N, Tanaka KF, Mimura M, Shibuya I, Tsubota K., Free PMC Article | 03/16/2019 |
| Data support a functional role for serotonergic signaling in the mesolimbic pathway on motivated behavior, and demonstrate that 5-HT3 serotonin receptors differentially modulate food consumption in a region-dependent manner. | Contrasting effects of 5-HT(3) receptor stimulation of the nucleus accumbens or ventral tegmentum on food intake in the rat.
Pratt WE, Lin P, Pierce-Messick Z, Ilesanmi AO, Clissold KA., Free PMC Article | 12/16/2017 |
| This study demonstrates that AITC-induced nociception in vivo depends on TRPA1 and is decreased by the blockade of the NK1 receptor for SP, the H1 receptor for histamine and the 5-HT1A and 3 receptors for 5-HT | TRPA1, substance P, histamine and 5-hydroxytryptamine interact in an interdependent way to induce nociception.
Fischer L, Lavoranti MI, de Oliveira Borges M, Miksza AF, Sardi NF, Martynhak BJ, Tambeli CH, Parada CA. | 07/29/2017 |
| Study concludes that the serotonin 3 receptor does not play a unique role in mediating stress-induced hyperalgesia related to temporomandibular joint nociception. | Inhibition of temporomandibular joint input to medullary dorsal horn neurons by 5HT3 receptor antagonist in female rats.
Okamoto K, Katagiri A, Rahman M, Thompson R, Bereiter DA., Free PMC Article | 03/5/2016 |
| rats were trained in an operant conditioning task while receiving fluoxetine), tianeptine (serotonin reuptake enhancer, 10mg/kg), buspirone, risperidone (5-HT2A antagonist, 1mg/kg), ondansetron (5-HT3 antagonist, 2mg/kg) or vehicle | Dual role of serotonin in the acquisition and extinction of reward-driven learning: involvement of 5-HT1A, 5-HT2A and 5-HT3 receptors.
Frick LR, Bernardez-Vidal M, Hocht C, Zanutto BS, Rapanelli M. | 09/12/2015 |
| The inhibition of I(5-HT3) by WIN55,212-2 is probably new one of peripheral analgesic mechanisms of WIN55,212-2, but the mechanism by which WIN55,212-2 inhibits I(5-HT3) warrants further investigation. | Inhibition of 5-HT(3) receptors-activated currents by cannabinoids in rat trigeminal ganglion neurons.
Shi B, Yang R, Wang X, Liu H, Zou L, Hu X, Wu J, Zou A, Liu L. | 09/13/2014 |
| Endogenously released 5-HT inhibits A and C fiber-evoked synaptic transmission in the rat spinal cord by the facilitation of GABA/glycine and 5-HT release via 5-HT(2A) and 5-HT(3) receptors. | Endogenously released 5-HT inhibits A and C fiber-evoked synaptic transmission in the rat spinal cord by the facilitation of GABA/glycine and 5-HT release via 5-HT(2A) and 5-HT(3) receptors.
Iwasaki T, Otsuguro K, Kobayashi T, Ohta T, Ito S. | 02/8/2014 |
| glucose may also be able to modulate the ability of GI vagal afferent neurons to respond to the released 5-HT, via regulation of neuronal 5-HT(3) receptors | Glucose-dependent trafficking of 5-HT3 receptors in rat gastrointestinal vagal afferent neurons.
Babic T, Troy AE, Fortna SR, Browning KN., Free PMC Article | 06/8/2013 |
| Activation of 5-HT3 receptors in the posterior insular cortex is important for nausea-induced conditioned disgust reactions. Those in the anterior IC are involved in the production of conditioned taste avoidance. | Double dissociation between regulation of conditioned disgust and taste avoidance by serotonin availability at the 5-HT(3) receptor in the posterior and anterior insular cortex.
Tuerke KJ, Limebeer CL, Fletcher PJ, Parker LA., Free PMC Article | 01/26/2013 |
| Acute myocardial ischemia augments the Bezold-Jarisch reflex induced via activation of TRPV1 and 5-HT(3) receptors located on sensory vagal nerves in the heart. | Acute myocardial ischemia enhances the vanilloid TRPV1 and serotonin 5-HT3 receptor-mediated Bezold-Jarisch reflex in rats.
Lupiński SŁ, Schlicker E, Pędzińska-Betiuk A, Malinowska B. | 11/17/2012 |
| Spinal 5-HT(3) receptors play an important role during development and maintenance of pain evoked long-term behaviors. | Role of peripheral and spinal 5-HT(3) receptors in development and maintenance of formalin-induced long-term secondary allodynia and hyperalgesia.
Bravo-Hernández M, Cervantes-Durán C, Pineda-Farias JB, Barragán-Iglesias P, López-Sánchez P, Granados-Soto V. | 09/29/2012 |
| 5-HT3R may play a role in initiation of the nociceptive response. | [Interaction of 5-HT2 and 5-HT3 receptor subtype in 5-HT-induced nociceptive responses in peripheral primary sensory nerve ending].
Zhang J, Hu WP, Zhou KC, Luo JL, Fan YZ, Ru LQ, Li ZW. | 06/2/2012 |
| Up-regulation of 5-HT3 and 5-HT4 receptors expression in the mucosal/submucosal layer is involved to restore the delayed transit after the parasympathetic denervation in rats. | The role of 5-HT3 and 5-HT4 receptors in the adaptive mechanism of colonic transit following the parasympathetic denervation in rats.
Tong W, Kamiyama Y, Ridolfi TJ, Zietlow A, Zheng J, Kosinski L, Ludwig K, Takahashi T., Free PMC Article | 01/7/2012 |
| 5-HT3 receptors in the basal forebrain exert a tonic sympathoinhibitory action that is mediated via the local release of angiotensin in the septal nuclear complex. | Blockade of 5-HT3 receptors at septal area increase blood pressure in unanaesthetized rats.
Urzedo-Rodrigues LS, Ferreira HS, Almeida DO, Medeiros JP, Batista A, de Castro e Silva E, Fregoneze JB. | 11/12/2011 |
| Data indicate that the hypotensive response observed after pharmacological stimulation of central 5-HT(3) receptors depends on the functional integrity of brain mu, kappa and delta opioid receptors. | Multiple opioid receptors mediate the hypotensive response induced by central 5-HT(3) receptor stimulation.
Fregoneze JB, Oliveira EF, Ribeiro VF, Ferreira HS, De Castro E Silva E. | 09/3/2011 |
| 5-HT(3) receptor-mediated somatostatin-dependent secretoinhibitory pathway is suppressed in the water-immersion restraint stressed rats | Colonic submucosal 5-HT(3) receptor-mediated somatostatin-dependent secretoinhibitory pathway is suppressed in water-immersion restraint stressed rats.
Li Y, Li XF, Hua Guo, Xu JD, Zhang XH, Li LS, Feng XY, Zhang Y, Duan ZP, Zhu JX. | 06/18/2011 |
| results of this study suggest that 5-HT(3) receptors in the posterior ventral tegmental area of the alcohol-preferring rat may be involved in regulating ethanol self-administration | Serotonin-3 receptors in the posterior ventral tegmental area regulate ethanol self-administration of alcohol-preferring (P) rats.
Rodd ZA, Bell RL, Oster SM, Toalston JE, Pommer TJ, McBride WJ, Murphy JM., Free PMC Article | 12/4/2010 |
| results suggest that 5-HT is released from serotoninergic neurons, their processes and enterochromaffin cells. The effect of 5-HT mediated by 5-HT3 receptors involves distinct neuronal and non-neuronal pathways which modulate gastric acid secretion. | Effects of serotonin on acid secretion in isolated rat stomach: the role of 5-HT3 receptors.
Lai YC, Ho Y, Huang KH, Tsai LH. | 05/3/2010 |
| GDNF promotes synaptic communication in cultured myenteric neurons. It also up-regulates 5-HT(3a)-receptor expression via modulation of Kv channel activity. | Glial cell-derived neurotrophic factor enhances synaptic communication and 5-hydroxytryptamine 3a receptor expression in enteric neurons.
Zeng F, Watson RP, Nash MS. | 05/3/2010 |
| Results demonstrate a time-dependent vagal afferent modulation of chronic allergen-sensitized visceral hyperalgesia, which may involve a 5-HT(3)R pathway. | 5-HT 3 receptors mediate the time-dependent vagal afferent modulation of nociception during chronic food allergen-sensitized visceral hyperalgesia in rats.
Chen S, Li J, Zhang L, Dong X, Gao W, Mo J, Chen H, Xiao S, Li Y. | 01/21/2010 |
| These results demonstrate that hypoxia recruits a 5-HT pathway to cardiac vagal neurons that activates 5-HT3 receptors on CVNs to maintain parasympathetic cardiac activity during hypoxia. | The role of 5-HT3 and other excitatory receptors in central cardiorespiratory responses to hypoxia: implications for sudden infant death syndrome.
Dergacheva O, Kamendi H, Wang X, Pinol RM, Frank J, Jameson H, Gorini C, Mendelowitz D., Free PMC Article | 01/21/2010 |