| Role of heme oxygenase in the regulation of the renal hemodynamics in a model of sex-dependent programmed hypertension by maternal diabetes. | Role of heme oxygenase in the regulation of the renal hemodynamics in a model of sex-dependent programmed hypertension by maternal diabetes.
Martínez-Gascón LE, Ortiz MC, Galindo M, Sanchez JM, Sancho-Rodríguez N, Albaladejo-Otón MD, Rodríguez Mulero MD, Rodriguez F. | 02/12/2022 |
| Complex Formation of Heme Oxygenase-2 with Heme Is Competitively Inhibited by the Cytosolic Domain of Caveolin-1. | Complex Formation of Heme Oxygenase-2 with Heme Is Competitively Inhibited by the Cytosolic Domain of Caveolin-1.
Takemoto M, Sakamoto H, Higashimoto Y, Taira J. | 11/22/2021 |
| Aorta HO-2 histological scores (HSCORE) of hypertensive rats were lower, while SBP was higher. Swimming caused enhancement of HO-2 immunostaining in aorta endothelium and adventitia of SHR. Exercise induced elevation of blood COHb index in SHR. Synchronous BP lowering effect of exercise was observed. | Contribution of Heme Oxygenase 2 to Blood Pressure Regulation in Response to Swimming Exercise and Detraining in Spontaneously Hypertensive Rats.
Kilic-Toprak E, Kilic-Erkek O, Abban-Mete G, Caner V, Baris IC, Turhan G, Kucukatay V, Senol H, Kuru O, Bor-Kucukatay M., Free PMC Article | 12/22/2018 |
| This experiments shown here indicate that HO-2 and HO-1 are differentially regulated across sexual experience and that the two CO-producing enzymes are expressed in distinct but overlapping populations of cells in medial preoptic area. | Increased expression of carbon monoxide-producing enzymes in the MPOA after sexual experience in male rats.
Robison CL, McHenry JA, Hull EM. | 07/1/2017 |
| The increased HO activity and expression in females might play a role in the sexual dimorphism of cardiovascular ischemia susceptibility during the reproductive age. | Sexual dimorphism of cardiovascular ischemia susceptibility is mediated by heme oxygenase.
Pósa A, Kupai K, Ménesi R, Szalai Z, Szabó R, Pintér Z, Pálfi G, Gyöngyösi M, Berkó A, Pávó I, Varga C., Free PMC Article | 05/17/2014 |
| The distribution of neurons expressing heme oxygenase-2 (HO-2-positive neurons) in the nuclei of various parts of the brainstem was determined. | [The distribution of heme oxygenase-2 in the brainstem nuclei of rats].
Kotsiuba AY, Chertok M. | 07/20/2013 |
| HO mRNA levels display isoform-specific changes: those of HO-2 do not change appreciably, whereas those of HO-1 increase significantly in 2-h endotoxemia, with or without obstructive jaundice. | Effects of Kupffer cell blockade on the hepatic expression of metallothionein and heme oxygenase genes in endotoxemic rats with obstructive jaundice.
Abrahám S, Hermesz E, Szabó A, Ferencz A, Jancsó Z, Duda E, Abrahám M, Lázár G, Lázár G Jr. | 03/3/2012 |
| Heme oxyenase-1 and -2 in the nephron inhibit tubuloglomerular feedback by releasing CO and biliverdin. CO's inhibitory effect is mediated by the soluble-guanylate-cyclase/cGMP signaling pathway, whereas biliverdin probably acts by reducing O2-. | Heme oxygenase metabolites inhibit tubuloglomerular feedback in vivo.
Wang H, Garvin JL, D'Ambrosio MA, Falck JR, Leung P, Liu R, Ren Y, Carretero OA., Free PMC Article | 06/25/2011 |
| Data show that siRNA blockage of BVR protein expression in cardiomyocytes inhibits HO-2 protein induction but not vice versa. | The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters β-adrenergic receptor ligand-mediated cardiac dysfunction.
Ding B, Gibbs PE, Brookes PS, Maines MD., Free PMC Article | 03/12/2011 |
| The expression and distribution of NADPH-d and HO-2 suggest that carbon monoxide and nitric oxide are likely neurotransmitters and might function in the processing orofacial signal in the spinal trigeminal nucleus together. | Distribution of heme oxygenase-2 and NADPH-diaphorase in the spinal trigeminal nucleus of the rat.
Fan W, Huang F, Dong W, Gao Z, Li C, Zhu X, Li D, He H. | 06/14/2010 |
| HO-2 protein expression upregulation following hypoxia-ischemia coupled with an increase in HO-1 immunoreactivity suggests that this response may be implicated in reducing cell death or repairing damage induced by cerebral ischemia | Cerebral heme oxygenase 1 and 2 spatial distribution is modulated following injury from hypoxia-ischemia and middle cerebral artery occlusion in rats.
Sutherland BA, Rahman RM, Clarkson AN, Shaw OM, Nair SM, Appleton I. | 01/21/2010 |
| At least one HO product (presumably carbon monoxide) inhibits cholesterol transport to the inner mitochondrial membrane and Leydig cell steroidogenesis by binding to the heme group of the cytochrome P450 enzymes. | Effects of heme oxygenase isozymes on Leydig cells steroidogenesis.
Piotrkowski B, Monzón CM, Pagotto RM, Reche CG, Besio M, Cymeryng CB, Pignataro OP. | 01/21/2010 |
| HO-1 and HO-2 are expressed in the vaginal smooth muscle of the female rats, and their decreased expressions are correlated with the lowered level of plasma estradiol. | [Expressions of HO-1 and HO-2 in the vaginal smooth muscle of ovariectomized female rats].
Xia C, Jiang R. | 01/21/2010 |
| Heme oxygenase-2 is necessary for the excitatory response of cultured neonatal rat rostral ventrolateral medulla neurons to hypoxia. | Heme oxygenase is necessary for the excitatory response of cultured neonatal rat rostral ventrolateral medulla neurons to hypoxia.
D'Agostino D, Mazza E Jr, Neubauer JA., Free PMC Article | 01/21/2010 |
| NADPH-diaphorase and HO-2 positive neurons appeared the same pattern | Expression and colocalization of NADPH-diaphorase and heme oxygenase-2 in trigeminal ganglion and mesencephalic trigeminal nucleus of the rat.
Fan W, Dong W, Leng S, Li D, Cheng S, Li C, Qu H, He H. | 01/21/2010 |
| Elevations of vascular eNOS and HO-1/HO-2 may contribute to enhanced vasodilation, which can be offset by intense training and elevation in vascular iNOS. | Effects of different levels of exercise volume on endothelium-dependent vasodilation: roles of nitric oxide synthase and heme oxygenase.
Sun MW, Zhong MF, Gu J, Qian FL, Gu JZ, Chen H. | 01/21/2010 |
| An increase in HO2 and DMT1 mRNA level was induced after chronic exposure to depleted uranium. | Renal anemia induced by chronic ingestion of depleted uranium in rats.
Berradi H, Bertho JM, Dudoignon N, Mazur A, Grandcolas L, Baudelin C, Grison S, Voisin P, Gourmelon P, Dublineau I. | 01/21/2010 |
| subcellular location of HO-2 is consistent with the RME hypothesis for heme uptake and suggests a role in heme degradation. | Subcellular location of heme oxygenase 1 and 2 and divalent metal transporter 1 in relation to endocytotic markers during heme iron absorption.
West AR, Oates PS. | 01/21/2010 |
| HO-2 is expressed by aortic endothelial cells early during hypoxic exposure and impairs ET-1-mediated potentiation of contraction to alpha-adrenoceptor stimulation. | Interaction between endothelial heme oxygenase-2 and endothelin-1 in altered aortic reactivity after hypoxia in rats.
Govindaraju V, Teoh H, Hamid Q, Cernacek P, Ward ME. | 01/21/2010 |
| Spinal cord injury has the capacity to induce upregulation of HO-2. Endogenous serotonin is involved in HO-2 expression in spinal cord. | Depletion of endogenous serotonin synthesis with p-CPA attenuates upregulation of constitutive isoform of heme oxygenase-2 expression, edema formation and cell injury following a focal trauma to the rat spinal cord.
Sharma HS, Westman J. | 01/21/2010 |
| HO-2 play a major role by sequestering NO derived radical and suppressing inflammatory response. | The heme oxygenase system and cellular defense mechanisms. Do HO-1 and HO-2 have different functions?
Maines MD, Panahian N. | 01/21/2010 |
| Ho-2 level increased in cardiac myocytes one-month after diabetes mellitus. | Heme oxygenase in diabetes-induced oxidative stress in the heart.
Farhangkhoee H, Khan ZA, Mukherjee S, Cukiernik M, Barbin YP, Karmazyn M, Chakrabarti S. | 01/21/2010 |
| Uterine HO activity could regulate uterine quiescence in pregnancy via cGMP and it may contribute to the defense against oxidative stress. | Heme oxygenase-carbon monoxide (HO-CO) system in rat uterus: effect of sexual steroids and prostaglandins.
Cella M, Farina MG, Keller Sarmiento MI, Chianelli M, Rosenstein RE, Franchi AM. | 01/21/2010 |
| carotid body cells demonstrated HO-2-dependent hypoxic BK channel inhibition, which indicates that HO-2 is an oxygen sensor that controls channel activity during oxygen deprivation | Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel.
Williams SE, Wootton P, Mason HS, Bould J, Iles DE, Riccardi D, Peers C, Kemp PJ. | 01/21/2010 |
| high-potassium intake increases HO-2 expression in the kidney and that HO-dependent metabolites of heme, presumably CO, play a significant role in the regulation of Na+ transport in the loop of Henle | Inhibition of heme oxygenase decreases sodium and fluid absorption in the loop of Henle.
Wang T, Sterling H, Shao WA, Yan Q, Bailey MA, Giebisch G, Wang WH. | 01/21/2010 |