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    MEG8 maternally expressed 8, small nucleolar RNA host gene [ Homo sapiens (human) ]

    Gene ID: 79104, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    LncRNA MEG8 ameliorates Parkinson's disease neuro-inflammation through miR-485-3p/FBXO45 axis.

    LncRNA MEG8 ameliorates Parkinson's disease neuro-inflammation through miR-485-3p/FBXO45 axis.
    Lin X, Tao T, He X, Mao L, Pan L, Chen L.

    03/29/2024
    Silencing of lncRNA MEG8 Represses the Viability, Migration, and Invasion of Wilms' Tumor Cells through Mediating miR-23a-3p/CRK Axis.

    Silencing of lncRNA MEG8 Represses the Viability, Migration, and Invasion of Wilms' Tumor Cells through Mediating miR-23a-3p/CRK Axis.
    Shen J, Shu Q.

    10/22/2022
    MEG8: An Indispensable Long Non-coding RNA in Multiple Cancers.

    MEG8: An Indispensable Long Non-coding RNA in Multiple Cancers.
    Du Z, Tan F, Chen J, Wang B, Liu Y, Zhao F, Wu Y, Yuan C.

    08/27/2022
    MEG8 regulates Tissue Factor Pathway Inhibitor 2 (TFPI2) expression in the endothelium.

    MEG8 regulates Tissue Factor Pathway Inhibitor 2 (TFPI2) expression in the endothelium.
    Kremer V, Bink DI, Stanicek L, van Ingen E, Gimbel T, Hilderink S, Günther S, Nossent AY, Boon RA., Free PMC Article

    03/5/2022
    Knockdown of lncRNA MEG8 inhibits cell proliferation and invasion, but promotes cell apoptosis in hemangioma, via miR203induced mediation of the Notch signaling pathway.

    Knockdown of lncRNA MEG8 inhibits cell proliferation and invasion, but promotes cell apoptosis in hemangioma, via miR‑203‑induced mediation of the Notch signaling pathway.
    Hu Z, Liu X, Guo J, Zhuo L, Chen Y, Yuan H., Free PMC Article

    02/12/2022
    LncRNA MEG8 is upregulated in gestational diabetes mellitus (GDM) and predicted kidney injury.

    LncRNA MEG8 is upregulated in gestational diabetes mellitus (GDM) and predicted kidney injury.
    Zhang W, Cao D, Wang Y, Ren W.

    12/25/2021
    LncRNA MEG8 promotes tumor progression of non-small cell lung cancer via regulating miR-107/CDK6 axis.

    LncRNA MEG8 promotes tumor progression of non-small cell lung cancer via regulating miR-107/CDK6 axis.
    Liu Y, Li L, Shang P, Song X.

    09/4/2021
    LncRNA MEG8 plays an oncogenic role in hepatocellular carcinoma progression through miR-367-3p/14-3-3zeta/TGFbetaR1 axis.

    LncRNA MEG8 plays an oncogenic role in hepatocellular carcinoma progression through miR-367-3p/14-3-3ζ/TGFβR1 axis.
    Lou J, Yan W, Li QY, Zhu AK, Tan BQ, Dong R, Zou XZ, Liu T.

    08/21/2021
    Identification of MEG8/miR-378d/SOBP axis as a novel regulatory network and associated with immune infiltrates in ovarian carcinoma by integrated bioinformatics analysis.

    Identification of MEG8/miR-378d/SOBP axis as a novel regulatory network and associated with immune infiltrates in ovarian carcinoma by integrated bioinformatics analysis.
    Lei J, He ZY, Wang J, Hu M, Zhou P, Lian CL, Hua L, Wu SG, Zhou J., Free PMC Article

    07/31/2021
    LncRNA MEG8 promotes TNF-alpha expression by sponging miR-454-3p in bone-invasive pituitary adenomas.

    LncRNA MEG8 promotes TNF-α expression by sponging miR-454-3p in bone-invasive pituitary adenomas.
    Zhu HB, Li B, Guo J, Miao YZ, Shen YT, Zhang YZ, Zhao P, Li CZ., Free PMC Article

    07/24/2021
    Silencing long non-coding RNA MEG8 inhibits the proliferation and induces the ferroptosis of hemangioma endothelial cells by regulating miR-497-5p/NOTCH2 axis.

    Silencing long non-coding RNA MEG8 inhibits the proliferation and induces the ferroptosis of hemangioma endothelial cells by regulating miR-497-5p/NOTCH2 axis.
    Ma Q, Dai X, Lu W, Qu X, Liu N, Zhu C.

    07/24/2021
    Meg8 suppresses hepatic stellate cells activation and hepatocyte epithelial-mesenchymal transition through inhibiting the Notch pathway.

    LncRNA Meg8 suppresses activation of hepatic stellate cells and epithelial-mesenchymal transition of hepatocytes via the Notch pathway.
    Chen T, Lin H, Chen X, Li G, Zhao Y, Zheng L, Shi Z, Zhang K, Hong W, Han T.

    08/13/2020
    MEG8 regulates the proliferation and migration of VSMCs via the MEG8/miR-181a/PPARalpha axis.

    LncRNA MEG8 regulates vascular smooth muscle cell proliferation, migration and apoptosis by targeting PPARα.
    Zhang B, Dong Y, Zhao Z.

    11/30/2019
    Endogenous MEG8 lncRNA is indispensable for TGF-beta-induced epithelial-mesenchymal transition in A549 lung cancer and Panc1 pancreatic cancer cells.

    MEG8 long noncoding RNA contributes to epigenetic progression of the epithelial-mesenchymal transition of lung and pancreatic cancer cells.
    Terashima M, Ishimura A, Wanna-Udom S, Suzuki T., Free PMC Article

    06/29/2019
    MEG8-DMR is hypermethylated in each of 13 non-deletion Temple syndrome patients.

    New insights into the imprinted MEG8-DMR in 14q32 and clinical and molecular description of novel patients with Temple syndrome.
    Beygo J, Küchler A, Gillessen-Kaesbach G, Albrecht B, Eckle J, Eggermann T, Gellhaus A, Kanber D, Kordaß U, Lüdecke HJ, Purmann S, Rossier E, van de Nes J, van der Werf IM, Wenzel M, Wieczorek D, Horsthemke B, Buiting K., Free PMC Article

    12/16/2017
    MEG8, located in a cluster of imprinted genes on chromosome 14q32.3, is preferentially expressed from the maternal allele.

    Human-ovine comparative sequencing of a 250-kb imprinted domain encompassing the callipyge (clpg) locus and identification of six imprinted transcripts: DLK1, DAT, GTL2, PEG11, antiPEG11, and MEG8.
    Charlier C, Segers K, Wagenaar D, Karim L, Berghmans S, Jaillon O, Shay T, Weissenbach J, Cockett N, Gyapay G, Georges M., Free PMC Article

    10/26/2010
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