| OTU deubiquitinase, ubiquitin aldehyde binding 2 (OTUB2) modulates the stemness feature, chemoresistance, and epithelial-mesenchymal transition of colon cancer via regulating GINS complex subunit 1 (GINS1) expression. | OTU deubiquitinase, ubiquitin aldehyde binding 2 (OTUB2) modulates the stemness feature, chemoresistance, and epithelial-mesenchymal transition of colon cancer via regulating GINS complex subunit 1 (GINS1) expression.
Zhu W, Wu C, Liu Z, Zhao S, Huang J., Free PMC Article | 10/8/2024 |
| OTUB2 silencing promotes ovarian cancer via mitochondrial metabolic reprogramming and can be synthetically targeted by CA9 inhibition. | OTUB2 silencing promotes ovarian cancer via mitochondrial metabolic reprogramming and can be synthetically targeted by CA9 inhibition.
Nan Y, Wu X, Luo Q, Chang W, Zhao P, Zhang L, Liu Z., Free PMC Article | 08/1/2024 |
| Exploring the regulatory role of FBXL19-AS1 in triple-negative breast cancer through the miR-378a-3p/OTUB2 axis. | Exploring the regulatory role of FBXL19-AS1 in triple-negative breast cancer through the miR-378a-3p/OTUB2 axis.
Guo C, Zhang M, Jin X, Zhu C, Qian J, Tao M. | 05/9/2024 |
| Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1. | Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1.
Ren W, Xu Z, Chang Y, Ju F, Wu H, Liang Z, Zhao M, Wang N, Lin Y, Xu C, Chen S, Rao Y, Lin C, Yang J, Liu P, Zhang J, Huang C, Xia N., Free PMC Article | 01/5/2024 |
| RBM15 m[6] A modification-mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling. | RBM15 m(6) A modification-mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling.
Song Y, Wu Q. | 08/9/2023 |
| Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2. | Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2.
Ikeuchi K, Ivic N, Buschauer R, Cheng J, Fröhlich T, Matsuo Y, Berninghausen O, Inada T, Becker T, Beckmann R., Free PMC Article | 06/2/2023 |
| Deubiquitinase OTUB2 promotes intrahepatic cholangiocarcinoma progression by stabilizing the CTNNB1-ZEB1 axis. | Deubiquitinase OTUB2 promotes intrahepatic cholangiocarcinoma progression by stabilizing the CTNNB1-ZEB1 axis.
Wang J, Dong Y, Wei Z, Zhang Y, Wu N, Zhang C, Zhang Y, Zi R, Hao J, Liang H, Chen J. | 03/21/2023 |
| OTUB2 promotes the progression of endometrial cancer by regulating the PKM2-mediated PI3K/AKT signaling pathway. | OTUB2 promotes the progression of endometrial cancer by regulating the PKM2-mediated PI3K/AKT signaling pathway.
Zhang Q, Zhang J, Yao A, Tian X, Han Z, Yuan Y, Tao K, Yang X. | 01/21/2023 |
| Knockdown of otubain 2 inhibits liver cancer cell growth by suppressing NF-kappaB signaling. | Knockdown of otubain 2 inhibits liver cancer cell growth by suppressing NF-κB signaling.
Gu ZL, Huang J, Zhen LL. | 07/17/2021 |
| OTUB2 Promotes Homologous Recombination Repair Through Stimulating Rad51 Expression in Endometrial Cancer. | OTUB2 Promotes Homologous Recombination Repair Through Stimulating Rad51 Expression in Endometrial Cancer.
Wan Q, Chen Q, Cai D, Zhao Y, Wu X., Free PMC Article | 07/10/2021 |
| Activation and selectivity of OTUB-1 and OTUB-2 deubiquitinylases. | Activation and selectivity of OTUB-1 and OTUB-2 deubiquitinylases.
Sivakumar D, Kumar V, Naumann M, Stein M., Free PMC Article | 12/26/2020 |
| Taken together, the present study provides the first evidence that OTUB2 acts as a pivotal driver in non-small cell lung cancer tumorigenesis by stabilizing U2AF2 and activating the AKT/mTOR pathway and the Warburg effect. | OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer.
Li J, Cheng D, Zhu M, Yu H, Pan Z, Liu L, Geng Q, Pan H, Yan M, Yao M., Free PMC Article | 12/7/2019 |
| By elucidating a novel SUMOylation-mediated control mechanism of YAP/TAZ signaling in breast cancer metastasis, we have revealed previously unknown interplay between oncogenic KRAS and EGFR signaling and YAP/TAZ protein stability. | OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ.
Zhang Z, Du J, Wang S, Shao L, Jin K, Li F, Wei B, Ding W, Fu P, van Dam H, Wang A, Jin J, Ding C, Yang B, Zheng M, Feng XH, Guan KL, Zhang L. | 06/8/2019 |
| Data indicate the eubiquitinating enzyme otubain2 (OTUB2) as a regulator of GLI family zinc finger 2 (Gli2) protein degradation. | Regulation of Gli2 stability by deubiquitinase OTUB2.
Li XY, Mao XF, Tang XQ, Han QQ, Jiang LX, Qiu YM, Dai J, Wang YX. | 06/1/2019 |
| OTUB2 fine-tunes the speed of double-strand break-induced ubiquitination so that the appropriate DNA repair pathway is chosen | Fine-tuning of DNA damage-dependent ubiquitination by OTUB2 supports the DNA repair pathway choice.
Kato K, Nakajima K, Ui A, Muto-Terao Y, Ogiwara H, Nakada S. | 04/26/2014 |
| OTUB2 is a novel promoter of viability and insulin secretion in human beta cells. OTUB2 acts through the inhibition of NF-kappaB signalling. | Otubain 2 is a novel promoter of beta cell survival as revealed by siRNA high-throughput screens of human pancreatic islets.
Beck A, Vinik Y, Shatz-Azoulay H, Isaac R, Streim S, Jona G, Boura-Halfon S, Zick Y. | 12/28/2013 |
| Findings suggest that OTUB1 and OTUB2 negatively regulate virus-triggered type I IFN induction and cellular antiviral response by deubiquitinating TRAF3 and -6. | Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6.
Li S, Zheng H, Mao AP, Zhong B, Li Y, Liu Y, Gao Y, Ran Y, Tien P, Shu HB., Free PMC Article | 05/31/2010 |
| Data report the first crystal structure of an OTU superfamily protein, otubain 2, at 2.1 A resolution and propose a model for otubain-ubiquitin binding. | Crystal structure of human otubain 2.
Nanao MH, Tcherniuk SO, Chroboczek J, Dideberg O, Dessen A, Balakirev MY., Free PMC Article | 01/21/2010 |