| Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons. | Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons.
Subkhangulova A, Gonzalez-Lozano MA, Groffen AJA, van Weering JRT, Smit AB, Toonen RF, Verhage M., Free PMC Article | 09/28/2023 |
| Genetic ablation of synaptotagmin-9 alters tomosyn-1 function to increase insulin secretion from pancreatic beta-cells improving glucose clearance. | Genetic ablation of synaptotagmin-9 alters tomosyn-1 function to increase insulin secretion from pancreatic β-cells improving glucose clearance.
Rahman MM, Pathak A, Schueler KL, Alsharif H, Michl A, Alexander J, Kim JA, Bhatnagar S., Free PMC Article | 07/19/2023 |
| Data indicate that bidirectional moving tomosyn-1 (Stxbp5) and tomosyn-2 (Stxbp5l) puncta were observed. | Tomosyn associates with secretory vesicles in neurons through its N- and C-terminal domains.
Geerts CJ, Mancini R, Chen N, Koopmans FTW, Li KW, Smit AB, van Weering JRT, Verhage M, Groffen AJA., Free PMC Article | 10/14/2017 |
| Mouse Embryonic Stem (mES) cells self-differentiated into arginine vasopressin (AVP) neurons (mES-AVP) that expressed tomosyn and two transmembrane SNARE proteins, including SNAP25 and syntaxin1. Tomosyn negatively regulates arginine vasopressin secretion in embryonic stem cell-derived neurons. | Tomosyn Negatively Regulates Arginine Vasopressin Secretion in Embryonic Stem Cell-Derived Neurons.
Takeuchi S, Iwama S, Takagi H, Kiyota A, Nakashima K, Izumida H, Fujisawa H, Iwata N, Suga H, Watanabe T, Kaibuchi K, Oiso Y, Arima H, Sugimura Y., Free PMC Article | 06/3/2017 |
| PIASgamma-dependent modification of tomosyn-1 with SUMO-2/3 presents a novel mechanism to adapt secretory strength to the dynamic synaptic environment. | Tomosyn interacts with the SUMO E3 ligase PIASγ.
Geerts CJ, Jacobsen L, van de Bospoort R, Verhage M, Groffen AJ., Free PMC Article | 04/2/2016 |
| STXBP5 inhibits endothelial exocytosis and promotes platelet secretion | Syntaxin-binding protein STXBP5 inhibits endothelial exocytosis and promotes platelet secretion.
Zhu Q, Yamakuchi M, Ture S, de la Luz Garcia-Hernandez M, Ko KA, Modjeski KL, LoMonaco MB, Johnson AD, O'Donnell CJ, Takai Y, Morrell CN, Lowenstein CJ., Free PMC Article | 02/14/2015 |
| STXBP5 is required for normal arterial hemostasis, due to its contributions to platelet granule cargo packaging and secretion | Platelet secretion and hemostasis require syntaxin-binding protein STXBP5.
Ye S, Huang Y, Joshi S, Zhang J, Yang F, Zhang G, Smyth SS, Li Z, Takai Y, Whiteheart SW., Free PMC Article | 02/14/2015 |
| regulates SNARE complex formation and synaptic vesicle fusion. (review) | [Roles of tomosyn in regulated synaptic vesicle fusion].
Yamamoto Y, Sakisaka T. | 01/29/2011 |
| It regulates vesicle fusion. (review) | [Novel roles of tomosyn in regulated vesicle fusion].
Sakisaka T. | 03/1/2010 |
| Tomosyn inhibits neurotransmitter release by catalyzing oligomerization of the SNARE complex through the N-terminal WD-40 repeat domain in addition to the inhibitory activity of the C-terminal (VAMP)-like domain. | Dual inhibition of SNARE complex formation by tomosyn ensures controlled neurotransmitter release.
Sakisaka T, Yamamoto Y, Mochida S, Nakamura M, Nishikawa K, Ishizaki H, Okamoto-Tanaka M, Miyoshi J, Fujiyoshi Y, Manabe T, Takai Y., Free PMC Article | 01/21/2010 |
| Interacts with SNAP23 and Syntaxin4 and plays a role in Insulin-stimulated GLUT4 translocacion. | Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation.
Widberg CH, Bryant NJ, Girotti M, Rea S, James DE. | 01/21/2010 |
| Tomosyn-1 is involved in a post-docking event that prepares secretory granules for fusion and is necessary to sustain exocytosis of pancreatic beta-cells in response to insulin secretagogues. | Tomosyn-1 is involved in a post-docking event required for pancreatic beta-cell exocytosis.
Cheviet S, Bezzi P, Ivarsson R, Renström E, Viertl D, Kasas S, Catsicas S, Regazzi R. | 01/21/2010 |
| The interaction between syntaxin4 and Munc18c in adipocytes results in enhancement of insulin-stimulated GLUT4 externalization. | Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization.
Kanda H, Tamori Y, Shinoda H, Yoshikawa M, Sakaue M, Udagawa J, Otani H, Tashiro F, Miyazaki J, Kasuga M., Free PMC Article | 01/21/2010 |
| In the pancreatic beta-cell, tomosyn negatively regulates insulin exocytosis. | Tomosyn is expressed in beta-cells and negatively regulates insulin exocytosis.
Zhang W, Lilja L, Mandic SA, Gromada J, Smidt K, Janson J, Takai Y, Bark C, Berggren PO, Meister B. | 01/21/2010 |