| circ_0000592 facilitates the progression of esophageal squamous cell carcinoma via miR-155-5p/FZD5 axis. | circ_0000592 facilitates the progression of esophageal squamous cell carcinoma via miR-155-5p/FZD5 axis.
He J, Yu K, Liang G, Shen W, Tian H. | 08/6/2024 |
| Exploiting spatiotemporal regulation of FZD5 during neural patterning for efficient ventral midbrain specification. | Exploiting spatiotemporal regulation of FZD5 during neural patterning for efficient ventral midbrain specification.
Yang A, Chidiac R, Russo E, Steenland H, Pauli Q, Bonin R, Blazer LL, Adams JJ, Sidhu SS, Goeva A, Salahpour A, Angers S., Free PMC Article | 03/11/2024 |
| Insilco prediction of the role of the FriZZled5 gene in colorectal cancer. | Insilco prediction of the role of the FriZZled5 gene in colorectal cancer.
Hosseini-Abgir A, Naghizadeh MM, Igder S, Miladpour B. | 09/20/2023 |
| A desert lncRNA HIDEN regulates human endoderm differentiation via interacting with IMP1 and stabilizing FZD5 mRNA. | A desert lncRNA HIDEN regulates human endoderm differentiation via interacting with IMP1 and stabilizing FZD5 mRNA.
Lu P, Yang J, Li M, Wen S, Zhang T, Yan C, Liu R, Xiao Y, Wang X, Jiang W., Free PMC Article | 05/15/2023 |
| Single-Cell Characterization of the Frizzled 5 (Fz5) Mutant Mouse and Human Persistent Fetal Vasculature (PFV). | Single-Cell Characterization of the Frizzled 5 (Fz5) Mutant Mouse and Human Persistent Fetal Vasculature (PFV).
Chen Y, Wu C, Peng S, Guo D, Ouyang H, Wei Y, Ju R, Ding X, Xie Z, Liu C., Free PMC Article | 03/24/2023 |
| Individuals with heterozygous variants in the Wnt-signalling pathway gene FZD5 delineate a phenotype characterized by isolated coloboma and variable expressivity. | Individuals with heterozygous variants in the Wnt-signalling pathway gene FZD5 delineate a phenotype characterized by isolated coloboma and variable expressivity.
Holt R, Goudie D, Verde AD, Gardham A, Ramond F, Putoux A, Sarkar A, Clowes V, Clayton-Smith J, Banka S, Cortazar Galarza L, Thuret G, Ubeda Erviti M, Zurutuza Ibarguren A, Sáez Villaverde R, Tamayo Durán A, Ayuso C, Bax DA, Plaisancie J, Corton M, Chassaing N, Calvas P, Ragge NK. | 01/28/2023 |
| Aberrant Cholesterol Metabolism and Wnt/beta-Catenin Signaling Coalesce via Frizzled5 in Supporting Cancer Growth. | Aberrant Cholesterol Metabolism and Wnt/β-Catenin Signaling Coalesce via Frizzled5 in Supporting Cancer Growth.
Zheng S, Lin J, Pang Z, Zhang H, Wang Y, Ma L, Zhang H, Zhang X, Chen M, Zhang X, Zhao C, Qi J, Cao L, Wang M, He X, Sheng R., Free PMC Article | 10/15/2022 |
| RNF43 R117fs mutant positively regulates Wnt/beta-catenin signaling by failing to internalize FZD expressed on the cell surface. | RNF43 R117fs mutant positively regulates Wnt/β-catenin signaling by failing to internalize FZD expressed on the cell surface.
Cho AR, Sul HJ, Kim YJ, Kim B, Zang DY., Free PMC Article | 05/14/2022 |
| Cardiac Wnt5a and Wnt11 promote fibrosis by the crosstalk of FZD5 and EGFR signaling under pressure overload. | Cardiac Wnt5a and Wnt11 promote fibrosis by the crosstalk of FZD5 and EGFR signaling under pressure overload.
Zou Y, Pan L, Shen Y, Wang X, Huang C, Wang H, Jin X, Yin C, Wang Y, Jia J, Qian J, Zou Y, Gong H, Ge J., Free PMC Article | 02/5/2022 |
| WNT7B represses epithelial-mesenchymal transition and stem-like properties in bladder urothelial carcinoma. | WNT7B represses epithelial-mesenchymal transition and stem-like properties in bladder urothelial carcinoma.
Na L, Wang Z, Bai Y, Sun Y, Dong D, Wang W, Zhao C. | 01/1/2022 |
| FZD5 prevents epithelial-mesenchymal transition in gastric cancer. | FZD5 prevents epithelial-mesenchymal transition in gastric cancer.
Dong D, Na L, Zhou K, Wang Z, Sun Y, Zheng Q, Gao J, Zhao C, Wang W., Free PMC Article | 01/1/2022 |
| FZD5 regulates cellular senescence in human mesenchymal stem/stromal cells. | FZD5 regulates cellular senescence in human mesenchymal stem/stromal cells.
Harada S, Mabuchi Y, Kohyama J, Shimojo D, Suzuki S, Kawamura Y, Araki D, Suyama T, Kajikawa M, Akazawa C, Okano H, Matsuzaki Y., Free PMC Article | 12/11/2021 |
| Confirming and expanding the phenotypes of FZD5 variants: Coloboma, inferior chorioretinal hypoplasia, and high myopia. | Confirming and expanding the phenotypes of FZD5 variants: Coloboma, inferior chorioretinal hypoplasia, and high myopia.
Jiang Y, Ouyang J, Li S, Xiao X, Sun W, Zhang Q., Free PMC Article | 11/6/2021 |
| Confirmation of FZD5 implication in a cohort of 50 patients with ocular coloboma. | Confirmation of FZD5 implication in a cohort of 50 patients with ocular coloboma.
Aubert-Mucca M, Pernin-Grandjean J, Marchasson S, Gaston V, Habib C, Meunier I, Sigaudy S, Kaplan J, Roche O, Denis D, Bitoun P, Haye D, Verloes A, Calvas P, Chassaing N, Plaisancié J., Free PMC Article | 08/21/2021 |
| FZD5 contributes to TNBC proliferation, DNA damage repair and stemness. | FZD5 contributes to TNBC proliferation, DNA damage repair and stemness.
Sun Y, Wang Z, Na L, Dong D, Wang W, Zhao C., Free PMC Article | 04/13/2021 |
| Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling. | Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling.
Tsutsumi N, Mukherjee S, Waghray D, Janda CY, Jude KM, Miao Y, Burg JS, Aduri NG, Kossiakoff AA, Gati C, Garcia KC., Free PMC Article | 02/13/2021 |
| Study shows that FZD5 exhibited a conformational change after the addition of WNT-5A, FZD5 activated Galphaq and its downstream effectors upon stimulation. | FZD(5) is a Gα(q)-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs.
Wright SC, Cañizal MCA, Benkel T, Simon K, Le Gouill C, Matricon P, Namkung Y, Lukasheva V, König GM, Laporte SA, Carlsson J, Kostenis E, Bouvier M, Schulte G, Hoffmann C. | 10/26/2019 |
| The current study demonstrates a pro-angiogenic role of Fzd5, which was shown to be involved in endothelial tubule formation, cell cycle progression and migration, and partly does so by repression of PKC/Ets1-mediated transcription of Flt1 and Angpt2. | Endothelial loss of Fzd5 stimulates PKC/Ets1-mediated transcription of Angpt2 and Flt1.
Brandt MM, van Dijk CGM, Chrifi I, Kool HM, Bürgisser PE, Louzao-Martinez L, Pei J, Rottier RJ, Verhaar MC, Duncker DJ, Cheng C., Free PMC Article | 10/26/2019 |
| Results showed that mRNA expression of FZD5 was upregulated in nasal polyps and significantly higher in nasal polyp samples from patients with eosinophilic chronic rhinosinusitis (CRSwNP) than in those with non-eosinophilic CRSwNP. These findings demonstrate that FZD5 expression in nasal mucosal epithelial cells is correlated with inflammatory cells and might play a role in the pathogenesis of eosinophilic CRSwNP. | Upregulation of FZD5 in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps by Epigenetic Modification.
Kim JY, Cha MJ, Park YS, Kang J, Choi JJ, In SM, Kim DK., Free PMC Article | 09/7/2019 |
| oligomerizations of FZDs and LRP5/6 can integrate the cytoplasmic protein Dishevelled into the LRP5/6 signalosome, resulting in a robust activation of ligand-independent beta-catenin signaling | Oligomerization of Frizzled and LRP5/6 protein initiates intracellular signaling for the canonical WNT/β-catenin pathway.
Hua Y, Yang Y, Li Q, He X, Zhu W, Wang J, Gan X., Free PMC Article | 04/20/2019 |
| KLF9 suppressed tumorigenicity of the pancreatic ductal adenocarcinoma by negatively regulating frizzled-5. | Krüppel-like factor 9 suppressed tumorigenicity of the pancreatic ductal adenocarcinoma by negatively regulating frizzled-5.
Ji P, Fan X, Ma X, Wang X, Zhang J, Mao Z. | 10/13/2018 |
| miR-224 down-regulated the Wnt/beta-catenin signaling possibly by binding to Frizzled 5 and inhibited proliferation and migration of breast cancer cells | MicroRNA-224 inhibits proliferation and migration of breast cancer cells by down-regulating Fizzled 5 expression.
Liu F, Liu Y, Shen J, Zhang G, Han J., Free PMC Article | 02/24/2018 |
| FZD5 is required for the growth of RNF43-mutant pancreatic ductal adenocarcinoma cells. | Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.
Steinhart Z, Pavlovic Z, Chandrashekhar M, Hart T, Wang X, Zhang X, Robitaille M, Brown KR, Jaksani S, Overmeer R, Boj SF, Adams J, Pan J, Clevers H, Sidhu S, Moffat J, Angers S. | 08/19/2017 |
| Long non-coding RNA FTH1P3 facilitates oral squamous cell carcinoma progression by regulating miR-224-5p and FZD5. | Long non-coding RNA FTH1P3 facilitates oral squamous cell carcinoma progression by acting as a molecular sponge of miR-224-5p to modulate fizzled 5 expression.
Zhang CZ. | 02/18/2017 |
| Novel frameshift mutation in FZD5 in a large, extended family was identified in which non-syndromic OC segregated as an autosomal dominant disorder. Functional analysis of the mutant protein, using zebrafish, mouse retinal explants and co-culture assays, strongly suggests a dominant-negative effect on WNT signaling, which is likely responsible for optic fissure closure defects. | A secreted WNT-ligand-binding domain of FZD5 generated by a frameshift mutation causes autosomal dominant coloboma.
Liu C, Widen SA, Williamson KA, Ratnapriya R, Gerth-Kahlert C, Rainger J, Alur RP, Strachan E, Manjunath SH, Balakrishnan A, Floyd JA, UK10K Consortium, Li T, Waskiewicz A, Brooks BP, Lehmann OJ, FitzPatrick DR, Swaroop A., Free PMC Article | 01/28/2017 |