| Mechanisms underlying Myosin 10's contribution to the maintenance of mitotic spindle bipolarity. | Mechanisms underlying Myosin 10's contribution to the maintenance of mitotic spindle bipolarity.
Yim YI, Pedrosa A, Wu X, Chinthalapudi K, Cheney RE, Hammer JA., Free PMC Article | 01/16/2024 |
| Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe skeletal muscle hypoplasia in postnatal mice. | Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe skeletal muscle hypoplasia in postnatal mice.
Hitachi K, Kiyofuji Y, Yamaguchi H, Nakatani M, Inui M, Tsuchida K. | 12/17/2022 |
| MYH10 Governs Adipocyte Function and Adipogenesis through Its Interaction with GLUT4. | MYH10 Governs Adipocyte Function and Adipogenesis through Its Interaction with GLUT4.
Kislev N, Mor-Yossef Moldovan L, Barak R, Egozi M, Benayahu D., Free PMC Article | 03/26/2022 |
| Filopodia powered by class x myosin promote fusion of mammalian myoblasts. | Filopodia powered by class x myosin promote fusion of mammalian myoblasts.
Hammers DW, Hart CC, Matheny MK, Heimsath EG, Lee YI, Hammer JA 3rd, Cheney RE, Sweeney HL., Free PMC Article | 10/30/2021 |
| Conditional Myh9 and Myh10 inactivation in adult mouse renal epithelium results in progressive kidney disease. | Conditional Myh9 and Myh10 inactivation in adult mouse renal epithelium results in progressive kidney disease.
Otterpohl KL, Busselman BW, Ratnayake I, Hart RG, Hart KR, Evans CM, Phillips CL, Beach JR, Ahrenkiel P, Molitoris BA, Surendran K, Chandrasekar I., Free PMC Article | 06/12/2021 |
| MYH10 plays an essential and non-redundant role in cytokinesis during meiotic cell divisions of the male germline. | Non-muscle myosin IIB is essential for cytokinesis during male meiotic cell divisions.
Yang F, Wei Q, Adelstein RS, Wang PJ., Free PMC Article | 11/25/2020 |
| contact guidance is preserved following loss of NM2B and that expression of NM2A alone is sufficient to establish an appropriate orientation of the cells. | The role of nonmuscle myosin 2A and 2B in the regulation of mesenchymal cell contact guidance.
Zhovmer AS, Tabdanov ED, Miao H, Wen H, Chen J, Luo X, Ma X, Provenzano PP, Adelstein RS., Free PMC Article | 07/28/2020 |
| knockdown of NMIIA or NMIIB lowers the growth rate and tumor volume of 3-methylcholanthrene-induced tumor in vivo. | Nonmuscle myosin IIA and IIB differentially modulate migration and alter gene expression in primary mouse tumorigenic cells.
Halder D, Saha S, Singh RK, Ghosh I, Mallick D, Dey SK, Ghosh A, Das BB, Ghosh S, Jana SS., Free PMC Article | 01/11/2020 |
| These findings reveal critical roles for Myh10 in alveologenesis at least in part via the regulation of extracellular matrix remodeling. | Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease.
Kim HT, Yin W, Jin YJ, Panza P, Gunawan F, Grohmann B, Buettner C, Sokol AM, Preussner J, Guenther S, Kostin S, Ruppert C, Bhagwat AM, Ma X, Graumann J, Looso M, Guenther A, Adelstein RS, Offermanns S, Stainier DYR., Free PMC Article | 04/27/2019 |
| data therefore reveal a role for NMIIA and NMIIB as negative regulators of proliferation in the mammary epithelium. | Mosaic loss of non-muscle myosin IIA and IIB is sufficient to induce mammary epithelial proliferation.
Nguyen-Ngoc KV, Silvestri VL, Georgess D, Fairchild AN, Ewald AJ., Free PMC Article | 05/26/2018 |
| A novel mechanism linking epicardial formation and epicardial function to the activity of the cytoplasmic motor protein NMIIB. | Nonmuscle myosin IIB regulates epicardial integrity and epicardium-derived mesenchymal cell maturation.
Ma X, Sung DC, Yang Y, Wakabayashi Y, Adelstein RS., Free PMC Article | 02/10/2018 |
| Positional cloning and candidate gene analysis revealed that the EHC phenotype results from a point mutation in a splice donor site of the Myh10 gene, which encodes NMHC IIB. Our studies on the EHC mutant demonstrate a requirement for NMHC IIB in epicardial function and coronary vessel formation, highlighting the importance of this protein in cardiac development and ultimately, embryonic survival. | Non-muscle myosin IIB (Myh10) is required for epicardial function and coronary vessel formation during mammalian development.
Ridge LA, Mitchell K, Al-Anbaki A, Shaikh Qureshi WM, Stephen LA, Tenin G, Lu Y, Lupu IE, Clowes C, Robertson A, Barnes E, Wright JA, Keavney B, Ehler E, Lovell SC, Kadler KE, Hentges KE., Free PMC Article | 12/2/2017 |
| Data show that deletion of myosin heavy chain II-A (Myh9)/myosin heavy chain II-B (Myh10) caused severe hydroureter/hydronephrosis at birth. | Non-muscle myosin II deletion in the developing kidney causes ureter-bladder misconnection and apical extrusion of the nephric duct lineage epithelia.
Haque F, Kaku Y, Fujimura S, Ohmori T, Adelstein RS, Nishinakamura R., Free PMC Article | 09/30/2017 |
| Hsc70 interacts with FILIP to mediate its effects on non-muscle myosin IIb and to regulate spine morphology | Subcellular distribution of non-muscle myosin IIb is controlled by FILIP through Hsc70.
Yagi H, Takabayashi T, Xie MJ, Kuroda K, Sato M., Free PMC Article | 09/9/2017 |
| cytokinesis failure in megakaryocytes is the consequence of both the absence of NMIIB and a low RhoA activity that impairs NMIIA localization at the cleavage furrow through increased actin turnover. | Activity of nonmuscle myosin II isoforms determines localization at the cleavage furrow of megakaryocytes.
Roy A, Lordier L, Mazzi S, Chang Y, Lapierre V, Larghero J, Debili N, Raslova H, Vainchenker W. | 08/5/2017 |
| The experimental and in silico results suggest two divergent evolutionary pathways: NMIIA and NMIIB evolved to possess S100A4-dependent and -independent regulations, respectively. | Structural determinants governing S100A4-induced isoform-selective disassembly of nonmuscle myosin II filaments.
Kiss B, Kalmár L, Nyitray L, Pál G. | 06/24/2017 |
| The novel finding that calponin 2 regulates myosin-dependent CTF in non-muscle cells demonstrates a mechanism for controlling cell motility-based functions | Deletion of Calponin 2 in Mouse Fibroblasts Increases Myosin II-Dependent Cell Traction Force.
Hossain MM, Zhao G, Woo MS, Wang JH, Jin JP. | 05/7/2017 |
| Study suggests that NMIIB remains constitutively active in support of methamphetamine associations, continuing to drive actin polymerization, such that memories associated with methamphetamine can be selectively targeted without the need for retrieval days to weeks after learning | Nonmuscle myosin IIB as a therapeutic target for the prevention of relapse to methamphetamine use.
Young EJ, Blouin AM, Briggs SB, Sillivan SE, Lin L, Cameron MD, Rumbaugh G, Miller CA., Free PMC Article | 01/14/2017 |
| A central biophysical role for NMIIB in nuclear translocation during 3D invasive migration. | Non-muscle myosin IIB is critical for nuclear translocation during 3D invasion.
Thomas DG, Yenepalli A, Denais CM, Rape A, Beach JR, Wang YL, Schiemann WP, Baskaran H, Lammerding J, Egelhoff TT., Free PMC Article | 11/7/2015 |
| We have discovered that NMIIB is the major isoform regulating Schaffer collateral inputs, and that this regulation is restricted to early postnatal development. | Input-specific regulation of hippocampal circuit maturation by non-muscle myosin IIB.
Ozkan ED, Aceti M, Creson TK, Rojas CS, Hubbs CR, McGuire MN, Kakad PP, Miller CA, Rumbaugh G., Free PMC Article | 10/10/2015 |
| regulates morphogenesis of immature nephrons | Nonmuscle Myosin II Regulates the Morphogenesis of Metanephric Mesenchyme-Derived Immature Nephrons.
Recuenco MC, Ohmori T, Tanigawa S, Taguchi A, Fujimura S, Conti MA, Wei Q, Kiyonari H, Abe T, Adelstein RS, Nishinakamura R., Free PMC Article | 07/25/2015 |
| These results supported the hypothesis that, like NMHC-IIA, NMHC-IIB associated with herpes simplex virus 1 gB and mediated herpes simplex virus 1 entry. | Nonmuscle myosin heavy chain IIb mediates herpes simplex virus 1 entry.
Arii J, Hirohata Y, Kato A, Kawaguchi Y., Free PMC Article | 04/11/2015 |
| Point mutation in Myh10 causes major defects in heart development and ventral body wall closure. | A point mutation in Myh10 causes major defects in heart development and body wall closure.
Ma X, Adelstein RS., Free PMC Article | 04/4/2015 |
| The C-terminal domain of MYH10 is responsible for the specific localization of myosin II in megakaryocyte contractile ring. | Carboxyl-terminal-dependent recruitment of nonmuscle myosin II to megakaryocyte contractile ring during polyploidization.
Badirou I, Pan J, Legrand C, Wang A, Lordier L, Boukour S, Roy A, Vainchenker W, Chang Y., Free PMC Article | 01/3/2015 |
| The results of this study propose a pivotal role of NM II in cytoskeleton organization during microglial activation. | A pivotal role of nonmuscle myosin II during microglial activation.
Janßen S, Gudi V, Prajeeth CK, Singh V, Stahl K, Heckers S, Skripuletz T, Pul R, Trebst C, Tsiavaliaris G, Stangel M. | 12/20/2014 |